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| 1 | Where were the monsoon regions and arid zones in Asia prior to the Tibetan Plateau uplift?显示文摘The impact of the Tibetan Plateau uplit on the Asian monsoons and inland arid climates is an important but also controversial question in studies of paleoenvironmental change during the Cenozoic. In order to achieve a good understanding of the background for the formation of the Asian monsoons and arid environments, it is necessary to know the characteristics of the distribution of monsoon regions and arid zones in Asia before the plateau uplit. In this study, we discuss in detail the paterns of distribution of the Asian monsoon and arid regions before the plateau uplit on the basis of modeling results without topography from a global coupled atmosphere–ocean general circulation model, compare our results with previous simulation studies and available biogeological data, and review the uncertainties in the current knowledge. Based on what we know at the moment, tropical monsoon climates existed south of 20?N in South and Southeast Asia before the plateau uplit, while the East Asian monsoon was entirely absent in the extratropics. hese tropical monsoons mainly resulted from the seasonal shits of the Inter-Tropical Convergence Zone. here may have been a quasi-monsoon region in central-southern Siberia. Most of the arid regions in the Asian continent were limited to the latitudes of 20–40?N, corresponding to the range of the subtropical high pressure year-around. In the meantime, the present-day arid regions located in the relatively high latitudes in Central Asia were most likely absent before the plateau uplit. he main results from the above modeling analyses are qualitatively consistent with the available biogeological data. hese results highlight the importance of the uplit of the Tibetan Plateau in the Cenozoic evolution of the Asian climate patern of dry–wet conditions. Future studies should be focused on efects of the changes in land–sea distribution and atmospheric CO2 concentrations before and ater the plateau uplit, and also on cross-comparisons between numerical simulations and geological evidence, so that a comprehensive understanding of the evolution of the Cenozoic paleoenvironments in Asia can be achieved. | Xiaodong Liu Qingchun Guo Zhengtang Guo Zhi-Yong Yin Buwen Dong Robin Smith | 2015 | National Science Review2015，2，4： | 12 |
| 2 | Continental drift, plateau uplift, and the evolutions of monsoon and arid regions in Asia, Africa, and Australia during the Cenozoic显示文摘Monsoon and arid regions in the Asia-Africa-Australia(A-A-A) realm occupy more than 60% of the total area of these continents. Geological evidence showed that significant changes occurred to the A-A-A environments of the monsoon and arid regions, the land-ocean configuration in the Eastern Hemisphere, and the topography of the Tibetan Plateau(TP) in the Cenozoic. Motivated by this background, numerical experiments for 5 typical geological periods during the Cenozoic were conducted using a coupled ocean-atmosphere general circulation model to systemically explore the formations and evolutionary histories of the Cenozoic A-A-A monsoon and arid regions under the influences of continental drift and plateau uplift. Results of the numerical experiments indicate that the timings and causes of the formations of monsoon and arid regions in the A-A-A realm were very different. The northern and southern African monsoons existed during the mid-Paleocene, while the South Asian monsoon appeared in the Eocene after the Indian Subcontinent moved into the tropical Northern Hemisphere. In contrast, the East Asian monsoon and northern Australian monsoon were established much later in the Miocene. The establishment of the tropical monsoons in northern and southern Africa, South Asia, and Australia were determined by both the continental drift and seasonal migration of the Inter-Tropical Convergence Zone(ITCZ), while the position and height of the TP were the key factor for the establishment of the East Asian monsoon. The presence of the subtropical arid regions in northern and southern Africa,Asia, and Australia depended on the positions of the continents and the control of the planetary scale subtropical high pressure zones, while the arid regions in the Arabian Peninsula and West Asia were closely related to the retreat of the Paratethys Sea. The formation of the mid-latitude arid region in the Asian interior, on the other hand, was the consequence of the uplift of the TP.These results from this study provide insight to the important roles played by the earth's tectonic boundary conditions in the formations and evolutions of regional climates during geological times. | Xiaodong LIU Buwen DONG Zhi-Yong YIN Robin S.SMITH Qingchun GUO | 2019 | Science China Earth Sciences2019，62，7： | 5 |
| 3 | β-catenin activation in hair follicle dermal stem cells in duces ectopic hair outgrowth and skin fibrosis显示文摘Hair follicle dermal sheath(DS)harbors hair follicle dermal stem cells(hfDSCs),which can be recruited to replenish DS and dermal papilla(DP).Cultured DS cells can differentiate into various cell lineages in vitro.However,it is unclear how its plasticity is modulated in vivo.Wnt/β-catenin signaling plays an important role in maintaining stem cells of various lineages and is required for HF development and regeneration.Here we report that activation ofβ-catenin in DS generates ectopic HF outgrowth(EF)by reprogramming HF epidermal cells and DS cells themselves,and endows DS cells with hair inducing ability.Epidermal homeostasis of pre-existing HFs is disrupted.Additionally,cell-autonomous progressive skin fibrosis is prominent in dermis,where the excessive fibroblasts largely originate from DS.Gene expression analysis of purified DS cells with activatedβ-catenin revealed significantly increased expression of Bmp,Fgf,and Notch ligands and administration of Bmp,Fgf,or Notch signaling inhibitor attenuates EF formation.In summary,our findings advance the current knowledge of high plasticity of DS cells and provide an insight into understanding how Wnt/β-catenin signaling controls DS cell behaviors. | Yixin Tao Qingchun Yang Lei Wang Jie Zhang Xuming Zhu Qianqian Sun Yunbin Han Qian Luo Yushu Wang Xizhi Guo Ji Wu Baojie Li Xiao Yang Lin He Gang Ma | 2019 | Journal of Molecular Cell Biology2019，11，1： | 4 |
| 4 | Long-term Fiber Photometry for Neuroscience Studies显示文摘Fiber photometry is a sensitive and easy way to detect changes in fluorescent signals. The combination of fiber photometry with various fluorescent biomarkers has substantially advanced neuroscience research over the last decade. Despite the wide use of fiber photometry in biomedical fields, the lack of a detailed and comprehensive protocol has limited progress and sometimes complicated the interpretation of data. Here, we describe detailed procedures of fiber photometry for the long-term monitoring of neuronal activity in freely-behaving animals, including surgery, apparatus setup, data collection, and analysis. | Yi Li Zhixiang Liu Qingchun Guo Minmin Luo | 2019 | Neuroscience Bulletin2019，35，3： | 3 |
| 5 | Evolution of Neolithic site distribution(9.0–4.0 ka BP) in Anhui,East China显示文摘Based on archaeological surveys of Neolithic cultural development and GIS spatial analysis,this study reproduced the main characteristics of temporal distribution and settlement selection of the sites from the Neolithic Age in Anhui and identified a relationship between environmental evolution and human activity.The results show that altitude,slope direction,and slope gradient were consistent among the settlements at different stages of the Neolithic Age in Anhui,and the sites were mostly distributed in hilly and plain areas on southeast-or south-facing slopes of low gradients close to rivers.We determined that early Neolithic Age(9.0–7.0 ka BP) sites were scattered in small numbers and likely had little cultural exchange with communities of other provinces.The environmental characteristics of various regions in Anhui indicated that the climate was warm and humid with extensive water distribution.The sites of the mid Neolithic Age(7.0–5.0 ka BP) increased rapidly with wide distribution.They were mainly distributed in the plain area north of the Huaihe River and the southwestern areas of Anhui.In the mid Neolithic Age,the warm and humid climate gradually dried,and our ancestors slowly developed cultural exchanges.The largest number of sites existed during the late Neolithic Age(5.0–4.0 ka BP),and were distributed throughout the province.During this period,the overall climate was relatively dry,but humans could still obtain water and other resources through migration.The relatively benign climate facilitated cultural interaction and exchange,which increased during this time,and the Wanjiang culture matured.We also determined that as early civilization evolved,cultures in different regions responded differently to environmental changes.In humid subtropical regions,especially in low-lying plains and areas beside lakes,rivers,and coastal areas,the relatively dry climate in the late period of the middle Holocene,prefaced by a period of high humidity,was conducive to the development of human culture.The evidence from the Neolithic settlements in Anhui therefore reflects this subtropical man-land relationship between cultural development and environmental conditions. | WU Li SUN Xiaoling SUN Wei ZHU Cheng ZHU Tongxin LU Shuguang ZHOU Hui GUO Qingchun GUAN Houchun XIE Wei KE Rui LIN Guiping | 2020 | Journal of Geographical Sciences2020，30，9： | 2 |
| 6 | Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients显示文摘 | Dekai Qiu Qixia Wang Hui Wang Qing Xie Guoqing Zang Hong Jiang Chuantao Tu Jinsheng Guo Shuncai Zhang Jianshe Wang Yi Lu Ying Han Lei Shen Xiaoyu Chen Xiqi Hu Xiaojin Wang Chengwei Chen Qingchun Fu Xiong Ma | 2010 | Journal of Hepatology2010，，： | 2 |
| 7 | Combination of MALDI-TOF mass spectrometry with immobilized enzyme microreactor for peptide mapping显示文摘 | Honghai Jiang Hanfa Zou Hailin Wang Qiang Zhang Jianyi Ni Qingchun Zhang Zhong Guo Xiaoming Chen | 2000 | Science in China Series B: Chemistry2000，，6： | 1 |
| 8 | A method for the analysis of low-mass molecules by MALDI-TOF mass spectrometry显示文摘 | Guo Zhong Zhang Qingchun Zou Hanfa | 2002 | Anal Chem2002，74，7： | 1 |
| 9 | INFLUENCES OF TRACE ADDITIONS OF STRONTIUM AND PHOSPHORUS ON ELECTRICAL RESISTIVITY AND VISCOSITY OF LIQUID Al-Si ALLOYS显示文摘INFLUENCESOFTRACEADDITIONSOFSTRONTIUMANDPHOSPHORUSONELECTRICALRESISTIVITYANDVISCOSITYOFLIQUIDAlSiALLOYS①GuiManchang,JiaJun,... | Gui Manchang, Jia Jun *, Li Qingchun *, Guo Wenquan Institute of Aeronautical Materials, Beijing 100095 * Harbin Institute of Technology, Harbin 150001 Institute of Metal Research, Chinese Academy of Sciences, Shenyang 11015 | 1997 | 中国有色金属学会会刊:英文版1997，7，4： | 1 |
| 10 | Effect of medium on friction and wear properties of compacted graphite cast iron processed by biomimetic coupling laser remelting process 显示文摘 | Guo Qingchun Zhou Hong Wang Chengtao | 2009 | Applied Surface Science2009，255，： | 1 |
| 11 | Influence of processing medium on frictional wear properties of ball bearing steel prepared by laser surface melting coupled with bionic principles显示文摘 | Hong Zhou Chengtao Wang Qingchun Guo Jiaxiang Yu Mingxing Wang Xunlong Liao Yu Zhao Luquan Ren | 2010 | Journal of Alloys and Compounds2010，，2： | 1 |
| 12 | Fabrication of magnetically responsive anti-fouling and easy-cleaning nanofiber membrane and its application for efficient oil-water emulsion separation显示文摘The magnetically responsive anti-fouling nanofiber membrane(MRANM)was fabricated for efficient oilwater emulsion separation,which could be cleaned using oscillating magnetic field.MRANM was prepared by grafting superparamagnetic Fe_(3)O_(4) nanoparticles onto the surface of electrospun polyacrylonitrile nanofiber membrane(PANM).Compared with PANM,the water contact angle of MRANM decreased from 104°to 0°,indicating that the hydrophilicity of the membrane was significantly improved.For the emulsions of hexadecane,octane and rapeseed oil,the separation efficiency was 98.04%,96.59%and 92.67%,respectively.After the treatments in oscillating magnetic field,the separation efficiency kept above 95%after 8 times recycling,which indicated that the MRANM had good regenerability and reusability.The as-fabricated membrane with magnetic responsiveness facilitated an effective method for solving the membrane fouling problem during practical applications of separation high viscosity oil-water emulsion. | Yajie Wang Zhiwei Guo Yujie Yang Yanxiang Li Qingchun Guo Peilin Cui Wangliang Li | 2022 | Chinese Journal of Chemical Engineering2022，35，1： | 1 |
| 13 | Genetic basis of grain yield heterosis in an “immortalized F 2 ” maize population显示文摘 | Tingting Guo Ning Yang Hao Tong Qingchun Pan Xiaohong Yang Jihua Tang Jiankang Wang Jiansheng Li Jianbing Yan | 2014 | Theoretical and Applied Genetics2014，，10： | 1 |
| 14 | Generation of gene-target dogs using CRISPR/Cas9 system显示文摘Dear Editor,Dogs(Canis familiaris)serve as human companions and are raised to herd livestock,aid hunters,guard homes,perform police and rescue work,and guide the blind.Dogs exhibit close similarities to humans in terms of metabolic,physiological,and anatomical characteristics,and thus are ideal genetic and clinical models to study human diseases(Tsai et al.,2007).Gene target technology is a powerful tool to create new strains of animals with favorable traits.However,thus far,gene-target dogs have not been developed due to their unique species-specific reproductive characteristics,which limits the applications of dogs especially in the field of biomedical research.Recently,clustered regularly interspaced short palindromic repeats(CRISPRs)/CRISPR-associated(Cas)9 system was applied to edit specific genes with a high efficiency(Cong et al.,2013;Mali et al.,2013).Here we attempt to explore the feasibility of producing gene knockout(KO)dogs by using this technology.Beagle dog,the most widely used breed in biomedical research,was used as our animal model.Myostatin(MSTN)was chosen as the first gene of interest. | Qingjian Zou Xiaomin Wang Yunzhong Liu Zhen Ouyang Haibin Long Shu Wei Jige Xin Bentian Zhao Sisi Lai Jun Shen Qingchun Ni Huaqiang Yang Huilin Zhong Li Li Minhua Hu Quanjun Zhang Zhidong Zhou Jiaxin He Quanmei Yan Nana Fan Yu Zhao Zhaoming Liu Lin Guo Jiao Huang Guanguan Zhang Jun Ying Liangxue Lai Xiang Gao | 2015 | Journal of Molecular Cell Biology2015，7，6： | 1 |
| 15 | COLLISION COARSENING OF DISPERSION DROPLETS IN SOLIDIFICATION PROCESS OF MONOTECTIC ALLOY显示文摘COLLISIONCOARSENINGOFDISPERSIONDROPLETSINSOLIDIFICATIONPROCESSOFMONOTECTICALLOY￥ZhaoJiuzhou;GuoJingjie;JiaJun;LiQingchun(Scho... | Zhao, Jiuzhou Guo, Jingjie Jia, Jun Li, Qingchun | 1995 | 中国有色金属学会会刊:英文版1995，5，2： | 1 |
| 16 | All-fiber-transmission photometry for simultaneous optogenetic stimulation and multi-color neuronal activity recording显示文摘Manipulating and real-time monitoring of neuronal activities with cell-type specificity and precise spatiotemporal resolution during animal behavior are fundamental technologies for exploring the functional connectivity, information transmission, and physiological functions of neural circuits in vivo. However, current techniques for optogenetic stimulation and neuronal activity recording mostly operate independently. Here, we report an all-fiber-transmission photometry system for simultaneous optogenetic manipulation and multi-color recording of neuronal activities and the neurotransmitter release in a freely moving animal. We have designed and manufactured a wavelength-independent multi-branch fiber bundle to enable simultaneous optogenetic manipulation and multi-color recording at different wavelengths. Further, we combine a laser of narrow linewidth with the lock-in amplification method to suppress the optogenetic stimulation-induced artifacts and channel crosstalk. We show that the collection efficiency of our system outperforms a traditional epi-fluorescence system. Further, we demonstrate successful recording of dynamic dopamine(DA) responses to unexpected rewards in the nucleus accumbens(NAc) in a freely moving mouse. We also show simultaneous dual-color recording of neuronal Ca2+ signals and DA dynamics in the NAc upon delivering an unexpected reward and the simultaneous optogenetic activating at dopaminergic terminals in the same location. Thus, our multi-function fiber photometry system provides a compatible, efficient, and flexible solution for neuroscientists to study neural circuits and neurological diseases. | Zhongyang Qi Qingchun Guo Shu Wang Mingyue Jia Xinwei Gao Minmin Luo Ling Fu | 2022 | Opto-Electronic Advances2022，5，12： | 0 |
| 17 | Insight into coupled Ni-Co dual-metal atom catalysts for efficient synergistic electrochemical CO_(2)reduction显示文摘The development of highly active,selective,and stable electrocatalysts can facilitate the effective implementation of electrocatalytic CO_(2)conversion into fuels or chemicals for mitigating the energy crisis and climate problems.Therefore,it is necessary to achieve the goal through reasonable material design based on the actuality of the operational active site at the molecular scale.Inspired by the stimulating synergistic effect of coupled heteronuclear metal atoms,a novel Ni-Co atomic pairs configuration(denoted as NiN_(3)?CoN_(3)-NC)active site was theoretically screened out for improving electrochemical CO_(2)reduction reaction(CO_(2)RR).The structure of NiN_(3)?CoN_(3)-NC was finely regulated by adjusting Zn content in the precursors Zn/Co/Ni-zeolite imidazolate frameworks(Zn/Co/Ni-ZIFs)and pyrolysis temperature.The structural features of NiN_(3)?CoN_(3)-NC were systematically confirmed by aberration-corrected HAADF-STEM coupled with 3D atom-overlapping Gaussian-function fitting mapping,XAFS,and XRD.The results of theoretical calculations reveal that the synergistic effect of Ni-Co atomic pairs can effectively promote the*COOH intermediate formation and thus the overall CO_(2)RR kinetic was improved,and also restrained the competitive hydrogen evolution reaction.Due to the attributes of Ni-Co atomic pairs configuration,the developed NiN_(3)?CoN_(3)-NC with superior catalytic activity,selectivity,and durability,with a high turnover frequency of 2265 h^(-1)at-1.1 V(vs.RHE)and maximum Faradaic efficiency of 97.7%for CO production.This work demonstrates the great potential of DACs as highly efficient catalysts for CO_(2)RR,provides a useful strategy to design heteronuclear DACs,exploits the synergistic effect of multiple metal sites to facilitate complex CO_(2)RR catalytic reactions,and inspires more efforts to develop the potential of DACs in various fields. | Qingchun Zhang Di Liu Yaping Zhang Zhiliang Guo Minpeng Chen Yuyun Chen Bo Jin Yingze Song Hui Pan | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 18 | On the‘ENGO+focal firm’governance strategies of pollution of small and medium suppliers显示文摘Presently,the environmental pollution problem,especially that of the small and medium-sized enterprises,has become a bottleneck restricting the high-quality development of China’s economy.It is imperative to accelerate the construction of a collaborative governance system with multiple subject participation.The behavior modes of Environmental Non-governmental Organizations(ENGOs),a key player in environmental care,in collaborating with core enterprises to control pollution from small and medium-sized suppliers should be explored.Therefore,we constructed a collaborative governance system consisting of ENGOs,focal firms and small and medium-sized suppliers.Then a two-stage game model was established to analyze the strategies of the governance system.Specifically,we studied the collaborative green cooperation strategy and antagonistic pressure supervision strategy between ENGOs and focal firms,analyzed factors influencing the strategic choices of each subject,and gave the advantages of the cooperation strategies through further comparisons.The results showed that:Under the cooperation strategy,ENGOs provided knowledge of environmental protection to the focal firms,then both the audit efforts of focal firms and the environmental protection efforts of small and medium-sized suppliers were effectively improved.Since ENGOs could not fully obtain the pollution information of small and medium-sized suppliers or accurately trace it from their downstream focal firms,it was difficult to drive the supply chain’s endogenous governance by this external monitoring of ENGOs,making the effect of pressure supervision strategy limited.The effectiveness of green cooperation strategy was positively correlated with the knowledge absorption capacity of focal firms,the unit product revenue,and the focal firms'violation penalties for small and medium-sized suppliers.When ENGOs'violation penalties for small and medium-sized suppliers were higher,or the reputation loss of focal firms was higher,more unfavorable conditions of green cooperation strategy could be achieved.Accordingly,ENGOs should choose to cooperate with focal firms with strong knowledge absorption ability and high profit per product;focal firms should learn environmental protection knowledge to improve the screening standards and review capabilities,and promote the achievement of green cooperation strategy conditions by strengthening active information disclosure;the government should promote the collaboration between ENGOs and focal firms by issuing environmental guidelines. | Yumei Jiang Qingchun Meng Ying Guo Ziran Wang | 2021 | Chinese Journal of Population,Resources and Environment2021，19，3： | 0 |
| 19 | EUTECTIC GROWTH OF CAST IRON UNDER RAPID SOLIDIFICATION显示文摘The eutectic growth of cast iron during rapid solidification has been studied with laser remelt-ing and deep etching technology.A new mode of mushroom eutectic growth was observed oth-er than the usual honeycomb and lamellar ones.The mushroom eutectic growth may finallyform the lamellar dendritic structure. | GUO Jingjie JIA Jun LI Qingchun LI Bangsheng Harbin Institute of Technology,Harbin,China | 1992 | Acta Metallurgica Sinica(English Letters)1992，5，3： | 0 |
| 20 | A neuropsin-based optogenetic tool for precise control of Gq signaling显示文摘G_(q)-coupled receptors regulate numerous physiological processes by activating enzymes and inducing intracellular Ca^(2+)signals.There is a strong need for an optogenetic tool that enables powerful experimental control over G_(q) signaling.Here,we present chicken opsin 5(cOpn5)as the long sought-after,single-component optogenetic tool that mediates ultra-sensitive optical control of intracellular G_(q) signaling with high temporal and spatial resolution.Expressing cOpn5 in HEK 293T cells and primary mouse astrocytes enables blue light-triggered,G_(q)-dependent Ca^(2+) release from intracellular stores and protein kinase C activation.Strong Ca^(2+) transients were evoked by brief light pulses of merely 10 ms duration and at 3 orders lower light intensity of that for common optogenetic tools.Photostimulation of cOpn5-expressing cells at the subcellular and single-cell levels generated fast intracellular Ca^(2+)transition,thus demonstrating the high spatial precision of cOpn5 optogenetics.The cOpn5-mediated optogenetics could also be applied to activate neurons and control animal behavior in a circuit-dependent manner.cOpn5 optogenetics may find broad applications in studying the mechanisms and functional relevance of G_(q) signaling in both non-excitable cells and excitable cells in all major organ systems. | Ruicheng Dai Tao Yu Danwei Weng Heng Li Yuting Cui Zhaofa Wu Qingchun Guo Haiyue Zou Wenting Wu Xinwei Gao Zhongyang Qi Yuqi Ren Shu Wang Yulong Li Minmin Luo | 2022 | Science China(Life Sciences)2022，65，7： | 0 |
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