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| 1 | FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway显示文摘成纤维细胞生长因素 21 (FGF21 ) , FGF 总科的一个最近识别的成员,主要从肝和脂肪质的纸巾被分泌并且在改进新陈代谢的症候群和动态平衡起一个重要作用。这研究的目的是在含酒精的脂肪肝疾病(AFLD ) 评估 FGF21 的角色并且决定它是否在 AFLD 上有治疗学的效果。在这份报纸,我们在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型在导致白酒的肝损害上测试了 FGF21 的效果。男千米;公里老鼠每天收到了 5 g/kg 乙醇 gavage 的单个剂量 6 个星期,它导致了重要脂肪肝和肝损害。导致白酒的脂肪肝房间模型被在 75 公里的最后的集中增加乙醇进 HepG2 房间文化的媒介 9 天完成。结果与 recombinant FGF21 显示出那个处理在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型的改善含酒精的脂肪肝和肝损害。另外, FGF21 处理下面调整丰满的酸的肝的表示合成的关键酶,激活的肝的 AMPK-SIRT1 小径和显著地下面调整的肝的氧化压力蛋白质。一起拿, FGF21 由 AMPK-SIRT1 小径的激活在 vitro 并且在 vivo 改正 AFLD 的多重新陈代谢的参数。 | Shenglong Zhu Lei Ma Yunzhou Wu Xianlong Ye Tianyuan Zhang Qingyang Zhang Lubna Muhi Rasoul Yunye Liu MO Guo Bing Zhou Guiping Ren Deshan Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 11 |
| 2 | Vibration suppression of a large flexible spacecraft for on-orbit operation显示文摘Flexible appendages, such as solar panels, communication antennas and other large structures, are mounted on the base of a space robot and target satellite. The vibration of the flexible structure is excited by operations of a space manipulator. It is very challenging to control the vibration of large flexible appendages for on-orbit operation and, especially when the manipulator operates a non-cooperative target with unknown structural parameters and vibration information. In this study, a hybrid control method is proposed based on wave-based control and PD control methods to control the motion of a manipulator while suppressing the vibration of appendages. First, the rigid-flexible coupled dynamic model of a compounded system is established.This is followed by designing a hybrid control strategy combining wave-based control and PD control for restto-rest maneuvers based on the characteristics of the compounded system. Finally, the simulation of a 3D compounded system is provided to verify the effectiveness of the presented approach. The simulation results indicate that the space robot can successfully berth the target while suppressing the vibrations of the structure. | Deshan MENG Houde LIU Yanan LI Wenfu XU Bin LIANG | 2017 | Science China(Information Sciences)2017，60，5： | 6 |
| 3 | Grain in- terface modification and magnetic properties of Nd-Fe-B sin- tered magnets 显示文摘 | Deshan Li Shunji Suzuki Takashi Kawasaki | 2008 | Japanese Journal of Applied Physics2008，47，10： | 1 |
| 4 | Distribution and possible role of PDGF-AA and PDGFR-α in the gastrointestinal tract of adult guinea pigs显示文摘 | Fangxiao Chan Yong Liu Haimei Sun Xiaoshuang Li Hongwei Shang Dongying Fan Jing An Deshan Zhou | 2010 | Virchows Archiv2010，，3： | 1 |
| 5 | Chimeric anti-IL-17 full-length monoclonal antibody is a novel potentialcandidate for the treatment of rheumatoid arthritis显示文摘 | Fuliang Bai Hui Tian Zeshan Niu Mingyao Liu Guiping Ren Yinhang Yu Tian Sun Siming Li Deshan Li | 2014 | International Journal of Molecular Medicine2014，，3： | 1 |
| 6 | Fibroblast growth factor (FGF)-21 signals through both FGF receptor-1 and 2显示文摘Fibroblast growth factor (FGF)-21 is a member of the FGF superfamily based on sequence homology. However, unlike most members of this family it does not show any mitogenic activity in all cell types tested. The objective of this study is to identify and characterize receptors for this molecule. Sequencing of the cDNA clones from 3T3-L1 adipocytes indicates that the only isoforms for FGFR-1 and 2 expressed in 3T3-L1 cells are 1IIIc and 2IIIc, respectively, suggesting that FGF-21 regulates glucose metabolism in 3T3-L1 adipocytes through FGFR-1IIIc and FGFR-2IIIc. | REN GuiPing, YIN JieChao, WANG WenFei, LI Lu & LI DeShan College of Life Science, Northeast Agricultural University, Harbin 150030, China | 2010 | Science China(Life Sciences)2010，53，8： | 1 |
| 7 | Effect of Yiqi Bushen prescription on hippocampal neuronal apoptosis in diabetic rats显示文摘This study investigated the neuroprotective effect of Yiqi Bushen prescription (YQBS, supplementing qi and tonifying kidney) on neuronal cell apoptosis. Following YQBS treatment, the number of surviving hippocampal neurons increased, anti-apoptotic Bcl-2 expression increased and pro-apoptotic Bax expression decreased. In addition, diabetic rats exhibited improved learning and memory. YQBS treatment also increased Bcl-2 mRNA expression and the ratio of Bcl-2/Bax, but decreased levels of hypoxia-inducible factor-1α mRNA and Bax mRNA expression after high-glucose/hypoxia-induced injury. Results demonstrated that YQBS inhibited hippocampal neuronal apoptosis by decreasing hypoxia-inducible factor-1α expression and increasing Bcl-2 expression, thereby improving cognitive impairment in diabetic rats. | Deshan Liu Weiwei Lin Wei Gao Ping Chang Wei Li | 2011 | Neural Regeneration Research2011，6，21： | 1 |
| 8 | Cooperative planning ofmulti-agent systems based on task-oriented knowledge fusion with graph neural networks显示文摘Cooperative planning is one of the critical problems in the field of multi-agent system gaming.This work focuses on cooperative planning when each agent has only a local observation range and local communication.We propose a novel cooperative planning architecture that combines a graph neural network with a task-oriented knowledge fusion sampling method.Two main contributions of this paper are based on the comparisons with previous work:(1)we realize feasible and dynamic adjacent information fusion using GraphSAGE(i.e.,Graph SAmple and aggreGatE),which is the first time this method has been used to deal with the cooperative planning problem,and(2)a task-oriented sampling method is proposed to aggregate the available knowledge from a particular orientation,to obtain an effective and stable training process in our model.Experimental results demonstrate the good performance of our proposed method. | Hanqi DAI Weining LU Xianglong LI Jun YANG Deshan MENG Yanze LIU Bin LIANG | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，7： | 0 |
| 9 | Sulfonate-containing Copolymers Prepared by Semi-Continuous Emulsion Copolymerizaiton of Styrene and Sodium Styrene Sulfonate显示文摘 | Shiming HUANG Wei XIE Chengyou KAN Yajie LI Deshan LIU | 2005 | 复旦学报(自然科学版)2005，44，5： | 0 |
| 10 | Influences of Electrolytes on Soap-Free P(ST-MMA-AA) Emulsion Polymerization显示文摘 | Zeping LI Ronglong LI Yi DU Chengyou KAN Deshan LIU | 2005 | 复旦学报(自然科学版)2005，44，5： | 0 |
| 11 | Experimental investigation of damage identification for continuous railway bridges显示文摘Considering the issue of misjudgment in railway bridge damage identification,a method combining the step-by-step damage detection method with the statistical pattern recognition is proposed to detect the structural damage of a railway continuous girder bridge.The whole process of damage identification is divided into three identification substeps,namely,damage early warning,damage location,and damage extent identification.The multi-class pattern classification algorithm of C-support vector machine and the regression algorithm of ε-support vector machine are engaged to identify the damage location and damage extent,respectively.For verifying the proposed method,both of the proposed method and the optimization method are used to deal with the measured data obtained from a specific railway continuous girder model bridge.The results show that the proposed method can not only identify the damage location correctly,but also obtain the damage extent which is consistent with the experimental results accurately.By uncoupling finite element analysis and damage identification,normalizing the index,and seeking the separation hyper plane with maximum margin,the proposed method has more favorable advantages in generalization and anti-noise.As a result,it has the ability to identify the damage location and extent,and can be applied to the damage identification in real bridge structures. | Deshan SHAN Chunyu FU Qiao LI | 2012 | Journal of Modern Transportation2012，20，1： | 0 |
| 12 | Controlled synthesis of hierarchically-structured MnCo_2O_4 and its potential as a high performance anode material显示文摘To satisfy the upsurging demand for energy storage in modern society,anode materials which can deliver high capacity have been intensively researched for the next generation lithium ion batteries.Typically,the binary MnCo_2O_4 with a characteristic coupled metal cations showed promising potential due to its high theoretical capacity and low cost.Here,by means of a well-designed synthesis control,we demonstrated a scalable process to achieve a hierarchical structure of MnCo_2O_4,which existed as uniform microspheres with embedded mesopores,showing favorable structural characters for high performance during a fast charge/discharge process.Our synthesis highlighted the importance of sodium salicylate as an essential additive to control the precipitation of the two involved metal cations.It was proved that a dual role was played sodium salicylate which cannot only facilitate the formation of microspheric shape,but also act as an effective precursor for the creation of inner mesopores.We confirmed that the hierarchically-structured MnCo_2O_4 showed outstanding performance when it was tested as an anode material in lithium ion batteries as revealed by its extraordinary cycling stability and high rate capability. | Zixiao Wu Fuhai Li Yonggang Sun Deshan Bin Junyu Piao Xijie Lin Xiaochan Liu Anmin Cao Li-Jun Wan | 2017 | Science China Chemistry2017，60，9： | 0 |
| 13 | Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells显示文摘全身的豺狼座 erythematosus (SLE ) 的一个特点是由汽车反应的 B 房间的各种各样的自身抗体的一致生产。Interferon-α(IFN-α) 发信号高度在 SLE B 房间被激活并且由 B 房间在抗体反应起一个重要作用。以前的研究证明了 CD180 否定的 B 房间,戏剧性地在 SLE 病人被增加,为自身抗体的生产负责。然而,在 CD180 和 IFN-α 之间的协会;未知的发信号的遗体。在现在的学习,我们在调整 IFN-α 的激活上探索了 CD180 的效果;在 B 房间发信号。我们发现 CD180 否定的 B 房间的数字在 MRL/Mp-Fas (lpr/lpr ) 被增加豺狼座容易的老鼠与野类型的老鼠相比。Phenotypic 分析证明 CD180 否定的 B 房间包括了 CD138 + plasmablast/plasma 房间和 GL-7 + 幼芽的中心(GC ) B 房间。尤其是, CD180 的结扎显著地禁止了 IFN-α信号变换器的导致的 phosphorylation 和抄写 2 的使活跃之物(STAT-2 ) 和以在 vitro 的一种 Lyn-PI3K-BTK-dependent 方式的刺激 IFN 的基因(ISG ) 的表示。而且, CD180 的结扎能也禁止 IFN-α在在 vivo 的 B 房间的导致的 ISG 表示。而且,像使用费的受体 7 并且像使用费的受体 9 发信号小径能显著地 downregulate CD180 表示并且调制在 IFN-α 的激活上发信号的 CD180 的禁止的效果;发信号。一起,我们的结果加亮在 CD180 否定的 B 房间的增加的比例和 IFN-α 的激活之间的靠近的协会;在 SLE 发信号。我们的数据提供分子的卓见进 IFN-α 的机制;在为 SLE 处理的 SLE B 房间和一条潜在的治疗学的途径的发信号的激活。 | Ming You Guanjun Dong Fanlin Li Feiya Ma Jing Ren Yujun Xu Huimin Yue Ruijing Tang Deshan Ren Yayi Hou | 2017 | Cellular & Molecular Immunology2017，14，2： | 0 |
| 14 | ON THE STABILITY OF LAVES PHASES显示文摘ONTHESTABILITYOFLAVESPHASES￥Li,Chonghe;Kang,Deshan;Qin,Pei;Chen,Nianyi(ShanghaiInstituteofMetallurgy,ChineseAcademyofSciences... | Chonghe, Li Deshan, Kang Pei, Qin Nianyi, Chen | 1995 | 中国有色金属学会会刊:英文版1995，5，3： | 0 |
| 15 | Three-Dimensional Analytical Modeling of Axial-Flux Permanent Magnet Drivers显示文摘In this paper, the axial-flux permanent magnet driver is modeledand analyzed in a simple and novel way under three-dimensional cylindricalcoordinates. The inherent three-dimensional characteristics of the deviceare comprehensively considered, and the governing equations are solved bysimplifying the boundary conditions. The axial magnetization of the sectorshapedpermanent magnets is accurately described in an algebraic form bythe parameters, which makes the physical meaning more explicit than thepurely mathematical expression in general series forms. The parameters of theBessel function are determined simply and the magnetic field distribution ofpermanent magnets and the air-gap is solved. Furthermore, the field solutionsare completely analytical, which provides convenience and satisfactoryaccuracy for modeling a series of electromagnetic performance parameters,such as the axial electromagnetic force density, axial electromagnetic force,and electromagnetic torque. The correctness and accuracy of the analyticalmodels are fully verified by three-dimensional finite element simulations and a15 kW prototype and the results of calculations, simulations, and experimentsunder three methods are highly consistent. The influence of several designparameters on magnetic field distribution and performance is studied and discussed.The results indicate that the modeling method proposed in this papercan calculate the magnetic field distribution and performance accurately andrapidly, which affords an important reference for the design and optimizationof axial-flux permanent magnet drivers. | Wenhui Li Dazhi Wang Shuo Cao Deshan Kong Sihan Wang Zhong Hua | 2023 | Computers, Materials & Continua2023，，4： | 0 |
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