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| 1 | Elderly healthcare service at the community health centers in the Pearl River Delta region,China显示文摘Objective:The recent population census showed China had officially become a graying society.In the meantime,China also faces a growing burden of non-communicable diseases.Since 2009,a series of policies have been implemented to enhance primary care at the community level.This study describes the elderly care services provided in the differently organized community health centers(CHCs).Methods:It covered 13 CHCs of six cities located within the Pearl River Delta(PRD)region.In-depth interviews were conducted with a total of 59 health administrators,CHC managers,and CHC doctors regarding elderly care.Results:The study found that accessibility of healthcare for elders has been improved due to the development of health insurance schemes as well as preferential policy to encourage the CHC utilization by the elderly.All the CHCs provide health examinations and chronic disease management to the permanent elderly within their catchment district.However,some preventative care such as fall prevention,immunization and mental health management are not provided.Conclusion:Key barriers include low capacity of health service providers in the CHCs,and a lack of government investment in CHCs.Our report provides an empirical evidence for the health care reform in China. | NAN YANG XIAOLIN WEI HAITAO LI ZHENZHEN ZHANG JAMIE RODAS SAMUEL YS WONG MARTIN CS WONG YANG GAO JIAJI WANG DONALD KT LI JINLING TANG SIAN GRIFFITHS | 2013 | Family Medicine and Community Health2013，1，1： | 5 |
| 2 | 持续性红细胞生成素受体激活剂静脉给药在慢性肾脏病透析患者中纠正贫血的疗效、安全性和耐受性显示文摘目的评估持续性红细胞生成素受体激活剂(CERA)每2周1次静脉给药与红细胞生成素13(EPO-β)相比在慢性肾脏病(CKD)透析患者中纠正贫血的疗效和安全性。方法采用开放、随机、平行、阳性对照、多中心临床试验方法。正在接受血液透析或腹膜透析且8周内未接受红细胞生成刺激剂(ESA)治疗的CKD贫血成年患者,随机(1:1)接受CERA每2周1次静脉注射(CERA组,n=132例)或EPO-β每周3次静脉注射(EPO组,n=133例)持续治疗24周(包括16周纠正期和8周疗效评估期)。此后对达到目标血红蛋白(Hb)值(定义为首次给药后24周内在未输注红细胞的情况下,Hb≥110g/L且与基线值相比上升≥10g/L)的患者继续分别维持CERA或EPO-β治疗28周,以观察长期安全及耐受性。CERA的起始剂量为0.4μg/k。主要研究终点为前24周的Hb反应率及评估期(17-24周)Hb与基线值相比的变化。结果共计232例患者(87.5%)完成了前24周的治疗,198例患者(74.7%)完成了整个研究(52周)的治疗。CERA治疗组前24周的Hb反应率为87.12%[95%CI(80.2%-92.3%)]。根据其95%CI的下限高于60%(P〈0.01),认为CERA每2周1次静脉给药能有效纠正CKD贫血。符合方案(PP)人群中CERA组与EPO组评估期Hb相对基线变化的差异为-4.7g/L[95%CI(-7.38g/L-1.92g/L)]。根据其95%CI的下限大于预先设定的非劣效性界值-7.5g/L(P=0.0205),认为CERA纠正CKD贫血后维持Hb非劣效于EPO-β。在28周的延长期间两组的Hb水平均保持稳定。研究期间CERA组和EPO组的安全性结果相当,分别有50.0%及54.6%的患者报告了至少1件不良事件(AE),AE与研究人群的特征一致。结论在未接受ESA治疗的CKD透析患者中,每两周静脉注射1次CERA可有效纠正贫血,且纠正贫血后维持Hb非劣效于EPO-β治疗。CKD透析患者对于长期静脉注射给药CERA总体上耐受性良好。 | 钱家麒 陈楠 梅长林 刘文虎 侯凡凡 史伟 陈江华 陈香美 李文歌 顾勇 刘必成 丁小强 王莉 Philip KT LI 于凌博 田劲 | 2012 | 中华肾脏病杂志2012，28，11： | 3 |
| 3 | Cucurb-itacin B induces apoptosis and S phase cell cycle arrest in BEL-7402human hepatocellular carcinoma cells and is effective via oral admin-istration显示文摘 | Chan KT Meng FY Li Q Ho CY Lam TS To Y | 2010 | Cancer Lett2010，294，1： | 1 |
| 4 | Activation of the JNK pathway promotes phosphorylation and degradation of BimEL--a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia显示文摘 | Leung KT Li KK Sun SS Chan PK | 2008 | Carcinogenesis2008，29，3： | 1 |
| 5 | Post-synaptic density-95(PSD-95 ) binding capacity of G-protein-coupled receptor 30(GPR30) , an estrogen receptor that can be identified in hippocampaldendritic spines显示文摘 | Akama KT Thompson LI Milner TA | 2013 | J Biol Chem2013，288，9： | 1 |
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| 8 | Molecular cloning of a novel tissue-specific gene from human nasopharyngeal epithelium 显示文摘 | Li ZK Yao KT Cao Y | 1999 | Gene1999，237，1： | 1 |
| 9 | Effective connectivity anomalies in human amblyopia 显示文摘 | Li X Mullen KT Thompson B Hess RF | 2011 | Neuroimage2011，54，2： | 1 |
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| 11 | Electrocardiographic algorithms for predicting the complexity of coronary artery lesions in ST-segment elevation myocardial infarction in ED显示文摘 | Cheng KH Chu CS Li KT | 2008 | Am J Emerg Med2008，26，1： | 1 |
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| 13 | Expression of hypoxia - inducible factor- a in human periodontal tissue显示文摘 | Ng KT Li JP Ng KM | 2011 | J Periodontol2011，82，1： | 1 |
| 14 | CuI4A is required for hematopoiet- ic cell viability and its deficiency leads to apoptosis 显示文摘 | Churl KT Waning DL Li B | 2008 | Blood2008，112，： | 1 |
| 15 | Activation of the JNK pathway promotes phosphorylation and degradation of BimEL-a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia显示文摘 | Leung KT Li KK Sun SS | 2008 | Carcinogenesis2008，29，3： | 1 |
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| 17 | Intraoperative computed tomography with integrated navigation in percutaneous iliosacral screwing显示文摘 | Peng KT Li YY Hsu WH | 2013 | Injury2013，44，2： | 1 |
| 18 | Prognosis and clinicopathology of CX- CR4 in colorectal cancer patients: a Meta- analysis 显示文摘 | Li LN Jiang KT Tan P | 2015 | Asian Pac J Cancer Prev2015，16，9： | 1 |
| 19 | Interrelationship between cellular nucleotide excision repair,cisplatin cytotoxicity HER-2/neu gene expression,and EGFR in NSCLC显示文摘 | Tsai CM Chang KT Li L | 2000 | Jpn J Cancer Res2000，91，2： | 1 |
| 20 | Performance of the enhanced Abbott Ax SYM cardiac troponin I reagent in patients with heterophilic antibodies显示文摘 | Yeo KT Storm CA Li Y | 2000 | Clin Chim Acta2000，292，12： | 1 |
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