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| 1 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 2 | Progress on design and related R&D activities for the water-cooled breeder blanket for CFETR显示文摘The water-cooled ceramic breeder (WCCB) blanket is one of the blanket candidates for Chinese fusion engineering testing reactor (CFETR) and is being developed at the Institute of Plasma Physics, Chinese Academy of Sciences (ASIPP). This paper reviews design and evolution of the WCCB blanket for CFETR, and presents a new WCCB blanket design according to the latest CFETR core parameters (major and minor radii are R = 7.2 m and a = 2.2 m, respectively) and missions. This new design is expected to satisfy multiple CFETR operation modes of 0.2, 0.5, 1.0, and 1.5 GW fusion power and achieve tritium self-sufficiency. The feasibility of the updated blanket design is evaluated from the aspects of neutronics and thermo-hydraulics. Furthermore, the research and development (R&D) activities supporting to the WCCB blanket for CFETR are reported, including the design code, the water loop experiments, the pebble bed modeling and experiments, and the components fabrication technology. | Songlin Liu Xiaoman Cheng Xuebin Ma Lei Chen Kecheng Jiang Xia Li Hui Bao Jichao Wang Wanjing Wang Changhong Peng Peng Lu Min Li Kai Huang | 2019 | Theoretical & Applied Mechanics Letters2019，9，3： | 6 |
| 3 | Danggui-shaoyao-san, a traditional Chinese medicine prescription, alleviates the orthodontic pain and inhibits neuronal and microglia activation显示文摘 | Li Hongshi Gu Zexu Wu Li'an Xia Liang Zhou Kecheng E Lingling Wang Dongsheng Kou Junping Liu Hongchen | 2014 | Chinese Medical Journal2014，，20： | 4 |
| 4 | Proteomics provides individualized options of precision medicine for patients with gastric cancer显示文摘While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been minimal.GC patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical benefit.There is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted therapy.Here,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of GC.We identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery set.The 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation set.Further,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care. | Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao Xiaotian Ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan Wang Shiqi Wang Gang Ji Jipeng Li Yongzhan Nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi Wang Lin Chen Qingchuan Zhao Hongwei Wang Lin Shen Jun Qin | 2021 | Science China(Life Sciences)2021，64，8： | 3 |
| 5 | Vibrational characteristics of rotating soft cylinders显示文摘Rotating structural components are omnipresent in engineering structures and natural world. This work investigates the effects of the centrifugal and Coriolis forces on the free vibrational characteristics of soft cylinders rotating with respect to the axis of symmetry based on the nonlinear elasticity and linear incremental theories. The formulations indicate that the biasing deformation, instantaneous elastic moduli, and incremental equations of motion strongly depend on the rotating speed. The characteristic equation for the natural frequency is derived using the state-space method and approximate laminate technique.The numerical examples included in this work demonstrate that the centrifugal and Coriolis forces might have significant effects on the vibrational characteristics of the cylinder. Results of this work will benefit the design and control of novel engineering systems with rotating soft cylinders or shafts. | Kecheng Li Yinnan Zhang Haifei Zhan Yangkun Du Chaofeng Li | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，5： | 2 |
| 6 | Energy utilization evaluation of CCHP systems显示文摘 | Hui Li Lin Fu Kecheng Geng Yi Jiang | 2005 | Energy & Buildings2005，，3： | 2 |
| 7 | Cyclic Ether Contaminant Removal from Water Using Nonporous Adaptive Pillararene Crystals via Host-Guest Complexation at the Solid-Solution Interface显示文摘Te removal of soluble cyclic ether contaminants,such as dioxane and THF,produced in industrial chemical processes from water is of great importance for environmental protection and human health.Here we report that nonporous adaptive crystals of perethylated pillar[5]arene(EtP5)and pillar[6]arene(EtP6)work as adsorbents for cyclic ether contaminant removal via hostguest complexation at the solid-solution interface.Nonporous EtP6 crystals have the ability to adsorb dioxane from water with the formation of 1:2 host-guest complex crystals,while EtP5 crystals cannot.However,both guest-free EtP5 and EtP6 crystals remove THF from water with EtP5 having a better capacity.Tis is because EtP5 forms a 1:2 host-guest complex with THF via host-guest complexation at the solid-solution interface while EtP6 forms a 1:1 host-guest complex with THF.EtP6 also shows the ability to selectively remove dioxane from water even in the presence of THF.Moreover,the reversible transitions between nonporous guestfree EtP5 and EtP6 structures and guest-loaded structures make them highly recyclable. | Yujuan Zhou Kecheng Jie Run Zhao Errui Li Feihe Huang | 2019 | Research2019，，1： | 2 |
| 8 | Effect of B203 and CuO additions on the sintering temperature and microwave dielectric properties of 3Li20-Nb205 3TiO2 ceramics显示文摘 | Huanfu Zhou Hong Wang Kecheng Li | 2009 | Journal of Materials Science:Mater Electron2009，20，： | 1 |
| 9 | Adhesion characteris- tics of aramid fibre-fibrids in a sheet hot calendering process 显示文摘 | ZHANG Sufeng ZHANG Meiyun LI Kecheng | 2010 | Appita Journal2010，63，1： | 1 |
| 10 | Measurement of wet fiber flexibility by confocal laser scanning microscopy 显示文摘 | Yah Dongbo Li Kecheng | 2008 | Journal of Materials Sci- ence2008，43，8： | 1 |
| 11 | Compar- ative study on the dynamic heat transfer characteristics of PCM-filled glass window and hollow glass window 显示文摘 | Shuhong Li Kecheng Zhong Yingying Zhou | 2014 | Energy and Buildings2014，85，： | 1 |
| 12 | Energy utilization evalu- ation of CCHP systems 显示文摘 | Hui Li Lin Fu Kecheng Geng Yi Jiang | 2006 | Energy and Buildings2006，38，： | 1 |
| 13 | Adhesion char- acteristics of aramid fibre fibrids in a sheet hot calendering proeess显示文摘 | Sufeng Zhang Meiyun Zhang Kecheng Li | 2010 | Appita Journal2010，63，1： | 1 |
| 14 | Energy utilization evaluation of CCHP systems显示文摘 | Hui Li Lin Fu Kecheng Geng | 2006 | Energy and Buildings2006，38，： | 1 |
| 15 | Effect of B2O3 and CuO additions on the sintering temperature and microwave dielectric properties of 3Li2O–Nb2O5–3TiO2 ceramics显示文摘 | Huanfu Zhou Hong Wang Kecheng Li Xi Yao | 2009 | Journal of Materials Science: Materials in Electronics2009，，3： | 1 |
| 16 | Principles and implementations of hierarchical region defensive systems of power grid显示文摘 | Lin Xiangning Li Zhengtian Wu Kecheng | 2009 | IEEE Transactions on Power Delivery2009，24，1： | 1 |
| 17 | Energy utilization evaluation of CCHP systems 显示文摘 | LI H FU L KECHENG G | 2006 | Energy & Buildings2006，，5： | 1 |
| 18 | Ef feet of B2O3 and CuO additions on the sintering temperature and microwave dielectric properties of 3Li2O-Nb2O5-3YiO2 ceramics显示文摘 | Huanfu Zhou Hong Wang Kecheng Li and Xi Yao | 2009 | J Mater Sci:Mater Electron2009，20，： | 1 |
| 19 | Knowledge-based clinical pathway for medical quality improvement显示文摘 | Hongqiao Yang Weizi Li Kecheng Liu Junping Zhang | 2012 | Information Systems Frontiers2012，，1： | 1 |
| 20 | Efficient extraction of lignin from black liquor via a novel membrane-assisted electrochemical approach显示文摘 | Wei Jin Rasha Tolba Jiali Wen Kecheng Li Aicheng Chen | 2013 | Electrochimica Acta2013，，： | 1 |
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