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| 1 | Metabolic profiling analysis of a D-galactosamine/lipopolysaccharide- induced mouse model of fulminant hepatic failure显示文摘 | Feng, B Wu, SM Lv, S Liu, F Chen, HS Yan, XZ Li, Y Dong, FT Wei, L | 2007 | 中国生物学文摘2007，21，11： | 23 |
| 2 | Zircon U-Pb dating of Shuiquangou alkaline complex intrusives, northwestern Hebei Province显示文摘SUPER large gold deposits related to alkaline intrusions have been found in America,Canada,Australia,Papua New Guinea and elsewhere.Dongping gold deposit with superlarge potentialhas also been found in Shuiquangou alkaline complex intrusions,northwestern Hebei Province,China.One of the keys to resolving the possible genetic relationship between gold deposits andore-host alkaline intrusions is to determine their formation ages.This note dates the Shuiquan-gou intrusions with zircon U-Pb method. | Mo, CH Liang, HY Wang, XZ Cheng, JP Li, HM | 1997 | Chinese Science Bulletin1997，42，9： | 6 |
| 3 | Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives显示文摘Aim: To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent anti-inflammatory activi-ties after being converted to their parent compounds in vivo. Methods: To introduce an amino acid, celecoxib analogs containing amino or methylamino group were synthesized first through multi-step chemical reactions. All the synthesized compounds were screened in an intact cell-based assay in vitro and in carrageenan-induced mouse paw edema in vivo. Some active compounds were selected for further evaluation in a carrageenan-induced rat paw edema model. The preliminary pharmacokinetics experiments were conducted using high performance liquid chromatography/mass spectrometry (HPLC/MS). Results: Celecoxib, 6 of the 1,5-diarylpyrazole class of celecoxib analogs, and their amino acid derivatives (hydrochloride salts) were synthesized. In vitro screening, the hydrochloride salts showed decreased inhibitory effects on cyclooxygenase (COX)- 1 and COX-2 compared with their parent compounds, but some exhibited potent anti-inflammatory activity in vivo. Compound 4a was selected for further evaluation, and its anti-inflammatory effect was equivalent to that of celecoxib after oral administration in the carrageenan-induced rat paw edema model. At three doses (25 mg/kg, 50 mg/kg, and 100 mg/kg) the percentage inhibition on edema was 20.7%, 52.6%, and 62.6% (for compound 4a) and 27.8%, 38.4%, and 40.1% (for celecoxib), respectively. Preliminary pharmacokinetic evaluations support the hypothesis that compound 4a was actually converted to its parent compound, compound 4. Conclusion: The compound bound with amino acid acts like prodrug, which can exert anti-inflammatory effect similar to celecoxib after being converted to its parent compound. This finding will be of great benefit in carrying out structural modifications of prodrug-like selective COX-2 inhibitors. | Li MH Yin LL Cai MJ Zhang WY Huang Y Wang X Zhu XZ Shen JK | 2005 | Acta Pharmacologica Sinica2005，26，7： | 2 |
| 4 | Efflux-mediated drug resistance in bacteria 显示文摘 | Li XZ Nikaido H | 2004 | Drugs2004，64，2： | 1 |
| 5 | Apoplosis of breast cancer cell MCF-7 induced by norcantharidin(NCTD)显示文摘 | Sang JL Li XZ Zhang HJ | 2002 | Cell Res2002，12，3： | 1 |
| 6 | Pbotocatalytic degradation of an odorous pollutant:2-mercaptobenzothiazole in aqueous suspension using Nd3+-TiO2 catalysts显示文摘 | Li FB Li XZ Ng KH | 2006 | Industry Engineering Chemical Research2006，45，1： | 1 |
| 7 | Transformation of adrenal medullary chromaffin cells increases asthmatic susceptibility in pups from allergen-sensitized rats显示文摘 | Feng JT Wu XM Li XZ | 2012 | Respir Res2012，13，： | 1 |
| 8 | Spread and development of lapa- roscopie surgery for gastric tumors in mainland China: initial expe- riences 显示文摘 | Chen XZ Li YY Hn JK | 2012 | Hepatogastroenterology2012，59，114： | 1 |
| 9 | The effects of venlafaxine on cortical motor area activity in healthy subjects: a pilot study 显示文摘 | Li CY Song XZ Han LX | 2014 | J Clin Psycho- pharmacol2014，34，1： | 1 |
| 10 | Low-dose ropivacaine-sufentanil spinal anaesthesia for Caesarean delivery:a randomized trial显示文摘 | Qian XW Chen XZ Li DB | 2008 | Int J Obstet Anesth2008，17，4： | 1 |
| 11 | Benefit from synchronous portal-superior mesenteric vein resection during pancreaticoduodenectomy for canc- er:a meta-analysis显示文摘 | Yu XZ Li J Fu DL | 2014 | Eur J Surg Oncol2014，40，4： | 1 |
| 12 | High prcvance of thalassemia in mi- grant population in Guangdong province,China显示文摘 | Li B Zhang XZ Yin AH | 2014 | BMC Public Health2014，14，： | 1 |
| 13 | Protection against influenza virus infection in BALB/c mice immunized with a single dose of neuraminidase-expressing DNAs by electroporation显示文摘 | Chen JJ Fang F Li XZ | 2005 | Vaccine2005，23，34： | 1 |
| 14 | Photocatalytic activity of Ca^3+-TiO2 for 2-mercaptobenzothiazole degradation in aqueous suspension for odour control显示文摘 | Li FB Li XZ Hou MF | 2005 | Applied Catalysis A2005，285，12： | 1 |
| 15 | Efflux-mediated drug resistance in bacteria:an update显示文摘 | Li XZ Nikaido H | 2009 | Drugs2009，69，12： | 1 |
| 16 | Y-Shaped P (UA-Y-NIPAAm) Copolymer for Drug Delivery 显示文摘 | Li YY Zhang XZ Cheng H | 2006 | Biomacromolecules2006，7，： | 1 |
| 17 | Effects of fenofibrate and xuezhikang on high-fat diet-induced non-alcoholic fatty disease 显示文摘 | Hong XZ Li LD Wu LM | 2007 | Clin Exp Pharmacol Physiol2007，34，12： | 1 |
| 18 | Serum retinol-binding protein 4 levels in patients with diabetic retinopathy显示文摘 | Li ZZ Lu XZ Liu JB | 2010 | The Journal of International Medical Research2010，38，1： | 1 |
| 19 | Clinical features of punctate inner choroidopathy in Chinese patients 显示文摘 | Zhang XZ Wen F Zuo C Li M Chen H Huang S | 2011 | Retina2011，31，8： | 1 |
| 20 | Prophylactic and therapeutic benefits of COX-2 inhibitor on motility dysfunction in bowel obstruction:roles of PGE2 and EP receptors显示文摘 | Lin YM Li F Shi XZ | 2012 | Am J Physiol Gastrointest Liver Physiol2012，302，2： | 1 |
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