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| 1 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | Membrane-bound Fas ligand only is es- sential for Fas-induced apoptosis 显示文摘 | Lorraine A Lin T Lily L | 2009 | Nature2009，461，7264： | 1 |
| 3 | Bicylindrical Coordinate Formulation for the Leakage Flow through the Minimal Clearance in a Rolling piston Compressor显示文摘 | Ferreira R T S Lilie D E B Gasche J L | 1992 | Proceeding of Purdue Compressor Technology Conference1992，，： | 1 |
| 4 | Serum uric acid is a marker of inflammation and a marker of predicting the risk of developing CVD,stroke,renal failure and cancer显示文摘 | Lily L Wu James T | 2008 | Biomed Lab Sci2008，20，1： | 1 |
| 5 | Validation of hyperbolic model for water-hammer in deformable pipe显示文摘 | Hadj-Taieb E Lili T | 2000 | Journalof Fluid Engineering2000，122，1： | 1 |
| 6 | Assessment of cell type specific gene transfer of polyoma virus like particles presenting a tumor specific antibody Fv fragment显示文摘 | May T Gleiter S Lilie H | 2002 | J Virol Methods2002，105，1： | 1 |
| 7 | Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker显示文摘 | Lily L Wu James T Wu | 2002 | Clinica Chimica Acta2002，，1： | 1 |
| 8 | Validation of hyperbolic model for water - hammer in deformable pipes 显示文摘 | Lili T | 2000 | Journal of fluids engineering2000，122，3： | 1 |
| 9 | Membrane-bound Fas ligand only is essential for Fas-induced apoptosis显示文摘 | Lorraine A' R Lin T Lily L | 2009 | Nature2009，451，3： | 1 |
| 10 | Leaming user similarity and rating style for collaborative recommendation显示文摘 | Kwok-Wai C Lily F T | 2004 | Information Retrieval2004，7，34： | 1 |
| 11 | An Information Systems Security Risk Assessment Model Under Dempster-Shafer Theory of Belief Functions显示文摘 | Sun Lili Srivastava R P Mock T J | 2006 | Journal of Management Information Systems2006，22，4： | 1 |
| 12 | A role for uric acid in the progression of renal disease显示文摘 | KANG D H NAKAGAWA T FENG Lili | 2002 | Journal of the American Society of Nephrology2002，13，12： | 1 |
| 13 | Defective ribosomal products are the major source of antigenic peptides endogenously generated from influenza A vi- rus neuraminidase显示文摘 | BRIAN P D LILY L KAZUYO T | 2010 | J Immunol2010，184，3： | 1 |
| 14 | Clostridium botulinum spores in infant foods: a survey显示文摘 | Kautter D Lily A and solomon T | 1982 | Journal fo food Protection1982，45，11： | 1 |
| 15 | A study of the effect of nitrogen and air plasma immersion ion implantation treatments on the properties of carbon fiber显示文摘 | Leide Lili G da Silva Luciano Guimares Alves András Tóth | 2011 | IEEE Transactions on Plasma Science2011，39，11： | 1 |
| 16 | The Effects of Conflict,Trust,and Task Commitment on Project Team Performance显示文摘 | Porter T W Lily B S | 1996 | International Journal of Conflict Management1996，7，4： | 1 |
| 17 | Adaptor protein controlled oligomerization activates the AAA+; protein ClpC显示文摘 | Kirstein J Schlothauer T Dougan D A Lilie H Tischendorf G Mogk A Bernd B Turgay K | 2006 | The EMBO Journal2006，25，7： | 1 |
| 18 | PAPR analysis and reduction in WPDM systems显示文摘 | Aicha A B LiLi T Jabara S B | 2004 | IEEE Control Communications and Signal Processing2004，，1： | 1 |
| 19 | Enhanced absorption of gra- phene with one-dimensional photonic crystal 显示文摘 | LILI J T LIU N H LI J | 2012 | Appl Phys Lett2012，101，5： | 1 |
| 20 | Glycosylation, transport, and complex formation ofpalmitoyl protein thioesterase 1 (PPT1)-distinct characteristics in neurons显示文摘 | Lily A Von Schantz C Salonen T | 2007 | BMC Cell Biol2007，8，： | 1 |
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