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| 1 | Towards a global One Health index: a potential assessment tool for One Health performance显示文摘Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.Methods:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the indicators.Results:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be feasible.Conclusions:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promoting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge. | Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye Liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou | 2022 | Infectious Diseases of Poverty2022，11，3： | 3 |
| 2 | Production of hepatitis B surface antigen in transgenic plants for oral immunization 显示文摘 | LIZ J R YASMIN T CHARLES J A | 2000 | Nat Biotechnol2000，18，： | 1 |
| 3 | CO2 emissions embodied in international trade:evidence for Spain显示文摘 | Sánchez-Chóliz J Duarte R | | 0，，18： | 1 |
| 4 | Regulation of pri-miRNA processing by a long noncoding RNA transcribed from an uhraconserved region 显示文摘 | Liz J Portela A Soler M | 2014 | Mol Cell2014，55，： | 1 |
| 5 | The Liver in obesity and type 2 diabetes Mellitus显示文摘 | Liz Clark J Diehl AM | 2002 | Clin Liver Dis2002，6，4： | 1 |
| 6 | Periodic boundary value problem for integro-differential equations with general kernel显示文摘 | E Liz J J Nieto | 1994 | Dynamic Systems and Applications1994，，3： | 1 |
| 7 | The monotont iterative technique for eriodic boundary value problems of second order impulsive differentional equations显示文摘 | E LIZ J J NIEFJ | 1993 | Comment Mary Univ Caralin1993，，34： | 1 |
| 8 | Further evidence of the role of frizzled - related protein gene polymorphisms in osteoarthritis显示文摘 | Rodriguez - Lopez J Pombo - Suarez M Liz M | 2007 | Ann Rheum Dis2007，8，： | 1 |
| 9 | Periodic boundary value problems for integro-differential equations with General Kernel 显示文摘 | Liz E Nieto J J | 1994 | Dynamic Systems and Application1994，，3： | 1 |
| 10 | Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase显示文摘 | Fanni S. Kálmán Beáta Lizák Szilvia K. Nagy Tamás Mészáros Veronika Zámbó József Mandl Miklós Csala éva Kereszturi | 2013 | Biochimie2013，，7： | 1 |
| 11 | Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage显示文摘 | Samuel Garcia Myriam Liz Juan J Gomez-Reino | 2010 | Arthritis Res Ther2010，12，1： | 1 |
| 12 | Electrocrystallization process during deposition of Bi-Te films显示文摘 | Liu D W Liz J F | 2008 | J Electrochem Soc2008，155，： | 1 |
| 13 | Periodic boundary value problems for a class of functional differential equations显示文摘 | Liz E Nieto J J | 1996 | Journal of Math Ana Appl1996，，200： | 1 |
| 14 | Effective nurse parent communication: A study of parents ' perceptions in the NICU environment 显示文摘 | Liz J Woodhouse D Rowe J | 2007 | Patient Educ Couns2007，69，13： | 1 |
| 15 | Effect of Bi2O3 coatingon interfacial wettability and tensile properties of Alig'B4O33W/AI composite 显示文摘 | LiZ J Wang L D Yue H Y | 2007 | J Mater Sci2007，42，： | 1 |
| 16 | Iron isotope fractionation during skarn-type mineralization:A case study of Xinqiao Cu-S-Fe-Au deposit in the Middle-Lower Yangtze valley显示文摘 | Wang Y Zhu X K Mao J W LiZ H Cheng Y B | | 0，，： | 1 |
| 17 | CpG is-land hypermethylation-associated silencingof non-coding RNAs transcribed from ultra-conserved regions in human cancer 显示文摘 | Lujambio A Portela A Liz J | 2010 | Oncogene2010，29，48： | 1 |
| 18 | CO2 Emissions Embodied in International Trade:Evidence for Spain显示文摘 | Sánchez-Chóliz J Duarte R | 2004 | Energy Policy2004，，18： | 1 |
| 19 | DNA methylation determines nueleo- some occupancy in the 5'-CpG islands of tumor suppressor genes 显示文摘 | Portela A Liz J Nogales V | 2013 | Oneegene2013，32，47： | 1 |
| 20 | Perception and modification of plant flavonoid signals by rhizosphere microorganisms显示文摘 | LIZ J SHAWtPHIL MORRIS JOHN E HOOKER | 2006 | Environmental Microbiology2006，8，11： | 1 |
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