|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Role and Mechanisms of Double Negative Regulatory T Cells in the Suppression of Immune Responses显示文摘Accumulating evidence has demonstrated that regulatory T (Treg) cells play an important role in the maintenance of immunologic self-tolerance and in down-regulating various immune responses. Thus, there has recently been an increasing interest in studying the biology of Treg cells as well as their potential application in treating immune diseases. Many types of Treg cell subsets have been reported in a variety of disease models.Among these subsets, αβ-TCR+CD3+CD4-CD8- double negative (DN) Treg cells are defined by their capability of inhibiting immune responses via directly killing effector T cells in an antigen specific fashion. Furthermore,DN Treg cells have been shown to develop regulatory activity after encountering specific antigens, partially mediated by the acquisition of MHC-peptide complexes from antigen presenting cells (APCs). The presentation of acquired alloantigens on DN T cells allows for the specific interaction between DN Treg cells and alloantigen reactive effector T cells. Once the DN Treg and target cells have come into contact, killing is then mediated by Fas/Fas-ligand interactions, and perhaps through other unidentified pathways. Further characterization of the functions, molecular expression and mechanisms of activation of DN Treg cells will help in the development of novel therapies to induce antigen specific tolerance to self and foreign antigens. Cellular & Molecular Immunology. 2004;1(5):328-335. | WenhaoChen MeganS.Ford KevinJ.Young LiZhang | 2004 | Cellular & Molecular Immunology2004，1，5： | 20 |
| 2 | SPECIES DIVERSITY AND COMMUNITY STRUCTURE OF SUCKING LICE IN YUNNAN, CHINA显示文摘On the basis of investigating 9 counties (towns) in Yunnan Province of China, the species diversity and community structure of sucking lice on the body surface of small mammal hosts are studied in the paper. Species richness (S) is used to stand for the species diversity. The calculation of community diversity index and evenness are based on Shannon-Wiener's method. 2745 small mammals captured from the investigated sites belong to 10 families, 25 genera and 41 species in 5 orders (Rodentia, Insectivora, Scandentia, Logomorpha and Carnivora) while 18165 individuals of sucking lice collected from the body surface of the small mammal hosts are identified into 4 families, 6 genera and 22 species. The species of sucking lice are much less than the species of their hosts. Most species of small mammals have their fixed sucking lice on their body surface. One species of small mammals usually have few species of sucking lice (1 to 4 species). The close species of the hosts in the taxonomy are found to have the same or similar dominant species of sucking lice on their body surface. The results reveal that the species diversity of sucking lice on small mammals is very low with a very simple community structure. The results also imply there may be a close co-evolution relationship between the lice and the hosts. | Xian-guoGuo Ti-junQian Li-junGuo JingWang Wen-geDong LiZhang Zhi-minMa andWeiLi | 2004 | Entomologia Sinica2004，11，1： | 18 |
| 3 | Inhibitory effect of extracts of Ginkgo biloba leaveson VEGF-induced hyperpermeability of bovine coronary endothelial cells in vitro显示文摘AIM: To study whether extract of Ginkgo biloba (EGb) can protect against atherosclerosis. METHODS: Confluent monolayers of bovine coronary endothelial cells (BCECs), bovine coronary smooth muscle cells (BCSMCs), and cocultures of the two were incubated with medium containing VEGF and/or EGb, and flux of ^125I-labeled oxidized low density lipoprotein (ox-LDL) across the monolayers was measured. RESULTS: Incubation with VEGF significantly increased the permeability of BCEC monolayers to ^125I-ox-LDL in a time- and concentration-dependent manner, but had no effect on permeability of BCSMCs or endothelial cells-smooth muscle cells cocultures. EGb significantly inhibited the VEGF-induced hyperpermeability of BCECs. CONCLUSION: VEGF was important in the formation and development of atherosclerosis. The inhibition of VEGF-induced permeability by EGb suggests that extracts of Ginkgo biloba leaves may have important clinical applications in the treatment of cardiovascular diseases. | YanQIU Yao-chengRUI Tie-junLI LiZHANG Peng-yuanYANG | 2004 | Acta Pharmacologica Sinica2004，25，10： | 5 |
| 4 | 3D Finite Element Numerical Simulation of Residual Stresses on Electron Beam Welded BT20 Plates显示文摘A three-dimensional finite-element model (FEM) used for calculating electron beam (EB) welding temperature and stresses fields of thin plates of BT20 titanium has been developed in which the nonlinear thermophysical and thermo-mechanical properties of the material has been considered. The welding temperature field, the distributions of residual stresses in aswelded (AW) and electron beam local post-weld heat treatment (EBLPWHT) conditions have been successfully simulated.The results show that: (1) In the weld center, the maximum magnitude of residual tensile stresses of BT20 thin plates of Ti alloy is equal to 60%~ 70% of its yield strength σs. (2) The residual tensile stresses in weld center can be even decreased after EBLPWHT and the longitudinal tensile stresses are decreased about 50% compared to joints in AW conditions. (3)The numerical calculating results of residual stresses by using FEM are basically in agreement with the experimental results.Combined with numerical calculating results, the effects of electron beam welding and EBLPWHT on the distribution of welding residual stresses in thin plates of BT20 have been analyzed in detail. | LixingHUO FurongCHEN YufengZHANG LiZHANG FangjunLIU GangCHEN | 2004 | Journal of Materials Science & Technology2004，20，1： | 5 |
| 5 | Limited distribution and mechanism of the TetX4 tetracycline resistance enzyme显示文摘Tetracyclines,a group of antimicrobial agents targeting protein synthesis,have been extensively used in agricultural,veterinary,and clinic settings[1].The sporadic rise in tetracycline resistance is partially due to the occurrence of efflux pumps and/or ribosome protection[1,2].The growing body of tetracycline-inactivating enzymes(e.g.,TetX(X1 to X4)[3,4]and Tet(47 to 55)[5])represents an alternative mechanism for tetracycline resistance,and threatens the renewed interest of tigecycline as a last-resort defense against lethal infections with carbapenem-resistant Enterobacteriaceae and Acinetobacter species. | Yongchang Xu Lizhang Liu Jian Sun Youjun Feng | 2019 | Science Bulletin2019，64，20： | 4 |
| 6 | A microarray-based gastric carcinoma prewarning system显示文摘AIM: To develop a microarray-based prewarning system consisting of gastric cancer chip, prewarning data and analysissoftware for early detection of gastric cancer and pre-cancerous lesions.METHODS: Two high-density chips with 8 464 human cDNA sites were used to primarily identify potential genes specific for normal gastric mucosa, pre-cancerous lesion and gastric cancer. The low-density chips, composed of selected genes associated with normal gastric mucosa,precancerous lesion and gastric cancer, were fabricated and used to screen 150 specimens including 60 specimens of gastric cancer, 60 of pre-cancerous tissues and 30 of normal gastric mucosa. CAD software was used to screen out the relevant genes and their critical threshold values of expression levels distinguishing normal mucosa from pre-cancerous lesion and cancer. All data were stored in a computer database to establish a prewarning data library for gastric cancer. Two potential markers brcaa1 and ndr1were identified by Western blot and immunohistochemistry.RESULTS: A total of 412 genes associated with three stages of gastric cancer development were identified.There were 216 genes displaying higher expression in gastric cancer, 85 genes displaying higher expression in pre-cancerous lesion and 88 genes displaying higher expression in normal gastric mucosa. Also 15 genes associated with metastasis of gastric cancer and 8 genes associated with risk factors were screened out for target genes of diagnosis chip of early gastric cancer. The threshold values of 412 selected genes to distinguish gastric cancer, pre-cancerous lesion from normal gastric mucosa were defined as 6.01±2.40, 4.86±1.94 and 5.42±2.17, respectively. These selected 412 genes and critical threshold values were compiled into an analysis software, which can automatically provide reports by analyzing the results of 412 genes obtained by examining gastric tissues. All data were compiled into a prewarning database for gastric cancer by CGO software. Northern blot and immunohistochemistry analysis confirmed that gene and protein of brcaa1 displayed lower expression in normal gastric mucosa and higher expression in gastric cancer tissues, conversely, ndr1 displayed lower expression in gastric cancer and higher expression in normal gastric mucosa.CONCLUSION: The microarray-based prewarning system for gastric cancer was developed. This system consisted of gastric cancer-associated gene chip, prewarning data and analysis software, which has a high potential for applications in the early detection of gastric cancer. The two potential markers brcaa1 and ndr1 identified may be used to distinguish cancer status fand non-cancer status. | Da-XiangCui LiZhang Xiao-JunYan Ling-XiaZhang Jun-RongXu Yan-HaiGuo Gui-QiuJin GiovaniGomez DingLi ,Jin-RongZhao Fen-ChanHan JuZhang Jia-LeHu Dai-MingFan Hua-JianGao | 2005 | World Journal of Gastroenterology2005，11，9： | 4 |
| 7 | Oblongifolin C and guttiferone K extracted from Garcinia yunnanensis fruit synergistically induce apoptosis in human colorectal cancer cells in vitro显示文摘Oblongifolin C (OC ) 和 guttiferone K (GUTK ) 是从 Garcinia yunnanensis 胡提取的二 anticancer 混合物,但是他们由不同机制行动。在这研究,我们调查了是否 OC 和 GUTK 的联合(1:1 臼齿的比率) 能在 vitro 对人的 colorectal 癌症房间生产 synergistic anticancer 效果。为比较,我们也从 G yunnanensis 水果检验了乙醇摘录的 anticancer 功效,它包含 OC 和 GUTK 直到 5% 。独自比作 OC 和 GUTK,象乙醇摘录一样的 OC 和 GUTK 的联合更 potently 分别地与 3.4 mol/L 和 3.85 g/mL 的 IC 50 价值禁止了癌症房间生长。而且, OC 和 GUTK 在 HCT116 房间上显示了 synergistic 抑制:有 OC 和 GUTK 的合作处理独自与任何一个药比治疗导致了更突出的 apoptosis。而且, OC 和 GUTK 的联合显著地增加了 casapse-3 和 PARP 的劈开,和提高的细胞的 ROS 生产和增加的 JNK 蛋白质 phosphorylation。另外, OC 和 GUTK 的联合比在完全的媒介在剥夺营养素的条件下面施加了更强壮的效果,建议 autophagy 起了在调整调停 OC 、调停 GUTK 的房间死亡的一个必要作用。OC 和 GUTK 是贡献 G yunnanensis 的 anticancer 活动的主要部件,混合物在 vitro 在 HCT116 房间有导致 apoptosis 效果。 | Hui LI Xiao-xiao MENG LiZHANG Bao-jun ZHANG Xin-yu LIU Wen-wei FU Hong-shengTAN Yuan-zhi LAO Hong-xi XU | 2017 | Acta Pharmacologica Sinica2017，38，2： | 4 |
| 8 | In vivo and in situ detection of colorectal cancer using Fourier transform infrared spectroscopy显示文摘AIM: Real-time and rapid identification of the malignant tissue can be performed during or before surgical operation.Here we aimed to detect in vivo and in situ colorectal cancer by using Fourier transform infrared (FTIR) spectroscopy and fiber-optic technology.METHODS: A total of five patients with large intestine cancer were detected in vivo and in situ. Of them, three cases of colon cancer and one case of cecum cancer were detected intraoperatively and in vivo by using a FTIR spectrometer during surgical operation, and one case of rectum cancer was explored non-invasively and in vivo before the surgical operation. Normal and malignant colorectal tissues were detected in vivo and in situ using FTIR spectroscopy on the basis of fundamental studies.RESULTS: There were significant differences between FTIR spectra of normal and malignant colorectal tissues detected in vivo and in situ. Experimental results revealed that the spectral characteristics of normal and malignant tissues found in vivo and in situ were similar to those obtained from in vitro measurement in our previous fundamental research.CONCLUSION: FTIR fiber-optic attenuated total reflectance (ATR) spectroscopy can identify in situ and in vivo colorectal cancer. FTIR spectroscopic method with fiber optics is a non-invasive, rapid, accurate and in vivo cancer detection technique in clinical diagnosis. | Qing-BoLi ZhiXu Neng-WeiZhang LiZhang FanWang Li-MinYang Jian-ShengWang SuZhou Yuan-FuZhang Xiao-SiZhou Jing-SenShi Jin-GuangWu | 2005 | World Journal of Gastroenterology2005，11，3： | 3 |
| 9 | Detecting differential expression from RNA-seq data with expression measurement uncertainty显示文摘 | LiZHANG Songcan CHEN Xuejun LIU | 2015 | Frontiers of Computer Science2015，9，4： | 3 |
| 10 | FT-IR spectroscopic analysis of normal and cancerous tissues of esophagus显示文摘AIM: To investigate the special Fourier transform infraredspectroscopy (FT-IR) spectra in normal and cancerous tissuesof esophagus.METHODS: Twenty-seven pairs of normal and canceroustissues of esophagus were studied by using FT-IR and thespecial spectra characteristics were analyzed in differenttissues.RESULTS: Different spectra were found in normal andcancerous tissues. The peak at 1 550/cm was weak andwide in cancerous tissues but strong and high in normaltissues.The ratio of I1 647/I1 550 was 2.0 in normal tissuesand 2.36 in cancerous tissues (P<0.05). The ratio of Ⅰ1 550/I 1 080 was 4.5 in normal tissues and 3.4 in canceroustissues (P<0.01). The peak at 1453/cm was higher than at1 402/cm in normal tissue and lower than at 1 402/cm incancerous tissues.CONCLUSION: The results indicate that F-FIR may be used in clinical diagnosis. | Jian-ShengWang Jing-SenShi Yi-ZhuangXu XiaoDuan LiZhang JingWang Li-MingYang Shi-FuWeng Jin-GuangWu | 2003 | World Journal of Gastroenterology2003，9，9： | 2 |
| 11 | A Novel Missense Mutation(L^(296)Q)in Cholesteryl Ester Transfer Protein Gene Related to Coronary Heart Disease显示文摘Cholesteryl ester transfer protein (CETP) is a key participant in the, reverse transport of cholesterol from the peripheral tissues to the liver. To understand the role that CETP gene plays in the pathogenesis of coronary heart disease (CHD), the promoter region, all 16 exons and adjacent intronic regions of CETP gene were screened for single nucleotide polymorphisms (SNPs) in 203 CHD patients and 209 controls by a combination of PCR, denaturing high performance liquid chromatography (DHPLC),molecular cloning, and DNA sequencing. A novel missense mutation in the CETP geve was identified. This mutation (L^296Q) was a T-to-A conversion at codon 296 of exon 10 which replaced the codon for leucine (CTG) with the codon for glutamine (CAG). Association study revealed that L^296Q mutation was associated with CHD with a significantly higher mutant allele frequency in the CHD patients than that in the controls (0.160 vs. 0.091,x^2=9.014, P=0.003), and that the odds ratio for the development of CHD was 1.83 for the ^296Q allele carriers relative to ^296LL homozygotes. Statistical analyses demonstrated thai the mutant ^296Q allele carrier patients displayed significantly higher total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) concentrations than non-carrier patients. The results of the present study suggest that the L^296Q mutation is related to CHD, and the identification of new mutations in the CETP gene will afford the opportunity to investigate the relationship between CETP gene and CHD. | Ke-QinZHENG Si-ZhongZHANG LiZHANG De-JiaHUANG Lin-ChuanLIAO Yi-PingHOU | 2004 | Acta Biochimica et Biophysica Sinica2004，36，1： | 2 |
| 12 | Campylobacter concisus and other Campylobacter species in children with newly diagnosed Crohn’s disease显示文摘 | Si MingMan LiZhang Andrew S.Day Steven T.Leach Daniel A.Lemberg HazelMitchell | 2010 | Inflamm Bowel Dis2010，，6： | 2 |
| 13 | Phylogenetic performance of mitochondrial protein-coding genes of Oncomelania hupensis in resolving relationships between landscape populations显示文摘Oncomelania hupensis 是血吸虫 japonicum 的唯一的中间的主人,它在人的血吸虫血吸虫的传播起一个关键作用。O 的完全的 mitochondrial (mt ) 染色体。hupensis 被描绘了;然而, mt 的种系发生的表演蜗牛的编码蛋白质的基因(PCG ) 仍然保持不清楚。在这研究,在中国和菲律宾从四个不同生态的背景收集的蜗牛的 11 个整个 mt 染色体被定序。mt 染色体尺寸从 15183 到 15216bp,与从 32.4% ~ 33.4% 的 G+C 内容。15251 个人物的一个总数从多重顺序排列被产生。2711 (17.8%) 多态的地点,(1524 )56.22% 是吝啬地点。mt 染色体的种系发生的树用最小的进化,加入的邻居,最大的可能性的,最大的吝啬,和贝叶斯的树估计被重建方法,和二主要不同 clades 被识别:(i) 从多山的区域的 isolate;(ii ) 留下孤立哪个包括了三根内部树枝。13 PCG 的所有种系发生的树被运用 1000 产生自举复制并且与完全的 mtDNA 树相比,从 21.23% ~ 87.87%的分类精确性,在从 5 ~ 14 的 PCG 之间的种系发生的树的拓扑的距离。因此, PCG 的表演能被划分成好状况(COI, ND2, ND5,和 ND3 ) ,媒介(COII, ATP6, ND1, ND6, Cytb, ND4,和 COIII ) ,穷人(ATP8 和 ND4L ) 。这研究代表 O 的 mt 染色体差异的第一分析。hupensis 蜗牛和 mt PCG 的种系发生的性能。它介绍蜗牛人口能被分开成四处风景的清楚的证据在大陆中国的基因人口基于整个 mt 染色体。PCG 的种系发生的表演的鉴定为蜗牛用 mtDNA 标记提供新卓见进集中的基因差异学习。 | Shi-Zhu LI LiZHANG Lin MA Wei HU Shan LV Qin LIU Ying-Jun QIAN Qiang WANG Xiao-Nong ZHOU | 2013 | Journal of Systematics and Evolution2013，51，3： | 2 |
| 14 | Inertial force balance and ADAMS simulation of the oscillating sieve and return pan of a rice combine harvester显示文摘To reduce the inertial force of the oscillating sieve and return pan of a rice combine harvester,partial equilibrium was adopted.Firstly,based on the kinematic analysis of a slider-crank mechanism,the appropriate mass of counterweight intervals was achieved.Then,an ADAMS dynamic simulation was used to determine the optimum balance mass of the oscillating sieve and return pan individually.Considering the relative motion between the return pan and the oscillating sieve,the overall inertial force of the two parts would be reduced.The simulation results indicated that the optimum counterweight of the oscillating sieve was 15.5 kg based on an analysis of the movement tracks of the mass center and overall inertial force.The results also showed that the overall balance of inertial force not only reduced the counterweight but also decreased the overall inertial force of the oscillating sieve and return pan.Finally,a search for the most suitable crank initial angle of the return pan to reduce the overall inertial force and optimize the overall balance revealed three groups of initial angles:φ=0°,φ=45°,andφ=90°.The results indicated that arranging the initial angle of the crank of the oscillating sieve and return pan in the same position(φ=90°)was the most favorable for reducing the overall inertial force.In this situation,the optimum counterweight of the oscillating sieve was only 14.0 kg.The results can provide references for the design of the overall balance of the inertial force in the cleaning components of a combine harvester. | Chuncai Wei Lizhang Xu Jianting Wang Yaoming Li | 2018 | International Journal of Agricultural and Biological Engineering2018，11，1： | 2 |
| 15 | Expression of local renin and angiotensinogen mRNA in cirrhotic portal hypertensive patient显示文摘AIM: To investigate the expression of local renin and angiotensinogen mRNA in cirrhotic portal hypertensive patients.METHODS: The expression of local renin and angiotensinogen mRNA in the liver, splenic artery and vein of PH patients was detected by RT-PCR analysis.RESULTS: Expression of local renin mRNA in the liver of control group was (0.19±0.11), significantly lower than that in splenic artery(0.45±0.17)or splenic vein(0.39±0.12)respectively, (P<0.05). Expression of local angiotensinogen mRNA in the liver was (0.64±0.21), significantly higher than that in splenic artery(0.41±0.15) or in splenic vein (0.35±0.18)respectively, (P<0.05). Expression of local renin mRNA in the liver, splenic artery and vein of PH group was (0.78±0.28),(0.86±0.35) and (0.81±0.22) respectively, significantly higher than that in the control group, (P<0.05). Expression of local angiotensinogen mRNA in the liver, splenic artery and vein of PH group was (0.96±0.25), (0.83±0.18) and (0.79±0.23)respectively, significantly higher than that in the control group,(P<0.05). There was no significant difference between the liver, splenic artery and vein in the expression of local renin or local angiotensinogen mRNA in PH group, (P<0.05).CONCLUSION: In normal subjects the expression of local renin and angiotensinogen mRNA was organ specific, but with increase of the expression of LRAS, the organ-specificity became lost in cirrhotic patients. LRAS may contribute to increased resistance of portal vein with liver and formation of splanchnic vasculopathy. | LiZhang ZhengYang Bao-MinShi Da-PengLi Chong-YunFang Fa-ZuQiu | 2003 | World Journal of Gastroenterology2003，9，7： | 2 |
| 16 | Metformin improves cardiac function in rats via activation of AMP‐activated protein kinase显示文摘 | Xiao‐FangWang Jin‐YingZhang LingLi Xiao‐YanZhao Hai‐LongTao LiZhang | 2011 | Clinical and Experimental Pharmacology and Physiology2011，，2： | 2 |
| 17 | Clinical diagnosis and treatment of acute fatty liver of pregnancy: A literature review and 11 new cases显示文摘 | QiangWei LiZhang XinghuiLiu | 2010 | Journal of Obstetrics and Gynaecology Research2010，，4： | 2 |
| 18 | Internet-based investment environment information system:A case study on BKR of China显示文摘 | Hulin Lizhang | 1998 | IJGIS1998，，12： | 1 |
| 19 | A new strategy for determination of current efficiency during electro oxidation of aromatic compounds in a packed-bed system显示文摘 | WANG Lizhang ZHAO Yuemin GAO Qingyu | 2011 | Water Science and Technology2011，63，11： | 1 |
| 20 | Effect of calcination temperature and molar ratio of tin and manganese on capacitance of Ti/SnO2-Sb-Mn/fl-PbO2 electrode during phenol electro-oxidation 显示文摘 | LI Peng ZHAO Yuemin WANG Lizhang | 2015 | Journal of Electroanalytical Chemistry2015，747，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员