|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intratumor heterogeneity,microenvironment,and mechanisms of drug resistance in glioma recurrence and evolution显示文摘Glioma is the most common lethal tumor of the human brain.The median survival of patients with primary World Health Organization grade IV glioma is only 14.6 months.The World Health Organization classification of tumors of the central nervous system categorized gliomas into lower-grade gliomas and glioblastomas.Unlike primary glioblastoma that usually develop de novo in the elderly,secondary glioblastoma enriched with an isocitrate dehydrogenase mutant typically progresses from lower-grade glioma within 5-10 years from the time of diagnosis.Based on various evolutional trajectories brought on by clonal and subclonal alterations,the evolution patterns of glioma vary according to different theories.Some important features distinguish the normal brain from other tissues,e.g.,the composition of the microenvironment around the tumor cells,the presence of the blood-brain barrier,and others.The underlying mechanism of glioma recurrence and evolution patterns of glioma are different from those of other types of cancer.Several studies correlated tumor recurrence with tumor heterogeneity and the immune microenvironment.However,the detailed reasons for the progression and recurrence of glioma remain controversial.In this review,we introduce the different mechanisms involved in glioma progression,including tumor heterogeneity,the tumor microenvironment and drug resistance,and their pre-clinical implements in clinical trials.This review aimed to provide new insights into further clinical strategies for the treatment of patients with recurrent and secondary glioma. | Zhaoshi Bao Yongzhi Wang Qiangwei Wang Shengyu Fang Xia Shan Jiguang Wang Tao Jiang | 2021 | Frontiers of Medicine2021，15，4： | 10 |
| 2 | A classification of some regular p-groups and its applications显示文摘In this paper we classify regular p-groups with type invariants (e, 1, 1, 1) for e ≥ 2 and (1, 1, 1, 1, 1). As a by-product, we give a new approach to the classification of groups of order p5, p ≥ 5 a prime. | ZHANG Qinhai SONG Qiangwei XU Mingyao | 2006 | Science China Mathematics2006，49，3： | 9 |
| 3 | Finite p-groups whose nonnormal subgroups are metacyclic显示文摘For an odd prime p,we give a criterion for finite p-groups whose nonnormal subgroups are metacyclic,and based on the criterion,the p-groups whose nonnormal subgroups are metacyclic are classified up to isomorphism.This solves a problem proposed by Berkovich. | Qiangwei Song Haipeng Qu | 2020 | Science China Mathematics2020，63，7： | 2 |
| 4 | Reprogramming of phytopathogen transcriptome by a non-bactericidal pesticide residue alleviates its virulence in rice显示文摘Bacteria equipped with virulence systems based on highly bioactive small molecules can circumvent their host's defense mechanisms.Pathogens employing this strategy are currently threatening global rice production.In the present study,variations in the virulence of the highly destructive Barkholderiaplantarii were observed in different rice-producing regions.The environment-linked variation was not attributable to any known host-related or external factors.Co-occurrence analyses indicated a connection between reduced virulence and 5-Amino-l,3,4-thiadiazole-2-thiol(ATT),a non-bactericidal organic compound.ATT,which accumulates in rice plants during metabolization of specific agrochemicals,was found to reduce virulence factor secretion by B.plantarii up to 88.8%and inhibit pathogen virulence by hijacking an upstream signaling cascade.Detailed assessment of the newly discovered virulence inhibitor resulted in mechanistic insights into positive effects of ATT accumulation in plant tissues.Mechanisms of virulence alleviation were deciphered by integrating high-throughput data,gene knockout mutants,and molecular interaction assays.TroK,a histidine protein kinase in a two-component system that regulates virulence factor secretion,is likely the molecular target antagonized by ATT.Our findings provide novel insights into virulence modulation in an important plant-pathogen system that relies on the host's metabolic activity and subsequent signaling interference. | Haruna Matsumoto Yuan Qian Xiaoyan Fan Sunlu Chen Yanxia Nie Kun Qiao Dandan Xiang Xinzhong Zhang Meng Li Bo Guo Peilin Shen Qiangwei Wang Yunlong Yu Tomislav Cemava Mengcen Wang | 2022 | Fundamental Research2022，2，2： | 2 |
| 5 | Anticancer Drug Resistance of HeLa Cells Transfected With Rat Glutathione S-transferase pi Gene显示文摘To establish a cytologic expressing system of rat glutathione S-transferase pi (GST-pi) cDNA for detecting the resistance of HeLa cells to anticancer drugs. Methods The assessment was made with various anticancer drugs (adriamycin, mitomycin, cisplatinum and vincristine) that showed different cytotoxicities in transfectant HeLa cells with pSV-GT containing rat GST-pi cDNA (HeLa/pSV-GT) or control pSV-neo (HeLa/pSV-neo). Expression levels of GST-pi mRNA in HeLa/pSV-GT and HeLa/pSV-neo were measured by in situ hybridization using Digoxin-labelled cDNA probe. Results HeLa/pSV-GT expressed significantly high degree of GST-pi mRNA, whereas both HeLa/pSV-neo and HeLa cells had very low expression. Cytotoxicities of HeLa/pSV-GT and HeLa/pSV-neo with 4 anticancer drugs were measured by MTT assay. Drug concentrations for yielding 50% inhibition (IC50) in HeLa/pSV-GT by adriamycin, mitomycin and cisplatinum were 70.13 靏/mL, 10.95 靏/mL and 16.52 靏/mL, respectively. In contrast, IC50 in HeLa/pSV-neo was 10.34 靏/mL, 7.48 靏/mL and 13.70 靏/mL, respectively. The cytotoxicities of vincristine on both HeLa/pSV-GT and HeLa/pSV-neo were not significantly different. Conclusions Our findings suggest that HeLa/pSV-GT containing rat GST-pi cDNA is resistant to some anticancer drugs due to overexpression of GST-pi. Also, HeLa/pSV-GT cell line could serve as a useful cytogenetic model for further research. | WEICAO YANMENG QIANGWEI ZHAO-HUISHI LI-MEIJU FU-DEFANG | 2003 | Biomedical and Environmental Sciences2003，16，2： | 2 |
| 6 | Clinical diagnosis and treatment of acute fatty liver of pregnancy: A literature review and 11 new cases显示文摘 | QiangWei LiZhang XinghuiLiu | 2010 | Journal of Obstetrics and Gynaecology Research2010，，4： | 2 |
| 7 | Finite 2-groups whose length of chain of aonnormal subgroups is at most 2显示文摘 | Qiangwei SONG Qinhai ZHANG | 2018 | Frontiers of Mathematics in China2018，13，5： | 1 |
| 8 | Tetragonal (Ba, Ca) (Zr, Ti)O_(3) textured ceramics with enhanced piezoelectric response and superior temperature stability显示文摘Lead-free ceramics with both high piezoelectric response and good temperature stability are urgently demanded for electromechanical conversion devices.Unfortunately,owing to coexistence of poly-morphic phases near room temperature(RT),enhanced piezoelectric properties were usually achieved with occurrence of strong temperature dependence in modified BaTiO_(3)(BT)-based ceramics.In this work,we demonstrate that tailoring grain orientations of tetragonal BT-based ceramics can effectively produce substantially enhanced and thermally stabilized piezoelectric response.Both<001>c-and<111>c-oriented tetragonal(Ba_(0.85)Ca_(0.15))(Zr_(0.05)Ti_(0.95))O_(3)(BCZT)ceramics with texture degrees F>90%were synthesized via templated grain growth.Interestingly,the ceramics textured along the<001>c polar axis show much higher microscopic and macroscopic piezoelectric properties than those with nonpolar<111>c texture,indicating an“extender”ferroelectricity nature.Compared with randomly oriented samples,the<001>c-oriented ceramics exhibit simultaneously~1.6 times higher piezoelectric strain d_(33)^(*)(~760 pm/V),4.4 times higher piezoelectric figure of merit d_(33)×g_(33)(8.8×10^(-12) m^(2)/N),and better temperature stability(strain variation≤5%between RT and 110℃).Such thermally stabilized strain response can be mainly attributed to wide temperature range of tetragonal phase and stable domain structure.This work provides a promising route for further developing lead-free piezoceramics with high and temperature-insensitive performance,which can greatly broaden their application areas. | Qiangwei Kou Bin Yang Yuan Sun Shuai Yang Linjing Liu Hang Xie Yunfei Chang Shantao Zhang Fei Li | 2022 | Journal of Materiomics2022，8，2： | 1 |
| 9 | No role for human papillomavirus in esophageal squamous cell carcinoma in China显示文摘 | JillKoshiol Wen‐QiangWei Aimee R.Kreimer WenChen PattiGravitt Jian‐SongRen Christian C.Abnet Jian‐BingWang FarinKamangar Dong‐MeiLin Magnusvon Knebel‐Doeberitz YuZhang RaphaelViscidi Guo‐QingWang Maura L.Gillison Mark J.Roth Zhi‐WeiDong EstherKim Philip R | 2010 | Int. J. Cancer2010，，1： | 1 |
| 10 | Effects of tea polyphenols dip treatment on the quality of Catfish fillets during partial freezing storage显示文摘 | Liang Liya Yan Shijie Wang Qiangwei | 2012 | Advanced Materials Research2012，，： | 1 |
| 11 | No role for human papillomavirus in esophageal squamous cell carcinoma in China显示文摘 | JillKoshiol Wen‐QiangWei Aimee R.Kreimer WenChen PattiGravitt Jian‐SongRen Christian C.Abnet Jian‐BingWang FarinKamangar Dong‐MeiLin Magnusvon Knebel‐Doeberitz YuZhang RaphaelViscidi Guo‐QingWang Maura L.Gillison Mark J.Roth Zhi‐WeiDong EstherKim Philip R | 2010 | Int J Cancer2010，，1： | 1 |
| 12 | microRNA-29b Mediates the Antifibrotic Effect of Tanshinone IIA in Postinfarct Cardiac Remodeling显示文摘 | Fan Yang Ping Li Haiyu Li Qiangwei Shi Shuaibing Li Luosha Zhao | 2015 | Journal of Cardiovascular Pharmacology2015，，： | 1 |
| 13 | Intrinsic oxidation kinetics of sulfite catalyzed by peracetic acid under different water quality and light conditions显示文摘Oxidation of sulfite is an important process in wet flue gas desulfurization.Using highly purified water or distilled water as a reaction medium and a transparent or an opaque intermittent reaction apparatus,the intrinsic oxidation kinetics of sulfite catalyzed by peracetic acid was investigated under four dif-ferent conditions.The reaction order of the reagents and the activation energy were obtained.The re-sults indicate that water quality and light have no obvious effects on the reaction order and activation energy,but have an influence on the reaction rate constant.The mechanism of the intrinsic reaction is proposed.The results derived with this mechanism are in good agreement with the experimental re-sults. | WANG LiDong ZHAO Yi LI QiangWei CHEN ZhouYan LIU SongTao MA YongLiang HAO JiMing | 2009 | Science China Chemistry2009，52，1： | 1 |
| 14 | No role for human papillomavirus in esophageal squamous cell carcinoma in China显示文摘 | JillKoshiol Wen‐QiangWei Aimee R.Kreimer WenChen PattiGravitt Jian‐SongRen Christian C.Abnet Jian‐BingWang FarinKamangar Dong‐MeiLin Magnusvon Knebel‐Doeberitz YuZhang RaphaelViscidi Guo‐QingWang Maura L.Gillison Mark J.Roth Zhi‐WeiDong EstherKim Philip R | 2010 | Int J Cancer2010，，1： | 1 |
| 15 | Forecasting Tesla’s Stock Price Using the ARIMA Model显示文摘The stock market is an important economic information center.The economic benefits generated by stock price prediction have attracted much attention.Although the stock market cannot be predicted accurately,the stock market’s prediction of the trend of stock prices helps in grasping the operation law of the stock market and the influence mechanism on the economy.The autoregressive integrated moving average(ARIMA)model is one of the most widely accepted and used time series forecasting models.Therefore,this paper first compares the return on investment(ROI)of Apple and Tesla,revealing that the ROI of Tesla is much greater than that of Apple,and subsequently focuses on ARIMA model’s prediction on the available time series data,thus concluding that the ARIMA model is better than the Naïve method in predicting the change in Tesla’s stock price trend. | Qiangwei Weng Ruohan Liu Zheng Tao | 2022 | Proceedings of Business and Economic Studies2022，5，5： | 1 |
| 16 | Metabolic syndrome and its association with components of sarcopenia in older community-dwelling Chinese显示文摘Aging and obesity contribute to muscle dysfunction. This study aimed to determine the cross-sectional associations between components of metabolic syndrome (MetS) and sarcopenia in 251 older community- dwelling Chinese. The total fat-free mass was measured by dual-energy X-ray absorptiometry, muscle strength (handgrip strength) by a handheld dynamometer, physical performance by 4-meter walk, 5-time chair stand test, and the short physical performance battery (SPPB). MetS was defined using the International Diabetes Federation (IDF) criteria. The participants with MetS had a higher appendicular skeletal muscle mass (ASM) and relative ASM (RASM). The males with MetS had higher handgrip strength, and the females with MetS had higher SPPB scores. After adjusting for age and body mass index, the participants with an increased waist circumference had a higher ASM, and those with increased diastolic blood pressure (DBP) also had higher handgrip strength. The males with elevated fasting blood glucose (FBG) levels had a lower gait speed. Components of MetS, such as DPB and FBG, were associated with muscle strength and physical performance in older adults. These results suggest that muscle strength and function should be considered in treating older adults with MetS. | Qiangwei Tong Xiao Wang Yunlu Sheng Shu Chen Bin Lai Rong Lv Jing Yu | 2022 | The Journal of Biomedical Research2022，36，2： | 1 |
| 17 | Uniform-sized PLA nanoparticles: Preparation by premix membrane emulsification显示文摘 | QiangWei WeiWei | 2008 | Interna- tional Journal of Pharmaeeuties2008，359，： | 1 |
| 18 | A small molecule UPR modulator for diabetes identified by high throughput screening显示文摘Unfolded protein response(UPR) is a stress response that is specific to the endoplasmic reticulum(ER).UPR is activated upon accumulation of unfolded(or misfolded) proteins in the ER's lumen to restore protein folding capacity by increasing the synthesis of chaperones.In addition,UPR also enhances degradation of unfolded proteins and reduces global protein synthesis to alleviate additional accumulation of unfolded proteins in the ER.Herein,we describe a cell-based ultra-high throughput screening(uHTS) campaign that identifies a small molecule that can modulate UPR and ER stress in cellular and in vivo disease models.Using asialoglycoprotein receptor 1(ASGR) fused with Cypridina luciferase(CLuc) as reporter assay for folding capacity,we have screened a million small molecule library and identified APC655 as a potent activator of protein folding,that appears to act by promoting chaperone expression.Furthermore,APC655 improved pancreatic β cell viability and insulin secretion under ER stress conditions induced by thapsigargin or cytokines.APC655 was also effective in preserving β cell function and decreasing lipid accumulation in the liver of the leptin-deficient(ob/ob) mouse model.These results demonstrate a successful uHTS campaign that identified a modulator of UPR,which can provide a novel candidate for potential therapeutic development for a host of metabolic diseases. | Valeria Marrocco Tuan Tran Siying Zhu Seung Hyuk Choi Ana M.Gamo Sijia Li Qiangwei Fu Marta Diez Cunado Jason Roland Mitch Hull Van Nguyen-Tran Sean Joseph Arnab K.Chatterjee Nikki Rogers Matthew S.Tremblay Weijun Shen | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 1 |
| 19 | Multi-SVM classifier system with piecewise interpolation显示文摘 | Li Boyang Wang Qiangwei Hu Jinglu | 2013 | IEEJ Trans on Electrical and Electronic Engineering2013，8，2： | 1 |
| 20 | The Prototype Theory and Polysemy显示文摘 | Fu Qiangwei | 2017 | 校园英语2017，，47： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员