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| 1 | Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI显示文摘 | Wang L Zang Y He Y Liang M Zhang X Tian L Wu T Jiang T Li K | 2006 | 中国生物学文摘2006，20，10： | 84 |
| 2 | Invasive mechanism and management strategy of Bemisia tabaci(Gennadius) biotype B:Progress report of 973 Program on invasive alien species in China显示文摘Bemisia tabaci(Gennadius) biotype B,called a 'superbug',is one of the most harmful biotypes of this species complex worldwide.In this report,the invasive mechanism and management of B.tabaci biotype B,based on our 5-year studies,are presented.Six B.tabaci biotypes,B,Q,ZHJ1,ZHJ2,ZHJ3 and FJ1,have been identified in China.Biotype B dominates the other biotypes in many regions of the country.Genetic diversity in biotype B might be induced by host plant,geographical conditions,and/or insecticidal application.The activities of CarE(carboxylesterase) and GSTs(glutathione-S-transferase) in biotype B reared on cucumber and squash were greater than on other host plants,which might have increased its resistance to insecticides.The higher activities of detoxification enzymes in biotype B might be induced by the secondary metabolites in host plants.Higher adaptive ability of biotype B adults to adverse conditions might be linked to the expression of heat shock protein genes.The indigenous B.tabaci biotypes were displaced by the biotype B within 225 d.The asymmetric mating interactions and mutualism between biotype B and begomoviruses via its host plants speed up widespread invasion and displacement of other biotypes.B.tabaci biotype B displaced Trialeurodes vaporariorum(Westwood) after 4-7 generations under glasshouse conditions.Greater adaptive ability of the biotype B to adverse conditions and its rapid population increase might be the reasons of its successful displacement of T.vaporariorum.Greater ability of the biotype B to switch to different host plants may enrich its host plants,which might enable it to better compete with T.vaporariorum.Native predatory natural enemies possess greater ability to suppress B.tabaci under field conditions.The kairomones in the 3rd and 4th instars of biotype B may provide an important stimulus in host searching and location by its parasitoids.The present results provide useful information in explaining the mechanisms of genetic diversity,evolution and molecular eco-adaptation of biotype B.Furthermore,it provides a base for sustainable management of B.tabaci using biological and ecological measures. | WAN FangHao1,ZHANG GuiFen1,LIU ShuSheng2,LUO Chen3,CHU Dong4,ZHANG YouJun4,ZANG LianSheng2,JIU Min2,Lü ZhiChuang1,CUI XuHong1,ZHANG LiPing4,ZHANG Fan3,ZHANG QingWen5,LIU WanXue1,LIANG Pei5,LEI ZhongRen1 & ZHANG YongJun1 1 State Key Laboratory for Biology of Plant Diseases and Insect Pests,Institute of Plant Protection,Chinese Acadeny of Agriculture Sciences,Beijing 100094,China 2 Institute of Applied Entomology,Zhejiang University,Hangzhou 310029,China 3 Institute of Plant and Environment Protection,Beijing Academy of Agricultural and Forestry Sciences,Beijing 100089,China 4 Institute of Vegetables and Flowers,Chinese Acadeny of Agricullare Sciences,Beijing 100081,China 5 Department of Entomology,China Agriculture University,Beijing 100094,China | 2009 | Science China(Life Sciences)2009，52，1： | 30 |
| 3 | 非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系显示文摘尽管非维生素K拮抗口服抗凝剂(non-vitamin K antagonist oral anticoagulants, NOACs)越来越多地应用于预防血栓栓塞性疾病,但关于NOACs相关性脑出血的数据仍然有限。 | 刘青 叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH Reeves MJ Hernandez AF Bhatt DL Peterson ED Fonarow GC | 2018 | 中华高血压杂志2018，26，2： | 16 |
| 4 | Cytokine production during the inhibition of acute vascular rejection in a concordant hamster-to-rat cardiac xenotransplantation model显示文摘当前的学习的目的是调查 interleukin (IL ) 的角色的背景 -2, 干扰素(IFN ) ,在一致 hamster-to-rat 的 IL-4 和 IL-10 心脏的 xenotransplantation 模型。方法 A hamster-to-rat 心脏的移植作为金色的叙利亚的仓鼠心的接受者用 SD 老鼠被执行。60 只 SD 老鼠的一个总数被划分成四个组并且如下对待:控制组(n=15 ) ;脾切除术组(n=15 ) ;CsA 组(n=15 ) ;CsA + 脾切除术组(n=15 ) 。IL-2, IFN- , IL-4 和 IL-10 的层次被酶测量连接 immunosorbent 试金(ELISA ) 。Sera 在每个组在不同时间点被收获:白天 1,和 3 象日子一样,异种皮移植停止在控制组和 CsA 组跳动;白天 1, 3, 7, 14 和 30 在脾切除术组和 CsA+splenectomy 组。P-selectin 和细胞间的粘附 molecule-1 (ICAM-1 ) 的表示被异种皮移植的 immunohistochemical 分析在心脏的 xenotransplantation 以后检验。IL-2 和 IFN- 的结果浆液层次是 upregulated 在未经治疗(白天 3 ) 并且与 CsA + 脾切除术相比的对待脾切除术的动物(白天 7 ) 对待动物(白天 7 ) 。IL-10 是在跟随脾切除术 + CsA 的长期的幸存接受者的 upregulated。既不 P-selectin 也不 ICAM-1 表示在长期的幸存异种皮移植被检测。结论浆液 IL-2 和 IFN- 被提高跟随尖锐脉管的拒绝。浆液 IL-10 在跟随一致心脏的 xenotransplantation 的长期的幸存老鼠被相关到免疫力的抑制和保护的效果。 | ZHANG Xiao-gang Lü Yi WANG Bo LI Hui YU Liang LIU Chang WU Zheng LIU Xue-min | 2007 | Chinese Medical Journal2007，，2： | 10 |
| 5 | Indirect mineral carbonation of blast furnace slag with(NH4)2SO4 as a recyclable extractant显示文摘Large quantities of CO_2 and blast furnace slag are discharged in the iron and steel industry. Mineral carbonation of blast furnace slag can offer substantial CO_2 emission reduction and comprehensive utilisation of the solid waste. In this study, a recyclable extractant,(NH_4)_2SO_4, was used to extract calcium and magnesium from blast furnace slag(main phases of gehlenite and akermanite) by using low-temperature roasting to fix CO_2 through aqueous carbonation. The process parameters and efficiency of the roasting extraction, mineralisation, and Al recovery were investigated in detail. The results showed that the extractions of Ca, Mg, and Al can reach almost 100% at an(NH4)_2SO_4-to-slag mass ratio of 3:1 and at 370°C in 1 h. Adjusting the p H value of the leaching solution of the roasted slag to 5.5 with the NH_3 released during the roasting resulted in 99% Al precipitation, while co-precipitation of Mg was lower than 2%. The Mg-rich leachate after the depletion of Al and the leaching residue(main phases of CaSO_4 and SiO_2) were carbonated using(NH_4)_2CO_3 and NH_4HCO_3 solutions, respectively, under mild conditions. Approximately 99% of Ca and 89% of Mg in the blast furnace slag were converted into CaCO_3 and(NH_4)_2 Mg(CO_3)_2·4 H_2O,respectively. The latter can be selectively decomposed to magnesium carbonate at 100-200 °C to recover the NH_3 for reuse. In the present route, the total CO_2 sequestration capacity per tonne of blast furnace slag reached up to 316 kg, and 313 kg of Al-rich precipitate, 1000 kg of carbonated product containing CaCO_3 and SiO_2, and 304 kg of carbonated product containing calcium carbonate and magnesium carbonate were recovered simultaneously. These products can be used, respectively, as raw materials for the production of electrolytic aluminium, cement, and light magnesium carbonate to replace natural resources. | Jinpeng Hu Weizao Liu Lin Wang Qiang Liu Fang Chen Hairong Yue Bin Liang Li Lü Ye Wang Guoquan Zhang Chun Li | 2017 | Journal of Energy Chemistry2017，26，5： | 9 |
| 6 | 影响牙源性感染引起的下行性坏死性纵隔炎预后的危险因素显示文摘目的:下行性坏死性纵隔炎(DNM)是头颈部感染的严重并发症,由于缺乏对DNM的理解,死亡率过高。我们评估了牙源性DNM的临床特征、诊断、治疗和结果,并评估了影响DNM预后的危险因素,为临床实践提供了最新的概览。材料与方法:回顾性队列研究收集了2013年1月-2016年12月间因牙源性感染导致的DNM患者,分为存活组和死亡组。 | Qu L Liang X Jiang B 赵泽亮 | 2018 | 中国口腔颌面外科杂志2018，16，4： | 8 |
| 7 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 8 | Neuroprotective effects of the immunodepressant FTY720 on caspase-3 expression and neural apoptosis in a rat model of acute spinal cord injury显示文摘BACKGROUND:Studies on the immunodepressant FTY720 have primarily focused on organ transplantation and autoimmune disease therapy.However,the effects on caspase-3 expression and neural apoptosis following acute spinal cord injury remain uncertain.OBJECTIVE:To elucidate the underlying mechanism of the immunodepressant FTY720 to alleviate spinal cord injury by inhibiting expression of caspase-3 and neural apoptosis.DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at Central Laboratory of the Second Affiliated Hospital of Dalian Medical University from April to July 2009.MATERIALS:FTY720 was provided by Wuhan Yuancheng Technology Developing,China.METHODS:A total of 120 Sprague Dawley rats were randomly assigned to sham-surgery,model,and FTY720 groups.Spinal cord injury at the T9-10 segment was induced in model groups using the free-fall method.Following establishment of spinal cord injury at the T9-10 segment in the FTY720 group,rats were treated with an intragastric injection of 0.3 mL saline-diluted FTY720 (3 mg/kg).MAIN OUTCOME MEASURES:At 6,12,24,48,and 72 hours following spinal cord injury,caspase-3 expression was detected using streptavidin-peroxidase immunohistochemistry,and neural apoptosis was detected using the TUNEL method.RESULTS:Positive caspase-3 expression and neural apoptosis was not observed in the sham-surgery group at the various time points.The number of apoptotic cells increased with time after acute spinal cord injury,peaked at 24 hours following injury,and then gradually reduced.However,neural apoptosis remained at a high level.Caspase-3 expression positively correlated with neural apoptosis (r=0.864,P < 0.05).Caspase-3 expression and neural apoptosis significantly decreased following FTY720 therapy (P < 0.05).CONCLUSION:FTY720 significantly reduced caspase-3 expression and neural apoptosis in a rat model of acute spinal cord injury. | Liang Yang Decheng Lü Lianjie Zheng Zhaohui Wang Kai Tang Wei Zhang Xiaotian Li | 2010 | Neural Regeneration Research2010，5，9： | 7 |
| 9 | Transfusion transmitted virus infection in general populations and patients with various liver diseases in south China显示文摘INTRODUCTIONAlthough several specific detecting methods hadbeen applied to determine the hepatitis virus,therewas a lot of cryptogenic hepatitis without anyknown hepatitis infectious marker.Theprevalence of hepatitis G virus (HGV) (also knownas GB-C virus) infection has been reported to be 5%-13% in patients with non-A-E hepatitis andcirrhosis,however,there is little evidencesuggesting that HGV causes hepatitis in human. | Chen YP Liang WF Zhang L He HT Luo KX | 2000 | World Journal of Gastroenterology2000，6，5： | 7 |
| 10 | Preparation of the UPOV Guidelines for the Conduct of Tests for Distinctness, Uniformity and Stability–Tea Plant [Camellia sinensis (L.) O. Kuntze]显示文摘Distinctness, Uniformity and Stability (DUS) testing is the technical base of Plant Variety Protection (PVP) and the scientific basis for the approval of Plant Breeder’s Rights (PBR). DUS Test Guidelines are not only the technical manuals for the DUS testing authorities to conduct the testing, but also the technical standards for the competent authorities to examine the DUS of new varieties of plants. Tea plant, originated from Yunnan Province, China, is a very important woody cash species in the world. The International Union for the Protection of New Varieties of Plants (UPOV) DUS Test Guidelines for tea plant is the first Test Guidelines prepared by China for the UPOV. In this article, the subject, selection, and determination of characteristics, states of expression of characteristics and the selection of example varieties, assessment of the UPOV DUS Test Guidelines for tea plant were elucidated in detail. Finally, the proposal of PVP for tea plant in China was also proposed. The preparation of UPOV DUS Test Guidelines for tea plant will have important significance both for promoting the development of PVP and increasing the status of international PVP fields for China. | CHEN Liang YU Fu-lian YAO Ming-zhe Lü Bo YANG Kun DU Yuan-yuan | 2008 | Agricultural Sciences in China2008，7，2： | 7 |
| 11 | Decomposition behavior of CaSO_4 during potassium extraction from a potash feldspar-CaSO_4 binary system by calcination显示文摘The extraction of potassium from a tablet mixture of K-feldspar ore and CaSO_4by roasting was studied with a focus on the effects of the decomposition behavior of CaSO_4on the potassium extraction process.The roasted slags were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),energy-dispersive X-ray spectroscopy,and thermogravimetric(TG)analysis.The XRD analysis revealed that hydrosoluble mischcrystal K_2Ca_2(SO_4)_3was obtained by ion exchange of Ca^(2+)in CaSO_4and K^+in KAlSi_3O_8.Meanwhile,the intermediate product,SiO_2,separated from KAl Si_3O_8and reacted with CaSO_4to decompose CaSO_4.The SEM results showed that some blowholes emerged on the surface of the CaSO_4particles when they reacted with SiO_2at 1200°C,which indicates that SO_2and O_2gases were released from CaSO_4.The TG curves displayed that pure CaSO_4could not be decomposed below 1200°C,while the mixture of K-feldspar ore and CaSO_4began to lose weight at 1000°C.The extraction rate of potassium and decomposition rate of CaSO_4were 62%and 44%,respectively,at a mass ratio of CaSO_4to K-feldspar ore of 3:1,temperature of 1200°C,tablet-forming pressure of6 MPa,and roasting time of 2 h.The decomposition of CaSO_4reduced the potassium extraction rate;therefore,the required amount of CaSO_4was more than the theoretical amount.However,excess CaSO_4was also undesirable for the potassium extraction reaction because a massive amount of SO_2and O_2gas were derived from the decomposition of CaSO_4,which provided poor contact between the reactants.The SO_2released from CaSO_4decomposition can be effectively recycled. | Li Lü Chun Li Guoquan Zhang Xiaowei Hu Bin Liang | 2018 | Chinese Journal of Chemical Engineering2018，26，4： | 7 |
| 12 | Osteopontin gene polymorphism in association with systemic lupus erythematosus in Chinese patients显示文摘背景 Osteopontin ( OPN )是能在支持 T 淋巴细胞的激活起很多个作用的一个种 cytokine ,调整在 Th1 和 Th2 之间的平衡,参予导致房间的 immunologic 反应并且刺激 B 淋巴细胞表示多克隆 antibodies.Some 研究证明了 OPN 可以涉及这研究的 .The 目的是在位置 9250 点调查单个核苷酸多型性( SNP )的可能的协会在里面的全身的豺狼座 erythematosus ( SLE ) | XU An-ping BAI Jie Lü Jun LIANG Yan-yi LI Jin-gao LAI De-yuan WAN Xia HUANG Hu-hui | 2007 | Chinese Medical Journal2007，，23： | 6 |
| 13 | Ozone vertical variations during a typhoon derived from the OMI observations and reanalysis data显示文摘Typhoon is considered to play a key role in the dynamical exchange processes taking place between the troposphere and stratosphere.In this paper,the impact of typhoon on the ozone distribution in the upper troposphere and middle stratosphere is investigated using ozone profiles measured by Aura’s Ozone Monitoring Instrument and meteorological fields from reanalysis data.During the passage of Typhoon Hai-Tang in 2005 over the western North Pacific,low values of ozone column above 200 hPa and ozone mixing ratio between the upper troposphere and the middle stratosphere(from 200 to 50 hPa)are observed right above the typhoon’s track,a result due to the strong upward propagation of air associated with overshooting convection in typhoon.A comparative analysis of different stages of Hai-Tang suggests that in the region where typhoon has higher intensity the troposphere-to-stratosphere transport is enhanced.These results indicated that the typhoon has a significant impact on the ozone variation in the upper troposphere and the middle stratosphere. | FU YunFei XIAN Tao Lü DaRen LIU GuoSheng HENG ZhiWei SUN Liang LIU Qi WANG Yu YANG YuanJian | 2013 | Chinese Science Bulletin2013，58，32： | 5 |
| 14 | Effects of imidacloprid and thiamethoxam as seed treatments on the early seedling characteristics and aphid-resistance of oilseed rape显示文摘Seed treatments with the neonicotinoid insecticides imidacloprid and thiamethoxam were evaluated to determine whether the chemicals at effective concentrations for aphid control would influence the germination and early growth of oilseed rape,Brassica napus.Treatment with imidacloprid or thiamethoxam did not affect the cumulative germination rate,but significantly inhibited establishment potential by suppressing root system development in the cotyledon stage.However,these alterations in seedling development in the thiamethoxam-treated seeds appeared not to be detrimental as leaves developed;in contrast,for the seedlings with imidacloprid as seed treatment agent,a significantly decreased shoot/root ratio was still evident at the late two-leaf stage.After two leaves developed,chlorophyll content per leaf in the thiamethoxam treatment was significantly higher than that of the control,while chlorophyll content per leaf in the imidacloprid treatment remained close to that in the control.Most other parameters,i.e.,height,leaf area,weight of stem,leaf or root,and other growth indexes,between the treatments and the control showed no significant difference.Additionally,it was found that storage time of the treated seeds had a significant effect on cumulative germination rate.Treatment 30 d before planting significantly reduced germination relative to that of the control.All of the plants treated with neonicotinoids were shown to have significant anti-aphid characteristics that persisted until the end of the trial. | HUANG Liang ZHAO Chun-lin HUANG Fang BAI Run-e Lü Yao-bin YAN Feng-ming HAO Zhong-ping | 2015 | Journal of Integrative Agriculture2015，14，12： | 5 |
| 15 | Regenerative Role of Soil Seed Banks of Different Successional Stages in A Saline-alkaline Grassland in Northeast China显示文摘Soil seed banks can act as a potential seed source for natural revegetation and restoration. However, in a saline-alkaline grassland, it remains unclear how the stages of vegetation succession affect the characteristics of soil seed banks and the potential of soil seed banks of different successional stages for vegetation restoration. In this study, seasonal changes of the soil seed bank, and seed production and dispersal dynamics along degradation successional gradients were investigated in a saline-alkaline grassland in Northeast China, where the dominant grass during the 1960 s, Leymus chinensis was replaced with the secondary successional order of Puccinellia chinampoensis, Chloris virgata, and Suaeda salsa, together with bare patches. It was found that the soil seed bank composition varied according to the changing vegetation and had the highest species richness(7–16) in the climax successional stage, but had a low S?rensen similarity(0.22–0.37) with the aboveground vegetation. There was a high seed density of the soil seed bank(21 062–62 166/m2 in August and December) and also high S?rensen similarity index values(0.47–0.60) in the secondary successional stages of P. chinampoensis, C. virgata, and S. salsa. In bare patches, there were many seeds in the soil seed bank and some seedlings also appeared in the aboveground vegetation, indicating the existence of a persistent soil seed bank. Seed density and species richness differed substantially among the different successional stages, which was related to the reproductive characteristics of the standing plants in vegetation communities. Due to the lack of propagules of perennial species, especially the climax species of L. chinensis, in the soil, the successful restoration of the degraded saline-alkaline grassland was not possible. The study proved that in a degraded saline-alkaline grassland dominated by biennial or annual species, the soil seed bank was important for the revegetation of the current dominant plants, but not for the restoration of the original target species. Therefore, it is necessary to induce seeds or other propagules of the target perennial species. | MA Hongyuan LI Jingpeng YANG Fan Lü Xiaotao PAN Yuepeng LIANG Zhengwei | 2018 | Chinese Geographical Science2018，28，4： | 5 |
| 16 | Chinese medicine formulas for nonalcoholic fatty liver disease: Overview of systematic reviews显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)affects more than one-quarter of the global population.Due to the lack of approved chemical agents,many patients seek treatment from traditional Chinese medicine(TCM)formulas.A variety of systematic reviews have been published regarding the effectiveness and safety of TCM formulas for NAFLD.AIM To critically appraise available systematic reviews and sort out the high-quality evidence on TCM formulas for the management of NAFLD.METHODS Seven databases were systematically searched from their inception to 28 February 2020.The search terms included“non-alcoholic fatty liver disease,”“Chinese medicines,”“systematic review,”and their synonyms.Systematic reviews involving TCM formulas alone or in combination with conventional medications were included.The methodological quality and risk of bias of eligible systematic reviews were evaluated by using A Measure Tool to Assess Systematic Reviews 2(AMSTAR 2)and Risk of Bias in Systematic Review(ROBIS).The quality of outcomes was assessed by the Grading of Recommendations Assessment,Development and Evaluation(GRADE)system.RESULTS Seven systematic reviews were ultimately included.All systematic reviews were conducted based on randomized controlled trials and published in the last decade.According to the AMSTAR 2 tool,one systematic review was judged as having a moderate confidence level,whereas the other studies were rated as having a low or extremely low level of confidence.The ROBIS tool showed that the included systematic reviews all had a high risk of bias due to insufficient consideration of identified concerns.According to the GRADE system,only two outcomes were determined as high quality;namely,TCM formulas with the HuoXueHuaYu principle were better than conventional medications in ultrasound improvement,and TCM formulas were superior to antioxidants in alanine aminotransferase normalization.Other outcomes were downgraded to lower levels,mainly because of heterogeneity among studies,not meeting optimal information sample size,and inclusion of excessive numbers of small sample studies.Nevertheless,the evidence quality of extracted outcomes should be further downgraded when applying to clinical practice due to indirectness.CONCLUSION The quality of available systematic reviews was not satisfactory.Researchers should avoid repeatedly conducting systematic reviews in this area and focus on designing rigorous randomized controlled trials to support TCM formula applications. | Liang Dai Wen-Jun Zhou Linda L D Zhong Xu-Dong Tang Guang Ji | 2021 | World Journal of Clinical Cases2021，9，1： | 3 |
| 17 | Outcomes of Medicare beneficiaries hospitalised with transient ischaemic attack and stratification using the ABCD^(2) score显示文摘Background Long-term outcomes for Medicare beneficiaries hospitalised with transient ischaemic attack(TIA)and role of ABCD^(2) score in identifying high-risk individuals are not studied.Methods We identified 40825 Medicare beneficiaries hospitalised from 2011 to 2014 for a TIA to a Get With The Guidelines(GWTG)-Stroke hospital and classified them using ABCD^(2)s of mortality and rehospitalisation(all-cause,ischaemic stroke,haemorrhagic stroke,myocardial infarction,and gastrointestinal and intracranial haemorrhage)for high-risk versus low-risk groups adjusted for patient and hospital characteristics.Results Of the 40825 patients,35118(86%)were high risk(ABCD^(2)≥4)and 5707(14%)were low risk(ABCD^(2)=0-3).Overall rate of mortality during 1-year follow-up after hospital discharge for the index TIA was 11.7%,44.3% were rehospitalised for any reason and 3.6%were readmitted due to stroke.Patients with ABCD^(2) score≥4 had higher mortality at 1 year than not(adjusted HR 1.18,95%CI 1.07 to 1.30).Adjusted risks for ischaemic stroke,all-cause readmission and mortality/all-cause readmission at 1 year were also significantly higher for patients with ABCD^(2) score≥4 vs 0-3.In contrast,haemorrhagic stroke,myocardial infarction,gastrointestinal bleeding and intracranial haemorrhage risk were not significantly different by ABCD^(2) score.Conclusions This study validates the use of ABCD^(2) score for long-term risk assessment after TIA in patients aged 65 years and older.Attentive efforts for community-based follow-up care after TIA are needed for ongoing prevention in Medicare beneficiaries who were hospitalised for TIA. | Shreyansh Shah Li Liang Durgesh Bhandary Saga Johansson Eric E Smith Deepak L Bhatt Gregg C Fonarow Naeem D Khan Eric Peterson Janet Prvu Bettger | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 18 | Preparation of synthetic rutile via selective sulfation of ilmenite with(NH4)2SO4 followed by targeted removal of impurities显示文摘This paper describes a novel, facile chemical pathway for preparing synthetic rutile from ilmenite. The pathway consists of two primary units, i.e., selectively sulfating ilmenite, which was realized via roasting ilmenite with(NH_4)_2SO_4followed by selective thermal decomposition of the sulfated ilmenite, and targeted leaching of the impurities. The effects of the process parameters were systematically investigated. The results showed that the optimum sulfation conditions were a mass ratio of(NH_4)_2SO_4to ilmenite of 14, temperature of 360 °C, and time of 120 min with a sulfation ratio of ~ 95%. The optimum thermal decomposition conditions were480 °C in N_2 atmosphere, and nearly all Ti OSO_4 were decomposed with co-decomposition of Fe SO_4 of 23%. For acid leaching, the optimum conditions were 2.5 wt% HCl, 98 °C and 120 min. Under those conditions, 94.2% iron was removed with a Ti O_2 dissolution loss b 1%. For alkali leaching, 67% Si O_2 was removed in 5 wt% Na OH at102 °C for 1 h. A synthetic rutile with a Ti O_2 content N 92 wt% and total Mg O + Ca O b 1.5 wt% was obtained.Based on these results, a schematic flowsheet was proposed. Additionally, it was found that the decomposition of Fe SO_4 mixed with Ti OSO_4 under N_2was inhibited due to its oxidation to a higher thermal stability Fe_2(SO_4)_3by oxygen emitted from the decomposition of Ti OSO_4. At the same time, Ti OSO_4 decomposition was promoted due to the immediate in situ consumption of oxygen by Fe SO_4. The synergetic effect might be responsible for the enhanced selectivity of sulfated ilmenite thermal decomposition. | Weizao Liu Xiaomei Wang Zhenpu Lu Hairong Yue Bin Liang Li Lü Chun Li | 2017 | Chinese Journal of Chemical Engineering2017，25，6： | 3 |
| 19 | Non-junctional Cx32 mediates anti-apoptotic and pro-tumor effects via epidermal growth factor receptor in human cervical cancer cells显示文摘OBJECTIVE To investigate the role of connexin proteins(Cx),which form gap junctions(GJ),in progression and chemotherapeutic sensitivity of cervical cancer(CaC x).METHODS We analyze the expression of Cx26,Cx30,Cx32 and Cx43 in human specimens consisting of:Normal cervix(n=78),CaCx FIGO stageⅠ(n=148),CaCx FIGO stageⅡ(n=165).In CaCx cell lines,Hela-Cx32(induced expression by doxycycline),C-33A(endogenously express Cx32)and si Ha(transiently transfected plasmid with Cx32),we detected the role of Cx32 against tostreptonigrin/cisplatin-induced apopotosisin presence or absence of functional GJ through using GJ inhibitors or low density cultural.Furtherly,we observed the relativity of Cx32 and EGFR expression in human specimens.Also,we detected the role of EGFR signaling pathway in the process of Cx32 anti-apoptosis through suppressed EGFR expression by inhibitors or si RNA sequences in cell lines.RESULTS We firstly demonstrated the expression of Cx32 was highly upregulated and accumulated in cytoplasm in the CaCx specimens,and the degree of upregulation correlated with advanced FIGO stages.Thus,in three human cervical cell lines,Cx32 was shown to suppress apoptosis when GJ formation is inhibited.No matter in cases of CaCx or cell lines,Cx32 expression was highly correlated with expression of EGFR and the EGFR pathway is an essential component of the Cx32-induced anti-apoptotic effect.CONCLUSION Cx32,traditionally tumor suppressive protein,was shown to be tumor protective against chemotherapy through EGFR pathway in a GJ-independent way. | Yi-fan ZHAO Yong-chang LAI Hui GE Yun-quan GUO Xue FENG Jia SONG Qin WANG Li-xia FAN Andrew L HARRIS Xi-yan WANG Liang TAO | 2017 | 中国药理学与毒理学杂志2017，31，10： | 3 |
| 20 | Association of telomere length with authentic pluripotency of ES/iPS cells显示文摘Telomerase 和 telomeres 为干细胞的不定的复制是重要的。最近,体的房间的 telomeres 被发现是 reprogrammed 在导致的 pluripotent 干细胞(iPSCs ) 伸长。然而,在在胚胎的干细胞(转换字符) 或 iPSCs 的 vivo 的发展 pluripotency 的 telomeres 的角色直接没被探讨。我们证明有长 telomeres 的转换字符展出真发展 pluripotency,由完全的转换字符小狗以及 germline 能干的怪物的产生证实了在啮齿类动物可得到的最紧的测试。有短 telomeres 的转换字符显示出减少的 teratoma 形成和怪物生产,并且没能产生完全的转换字符小狗。Telomere 长度高度被相关(r > 0.8 ) 与转换字符的发展 pluripotency。短 telomeres 减少 proliferative 率或转换字符的能力,改变与 telomere epigenetics 有关的基因的表示,为 embryogenesis 重要的下面调整基因并且破坏细菌房间区别。而且,有更长的 telomeres 的 iPSCs 与短 telomeres 比那些与更高的效率产生怪物。我们功能的 telomeres 为 ESCs/iPSCs 的发展 pluripotency 是必要的并且建议那 telomere 长度可以提供一个珍贵标记评估干细胞 pluripotency 的数据表演,特别地当紧测试不是可行的时。 | Junjiu Huang Fang Wang Maja Okuka Na Liu Guangzhen Ji Xiaoying Ye Bingfeng Zuo Minshu Li Ping Liang William W Ge John CM Tsibris David L Keefe Lin Liu | 2011 | Cell Research2011，21，5： | 3 |
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