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4篇 您的检索式:作者名="Liangcheng DU"
    题名 作者 年代 出处 被引量
1Mycotoxin fumonisins: Health impacts and biosynthetic mechanism显示文摘Fumonisins 是在农业和食物工业的 mycotoxins 的最重要的组之一。他们被玉米的几普遍真菌的病原体生产。在导出玉米的食物的 Fumonisin 污染并且喂原因在家畜和姿势的几致命的疾病重要癌症风险到人(组 2B 致癌物) 。在最近的年里, fumonisins 在 mycotoxin 研究成为了一个热区域。这评论试图为 fumonisin 生合成和行动的模式在分子的机制的研究加亮进步。在 fumonisins 导致的细胞的效果的分子的基础的当前的理解被讨论。在帐篷离子的专辑被付在涉及 fumonisions 的生合成的单个基因酶的描述介绍进步。WANG Qiaomei WANG Jiansheng YU Fengan ZHU Xiangcheng Zaleta-Rivera Kathia DU Liangcheng 2006Progress in Natural Science:Materials International2006,16,1:3
2Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes显示文摘David J. Gonzalez Yuquan Xu Yu-Liang Yang Eduardo Esquenazi Wei-Ting Liu Anna Edlund Tram Duong Liangcheng Du István Molnár William H. Gerwick Paul R. Jensen Michael Fischbach Chih-Chuang Liaw Paul Straight Victor Nizet Pieter C. Dorrestein 2012Journal of Proteomics2012,,16:1
3Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases显示文摘越来越多的 cyclopeptides 作为 ribosomal 的产品被发现了合成小径。这些 cyclopeptides 的 biosynthetic 学习为环合揭示了有趣的新机制。这评论在环合机制加亮最近的发现因为 cyclopeptides 独立于 non-ribosomal 肽合成酶综合了,包括催化 endopeptidase 的环合,调停 intein 的环合,和肽催化合成酶的环合。这个信息可以帮助设计混合 ribosomal 和 non-ribosomal biosynthetic 系统与各种各样的 bioactivities 生产新奇 cyclopeptides。Wenyan Xu Liling Li Liangcheng Du Ninghua Tan 2011Acta Biochimica et Biophysica Sinica2011,43,10:0
4PRODUCTION OF NEW WAP-8294A CYCLODEPSIPEPTIDES BY THE BIOLOGICAL CONTROL AGENT LYSOBACTER ENZYMOGENES OH11显示文摘Naturally-occurring environmental microorganisms may provide ‘green’ andeffective biocontrol tools for disease management in agricultural crops. Due tothe constant threat of resistant pathogens there is a pressing and continualneed to search for new biocontrol tools. This study investigated the productionof new analogs of WAP-8294A compounds by the biocontrol agent Lysobacterenzymogenes OH11 through biosynthetic engineering. WAP-8294As are afamily of natural cyclic lipodepsipeptides with potent activity against Grampositive bacteria. A series of genetic manipulations was therefore conductedon the accessory genes in the WAP biosynthetic gene cluster. The resultingstrains containing a single-point mutation in ORF4, which was predicted toencode a 2-ketoglutarate dependent dioxygenase, produced deoxy-WAP8294As. This result provides evidence for the function of ORF4 in catalyzing βhydroxylation of the D-asparagine residue in WAP-8294As. In addition, six newanalogs of WAP-8294As were identified by UHPLC-HR-MS/MS. This is the firstattempt to produce new WAP-8294As in Lysobacter and shows that thespectrum of the biocontrol compounds may be expanded through themanipulation of biosynthetic genes.Jing ZHU Yuan CHEN Liangcheng DU 2022Frontiers of Agricultural Science and Engineering2022,9,1:0
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