|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5huqkwnw9bfbnx65cx.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 3 | BondCondition between Surface Layer and Immediate Layer inPorous Asphalt Pavement 显示文摘 | YANG Jun DAI Peng YU Liangming | 2007 | Journal of SoutheastUniversity2007，23，4： | 1 |
| 4 | NUMERICAL GEODYNAMIC MODELLING OF COUPLED MECHANO-THERMO-HYDROLOGICAL PROCESSES AND ITS APPLICATION IN PREDICTIVE EXPLORATION IN THE FENGHUANGSHAN ORE FIELD, TONGLING显示文摘Mineralisation is the result of the coupled multi-geodynamic processes in the crust. The coupled mechano-thermo-hydrological (MTH) processes are the basic physical processes that govern the location of the hydrothermal mineralization, which can be simulated in the computer by using of the numerical codes, such as FLAC. The numerical modeling results can be used not only to explain the features of existing ore deposits, but also to predict the favorable mineralization locations. This paper has summarized the basic equations describing coupled MHT processes in the water-saturated porous rocks, the principles of FLAC, and its application to the MHT processes related to copper mineralization in the Fenghuangshan ore field. We used the FLAC to simulate the syn-deformation cooling and fluid flowing evolution after the intrusion was emplaced and solidified. The modeling results suggest a most prospective exploration area where the subsequent exploration supported the prediction and the test bore hole disclosed the high quality copper ore bodies in the target, demonstrating a positive role of the numerical MTH modeling in facilitating predictive ore discovery. | LIU Liangming PENG Shenglin ZHANG Yanhua | 2005 | Geotectonica et Metallogenia2005，29，2： | 1 |
| 5 | High Temperature Creep behaviour of a Si_3N_4 Whisker Reinforced Al-Fe-V-Si Composite显示文摘The creep behaviour of β-Si3N4 whisker reinforced Al-8.5Fe-1.3V-1.7Si composite has been investigated at the temperature 773 and 823 K. The results are characterized by high stress exponent and high apparent creep activation energy The creep data can be interpreted based on the incorporation of a threshold Stress and a load transfer coefficient into the power-law creep equation. A good correlation between the normalized creep rate and normalized effective stress is available which demonstrates that the creep behaviour of both the alloy and the composite is controlled by the matrix lattice self-diffusion in AI. EXamination on microstructure shows that edge dislocations exist at the interfaces between two adjacent whiskers and the intedeces emit edge dislocations in parallel paired-columns. | Liangming PENG Shijie ZHU Haoran CHEN and Fugang WANG(Dept. of Materials Engineering,Dalian University of Technology, Dalian 116023, China)Zongyi MA and Jing BI(Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China) | 1998 | Journal of Materials Science & Technology1998，14，6： | 0 |
| 6 | A Numerical Study of Tidal Asymmetry: Preferable Asymmetry of Nonlinear Mechanisms in Xiangshan Bay, East China Sea显示文摘In-situ measurements in Xiangshan Bay, the East China Sea, show that the duration of the rising tide is shorter than that of the falling tide around the bay mouth, while it becomes much longer in the inner bay. A finite volume coastal ocean model(FVCOM) with an unstructured mesh was applied to simulate the asymmetric tidal field of Xiangshan Bay. The model reproduced the observed tidal elevations and currents successfully. Several numerical experiments were conducted to clarify the roles of primary mechanisms underlying the asymmetric tidal field. According to the model results, the time-varying channel depth and nonlinear advection prefer shorter duration of the rising tide in Xiangshan Bay, while the time-varying bay width favors longer duration of the rising tide. The overtides generated by these two opposite types of nonlinear mechanisms are out of phase, resulting in smaller M4 amplitude than the sumfold of each individual contribution. Although the bottom friction as a nonlinear mechanism contributes little to the generation of overtide M4, it is regarded as a mechanism that could cause a shorter duration of the rising tide, for it can slow down the M2 phase speed much more than it slows down the M4 phase speed. The time-varying depth, nonlinear advection and bottom friction are dominating factors around the bay mouth, while the time-varying width dominates in the inner bay, causing the tidal elevation asymmetry to be inverted along the bay. | XU Peng MAO Xinyan JIANG Wensheng ZHOU Liangming | 2014 | Journal of Ocean University of China2014，13，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员