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| 1 | A step-by-step multiple stimuli-responsive metal-phenolic network prodrug nanoparticles for chemotherapy显示文摘Currently,chemotherapy is the main clinical therapy of tumors.Depressingly,most chemotherapeutic drugs such as doxorubicin and paclitaxel(PTX)have poor water solubility,leading to low bioavailability and serious side effects.Till now,although a variety of nanoparticulate drug delivery systems have been designed to ameliorate the above disadvantage of chemotherapy drugs,their application is still severely limited due to the complex preparation,poor stability,low drug loading,and premature drug release.Herein,a metal phenolic network-based drug delivery system with superior stability,satisfactory drug loading capacity,good biocompatibility,reduced undesired premature release,and excellent anti-tumor ability has been established for achieving step-by-step multiple stimuli-responsive drug delivery.Firstly,the redox-responsive dimeric paclitaxel(diPTX)prodrug was synthesized.Then diPTX@Fe&tannic acid(diPTX@Fe&TA)complex nanoparticles with satisfactory PTX loading capacity were obtained by deposition of Fe&TA network complex on the nanocore of diPTX rapidly with a simple method.The diPTX@Fe&TA nanoparticles have a hydrodynamic diameter of 152.6±1.2 nm,long-term colloidal stability,and high PTX loading content of 24.7%.Besides,diPTX@Fe&TA could expose to the acidic lysosomal environment and the reduction cytoplasmic environment continuously,resulting in the sequential release of diPTX and PTX when it was phagocytosed by tumor cells.Meanwhile,PTX showed almost no release under physiological condition(pH 7.4),which effectively inhibited the undesirable premature release of PTX.More importantly,diPTX@Fe&TA could suppress the growth of tumor effectively in vivo,along with negligible toxicity for organs.This work developed a simple and novel approach for the construction of a stepwise multiple stimuli-responsive drug delivery system with superior stability and satisfactory drug loading capacity to inhibit tumor growth effectively. | Xiaoqing Yi Weijia Zeng Cui Wang Ying Chen Liangyuan Zheng Xinlin Zhu Yuqiu Ke Xiaoyan He Ying Kuang Qitong Huang | 2022 | Nano Research2022，15，2： | 1 |
| 2 | Online Analysis of Volatile Products from Bituminous Coal Pyrolysis with Syn- chrotron Vacuum Ultraviolet Photoionization Mass Spectrometry显示文摘 | Jia Liangyuan Weng Junjie Wang Yu | 2013 | Energy and Fuels2013，27，2： | 1 |
| 3 | In situ SR-CT Experimental Study on the Directional Sintering of High-Temperature Superconductor YBCO Materials in the Microwave Fields显示文摘YBa_(2)Cu_(3)O_(7-x)(YBCO)is a kind of high-temperature superconducting material that has important application in information,energy,medical treatment,etc.,and the superconducting properties of YBCO are closely related to its internal microstructure.In this study,the microwave heating method was adopted to prepare the YBCO materials.The internal 3 D online evolution observation based on the synchrotron radiation computed tomography technology shows that there was directional grain growth phenomenon of YBCO during microwave sintering process.In local regions with special microstructure,these particles grew to the same point.Here,the theoretical models of single and multiple particles in the microwave electromagnetic fields were established.Based on these theoretical models and finite element analysis,it shows that the YBCO particles can modulate the distribution of electromagnetic fields,resulting in the significantly higher electric field intensity at the particle junctions than other regions.Moreover,there were very high electric field intensity and temperature gradients in the directions of particle growth.These factors were crucial in directional sintering.These results will provide theoretical basis and technical guidance for the controllable preparation and performance optimization of the internal microstructure of superconducting materials in the preparation process. | Liangyuan Wang Lei Shen Yongcun Li Yuanjie Wang Yu Xiao Xingyi Zhang Feng Xu Xiaofang Hu | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，1： | 0 |
| 4 | Gain deeper insights into traditional Chinese medicines using multidimensional chromatography combined with chemometric approaches显示文摘Traditional Chinese medicines(TCMs)possess a rich historical background,unique theoretical framework,remarkable therapeutic efficacy,and abundant resources.However,the modernization and internationalization of TCMs have faced significant obstacles due to their diverse ingredients and unknown mechanisms.To gain deeper insights into the phytochemicals and ensure the quality control of TCMs,there is an urgent need to enhance analytical techniques.Currently,two-dimensional(2D)chromatography,which incorporates two independent separation mechanisms,demonstrates superior separation capabilities compared to the traditional one-dimensional(1D)separation system when analyzing TCMs samples.Over the past decade,new techniques have been continuously developed to gain actionable insights from complex samples.This review presents the recent advancements in the application of multidimensional chromatography for the quality evaluation of TCMs,encompassing 2D-gas chromatography(GC),2D-liquid chromatography(LC),as well as emerging three-dimensional(3D)-GC,3D-LC,and their associated data-processing approaches.These studies highlight the promising potential of multidimensional chromatographic separation for future phytochemical analysis.Nevertheless,the increased separation capability has resulted in higher-order data sets and greater demands for data-processing tools.Considering that multidimensional chromatography is still a relatively nascent research field,further hardware enhancements and the implementation of chemometric methods are necessary to foster its robust development. | Xinyue Yang Pingping Zeng Jin Wen Chuanlin Wang Liangyuan Yao Min He | 2024 | Chinese Herbal Medicines2024，16，1： | 0 |
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