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| 1 | A Realization Method for Transforming a Topology Optimization Design into Additive Manufacturing Structures显示文摘 | Shutian Liu Quhao Li Junhuan Liu Wenjiong Chen Yongcun Zhang | 2018 | Engineering2018，4，2： | 16 |
| 2 | Development of mouse preimplantation embryos in space显示文摘The development o f life beyond planet Earth is a long-standing quest of the human race,but whether normal mammalian embryonic development can occur in space is still unclear.Here,we show unequivocally that preimplantation mouse embryos can develop in space;but the rate of blastocyst formation and blastocyst quality are compromised.Additionally,the cells in the embryo contain severe DNA damage,while the genome of the blastocysts developed in space is globally hypomethylated with a unique set of differentially methylated regions.The developmental defects,DNA damage and epigenetic abnormalities can be largely mimicked by the treatment with ground-based low-dose radiation.However,the exposure to simulated microgravity alone does not cause major disruptions of embryonic development,indicating that radiation is the main cause for the developmental defects.This work advances the understanding of embryonic development in space and reveals long-term extreme low-dose radiation as a hazardous factor for mammalian reproduction. | Xiaohua Lei Yujing Cao Baohua Ma Yunfang Zhang Lina Ning Jingjing Qian Liwen Zhang Yongcun Qu Tao Zhang Dehong Li Qi Chen Junchao Shi Xudong Zhang Chiyuan Ma Ying Zhang Enkui Duan | 2020 | National Science Review2020，7，9： | 8 |
| 3 | An alternating direction method of multipliers for elliptic equation constrained optimization problem显示文摘We propose an alternating direction method of multipliers(ADMM)for solving the state constrained optimization problems governed by elliptic equations.The unconstrained as well as box-constrained cases of the Dirichlet boundary control,Robin boundary control,and right-hand side control problems are considered here.These continuous optimization problems are transformed into discrete optimization problems by the finite element method discretization,then are solved by ADMM.The ADMM is an efficient first order algorithm with global convergence,which combines the decomposability of dual ascent with the superior convergence properties of the method of multipliers.We shall present exhaustive convergence analysis of ADMM for these different type optimization problems.The numerical experiments are performed to verify the efficiency of the method. | ZHANGKai LI JingShi SONG YongCun WANG XiaoShen | 2017 | Science China Mathematics2017，60，2： | 4 |
| 4 | In situ investigation of SiC powder's microwave sintering by SR-CT technique显示文摘Microwave sintering is being developed as a novel technique for the preparation of dense structural ceramics,but the mature theory has not been established due to the technical difficulties.The synchrotron radiation X-ray computed tomography(SR-CT) technique was introduced for the first time into the study of microwave sintering to in-situ observe the microstructure evolution of silicon carbide(SiC) material in this paper.By applying the SR-CT technique,the reconstructed 2D and 3D images of the specimen were obtained and the double logarithm curve of mean neck size and time(Ln(x)-Ln(t)) were obtained from these reconstructed images.Various sintering phenomena including sintering neck growth during microwave treatment were observed from the reconstructed images.Furthermore,the differences in microstructure evolution and sintering kinetics between microwave and conventional sintering were analyzed based on the reconstructed images and the Ln(x)-Ln(t) curve.1) The sharp surface of grains near the contact region distinctly grew blunt and the sintering neck growth between these grains were obviously observed at the early stage.Besides,the larger particles grew faster than smaller ones.The main reason for these phenomena may be the micro-focusing effect of electric fields.2) During each of the three sintering stages,the sintering kinetics curve of double logarithm relationship between mean neck size and time shows a good linear relationship,but at the middle stage the slope of the curve increases dramatically,which is quite larger than conventional sintering.The preliminary interpretation for these extraordinary phenomena has been discussed in details. | LI YongCun XU Feng HU XiaoFang QU HongYan MIAO Hong ZHANG Zhong XIAO TiQiao | 2011 | Science China(Technological Sciences)2011，54，6： | 4 |
| 5 | Mudcake effects on wellbore stress and fracture initiation pressure and implications for wellbore strengthening显示文摘Although a large volume of mudcake filtration test data is available in the literature, effects of mudcake on wellbore strengthening cannot be quantified without incorporating the data into a stress-analysis model. Traditional models for determining fracture initiation pressure(FIP) either consider a wellbore with an impermeable mudcake or with no mudcake at all. An analytical model considering permeable mudcake is proposed in this paper. The model can predict pore pressure and stress profiles around the wellbore, and consequently the FIP, for different mudcake thickness, permeability, and strength. Numerical examples are provided to illustrate the effects of these mudcake parameters. The results show that a low-permeability mudcake enhances FIP, mainly through restricting fluid seepage and pore pressure increase in the nearwellbore region, rather than by mudcake strength. Fluid loss pressure(FLP) should be distinguished from FIP when a mudcake is present on the wellbore wall. Fracture may occur behind the mudcake at FIP without mudcake rupture. The small effect of mudcake strength on FIP does not mean its effect on FLP is small too. Mudcake strength may play an important role in maintaining integrity of the wellbore once a fracture has initiated behind the mudcake. | Yongcun Feng Xiaorong Li K.E.Gray | 2018 | Petroleum Science2018，15，2： | 3 |
| 6 | siRNA of ADAM17 gene induces apoptosis,proliferation inhibition and enhances the effects of genistein on HepG2 cells显示文摘Objective:To investigate the effects of siRNA of ADAM17 gene and genistein on apoptosis and the inhibition of proliferation in HepG2 cells in an attempt to seek an effective therapy for hepatocellular carinoma. Methods:Cells were divided into control groups and experimental groups and siRNA was used to silence the ADAM17 gene, alone and in combination with genistein. Cells were harvested at several time periods and assessed for proliferation and apoptosis. Proliferation was assayed by MTT at 24, 48, 72 and 96 hours following treatment and apoptosis was assessed by flow cytometric analysis at 48 hours. Results:In siRNA groups, proliferation of cells was significantly inhibited compared to the control groups at 24, 48 and 72 hours(P < 0.05), and apoptosis was significantly increased at 48 hours(P < 0.01); In genistein groups, proliferation was inhibited at 24, 48, 72 and 96 hours, and the apoptosis ratio was significantly increased at 48 hours(P < 0.01); while in the groups that received the combination of siRNA transfection and genistein treatment, there was a further significant decrease of proliferation and increase in apoptosis compared with either treatment alone. Conclusion:The ADAM17 gene could be an effective target, and genistein could be a useful agent, in the treatment of hepatocellular carcinoma. siRNA of ADAM17 gene and genistein both inhibited HepG2 cells proliferation and promoted apoptosis, and further, the combination of these treatments had a greater effect than either treatment alone. | Yongcun Liu Zuoren Wang Yuqiang Ji Feng Li | 2009 | Journal of Nanjing Medical University2009，23，2： | 2 |
| 7 | On-chip multiplexed single-cell patterning and controllable intracellular delivery显示文摘Conventional electroporation approaches show limitations in the delivery of macromolecules in vitro and in vivo.These limitations include low efficiency,noticeable cell damage and nonuniform delivery of cells.Here,we present a simple 3D electroporation platform that enables massively parallel single-cell manipulation and the intracellular delivery of macromolecules and small molecules.A pyramid pit micropore array chip was fabricated based on a silicon wet-etching method.A controllable vacuum system was adopted to trap a single cell on each micropore.Using this chip,safe single-cell electroporation was performed at low voltage.Cargoes of various sizes ranging from oligonucleotides(molecular beacons,22 bp)to plasmid DNA(CRISPR-Cas9 expression vectors,>9 kb)were delivered into targeted cells with a significantly higher transfection efficiency than that of multiple benchmark methods(e.g.,commercial electroporation devices and Lipofectamine).The delivered dose of the chemotherapeutic drug could be controlled by adjusting the applied voltage.By using CRISPR-Cas9 transfection with this system,the p62 gene and CXCR7 gene were knocked out in tumor cells,which effectively inhibited their cellular activity.Overall,this vacuum-assisted micropore array platform provides a simple,efficient,high-throughput intracellular delivery method that may facilitate on-chip cell manipulation,intracellular investigation and cancer therapy. | Zaizai Dong Yanli Jiao Bingteng Xie Yongcun Hao Pan Wang Yuanyuan Liu Junfeng Shi Chandani Chitrakar Stephen Black Yu-Chieh Wang LJames Lee Mo Li Yubo Fan Lingqian Chang | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 8 | Achieving a stable COF with the combination of“flat”and“twist”large-size rigid synthons for selective gas adsorption and separation显示文摘A new type of covalent organic framework(COF)was achieved using combination of structrally rigid and conformationally othorganal building blocks.The N-2-aryl-substituted triazole derivative(NAT-CHO)was prepared with co-planar conformation among the three aromatic rings as the“flat”building block.The 4,4,4,4-(ethene-1,1,2,2-tetrayl)tetraaniline)(ETTA)was applied as the“twist”building block.A 2 D sheet of network was obtained through imine formation.The resulting NAT-COF gave excellent thermal and chemical stability,survived aqueous solutions from p H 5 to 13.With large-size building blocks,the porous framework NAT-COF gave efficient gas adsorption with excellent selectivity of C3 propane over C1 me-thane,suggesting its potential application for selective gas capture and separation. | Jingyang Li Ying He Yongcun Zou Yan Yan Zhiguang Song Xiaodong Shi | 2022 | Chinese Chemical Letters2022，33，6： | 1 |
| 9 | Fabrication and characterization of aluminum nitride polymer matrix composites with high thermal conductivity and low dielectric constant for electronic packaging显示文摘 | Yongcun Zhou Hong Wang Lu Wang Ke Yu Zude Lin Li He Yuanyuan Bai | 2012 | Materials Science & Engineering B2012，，11： | 1 |
| 10 | Analysis on performance of a novel frost-free air-source heat pump system显示文摘 | Li Yongcun Chen Guangming Tang Liming Liu Lihua | 2011 | Building and Environment2011，，10： | 1 |
| 11 | SAR observation and model tracking of an oil spill event in coastal waters显示文摘 | Yongcun Cheng Xiaofeng Li Qing Xu Oscar Garcia-Pineda Ole Baltazar Andersen William G. Pichel | 2010 | Marine Pollution Bulletin2010，，2： | 1 |
| 12 | Analysis on performance of a novel frost-free air- source heat pump system 显示文摘 | Li Yongcun Chen Guangming Tang Liming | 2011 | Building and Environment2011，46，10： | 1 |
| 13 | SAR observation and model tracking of an oil spill event in coastal waters显示文摘 | Yongcun Cheng Xiaofeng Li Qing Xu Oscar Garcia-Pineda Ole Baltazar Andersen William G. Pichel | 2010 | Marine Pollution Bulletin2010，，2： | 1 |
| 14 | Interannual Variability of SST,SLA and Wind Waves in the Hawaii Area and Their Responses to ENSO显示文摘Time series of sea surface temperature (SST),wind speed and significant wave height (SWH) from meteorological buoys of the National Data Buoy Center (NDBC) are useful for studying the interannual variability and trend of these quantities at the buoy areas. The measurements from 4 buoys (B51001,B51002,B51003 and B51004) in the Hawaii area are used to study the responses of the quantities to EI Ni?o and Southern Oscillation (ENSO). Long-term averages of these data reflect precise seasonal and climatological characteristics of SST,wind speed and SWH around the Hawaii area. Buoy observations from B51001 suggest a significant warming trend which is,however,not very clear from the other three buoys. Compared with the variability of SST and SWH,the wind speeds from the buoy observations show an increasing trend. The impacts of EI Nio on SST and wind waves are also shown. Sea level data observed by altimeter during October 1992 to September 2006 are analyzed to investigate the variability of sea level in the Hawaii area. The results also show an increasing trend in sea level anomaly (SLA). The low-passed SLA in the Hawaii area is consistent with the inverse phase of the low-passed SOI (Southern Oscillation Index). Compared with the low-passed SOI and PDO (Pacific Decadal Oscillation),the low-passed PNA (Pacific-North America Index) has a better correlation with the low-passed SLA in the Hawaii area. | CHENG Yongcun XU Qing LIU Yuguang LI Chongyin RONG Zengzui ZONG Haibo XIU Peng YIN Xiaobin | 2008 | Journal of Ocean University of China2008，7，4： | 1 |
| 15 | In situ SR-CT Experimental Study on the Directional Sintering of High-Temperature Superconductor YBCO Materials in the Microwave Fields显示文摘YBa_(2)Cu_(3)O_(7-x)(YBCO)is a kind of high-temperature superconducting material that has important application in information,energy,medical treatment,etc.,and the superconducting properties of YBCO are closely related to its internal microstructure.In this study,the microwave heating method was adopted to prepare the YBCO materials.The internal 3 D online evolution observation based on the synchrotron radiation computed tomography technology shows that there was directional grain growth phenomenon of YBCO during microwave sintering process.In local regions with special microstructure,these particles grew to the same point.Here,the theoretical models of single and multiple particles in the microwave electromagnetic fields were established.Based on these theoretical models and finite element analysis,it shows that the YBCO particles can modulate the distribution of electromagnetic fields,resulting in the significantly higher electric field intensity at the particle junctions than other regions.Moreover,there were very high electric field intensity and temperature gradients in the directions of particle growth.These factors were crucial in directional sintering.These results will provide theoretical basis and technical guidance for the controllable preparation and performance optimization of the internal microstructure of superconducting materials in the preparation process. | Liangyuan Wang Lei Shen Yongcun Li Yuanjie Wang Yu Xiao Xingyi Zhang Feng Xu Xiaofang Hu | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，1： | 0 |
| 16 | Pressure performance for a thin-walled ring and turbulent-jet orifice modeled elastic squeeze film damper显示文摘This paper explores an analytical model for Elastic Ring Squeeze Film Damper(ERSFD) with thin-walled ring and turbulent-jet orifices, and uncovers its Oil Film Pressure Performance(OFPP). Firstly, the ring deformation is addressed by using the Fourier series expansion approach and the orifice outflow rate is characterized with the Prandtl boundary layer theory. Secondly, applying finite difference scheme, the influence of elastic ring flexibility, orifice diameter, and attitude angle on the OFPP is analyzed. Finally, Outer chamber pressure was measured experimentally at different rotor speeds. The results indicate that the outer chamber pressure coats an individual load-carrying region and spreads symmetrically pertaining to the attitude angle. Its amplitude drops as the elastic ring flexibility decreases but boosts with the reduction of the orifice diameter.For inner chamber pressure, the orifice diameter effects a similar trend to the outer cavity, but exhibits more stable distribution regarding the attitude angle. Minimizing the elastic ring flexibility causes an increase in amplitude. The model is validated by the test results giving that the outer chamber pressure shifts synchronously and periodically with the variation of the attitude angle,while the pressure amplitude increases slightly at higher rotor speeds. | Xiaomin YANG Haisheng YANG Yongcun CUI Yan LI Bingzhen JIANG Sier DENG | 2022 | Chinese Journal of Aeronautics2022，35，11： | 0 |
| 17 | Fracture development during disposal of hazardous drilling cuttings by deep underground injection: A review显示文摘Drilling fluids with complicated compositions are becoming more common as the oil and gas industry develops. The production of hazardous cuttings is increasing, which not only stifles the oil and gas industry’s development but also poses a severe environmental threat. Deep underground re-injection is a cost-effective and efficient method for dealing with hazardous cuttings. Numerous experiments and numerical studies on cuttings re-injection have been conducted in the past thirty years. However, there is still a divergence of views on the fracture development in the process of cuttings re-injection. A comprehensive review of existing studies is necessary to help researchers advance this technology. This paper provides a review of the fundamental studies on fracture behaviors during the deep underground re-injection of drilling cuttings. The limitations of the existing studies are also discussed to inspire new research endeavors. | Shuai Zhang Yongcun Feng Bin Li Jingen Deng Tie Geng Jincai Zhang | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，5： | 0 |
| 18 | Enhancing buckling capacity of a rectangular plate under uniaxial compression by utilizing an auxetic material显示文摘Auxetic materials have previously been shown to enhance various performances due to its unusual property of becoming fatter when uniaxially stretched and thinner when uniaxially compressed(i.e., the materials exhibit a negative Poisson's ratio). The current study focuses on assessing the potential of an auxetic material to enhance the buckling capacity of a rectangular plate under uniaxial compression. The in-plane translational restraint along the unloaded edges that was often neglected in open literature is taken into consideration in our buckling model proposed in this study. The closed-form expressions for the critical buckling coefficient of the rectangle are provided and the predicted results agree well with those determined by the finite element method. Furthermore, the results indicate that the buckling performance of a rectangular plate under uniaxial compression can be significantly improved by replacing the traditional material that has a positive Poisson's ratio with an auxetic material when there is in-plane translation restraint along the unloaded edges. | Zhang Yongcun Li Xiaobin Liu Shutian | 2016 | Chinese Journal of Aeronautics2016，29，4： | 0 |
| 19 | S/N-co-doped graphite nanosheets exfoliated via three-roll milling for high-performance sodium/potassium ion batteries显示文摘Due to its larger ionic radius,further studies are needed before graphite can be used as an anode for sodium/potassium-ion batteries(SIBs/KIBs).It is believed that doping and increasing the layer spacing can improve the Na+/K+storage.Herein,S/N co-doped graphite nanosheets(GNS)with an enlarged interlayer spacing of 0.39 nm were prepared via exfoliation with three-roll milling(TRM)combined with thiourea heated at different temperatures.This method generates abundant defects and active sites for GNS,as well as facilitates rapid access and transport of electrolytes and electrons/ions.The electrochemical results show that the S/N-doped GNS exfoliated 15 times and heated at 600°C(SNGNS15-600)with thiourea as the electrode delivers a discharge capacity of 94 mAh g–1 over 6000 cycles at 10 A g–1 with an enhanced rate capability and stable performance for application in SIBs.Calculations using density functional theory show that the increased interlayer spacing by TRM and S,N co-doping enhances the adsorption energies of Na+on graphite,thus improving the Na+storage.As the anode for KIBs,the SNGNS15-600 electrode has a capacity of 142 mAh g–1 after 5000 cycles at 0.5 A g–1.This study provides an essential theoretical basis for the effective exfoliation of layered graphite-based materials and their applications in energy storage. | Xin Wang Zhicong Luo Juntong Huang Zhi Chen Tong Xiang Zhijun Feng Jing Wang Sinong Wang Yongcun Ma Huiyong Yang Xibao Li | 2023 | Journal of Materials Science & Technology2023，，16： | 0 |
| 20 | Micromechanical mode-localized electric current sensor显示文摘This paper outlines the design of a novel mode-localized electric current sensor based on a mechanically sensitive element of weakly coupled resonator systems.With the advantage of a high voltage sensitivity of weakly coupled resonator systems,the current under test is converted to voltage via a silicon shunt resistor,which causes stiffness perturbation to one resonator.The mode-localization phenomenon alters the energy distribution in the weakly coupled resonator system.A theoretical model of current sensing is established,and the performance of the current sensor is determined:the sensitivity of the electric current sensor is 567/A,the noise floor is 69.3 nAA/Hz,the resolution is 183.6 nA,and the bias instability is 81.6 nA.The mode-localized electric current sensor provides a new approach for measuring sub-microampere currents for applications in nuclear physics,including for photocurrent signals and transistor leakage currents.It could also become a key component of a portable mode-localized multimeter when combined with a mode-localized voltmeter.In addition,it has the potential for use in studying sensor arrays to achieve higher resolution. | Han Li Zhao Zhang Luhan Zu Yongcun Hao Honglong Chang | 2022 | Microsystems & Nanoengineering2022，8，2： | 0 |
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