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| 1 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 2 | Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis显示文摘AIM: To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level. METHODS: Fat fed rats were used as a model for fatty liver disease and bile duct ligation in mice to investigate cirrhotic liver. Expression of AdipoR1 and AdipoR2 mRNA was determined by real time RT-PCR. AdipoR1 protein was analysed by immunoblot. Adiponectin was measured by ELISA. RESULTS: Systemic adiponectin is reduced in fat- fed rats but is elevated in mice after bile duct ligation (BDL). Hepatic adiponectin protein is lower in steatotic liver but not in the liver of BDL-mice when compared to controls. Adiponectin mRNA was not detected in human liver samples or primary human hepatocytes nor in rat liver but recombinant adiponectin is taken up by isolated hepatocytes in-vitro. AdipoR1 mRNA and AdipoR1 protein levels are similar in the liver tissue of control and fat fed animals whereas AdipoR2 mRNA is induced. AdipoR2 mRNA and AdipoR1 mRNA and protein is suppressed in the liver of BDL-mice. CONCLUSION: Our studies show reduced circulating adiponectin in a rat model of fatty liver disease whereas circulating adiponectin is elevated in a mouse model of cirrhosis and similar fi ndings have been described in humans. Diminished hepatic expression of adiponectinreceptors was only found in liver cirrhosis. | Markus Neumeier Claus Hellerbrand Erwin Gbele Roland Buettner Cornelius Bollheimer Johanna Weigert Andreas Schffler Thomas S Weiss Monika Lichtenauer Jürgen Schlmerich Christa Buechler | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 3 | Genetics,cytokines and human infectious disease:Lessons from weakly pathogenic mycobacteria and salmonellae显示文摘 | Ottenhoff TH Verreck FA Lichtenauer Kaligis EG | 2002 | Nature Genetics2002，32，1： | 1 |
| 4 | Impact of diabetes mellitus and its complications: survival and quality-of-life in critically ill patients显示文摘 | Katharina Bannier Michael Lichtenauer Marcus Franz Michael Fritzenwanger Bjoern Kabisch Hans-Reiner Figulla Ruediger Pfeifer Christian Jung | 2015 | Journal of Diabetes and Its Complications2015，，8： | 1 |
| 5 | A multimodal database for affect recognition and implicit tagging显示文摘 | Soleymani M Lichtenauer J Pun | 2012 | IEEE Transactions on Affective Computin_g2012，3，1： | 1 |
| 6 | Side population does not define stem cell-like cancer cells in the adrenocortical carcinoma cell line NCI h295R显示文摘 | Lichtenauer UD Shapiro I Geiger K Quinkler M Fassnacht M Nitschke R et ol | 2008 | Endocrinology2008，149，3： | 1 |
| 7 | Side population does not define stem cell- like cancer cells in the adrenocortical carci- noma cell line NCI h295R 显示文摘 | Lichtenauer UD Shapiro I Geiger K | 2008 | Endocrinology2008，149，3： | 1 |
| 8 | Genetics,cytokines and human infectious disease:lessons from weakly pathogenic myeobacteria and salmonellae显示文摘 | Ottenhoff TH Verreck FA Lichtenauer Kaligis EG | 2002 | Nature Genetics2002，32，1： | 1 |
| 9 | Genetics,cytokines and human infectious disease:Lessons from weakly pathogenic mycobacteria and salmonellae显示文摘 | Ottenhoff T H Verreck F A Lichtenauer Kaligis E G | 2002 | Nature Genetics2002，32，1： | 1 |
| 10 | Genetics,cytokines and human infectious disease:Lessons from weakly pathogenic mycobacteria and salmonellae显示文摘 | Ottenhoff TH Verreck FA Lichtenauer Kaligis EG | 2002 | Nat Genet2002，32，1： | 1 |
| 11 | Sign Ian- guage Recognition by Combining Statistical DTW and Inde- pendent Classification显示文摘 | Lichtenauer J F Hendriks E A Reinders M J T | 2008 | Pattern Analysis and Machine In- telligence IEEE Transactions on2008，30，1： | 1 |
| 12 | Hepatic progenitor cells from adult human livers for cell transplantation显示文摘 | Weiss TS Lichtenauer M | 2008 | Gut2008，57，： | 1 |
| 13 | Side population does not define stem cell-like cancer cells in the adrenocortical carcinoma cell line NCI h295R显示文摘 | Lichtenauer UD Shapiro I Geiger K | 2008 | Endocrinology2008，149，3： | 1 |
| 14 | Somatostatin receptor 2A expression in choroidal neovascularization secondary to age - related maeular degeneration 显示文摘 | Lambooij AC Kuijpers RW Van Lichtenauer Kaligis EG | 2000 | Invest Ophthalmol Vis Sci2000，41，8： | 1 |
| 15 | Side populationdoes not define stem cell-like cancer cells in theadrenocortical carcinoma cell line NCI h295H显示文摘 | Lichtenauer UD Shapiro I Geiger K | 2008 | Endocrinology2008，149，3： | 1 |
| 16 | Impact of diabetes mel- litus and its complications: Survival and quality - of - life in criti- cally ill patients显示文摘 | Bannier K Lichtenauer M Franz M | 2015 | Journal of Diabetes & Its Complications2015，29，8： | 1 |
| 17 | Secre- tome of apoptotic peripheral blood cells (APOSEC) atten- uates microvascular obstruction in a porcine closed chest reperfused acute myocardial infarction model:role of plate- let aggregation and vasodilation 显示文摘 | Hoetzenecker K Assinger A Lichtenauer M | 2012 | J Tissue Eng RegenMed2012，6，15： | 1 |
| 18 | Side population does not defme stem cell-like cancer cells in the adrenocortical carcinoma cell line NCI h295R显示文摘 | Lichtenauer UD Shapiro I Geiger K | 2008 | Endocrinology2008，149，3： | 1 |
| 19 | Side population does not define stem cell-like cancer cells in the adrenocortical carcinoma cell line NCI h295R显示文摘 | Lichtenauer UD Shapiro I GeigerK | | 0，，： | 1 |
| 20 | Characterization of NCI-H295R cells as an in vitro model of hyperaldosteronism 显示文摘 | Lichtenauer UD Shapiro I Osswald A | 2013 | Horm Metab Res2013，45，2： | 1 |
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