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| 1 | The M_S7.1 Yushu earthquake surface rupture and large historical earthquakes on the Garzê-Yushu Fault显示文摘As revealed by field investigations,the co-seismic surface rupture zone of the 2010 MS7.1 Yushu earthquake,Qinghai is a characteristic sinistral strike-slip feature consisting of three distinct sinistral primary ruptures,with an overall strike of 310°-320° and a total length of 31 km.In addition,an approximately 2-km-long en-echelon tensile fissure zone was found east of Longbao Town;if this site is taken as the north end of the rupture zone,then the rupture had a total length of ~51 km.The surface rupture zone is composed of a series of fissures arranged in an en-echelon or alternating relationship between compressive bulges and tensile fissures,with a measured maximum horizontal displacement of 1.8 m.The surface rupture zone extends along the mapped Garzê-Yushu Fault,which implicates it as the seismogenic fault for this earthquake.Historically,a few earthquakes with a magnitude of about 7 have occurred along the fault,and additionally traces of paleoearthquakes are evident that characterize the short-period recurrence interval of large earthquakes here.Similar to the seismogenic process of the 2008 Wenchuan earthquake,the Yushu earthquake is also due to the stress accumulation and release on the block boundaries resulting from the eastward expansion of Qinghai-Tibet Plateau.However,in contrast with the Wenchuan earthquake,the Yushu earthquake had a sinistral strike-slip mechanism resulting from the uneven eastward extrusion of the Baryan Har and Sichuan-Yunnan fault blocks. | CHEN LiChun WANG Hu RAN YongKang SUN XinZhe SU GuiWu WANG Ji TAN XiBin LI ZhiMin ZHANG XiaoQing | 2010 | Chinese Science Bulletin2010，55，31： | 17 |
| 2 | High precision topographic data on Lop Nor basin's Lake 'Great Ear' ? and the timing of its becoming a dry salt lake显示文摘High precision elevation measurements using DGPS were carried out along three representative tran- sects for the 'Great Ear' area, a dry salt lake within the Lop Nor basin. Results indicate that the Lop Nor basin is only 5.2 m deep and its lowest point occurs at the center of the 'Great Ear'. In addition, the basin is asymmetric - steeper in the southwest (0.19‰) and gentler in the northeast (0.09‰). Points along the same 'Great Ear' ring were found to have an identical elevation value, but different when from different ones (lower towards the center). The spacing of the 'Great Ear' rings was found to be closely related with the surface steepness. The closer the 'Great Ear' rings are spaced, the steeper the ground surface, and vice versa. These findings support the argument that the 'Great Ear' rings are the former shoreline trails left behind by Lop Nor water during the last few episodes of recession towards its total dry up. A comprehensive analysis of the high precision elevation data, historical accounts, aerial and satellite photographs and imagery, and official topographic maps of the study area suggests that the 'Great Ear' area in the Lop Nor basin was incorrectly mapped as being covered by a great body of water on the 1963 topographic maps. A re-interpretation of the 1958 aerial photographs and newer remote sensing imagery indicated that the 'Great Ear' ring structure was already in place in 1958 and it continued to appear on the subsequent remote sensing data without any major changes. It is estimated that lake water in the 'Great Ear' area of the Lop Nor basin disappeared between the late 1930s and early 1940s. | LI BaoGuo MA LiChun JIANG PingAn DUAN ZengQiang SUN DanFeng QIU HongLie ZHONG JunPing WU HongQi | 2008 | Chinese Science Bulletin2008，53，6： | 11 |
| 3 | Knockdown of S-phase Kinase-associated Protein-2 Expression in MCF-7 Inhibits Cell Growth and Enhances the Cytotoxic Effects of Epirubicin显示文摘S 阶段联系 kinase 的 protein-2 (Skp2 ) 在调停 ubiquitin 的解朊作用起一个关键作用,导致房间从的前进一对一个 proliferative 状态静止。Skp2 完了在许多肿瘤表示了并且相反地与 p27 表示相关,包括乳癌。在这研究,我们使用了小介入的 RNA (siRNAs ) 在人的乳癌 MCF-7 细胞禁止 Skp2 表示并且如果击倒,从而由 RNA 干扰(RNAi ) Skp2 调查将禁止乳癌细胞生长并且在 MCF-7 细胞上影响 epirubicin 的效果。三 Skp2 siRNA 构造被重新结合并且短暂地 transfected 人乳癌 MCF-7 房间。Skp2 的下面规定被反向的抄写聚合酶链反应和蛋白质印迹分析证实。我们证明 Skp2 siRNA 转染减少了 Skp2 蛋白质并且在 MCF-7 房间导致了 p27 蛋白质的累积。Skp2 siRNA 在 vitro 并且在 vivo 禁止了房间增长。由 RNAi 的 Skp2 击倒在 vitro 的增加的细胞的 apoptosis。有治疗进一步与 epirubicin 跟随的 Skp2 siRNA 的治疗禁止了癌症房间线的增长,与 epirubicin 跟随的控制 siRNA 相比。因此, Skp2 击倒由 RNAi 的表示禁止乳癌细胞生长并且提高 epirubicin 的效果。Skp2 的调停 siRNA 的基因 silencing 能是为在规定下面的 p27 的抑制的新奇癌症基因治疗。 | Lichun SUN Li CAI Yan YU Qingwei MENG Xuesong CHENG Yanbin ZHAO Guangjie SUI Fengmin ZHANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，12： | 6 |
| 4 | A comparative study of the characteristics of two Coxsackie A virus type 16 strains (genotype B)显示文摘Coxsackie A virus is one of the major pathogens associated with hand, foot and mouth disease (HFMD). The etiological characteristics of Coxsackie A virus type 16 (CA16) are thought to correlate with the pathological process of its infection. Two CA16 strains that were isolated from a severe HFMD patient presented with different plaque forms. This observation, along with biological analysis, indicated that the differences in the strains' biological characteristics, such as proliferation kinetics and immunogenicity, correlate with differences in their pathogenicity toward neonatal mice. Furthermore, these differences are thought to be associated with the sequence of the 5′ non-coding region of the viral genome and the VP1 structural region sequence. The results suggest that the biological and genetic characteristics of the CA16 viral strains are relevant to their pathogenicity. | YANG ErXia ZHAO Heng ZHANG Ying LIU JianSheng LIAO Yun WANG LiChun CUI PingFang YANG LiXian LIU LongDing DONG ChengHong DONG ShaoZhong SHAO CongWen JIANG Li SUN Le LI QiHan | 2012 | Science China(Life Sciences)2012，55，4： | 5 |
| 5 | Intestinal OCTN2-and MCT1-targeted drug delivery to improve oral bioavailability显示文摘Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs,thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.In particular,intestinal carnitine/organic cation transporter 2(OCTN2)and mono-carboxylate transporter protein 1(MCT1)possess high transport capacities and complementary distributions.Therefore,we outline recent developments in transporter-targeted oral drug delivery with regard to the OCTN2 and MCT1 proteins in this review.First,basic information of the two transporters is reviewed,including their topological structures,characteristics and functions,expression and key features of their substrates.Furthermore,progress in transporter-targeting prodrugs and nanoparticles to increase oral drug delivery is discussed,including improvements in the oral absorption of anti-inflammatory drugs,antiepileptic drugs and anticancer drugs.Finally,the potential of a dual transporter-targeting strategy is discussed. | Gang Wang Lichun Zhao Qikun jiang Yixin Sun Dongyang Zhao Mengchi Sun Zhonggui He Jin sun Yang Wang | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 3 |
| 6 | A new carbon phase with direct bandgap and high carrier mobility as electron transport material for perovskite solar cells显示文摘Rapid development of perovskite solar cells is challenged by the fact that current semiconductors hardly act as efficient electron transport materials that can feature both high electron mobility and a well-matched energy level to that of the perovskite.Here we show that T-carbon,a newly emerging carbon allotrope,could be an ideal candidate to meet this challenge.By using first-principles calculations and deformation potential theory,it is found that T-carbon is a semiconductor with a direct bandgap of 2.273 eV,and the energy level in the conduction band is lower than that of perovskite by 0.5 eV,showing a larger force of electron injection.Moreover,the calculated electron mobility can reach up to 2.36×10^(3) cm^(2) s^(–1) V^(–1),superior to conventional electron transport materials such as TiO2,ZnO and SnO2,which will facilitate more efficient electron separation and more rapid diffusion away from their locus of generation within the perovskite absorbers.Furthermore,the bandgap of T-carbon is highly sensitive to strain,thus providing a convenient method to tune the carrier transport capability.Overall,T-carbon satisfies the requirements for a potential efficient electron transport material and could therefore be capable of accelerating the development of perovskite solar cells. | Ping-Ping Sun Lichun Bai Devesh R.Kripalani Kun Zhou | 2019 | npj Computational Materials2019，，1： | 3 |
| 7 | Super-resolution reconstruction and higher-degree function deformation model based matching for Chang’E-1 lunar images显示文摘This article intends to solve the matching problem of 2C level lunar images by Chang’E-1(CE-1)lunar probe satellite.A line-scanner image matching method is proposed which represents deformation by the quadric function along the camera motion direction and bases on the deformation model for a relief terrain’s imaging on sensors of the satellite borne three-line scanner camera.A precise matching is carried out for the normal view,the frontward view,and the backward view images of the CE-1 by combining the proposed method with the standard correlation method.A super-resolution(SR)reconstruction algorithm based on the wavelet interpolation of non-uniformly sampled data is also adopted to realize SR reconstruction of CE-1 lunar images,which adds the recognizable targets and explores CE-1 lunar images to the full. | LI LiChun YU QiFeng YUAN Yun SHANG Yang LU HongWei SUN XiangYi | 2009 | Science China(Technological Sciences)2009，52，12： | 3 |
| 8 | JAK 2 V 617 F mutation and 46/1 haplotype in C hinese B udd‐ C hiari syndrome patients显示文摘 | Hui Wang Guixiang Sun Peijin Zhang Jing Zhang Er Gui Maoheng Zu Enzhi Jia Hao Xu Lichun Xu Jinpeng Zhang Zhaojun Lu | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 9 | What Does Ecological Marxism Mean For China? Ques- tions and Challenges for John Bellamy Foster显示文摘 | ZhiheWang Meijun Fan Hui Dong Dezhong Sun and Lichun Li | 2013 | Monthly Re- view2013，64，9： | 1 |
| 10 | Bacillus phytases: present scenario and future perspectives显示文摘 | FU Shijun SUN Jianyi QIAN Lichun | 2008 | Appl Biochem Biotechnol2008，151，1： | 1 |
| 11 | Antiandrogenic activity of pyrethroid pesticides and their metabolite in reporter gene assay显示文摘 | SUN Hong XU Xiaolin XU Lichun | 2007 | Chemosphere2007，66，3： | 1 |
| 12 | 传统止血和凝血试验与肝硬化急性上消化道出血的关系:一项回顾性研究显示文摘目的:回顾性比较伴与不伴急性上消化道出血(AUGIB)或急性食管静脉曲张出血(AEVB)的肝硬化患者止血/凝血指标的差异,包括血小板计数(PLT)、凝血酶原时间(PT)、国际标准化比率(INR)和活化部分凝血活酶时间(APTT)。方法:2012年1月至2014年6月间,共计1734例肝硬化患者纳入研究。根据其病史分为AUGIB组(497例)和无AUGIB组(1237例);同时根据内镜检查结果分为AEVB组(297例)和无AEVB组(1259例),另178例AUGIB患者由于缺乏内镜资料,既未入AEVB组,也未归入无AEVB组。结果:AUGIB组与无AUGIB组患者相比,PLT(99.99±89.90 vs 101.47±83.03,P=0.734)和APTT(42.96±15.20 vs 43.77±11.01,P=0.219)的差异无统计学意义,但PT显著延长(17.30±5.62 vs 16.03±4.68,P<0.001),INR显著增高(1.45±0.69 vs 1.31±0.59,P<0.001)。PT可以独立预测AUGIB的发生,PT越低,AUGIB出现的可能性越小(OR=0.968,95%CI:0.942-0.994)。AEVB组与无AEVB组患者相比,PLT显著减少(86.87±62.14 vs 101.74±83.62,P=0.004),APTT显著缩短(40.98±7.98 vs 43.72±10.97,P<0.001),但PT(16.53±3.71 vs 16.0464.68,P=0.088)和INR(1.35±0.41 vs 1.3160.59,P=0.225)的差异则无统计学意义。PLT可独立预测AEVB的发生,PLT越高,AEVB出现的可能性越大(OR=1.004,95%CI:1.002-1.006)。结论:PLT与肝硬化患者门脉高压出血密切相关。 | Jing Li Xingshun Qi Han Deng Ying Peng Lichun Shao Jiaxin Ma Xiaolin Sun Hongyu Li Xiaozhong Guo | 2016 | Gastroenterology Report2016，4，4： | 1 |
| 13 | Evaluation of androgen receptor transcriptional activities of bisphenoi A,octylphenol and nonylplie-nol in vitro显示文摘 | Xu Lichun Sun Hong Chen Jianfeng | 2005 | Toxicology2005，216，23： | 1 |
| 14 | Bacillus phytases: present scenario and future perspectives显示文摘 | FU Shijun SUN Jianyi QIAN Lichun | 2008 | Appl Biochem Biotechnol2008，151，1： | 1 |
| 15 | High Efficiency to Develop in Cainan Oilfield显示文摘There are two amazing constructions estab-lished in the desert:one is a designing,installa-tion,and production of the central treating station which have operated within one year,the other is 114 km second-class standard highway and 52 km third-class highway pass through。Therefore.wa-ter,electricity and road are all in access. | Zhao Lichun Sun Chuansheng and Chen Gengwen(Xinjiang Petroleum Administration Bureau) | 1994 | China Oil & Gas1994，1，4： | 0 |
| 16 | The Emergency Scientific Investigation on the Surface Rupture Zone of the M_S 7.1 Yushu Earthquake显示文摘The coseismic surface rupture zone of the seismogenic fault of the MS7.1 Yushu earthquake includes three left-stepping main ruptures, striking 300°~320°, in general. An approximately 2km-long en echelon tension fissure zone was found at Longbao town. The main rupture in the northern part is about 16km long, about 9km long in the middle part, and about 7km long in the southern part, with a total length of 34km. Each of the main ruptures consists of a series of en echelon sub-ruptures represented by a series of compression bulges alternating with tension fissures or by en echelon fissures. The rupture at Changusi, the southernmost of the ruptures, is characterized by vertical displacement, with a value of 50cm. The rupture zone shows left-lateral strike-slip characteristics. The maximal horizontal slip is on the northern main rupture, with a value of 1.8m. | Wang Ji Chen Lichun Tian Qinjian Li Zhimin Sun Xinzhe Zhang Xiaoqing | 2011 | Earthquake Research in China2011，25，4： | 0 |
| 17 | Comparative Studyon DC Flashover Characteristics of Iced Insulators with Various Test Methods显示文摘 | HU Jianlin LUO Mingwu JIANG Xingliang SUN Caixin ZHANG Zhijin SHU Lichun | 2012 | 高电压技术2012，38，8： | 0 |
| 18 | Physical Activity and Vascular Dilation Function in Healthy Middle-aged Individuals显示文摘Objective:Vascular dilation dysfunction has been linked with risk of cardiovascular disease.This study was undertaken to investigate the relationship between physical activity and vascular dilation function in healthy middle-aged adults to help explaining the effect of physical activity on preventing cardiovascular disease.Method:We recruited 91 healthy middle-aged adults to complete a self-report 7-day physical activity recall questionnaire and an exam of brachial artery flow-mediated dilation(FMD) and Nitroglycerin-mediated dilation(NMD) detected by ultrasound.The relationship between physical activity level(PAL) and FMD and NMD were explored.Result:Physical activity showed a significant and positive relationship with the brachial artery FMD,even after adjustment for possible confounding factors(r=0.363,P<0.01).The group of high physical activity level had the highest FMD.The means of FMD(%) in low,moderate and high PAL groups were respectively 8.70%±3.93%,9.01%±3.22% and 12.38±5.67% with significant difference between individuals of low and high PAL and between moderate and high PAL group(P<0.01).The means of NMD(%) is 25.13%±6.52%,24.38%±5.44% and 29.50%±7.25% respectively(P> 0.05) and there was no significant difference among three groups.There was no positive relation between PAL and FMD in premenopausal females but in men and postmenopausal females.Although individuals of high PAL have the best FMD,the moderate PAL can also retard FMD decrease with ageing.Conclusion:Maintaining high physical activity level can enhance endothelial-dependent vascular dilation,and moderate or high physical activity level can prevent endothelial-dependent vascular dilation declining with aging,which may contribute to decrease risk of cardiovascular disease in healthy middle-aged adults. | LIANG Qi LIU Donghong WANG Yuling SUN Bing LIN Fengqiao GAN Hanjing WU Guifu WANG Lichun MA Hong | 2009 | 中国康复医学杂志2009，24，6： | 0 |
| 19 | Identification and Analysis of Chemical Components in Zhideke Granules by UPLC-Q-Orbitrap HRMS显示文摘[Objectives]To identify and analyze chemical components in Zhideke Granules by ultra performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry(UPLC-Q-Orbitrap HRMS).[Methods]Zhideke Granules were isolated on a Thermo Hypersil Gold C18 column(2.1 mm×100 mm,1.9μm).The mobile phase was 0.1%formic acid acetonitrile and 0.1%formic acid aqueous solution(containing 10 mmol ammonium acetate)with gradient elution.Chemical components in Zhideke Granules were rapidly isolated and identified by HRMS in the positive and negative ion mode with full scan data-dependent two stage threshold-triggered mass modes(Full MS/dd-MS2).[Results]The secondary fragment ion information of the target compound was selected and compared with the compound reported in the databases and related literatures for further confirmation.In total,30 chemical compounds were identified,including 12 flavonoids and glycosides,9 organic acids,3 nitrogen-containing compounds,and 6 other components.[Conclusions]In this study,the UPLC-Q-Orbitrap HRMS was used for the first time to analyze the chemical components in Zhideke Granules.It is intended to provide a reference for the quality evaluation and further study of pharmacodynamic materials of Zhideke Granules. | Jie LIANG Guangqiang HUANG Zhengyi SUN Tanfang XIE Yaohua LI Jing QI Yue FENG Jianli LIANG Hua ZHU Lichun ZHAO | 2021 | Medicinal Plant2021，12，4： | 0 |
| 20 | Geochemical Characteristics of the Fluid Inclusions Trapped in Primary Gypsum of the Lop Nor Basin显示文摘Objective The Lop Nor Basin is a very important Quaternary potash-formation basin in China.It is a typical sulphatepotash brine mine with an average grade of 1.4%(KG)in underground concentrated brines.It is extraordinary that the reservoir of potassium-rich brines is glauberite stratum rather than halite rock.The anomalous potassium enrichment,advanced in relative early stage of | MA Lichun TANG Qingfeng WANG Xin SUN Xiaohong | 2016 | Acta Geologica Sinica(English Edition)2016，90，1： | 0 |
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