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| 1 | Soil salinization research in China: Advances and prospects显示文摘与气候变化的进展引起的环境恶化,土壤 salinization 是一个严重、成长的全球问题。当前,大约 7% 世界陆地表面被 salinization 威胁。中国是其土壤被这个问题严重地影响的一个国家,它由于它的广泛的区域,并且宽分发形成严肃的威胁到地区性的农业开发。在这评论,我们在过去的 70 年在中国为土壤 salinization 研究总结框架,估计存在的软弱在两个研究国内、国际的上下文,加亮趋势并且给关于在过去的 30 年的盐的土壤的全球研究的调查结果调音,并且为关于盐的土壤的未来研究建议六个主要领域和方向。 | LI Jianguo PU Lijie HAN Mingfang ZHU Ming ZHANG Runsen XIANG Yangzhou | 2014 | Journal of Geographical Sciences2014，24，5： | 90 |
| 2 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 3 | Moment-independent importance measure of basic random variable and its probability density evolution solution显示文摘To analyze the effect of basic variable on failure probability in reliability analysis,a moment-independent importance measure of the basic random variable is proposed,and its properties are analyzed and verified.Based on this work,the importance measure of the basic variable on the failure probability is compared with that on the distribution density of the response.By use of the probability density evolution method,a solution is established to solve two importance measures,which can efficiently avoid the difficulty in solving the importance measures.Some numerical examples and engineering examples are used to demonstrate the proposed importance measure on the failure probability and that on the distribution density of the response.The results show that the proposed importance measure can effectively describe the effect of the basic variable on the failure probability from the distribution density of the basic variable.Additionally,the results show that the established solution on the probability density evolution is efficient for the importance measures. | CUI LiJie,Lü ZhenZhou & ZHAO XinPan School of Aeronautics,Northwestern Polytechnical University,Xi’an 710072,China | 2010 | Science China(Technological Sciences)2010，53，4： | 41 |
| 4 | Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor显示文摘 | Lijie Wang Wei Xue Lei Yan Xiaosa Li Jia Wei Miaomiao Chen Jing Wu Bei Yang Li Yang Jia Chen | 2017 | Cell Research2017，27，10： | 26 |
| 5 | Chitosan conduits combined with nerve growth factor microspheres repair facial nerve defects显示文摘Microspheres containing nerve growth factor for sustained release were prepared by a compound method,and implanted into chitosan conduits to repair 10-mm defects on the right buccal branches of the facial nerve in rabbits.In addition,chitosan conduits combined with nerve growth factor or normal saline,as well as autologous nerve,were used as controls.At 90 days post-surgery,the muscular atrophy on the right upper lip was more evident in the nerve growth factor and normal saline groups than in the nerve growth factor-microspheres and autologous nerve groups.Electrophysiological analysis revealed that the nerve conduction velocity and amplitude were significantly higher in the nerve growth factor-microspheres and autologous nerve groups than in the nerve growth factor and normal saline groups.Moreover,histological observation illustrated that the diameter,number,alignment and myelin sheath thickness of myelinated nerves derived from rabbits were higher in the nerve growth factor-microspheres and autologous nerve groups than in the nerve growth factor and normal saline groups.These findings indicate that chitosan nerve conduits combined with microspheres for sustained release of nerve growth factor can significantly improve facial nerve defect repair in rabbits. | Huawei Liu Weisheng Wen Min Hu Wenting Bi Lijie Chen Sanxia Liu Peng Chen Xinying Tan | 2013 | Neural Regeneration Research2013，8，33： | 22 |
| 6 | Preoperative diagnosis of malignant pulmonary nodules in lung cancer screening with a radiomics nomogram显示文摘Background:Lung cancer is the most commonly diagnosed cancer worldwide.Its survival rate can be significantly improved by early screening.Biomarkers based on radiomics features have been found to provide important physiological information on tumors and considered as having the potential to be used in the early screening of lung cancer.In this study,we aim to establish a radiomics model and develop a tool to improve the discrimination between benign and malignant pulmonary nodules.Methods:A retrospective study was conducted on 875 patients with benign or malignant pulmonary nodules who underwent computed tomography(CT)examinations between June 2013 and June 2018.We assigned 612 patients to a training cohort and 263 patients to a validation cohort.Radiomics features were extracted from the CT images of each patient.Least absolute shrinkage and selection operator(LASSO)was used for radiomics feature selection and radiomics score calculation.Multivariate logistic regression analysis was used to develop a classification model and radiomics nomogram.Radiomics score and clinical variables were used to distinguish benign and malignant pulmonary nodules in logistic model.The performance of the radiomics nomogram was evaluated by the area under the curve(AUC),calibration curve and Hosmer-Lemeshow test in both the training and validation cohorts.Results:A radiomics score was built and consisted of 20 features selected by LASSO from 1288 radiomics features in the training cohort.The multivariate logistic model and radiomics nomogram were constructed using the radiomics score and patients’age.Good discrimination of benign and malignant pulmonary nodules was obtained from the training cohort(AUC,0.836;95%confidence interval[CI]:0.793-0.879)and validation cohort(AUC,0.809;95%CI:0.745-0.872).The Hosmer-Lemeshow test also showed good performance for the logistic regression model in the training cohort(P=0.765)and validation cohort(P=0.064).Good alignment with the calibration curve indicated the good performance of the nomogram.Conclusions:The established radiomics nomogram is a noninvasive preoperative prediction tool for malignant pulmonary nodule diagnosis.Validation revealed that this nomogram exhibited excellent discrimination and calibration capacities,suggesting its clinical utility in the early screening of lung cancer. | Ailing Liu Zhiheng Wang Yachao Yang Jingtao Wang Xiaoyu Dai Lijie Wang Yuan Lu Fuzhong Xue | 2020 | Cancer Communications2020，40，1： | 22 |
| 7 | p53 upregulated by HIF-la promotes hypoxiainduced G2/M arrest and renal fibrosis in vitro and in vivo显示文摘Hypoxia plays an important role in the genesis and progression of renal fibrosis.The underlying mechanisms, however, have not been sufficiently elucidated. We examined the role of p53 in hypoxia-induced renal fibrosis in cell culture (human and rat renal tubular epithelial cells) and a mouse unilateral ureteral obstruction (UUO) model. Cell cycle of tubular cells was determined by flow cytometry, and the expression of profibrogenic factors was determined by RT-PCR, immunohistochemistry, and western blotting. Chromatin immunoprecipitation and luciferase reporter experiments were performed to explore the effect of HIF-lα on p53 expression. We showed that, in hypoxic tubular cells, p53 upregulation suppressed the expression of CDK1 and cyclins Bl and DI, leading to cell cycle (G2/M) arrest (or delay) and higher expression of TGF-β, CTGF, collagens, and fibronectin. p53 suppression by siRNA or by a specific p53 inhibitor (PIF-α) triggered opposite effects preventing the G2/M arrest and profibrotic changes. In vivo experiments in the UUO model revealed similar antifibrotic results following intraperitoneal administration of PIF-α(2.2 mg/kg). Using gain-of-function, loss-of-function, and luciferase assays, we further identified an HRE3 region on the p53 promoter as the HIF-lα-binding site. The HIF-la-HRE3 binding resulted in a sharp transcriptional activation of p53. Collectively, we show the presence of a hypoxia-activated, p53-responsive profibrogenic pathway in the kidney. During hypoxia, p53 upregulation induced by HIF-la suppresses cell cycle progression, leading to the accumulation of G2/M cells, and activates profibrotic TGF-β and CTGF-mediated signaling pathways, causing extracellular matrix production and renal fibrosis. | Limin Liu Peng Zhang Ming Bai Lijie He Lei Zhang Ting Liu Zhen Yang Menglu Duan Minna Liu Baojian Liu Rui Du Qi Qian Shiren Sun | 2019 | Journal of Molecular Cell Biology2019，11，5： | 18 |
| 8 | IDO1 in cancer: a Gemini of immune checkpoints显示文摘Indoleamine 2,3-dioxygenase 1(IDO1)is a rate-limiting metabolic enzyme that converts the essential amino acid tryptophan(Trp)into downstream catabolites known as kynurenines.Coincidently,numerous studies have demonstrated that IDO1 is highly expressed in multiple types of human cancer.Preclinical studies have further introduced an interesting paradox:while single-agent treatment with IDO1 enzyme inhibitor has a negligible effect on decreasing the established cancer burden,approaches combining select therapies with IDO1 blockade tend to yield a synergistic benefit against tumor growth and/or animal subject survival.Given the high expression of IDO1 among multiple cancer types along with the lack of monotherapeutic efficacy,these data suggest that there is a more complex mechanism of action than previously appreciated.Similar to the dual faces of the astrological Gemini,we highlight the multiple roles of IDO1 and review its canonical association with IDO1-dependent tryptophan metabolism,as well as documented evidence confirming the dispensability of enzyme activity for its immunosuppressive effects.The gene transcript levels for IDO1 highlight its strong association with T-cell infiltration,but the lack of a universal prognostic significance among all cancer subtypes.Finally,ongoing clinical trials are discussed with consideration of IDO1-targeting strategies that enhance the efficacy of immunotherapy for cancer patients。 | Lijie Zhai Erik Ladomersky Alicia Lenzen Brenda Nguyen Ricky Patel Kristen L Lauing Meijing Wu Derek A Wainwright | 2018 | Cellular & Molecular Immunology2018，15，5： | 17 |
| 9 | Plasma induced degradation of Indigo Carmine by bipolar pulsed dielectric barrier discharge(DBD) in the water-air mixture显示文摘Degradation of the Indigo Carmine(IC) by the bipolar pulsed DBD in water-air mixture was studied. Effects of various parameters such as gas flow rate, solution conductivity, pulse repetitive rate and ect., on color removal efficiency of dying wastewater were investigated. Concentrations of gas phase O 3 and aqueous phase H 2O 2 under various conditions were measured. Experimental results showed that air bubbling facilitates the breakdown of water and promotes generation of chemically active species. Color removal efficiency of IC solution can be greatly improved by the air aeration under various solution conductivities. Decolorization efficiency increases with the increase of the gas flow rate, and decreases with the increase of the initial solution conductivity. A higher pulse repetitive rate and a larger pulse capacitor C\-p are favorable for the decolorization process. Ozone and hydrogen peroxide formed decreases with the increase of initial solution conductivity. In addition, preliminary analysis of the decolorization mechanisms is given. | ZHANGRuo-bing WUYan LIGuo-feng WANGNing-hui LIJie | 2004 | Journal of Environmental Sciences2004，16，5： | 16 |
| 10 | Novel Mobility Formula for Parallel Mechanisms Expressed with Mobility of General Link Group显示文摘The determination of virtual constraints is always one of the key and difficult problems in traditional mobility calculation.To make mobility calculation simple,considering avoiding virtual constraints,some new formulae have been presented,however these formulae can hardly intuitively reflect general link group’s restrictions on output member and its influences on independence of output parameters,which is premise to the judgment of the properties of mobility.Towards the problem to reveal the intrinsic relationship between the degree of freedom(DOF)of a mechanism,the link group,and the dimension of output parameters,also to avoid determination of virtual constraint,based on the new concepts of the'DOF of general link group'and'node parameters',a new formula in the calculation of the mobility of mechanisms is presented that is expressed with DOFs of the general link groups and rank of motion parameters of base point of the output link.It is named GOM(mobility of groups and output parameter)formula.On the basis of new concepts of'effective parameters'and'invalid parameters',a rule is put forward for solving the DOF of mechanisms with invalid parameters by GOM formula,that is,the base point parameters are the subset of effective parameters of link group.Thereafter,several examples are enumerated and the results coincide with the prototype data,which proves the validity of the proposed formula.Meanwhile,it is obtained that the necessary and sufficient condition for the judgment of output parameters independence is that each of the DOF of the link group is not less than zero.The proposed formula which is simple in calculation provides theoretical basis for the judgment of independence of output parameters and provides references for type synthesis of novel parallel mechanisms with independence requirements of their output parameters. | ZHANG Yitong LU Wenjuan MU Dejun YANG Yandong ZHANG Lijie ZENG Daxing | 2013 | Chinese Journal of Mechanical Engineering2013，26，6： | 14 |
| 11 | 超空泡回转体减阻特性研究(英文)显示文摘Drag reduction characteristics of supercavitating body of revolution was researched numerically with a bubble two-phase flow model embodied in commercial CFD code Fluent 6.0.The work included the effects of body shape on drag coefficient and supercavity sizes; supercavity control; drag coefficient Cd as a function of cavitation number; and the effect of the ratio of length L to diameter D on drag reduction rate. Research on drag reduction mechanism of supercavitation shows that supercavitation can reduce not only the friction drag coefficient but also the pressure drag coefficient. There may be a best combination among body shape, the ratio L/D, cavitation number, engineering feasibility and so on, which makes the drag reduction ratehighest. | FUHui-ping LUChuan-jing LIJie | 2004 | 船舶力学2004，8，3： | 14 |
| 12 | Advances in research on solid-state fermented feed and its utilization:The pioneer of private customization for intestinal microorganisms显示文摘With sustainable development of biotechnology,increasing attention has been placed on utilization of solid-state fermented feed(SFF).Solid-state fermented feed has been a candidate strategy to alleviate the contradiction between supply and demand of feed resources,ensure food hygiene safety,promoting energy conservation,and emission reduction.In production of SFF,a variety of organic acids,enzymes,vitamins,peptides,and other unknown growth factors are produced,which could affect performance of animals.Solid-state fermented feed produced by different fermentation techniques has great instability on different physiological stages of different animals,which hinders the application and standardized production of SFF.Herein,we summarize the current advances in the role of the characteristics of SFF prepared by different manufacturing technique and its research progress in animal experiments on growth performance,gastrointestinal ecology,and immune system,so as to provide references for further acquiring a relatively perfect set of SFF production and evaluation systems. | Lijie Yang Xiangfang Zeng Shiyan Qiao | 2021 | Animal Nutrition2021，，4： | 14 |
| 13 | A Nosocomial COVID-19 Outbreak Initiated by an Infected Dockworker at Qingdao City Port-Shandong Province, China, October, 2020显示文摘On October 10,2020,3 cases of coronavirus disease 2019(COVID-19)were detected via routine preadmission nucleic acid screening of inpatients and their visitors at Qingdao Central Hospital.The 3 cases were all related to the Qingdao Chest Hospital.An additional 9 cases were discovered and confirmed through tracing and testing contacts of the 3 initial cases.Viral isolates from all 12 cases were found to have high degrees of genetic homology with the viral isolate from a dockworker at Qingdao Port,referred to as Patient A in this report.A joint investigation team was formed to determine the source of infection and the scale of the outbreak,and to prevent further spread of the virus. | Qun Yuan Zengqiang Kou Fachun Jiang Zhongjie Li Lijie Zhang Huihui Liu Xiang Zhao Dianmin Kang Ruqin Gao Jie Lei | 2020 | China CDC weekly2020，2，43： | 12 |
| 14 | THE FLUCTUATION CHARACTERISTICS OF NATURAL AND VENTILATED CAVITIES ON AN AXISYMMETRIC BODY显示文摘Natural and ventilated cavitations generated on a smooth-nosed axisymmetric body were studied experimentally.The characteristics of small scale and localized fluctuations of “steady cavities” were measured by pressure transducers. Comparisons between natural and ventilated cavities at different measured points for several cavitation numbers were done. It was observed that the dominant fluctuations were concentrated in the frequency range of 0Hz-50Hz for all the cavitation cases, Similar shapes and magnitudes of the frequency spectra were detected for both natural and ventilated cavities. Much larger spectral amplitude in the cavity closure region suggested al fluctuations source. From partial cavitating flow to supercavitating flow, the dominant frequency and the corresponding amplitude decreased with decreasing cavitation number, which meant that cavity became more steady while developing. | FENGXue-mci LUChuan-jing HUTian-qun WULei LIJie | 2005 | Journal of Hydrodynamics2005，17，1： | 12 |
| 15 | Incorporating temporal variability to improve geostatistical analysis of satellite-observed CO_2 in China显示文摘Observations of atmospheric carbon dioxide (CO2 ) from satellites offer new data sources to understand global carbon cycling. The correlation structure of satellite-observed CO2 can be analyzed and modeled by geostatistical methods, and CO2 values at unsampled locations can be predicted with a correlation model. Conventional geostatistical analysis only investigates the spatial correlation of CO2 , and does not consider temporal variation in the satellite-observed CO2 data. In this paper, a spatiotemporal geostatistical method that incorporates temporal variability is implemented and assessed for analyzing the spatiotemporal correlation structure and prediction of monthly CO2 in China. The spatiotemporal correlation is estimated and modeled by a product-sum variogram model with a global nugget component. The variogram result indicates a significant degree of temporal correlation within satellite-observed CO2 data sets in China. Prediction of monthly CO2 using the spatiotemporal variogram model and spacetime kriging procedure is implemented. The prediction is compared with a spatial-only geostatistical prediction approach using a cross-validation technique. The spatiotemporal approach gives better results, with higher correlation coefficient (r2 ), and less mean absolute prediction error and root mean square error. Moreover, the monthly mapping result generated from the spatiotemporal approach has less prediction uncertainty and more detailed spatial variation of CO2 than those from the spatial-only approach. | ZENG ZhaoCheng LEI LiPing GUO LiJie ZHANG Li ZHANG Bing | 2013 | Chinese Science Bulletin2013，58，16： | 12 |
| 16 | Walnut-inspired microsized porous silicon/graphene core-shell composites for high-performance lithium-ion battery anodes显示文摘 | Wei Zhai Qing Ai Lina Chen Shiyuan Wei Deping Li Lin Zhang Pengchao Si Jinkui Feng Lijie Ci | 2017 | Nano Research2017，10，12： | 12 |
| 17 | Co-inhibition of methanogens for methane mitigation in biodegradable wastes显示文摘The inhibition effects and mechanisms of chlorinated methane and acetylene on methanogenesis in the anaerobic digestion process of the biodegradable wastes were investigated.It was found that both chloroform and acetylene could effectively inhibit methanogens while the biodegradability of the wastes was not affected.Acetylene inhibited the activity of methanogens,while chloroform inhibited metabolic process of methanogenesis.A central composite design(CCD) and response surface regression analysis(RSREG) were employed to determine the optimum conditions and interaction effects of chloroform and acetylene in terms of inhibition effciency,production of volatile fatty acids(VAF) and molar ratio of propionic acid to acetic acid.Chloroform had significant effect on enhancing the production of VFA(F = 121.3;p < 0.01),and acetylene promoted the inhibition effciency(F = 99.15;p < 0.05) more effectively than chloroform(F = 9.72;p > 0.05).In addition,a maximum molar ratio of propionic acid to acetic acid of 1.208 was estimated under the optimum conditions of chloroform concentration of 9.05 mg/kg and acetylene concentration of 3.6×10-3(V/V).Hence,methanogens in the wastes can be inhibited while the stabilization process of the biodegradable wastes can still work well,as propionic acid generated during the inhibition process could hardly be utilized by methanogens. | ZHAO Tiantao ZHANG Lijie CHEN Haoquan ZHAO Youcai | 2009 | Journal of Environmental Sciences2009，21，6： | 12 |
| 18 | Global Dynamic Modeling of Electro-Hydraulic 3-UPS/S Parallel Stabilized Platform by Bond Graph显示文摘Dynamic modeling of a parallel manipulator(PM) is an important issue. A complete PM system is actually composed of multiple physical domains. As PMs are widely used in various fields, the importance of modeling the global dynamic model of the PM system becomes increasingly prominent. Currently there lacks further research in global dynamic modeling. A unified modeling approach for the multi-energy domains PM system is proposed based on bond graph and a global dynamic model of the 3-UPS/S parallel stabilized platform involving mechanical and electrical-hydraulic elements is built. Firstly, the screw bond graph theory is improved based on the screw theory, the modular joint model is modeled and the normalized dynamic model of the mechanism is established. Secondly, combined with the electro-hydraulic servo system model built by traditional bond graph, the global dynamic model of the system is obtained, and then the motion, force and power of any element can be obtained directly. Lastly, the experiments and simulations of the driving forces, pressure and flow are performed, and the results show that, the theoretical calculation results of the driving forces are in accord with the experimental ones, and the pressure and flow of the first limb and the third limb are symmetry with each other. The results are reasonable and verify the correctness and effectiveness of the model and the method. The proposed dynamic modeling method provides a reference for modeling of other multi-energy domains system which contains complex PM. | ZHANG Lijie GUO Fei LI Yongquan LU Wenjuan | 2016 | Chinese Journal of Mechanical Engineering2016，29，6： | 11 |
| 19 | Stability analyses of vertically exposed cemented backfill:A revisit to Mitchell's physical model tests显示文摘Mitchell's solution is commonly used to determine the required strength of vertically exposed cemented backfill in mines. Developed for drained backfill, Mitchell model assumed a zero friction angle for the backfill. Physical model tests were performed. Good agreements were obtained between the required strengths predicted by the analytical solution and experimental results. However, it is well-known that zero friction angle can only be possible in terms of total stresses when geomaterials are submitted to unconsolidated and undrained conditions. A revisit to Mitchell's physical model tests reveals that both the laboratory tests performed for obtaining the shear strength parameters of the cemented backfill and the box stability tests were conducted under a condition close to undrained condition. This explains well the good agreement between Mitchell's solution and experimental results. Good agreements are equally obtained between Mitchell's experimental results and FLAC3 D numerical modeling of shortterm stability analyses of exposed cemented backfill. | Liu Guangsheng Li Li Yang Xiaocong Guo Lijie | 2016 | International Journal of Mining Science and Technology2016，26，6： | 11 |
| 20 | Controlled Nanocutting of Graphene显示文摘Rapid progress in graphene-based applications is calling for new processing techniques for creating graphene components with different shapes,sizes,and edge structures.Here we report a controlled cutting process for graphene sheets,using nickel nanoparticles as a knife that cuts with nanoscale precision.The cutting proceeds via catalytic hydrogenation of the graphene lattice,and can generate graphene pieces with specifi c zigzag or armchair edges.The size of the nanoparticle dictates the edge structure that is produced during the cutting.The cutting occurs along straight lines and along symmetry lines,defined by angles of 60ºor 120º,and is defl ected at free edges or defects,allowing practical control of graphene nano-engineering. | Lijie Ci Zhiping Xu Lili Wang Wei Gao Feng Ding Kevin F.Kelly Boris I.Yakobson Pulickel M.Ajayan | 2008 | Nano Research2008，1，2： | 11 |
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