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| 1 | Facile carbonaceous microsphere templated synthesis of Co3O4 hollow spheres and their electrochemical performance in supercapacitors显示文摘 | Hongmei Du Lifang Jiao Qinghong Wang Jiaqin Yang Lijing Guo Yuchang Si Yijing Wang Huatang Yuan | 2013 | Nano Research2013，6，2： | 5 |
| 2 | Insight into vitronectin structural evolution on material surface chemistries: The mediation for cell adhesion显示文摘Biomaterial surface chemistry engenders profound consequences on cell adhesion and the ultimate tissue response by adsorbing proteins from extracellular matrix,where vitronectin(Vn)is involved as one of the crucial mediator proteins.Deciphering the adsorption behaviors of Vn in molecular scale provides a useful account of how to design biomaterial surfaces.But the details of structural dynamics and consequential biological effect remain elusive.Herein,both experimental and computational approaches were applied to delineate the conformational and orientational evolution of Vn during adsorption onto self-assembled monolayers(SAMs)terminating with-COOH,-NH2,-CH3 and-OH.To unravel the interplay between cell binding and the charge and wettability of material surface,somatomedin-B(SMB)domain of Vn holding the RGD cell-binding motif was employed in molecular dynamics(MD)simulations,with orientation initialized by Monte Carlo(MC)method.Experimental evidences including protein adsorption,cell adhesion and integrin gene expressions were thoroughly investigated.The adsorption of Vn on different surface chemistries showed very complex profiles.Cell adhesion was enabled on all Vn-adsorbed surfaces but with distinct mechanisms mostly determined by conformational change induced reorientation.Higher amount of Vn was observed on negatively charged surface(COOH)and hydrophobic surface(CH3).However,advantageous orientations defined by RGD loop conditions were only obtained on the charged surfaces(COOH and NH2).Specifically,COOH surface straightened up the Vn molecules and accumulated them into a higher density,whereas CH3 surface squashed Vn and stacked them into higher density multilayer by tracking adsorption but with the RGD loops restrained.These findings may have a broad implication on the understanding of Vn functionality and would help develop new strategies for designing advanced biomaterials. | Tianjie Li Lijing Hao Jiangyu Li Chang Du Yingjun Wang | 2020 | Bioactive Materials2020，5，4： | 4 |
| 3 | Mechanistic insights into the adsorption and bioactivity of fibronectin on surfaces with varying chemistries by a combination of experimental strategies and molecular simulations显示文摘Fibronectin(Fn)is significant to the performance of biomaterials,and the chemistry of biomaterial surface play important roles in Fn adsorption and subsequent cell behavior.However,the“molecular scale”mechanism is still unclear.Herein,we combined experimental strategies with molecular simulations to solve this problem.We prepared self-assembled monolayers with varying chemistries,i.e.,SAMs-CH3,SAMs-NH2,SAMs-COOH and SAMs-OH,and characterized Fn adsorption and cell behaviors on them.Next,Monte Carlo method and all-atom molecular dynamics simulations were employed to reveal the orientation/conformation of Fn on surfaces.We found that SAMs-CH3 strongly adsorbed Fn via hydrophobic interactions,but show poor bioactivity as the low exposure of RGD/PHSRN motifs and the deformation of Fn.SAMs-NH2 and SAMs-COOH could adsorb Fn efficiently via vdW interactions,electrostatic interactions,hydrogen bonds and salt bridges.Fn exhibited excellent bioactivity for cell adhesion,proliferation and osteogenic differentiation as high exposure of bioactive motifs on SAMs-NH2,or as the activation of other inferior cell-binding motifs on SAMs-COOH.SAMs-OH showed poor Fn adsorption as the water film.However,the adsorbed Fn displayed non-negligible bioactivity due to high exposure of PHSRN motif and large degree of protein flexibility.We believe that the revealed mechanism presents great potential to rationally design Fn-activating biomaterials. | Lijing Hao Tianjie Li Lin Wang Xuetao Shi Yan Fan Chang Du Yingjun Wang | 2021 | Bioactive Materials2021，6，10： | 3 |
| 4 | Multi-objective open location-routing model with split delivery for opti- mized relief distribution in post-earthquake 显示文摘 | Wang Haijun Du Lijing Ma Shihua | 2014 | Trans- portation Research Part E2014，69，： | 1 |
| 5 | Mesoporous LiFePO 4 microspheres for rechargeable lithium-ion batteries显示文摘 | Juan Du Lifang Jiao Qiong Wu Yongchang Liu Zhan Qi Lijing Guo Yijing Wang Huatang Yuan | 2013 | Electrochimica Acta2013，，： | 1 |
| 6 | Synthesis and characterization of Li 2 FeP 2 O 7 /C nanocomposites as cathode materials for Li-ion batteries显示文摘 | Juan Du Lifang Jiao Qiong Wu Yongchang Liu Yanping Zhao Lijing Guo Yijing Wang Huatang Yuan | 2013 | Electrochimica Acta2013，，： | 1 |
| 7 | Remote Ischemic Preconditioning Reduces Cardiac Troponin I Release in Cardiac Surgery: A Meta-Analysis显示文摘 | Lijing Yang Guyan Wang Yingjie Du Bingyang Ji Zhe Zheng | 2014 | Journal of Cardiothoracic and Vascular Anesthesia2014，，3： | 1 |
| 8 | Multi-objective open location-routing model with split delivery for optimized relief distribution in post-earthquake显示文摘 | Wang Haijun Du Lijing Ma Shihua | 2014 | Transportation Research Part E2014，69，9： | 1 |
| 9 | Synthesis and characterization of high entropy(TiVNbTaM)_(2)AlC(M=Zr,Hf)ceramics显示文摘The high-entropy design of MAX phases is expected to confer superior properties,but its study was hindered by the complex synthesis method and limited purity of samples.In this work,two noteworthy types of high-entropy MAX phase structural ceramics,high-entropy(TiVNbTaM)_(2)AlC(M=Zr,Hf),were designed and prepared by the in-situ synthesis using spark plasma sintering(SPS).The microstructure and lattice parameters of sintered samples were determined.Compared with the single-component MAX phases,the highly pure high-entropy(TiVNbTaZr)_(2)AlC sample had good physical and mechanical properties,including electrical conductivity of 0.96×106Ω^(-1)·m^(-1),thermal expansion coefficient of 3.65×10^(-6) K^(-1),thermal conductivity of 8.98 W·m^(-1)·K^(-1),Vickers hardness of 9.80 GPa,flexural strength of 507 MPa,fracture toughness of 5.62 MPa·m^(1/2),and compressive strength of 1364 MPa,which exhibited the remarkable hardening-strengthening effect. | Lei Cao Qiqiang Zhang Lijing Du Shuai Fu Detian Wan Yiwang Bao Qingguo Feng Chunfeng Hu | 2024 | Journal of Advanced Ceramics2024，13，2： | 0 |
| 10 | Mediating Mesenchymal Stem Cells Responses and Osteopontin Adsorption via Oligo(ethylene glycol)-amino Mixed Self-assembled Monolayers显示文摘Oligo(ethylene glycol)(-OEG) and amino(-NH_2) mixed self-assembled monolayers(SAMs) were employed as model substrates to investigate the effect of charge density on the fate of mesenchymal stem cells(MSCs) and osteopontin(OPN) adsorption. We found that all surfaces presenting-NH_2 groups favored cell responses regardless of the surface charge. Meanwhile, OPN adsorption could remain stable on the mixed SAMs over a certain range of charge densities. Our work provides some insights into cell responses and protein adsorption to surface charge. | Lijing Hao Tianjie Li Naru Zhao Fuzhai Cui Chang Du Yingjun Wang | 2016 | Journal of Materials Science & Technology2016，32，9： | 0 |
| 11 | Impacts of oxygen deficiency on embryo life-history traits of migratory locust Locusta migratoria from low and high altitudes显示文摘Hypoxia challenges aerobic organisms in numerous environments,and hypoxic conditions may become more severe under future climate-change scenarios.The impact of hypoxia on the development of terrestrial insect embryos is not well understood.Here,to address this gap,embryonic life-history traits of migratory locust Locusta migratoria from low-altitude and high-altitude regions were compared under 2 oxygen levels:normoxia(i.e.,21 kPa oxygen partial pressure and mild hypoxia(i.e.,10 kPa oxygen partial pressure).Our results demonstrated that,whether reared under normoxia or mild hypoxia,L.migratoria from high-altitude populations had longer developmental times,reduced weight,and lower mean relative growth rate as compared with those from low-altitude populations.When transferred from normoxia to mild hypoxia,nearly all the tested lifehistory traits presented significant negative changes in the low-altitude populations,but not in the high-altitude populations.The factor'strain'alone explained 18.26%-54.59%of the total variation for traits,suggesting that the phenotypic differences between L.migratoria populations from the 2 altitudes could be driven by genetic variation.Significant genetic correlations were found between life-history traits,and most of these showed differentiation between the 2 altitudinal gradients.G-matrix comparisons showed significant structural differences between L.migratoria from the 2 regions,as well as several negative covariances(i.e.,trade-offs)between traits in the low-altitude populations.Overall,our study provides clear evidence that evolutionary divergence of embryonic traits between L.migratoria populations from different altitudes has occurred. | Xianliang Huang Qianli Du Lijing Wang Bing Chen | 2023 | Insect Science2023，30，3： | 0 |
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