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| 1 | Unravelling the complexity in achieving the 17 sustainable-development goals显示文摘It is now more than 3 years since the ratification of the 2030 Agenda for Sustainable Development framework[1]but,according to the latest progress report,unless the rate of progress increases,it is challenging that all of the Sustainable Development Goals(SDGs)will be achieved by 2030[2].With only 11 years remaining until the 2030 deadline,it has become imperative to develop a plan of action to enable the full agenda to be realized.Specifically,there is an urgent need for a holistic approach to clarify the interrelationships between the 17 SDGs,while also taking into account their complexity and their sometimes mutually reinforcing or conflicting nature.Trying to achieve these goals separately in succession is nonsensical,but pursuing them simultaneously is impractical[3]. | Bojie Fu Shuai Wang Junze Zhang Zengqian Hou Jinghai Li | 2019 | National Science Review2019，6，3： | 32 |
| 2 | Classification–coordination–collaboration:a systems approach for advancing Sustainable Development Goals显示文摘It is an urgent task to advance Sustainable Development Goals(SDGs)on different scales in the world.We propose a systems approach to combat this issue,namely‘classification–coordination–collaboration’.This approach allows SDGs to realize key breakthroughs over the short-term while achieving sweeping progress over the long run. | Bojie Fu Junze Zhang Shuai Wang Wenwu Zhao | 2020 | National Science Review2020，7，5： | 20 |
| 3 | Geochemical and isotopic characteristics of volcanic rocks from the northern East China Sea shelf margin and the Okinawa Trough显示文摘Volcanic rocks both from the northern East China Sea (NECS) shelf margin and the northern Okinawa Trough are subalkaline less aluminous,and lower in High Field Strength Elements (HFSE).These rocks are higher in Large Ion Lithophile Elements (LILE),thorium and uranium contents,positive lead anomalies,negative Nb-Ta anomalies,and enrichment in Light Rare Earth Elements (LREE).Basalts from the NECS shelf margin are akin to Indian Ocean Mid-Ocean Ridge Basalt (MORB),and rhyolites from the northern Okinawa Trough have the highest 207 Pb/ 204 Pb and 208 Pb/ 204 Pb ratios.The NECS shelf margin basalts have lower 87 Sr/ 86 Sr ratios,ε N d and σ 18 O than the northern Okinawa Trough silicic rocks.According to 40 K– 40 Ar isotopic ages of basalts from the NECS shelf margin,rifting of the Okinawa Trough may have been active since at least 3.65–3.86 Ma.The origin of the NECS shelf margin basalt can be explained by the interaction of melt derived from Indian Ocean MORB-like mantle with enriched subcontinental lithosphere.The basalts from both sides of the Okinawa Trough may have a similar origin during the initial rifting of the Okinawa Trough,and the formation of basaltic magmas closely relates to the thinning of continental crust.The source of the formation of the northern Okinawa Trough silicic rocks was different from that of the middle Okinawa Trough,which could have been generated by the interaction of basaltic melt with an enriched crustal component.From the Ryukyu island arc to East China,the Cenozoic basalts have apparently increasing trends of MgO contents and ratios of LREE to Heavy Rare Earth Elements (HREE),suggesting that the trace element variabilities of basalts may have been influenced by the subduction of the Philippine Sea plate,and that the effects of subduction of the Philippine Sea plate on the chemical composition of basaltic melts have had a decreasing effect from the Ryukyu island arc to East China. | ZENG Zhigang YU Shaoxiong WANG Xiaoyuan FU Yongtao YIN Xuebo ZHANG Guoliang WANG Xiaomei CHEN Shuai | 2010 | Acta Oceanologica Sinica2010，29，4： | 19 |
| 4 | Linking vegetation cover patterns to hydrological responses using two process-based pattern indices at the plot scale显示文摘Vegetation cover pattern is one of the factors controlling hydrological processes.Spatially distributed models are the primary tools previously applied to document the effect of vegetation cover patterns on runoff and soil erosion.Models provide precise estimations of runoff and sediment yields for a given vegetation cover pattern.However,difficulties in parameterization and the problematic explanation of the causes of runoff and sedimentation rates variation weaken prediction capability of these models.Landscape pattern analysis employing pattern indices based on runoff and soil erosion mechanism provides new tools for finding a solution.In this study,the vegetation cover pattern was linked with runoff and soil erosion by two previously developed pattern indices,which were modified in this study,the Directional Leakiness Index(DLI)and Flowlength.Although they use different formats,both indices involve connectivity of sources areas(interpatch bare areas).The indices were revised by bringing in the functional heterogeneity of the plant cover types and the landscape position.Using both artificial and field verified vegetation cover maps,observed runoff and sediment production on experiment plots,we tested the indices’efficiency and compared the indices with their antecedents.The results illustrate that the modified indices are more effective in indicating runoff at the plot/hillslope scale than their antecedents.However,sediment export levels are not provided by the modified indices.This can be attributed to multi-factor interaction on the hydrological process,the feedback mechanism between the hydrological function of cover patterns and threshold phenomena in hydrological processes. | LIU Yu FU BoJie Lü YiHe GAO GuangYao WANG Shuai ZHOU Ji | 2013 | Science China Earth Sciences2013，56，11： | 15 |
| 5 | Kiwifruit recognition at nighttime using artificial lighting based on machine vision显示文摘Most researches involved so far in kiwifruit harvesting robot suggest the scenario of harvesting in daytime for taking advantage of sunlight.A robot operating at nighttime can overcome the problem of low work efficiency and would help to minimize fruit damage.In addition,artificial lights can be used to ensure constant illumination instead of the variable natural sunlight for image capturing.This paper aims to study the kiwifruit recognition at nighttime using artificial lighting based on machine vision.Firstly,an RGB camera was placed underneath the canopy so that clusters of kiwifruits could be included in the images.Next,the images were segmented using an R-G color model.Finally,a group of image processing conventional methods,such as Canny operator were applied to detect the fruits.The image processing results showed that this capturing method could reduce the background noise and overcome any target overlapping.The experimental results showed that the optimal artificial lighting ranged approximately between 30-50 lx.The developed algorithm detected 88.3%of the fruits successfully. | Fu Longsheng Wang Bin Cui Yongjie Su Shuai Yoshinori Gejima Taiichi Kobayashi | 2015 | International Journal of Agricultural and Biological Engineering2015，8，4： | 14 |
| 6 | Distribution of serum prostate-specific antigen in Chinese healthy men: a population-based study显示文摘前列腺癌症的病态和死亡在最近的中国很快一直在增加的背景。有很少研究,调查前列腺特定的抗原(PSA ) 在健康中国人口的价值范围。我们执行了这研究从 2001 年 1 月在大健康中国 population.Methods 决定浆液 PSA 的分发到 2008 年 5 月, 30-79 年的 11 150 个健康的中国人为平淡的健康来到了我们的医院检查。没有前列腺癌症,前列腺外科的历史,或尿生殖的道感染的以前的诊断的所有题目被建议经历系统的浆液 PSA 测量和数字直肠的检查(DRE ) 。有正常 DRE 和 PSA 4.0 ng/ml 和那些 PSA 4.0 ng/ml 或反常 DRE,但是没有前列腺活体检视上的不利调查结果的人被包括(n=9358 ) 。年龄和浆液 PSA 集中通过 第95 百分位数浆液 PSA 集中是的逻辑回归 analysis.Results 被记录并且相关为 30~39 年的人,的 1.89 ng/ml 为 40~49 年的人的 2.19 ng/ml ,为人的 2.88 ng/ml 变老 50~59 年,为 60~69 年的人的 4.42 rng/ml ,和为 70~79 年的人的 6.52 ng/ml 。浆液 PSA 集中在 40 年里为人随0.97%的年度增加与年龄( P 0.0001 )相关,1.58%为 50 年里的人,3.04%为 60 年里的人,并且3.99%为在 70 years.Conclusions 的人,浆液 PSA 水平在比 40 年,不是在比 40 岁年轻的中国人老的中国人与年龄直接相关。中国人不到 60 岁超过 60 岁,不是在那些与白人相比有更低的 PSA 水平。 | YUAN Xiao-dong DONG Zhi-gang ZHANG Hui LIN Hai-yan SONG Xin-hong NIU Zhi-hong FU Qiang LIU Shuai SUN Zhi-jian LU Jia-ju | 2011 | Chinese Medical Journal2011，，8： | 12 |
| 7 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 8 | Rice St#pe Virus Interferes with S-acylation of Remorin and Induces Its Autophagic Degradation to Facilitate Virus Infection显示文摘 | Shuai Fu Yi Xu Chenyang Li Yi Li dianxiang Wu Xueping Zhou | 2018 | Molecular Plant2018，11，2： | 10 |
| 9 | Science and Prediction of Heavy Rainfall over China:Research Progress since the Reform and Opening-Up of New China显示文摘This paper reviews the major progress on development of the science and prediction of heavy rainfall over China since the beginning of the reform and opening-up of new China(roughly between 1980 and 2019).The progress of research on the physical mechanisms of heavy rainfall over China is summarized from three perspectives:1)the relevant synoptic weather systems,2)heavy rainfall in major sub-regions of China,and 3)heavy rainfall induced by typhoons.The development and application of forecasting techniques for heavy rainfall are summarized in terms of numerical weather prediction techniques and objective forecasting methods.Greatly aided by the rapid progress in meteorological observing technology and substantial improvement in electronic computing,studies of heavy rainfall in China have advanced to investigating the evolution of heavy-rain-producing storms and observational analysis of the cloud microphysical features.A deeper and more systematic understanding of the synoptic systems of importance to the production of heavy rainfall has also been developed.Operational forecast of heavy rainfall in China has changed from subjective weather event forecasts to a combination of both subjective and objective quantitative precipitation forecasts,and is now advancing toward probabilistic quantitative precipitation forecasts with the provision of forecast uncertainty information. | Yali LUO Jisong SUN Ying LI Rudi XIA Yu DU Shuai YANG Yuanchun ZHANG Jing CHEN Kan DAI Xueshun SHEN Haoming CHEN Feifan ZHOU Yimin LIU Shenming FU Mengwen WU Tiangui XIAO Yangruixue CHEN Huiqi LI Mingxin LI | 2020 | Journal of Meteorological Research2020，34，3： | 10 |
| 10 | Accessory Breast Cancer Occurring Concurrently with Bilateral Primary Invasive Breast Carcinomas:A Report of Two Cases and Literature Review显示文摘The development of accessory breast tissue,which is found anywhere along the milk line,is attributed to the failure of milk line remnants to regress during embryogenesis.Primary tumors may arise from any ectopic breast tissue.Accessory breast cancer occurring concurrently with primary invasive breast cancer is extremely rare.Two such cases were reported in this article.One was a 43-year-old Chinese female who exhibited bilateral breast cancer(invasive ductal carcinoma,not otherwise specified,IDC-NOS) and an accessory breast carcinoma(IDC-NOS) incidentally identified in her left axilla.The ectopic breast tissue in her right axilla presented with adenosis.The patient was surgically treated,followed by postoperative docetaxel epirubicin(TE) chemotherapy.The second case was a 53-year-old Chinese female with bilateral breast cancer(apocrine carcinoma) accompanied by an accessory breast carcinoma(IDC-NOS) in her right axilla that was also incidentally identified.The patient was surgically treated after three doses of cyclophosphamide epirubicin docetaxel(CET) neoadjuvant chemotherapy,followed by adjuvant chemotherapy of the same regimen. | Jin-yan Hao Cui-cui Yang Fang-fang Liu Yi-ling Yang Shuai Li Wei-dong Li Ya-qing Li Rong-gang Lang Yu Fan Estifanos Paulos Xin-min Zhang Li Fu | 2012 | Clinical oncology and cancer resexreh2012，9，3： | 8 |
| 11 | Qualitative analysis of chemical components in Lianhua Qingwen capsule by HPLC-Q Exactive-Orbitrap-MS coupled with GC-MS显示文摘The Lianhua Qingwen(LHQW) capsule is a popular traditional Chinese medicine for the treatment of viral respiratory diseases.In particular,it has been recently prescribed to treat infections caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).However,due to its complex composition,little attention has been directed toward the analysis of chemical constituents present in the LHQW capsule.This study presents a reliable and comprehensive approach to characterizing the chemical constituents present in LHQW by high-performance liquid chromatography-Q Exactive-Orbitrap mass spectrometry(HPLC-Q Exactive-Orbitrap-MS) coupled with gas chromatography-mass spectrometry(GC-MS).An automated library alignment method with a high mass accuracy(within 5 ppm) was used for the rapid identification of compounds.A total of 104 compounds,consisting of alkaloids,flavonoids,phenols,phenolic acids,phenylpropanoids,quinones,terpenoids,and other phytochemicals,were successfully characterized.In addition,the fragmentation pathways and characteristic fragments of some representative compounds were elucidated.GC-MS analysis was conducted to characterize the volatile compounds present in LHQW.In total,17 compounds were putatively characterized by comparing the acquired data with that from the NIST library.The major constituent was menthol,and all the other compounds were terpenoids.This is the first comprehensive report on the identification of the major chemical constituents present in the LHQW capsule by HPLC-Q Exactive-Orbitrap-MS,coupled with GCMS,and the results of this study can be used for the quality control and standardization of LHQW capsules. | Shuai Fu Rongrong Cheng Zixin Deng Tiangang Liu | 2021 | Journal of Pharmaceutical Analysis2021，11，6： | 8 |
| 12 | Poverty Reduction,Environmental Protection and Ecosystem Services:A Prospective Theory for Sustainable Development显示文摘Poverty reduction and environmental protection are two global tasks for sustainable development.The study perspective has changed over time,from narrowly focusing on poverty reduction to comprehensively strengthening human-welfare.We reviewed key references targeting the theoretical content and practical approach relying on poverty,environment protection and ecosystem services.We discussed the contradicting views on the relationship of poverty and environmental degradation,and then illustrated the study progress of a cutting-age topic-ecosystem services which pave a way to address poverty reduction and environmental protection together.At last,we investigated essential factors that affect the development and environmental protection.Considering the evolution of the concept of poverty,we found that the environment has occupied an increasing proportion in the cognizance of poverty.The relationship between poverty and environmental degradation is regional uniqueness.In practical aspect,projects based on the management and valuation assessment of ecosystem services draw researchers′attention all over the world.The appropriate scale,essential economic incentives,morality,law and social equality are key factors affecting individuals′decisions which directly relate to the sustainable development. | ZHEN Nahui FU Bojie LU Yihe WANG Shuai | 2014 | Chinese Geographical Science2014，24，1： | 8 |
| 13 | Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells显示文摘Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL)is a rare hereditary cerebrovascular disease caused by a NOTCH3 mutation.However,the underlying cellular and molecular mechanisms remain unidentified.Here,we generated non-integrative induced pluripotent stem cells(iPSCs)from fibroblasts of a CADASIL patient harboring a heterozygous NOTCH3 mutation(c.3226C>T,p.R1076C).Vascular smooth muscle cells(VSMCs)differentiated from CADASIL-specific iPSCs showed gene expression changes associated with disease phenotypes,including activation of the NOTCH and NF-kB signaling pathway,cytoskeleton disorganization,and excessive cell proliferation.In comparison,these abnormalities were not observed in vascular endothelial cells(VECs)derived from the patients iPSCs.Importantly,the abnormal upregulation of NF-kB target genes in CADASIL VSMCs was diminished by a NOTCH pathway inhibitor,providing a potential therapeutic strategy for CADASIL.Overall,using this iPSCbased disease model,our study identified clues for studying the pathogenic mechanisms of CADASIL and developing treatment strategies for this disease. | Chen Ling Zunpeng Liu Moshi Song Weiqi Zhang Si Wang Xiaoqian Liu Shuai Ma Shuhui Sun Lina Fu Qun Chu Juan Carlos Izpisua Belmonte Zhaoxia Wang Jing Qu Yun Yuan Guang-Hui Liu | 2019 | Protein & Cell2019，10，4： | 7 |
| 14 | Chemical Constituents from Roots of Flemingia philippinensis显示文摘Objective To study the chemical constituents from the roots of Flemingia philippinensis. Methods The chemical constituents were isolated and purified by combination of silica gel column, Sephadex LH-20, polyamide, and ODS column chromatography. The structures of the isolated compounds were identified by means of spectral data. Results Ten compounds were isolated from F. philippinensis and identified as isoderrone (1), dalparvin A (2), prunetin (3), 7,3′-dihydroxy-5,4′,5′-trimethoxyisoflavone (4), pratensein-7-O-β-D-glucoside (5), sissotrin (6), sophororicoside (7), formononetin (8), orobol (9), and biochanin A (10). Conclusion Compounds 1-6 are obtained from this plant for the first time. | Man-qin FU Dun DENG Shi-xiu FENG Ri-ming HUANG Shuai TIAN Sheng-xiang QIU | 2012 | Chinese Herbal Medicines2012，4，1： | 7 |
| 15 | Alignment of social and ecological structures increased the ability of river management显示文摘Large hydrologic basins involve multiple stakeholders, and coupled dynamic social and ecological processes. Managing such basins has long been a challenge. Balancing the demand for water from nature against that from humans is always difficult, particularly in arid watersheds. Here, we analyze potential institutional causes of ecological degradation and how it can be reversed by introducing new forms of governance. The framework and assumptions are illustrated using China’s second-largest endorheic basin, where empirical evidence shows that the introduction of a new governing authority connecting midstream and downstream actors facilitated the establishment of a new governance regime that is better aligned with the biophysical scales of the watershed. A trans-regional water allocation project initiated by the new higher-level authority successfully rescued downstream oases and restored a dried terminal lake. These outcomes suggest that when social and ecological structures are better aligned our ability to manage the interplay between social and ecological processes increases. However, the lack of direct connection between the actors of the middle and lower reaches resulted in the paradox of an increase in water demand. We therefore suggest that measures to stimulate the emergence of horizontal social ties linking different critical groups of actors across the watershed could further the alignment of the institutional and biophysical structures-without these changes sustainable management of river basins and other common pool resources will remain problematic. | Shuai Wang Bojie Fu Orjan Bodin Jianguo Liu Mengmeng Zhang Xiaoyan Li | 2019 | Science Bulletin2019，64，18： | 6 |
| 16 | Catalytic conversion of lignocellulosic biomass into chemicals and fuels显示文摘In the search of alternative resources to make commodity chemicals and transportation fuels for a low carbon future,lignocellulosic biomass with over 180-billion-ton annual production rate has been identified as a promising feedstock.This review focuses on the state-of-the-art catalytic transformation of lignocellulosic biomass into value-added chemicals and fuels.Following a brief introduction on the structure,major resources and pretreatment methods of lignocellulosic biomass,the catalytic conversion of three main components,i.e.,cellulose,hemicellulose and lignin,into various compounds are comprehensively discussed.Either in separate steps or in one-pot,cellulose and hemicellulose are hydrolyzed into sugars and upgraded into oxygen-containing chemicals such as 5-HMF,furfural,polyols,and organic acids,or even nitrogen-containing chemicals such as amino acids.On the other hand,lignin is first depolymerized into phenols,catechols,guaiacols,aldehydes and ketones,and then further transformed into hydrocarbon fuels,bioplastic precursors and bioactive compounds.The review then introduces the transformations of whole biomass via catalytic gasification,catalytic pyrolysis,as well as emerging strategies.Finally,opportunities,challenges and prospective of woody biomass valorization are highlighted. | Weiping Deng Yunchao Feng Jie Fu Haiwei Guo Yong Guo Buxing Han Zhicheng Jiang Lingzhao Kong Changzhi Li Haichao Liu Phuc T.T.Nguyen Puning Ren Feng Wang Shuai Wang Yanqin Wang Ye Wang Sie Shing Wong Kai Yan Ning Yan Xiaofei Yang Yuanbao Zhang Zhanrong Zhang Xianhai Zeng Hui Zhou | 2023 | Green Energy & Environment2023，8，1： | 6 |
| 17 | FG020326-loaded nanoparticle with PEG and PDLLA improved pharmacodynamics of reversing multidrug resistance in vitro and in vivo显示文摘目的: FG020326 ,新奇咪唑衍生物,是在 vitro 并且在 vivo.However 的一个有势力multidrug抵抗( MDR )调节的人, FG020326 是 insoluble.PEDLLA-FG020326 装载aFG020326 的 nanoparticle 与 diblock 共聚物被形成 poly (乙烯乙二醇) -block-poly(D,L-lactic 酸)(木钉: PDLLA , PEDLLA )那个罐头溶解 FG020326.This 工作在在 vitro 并且在 vivo.Methods 颠倒 MDR 上被打算到 PEDLLA-FG020326 的 evaluatethe 药效学: Cytotoxicitywas 由 tetrazolium assay.The | Wen-jing DENG Xiao-qiang YANG Yong-ju LIANG Li-ming CHEN Yan-yan YAN Xin-tao SHUAI Li-wu FU | 2007 | Acta Pharmacologica Sinica2007，28，6： | 5 |
| 18 | Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery for head and neck cancer显示文摘为头和颈癌症(SHNC ) 经历主要 oncological 外科的病人有医院的感染的特别地高的风险。我们试图在经历 SHNC 的病人为联系通风机的肺病(VAP ) 识别风险因素。学习包括了经历了在 2011 年 6 月和 2014 年 6 月之间的 SHNC 的 465 个病人。VAP,为 VAP 的风险因素,和 VAP 的生物方面的率回顾地被评估。VAP 的发生是 19.6%(n=95 ) 在要求了机械通风的超过 48 h 的病人。葡萄球菌(37.7%) , Enterobacteriaceae (32.1%) , Pseudomonas (20.8%) ,和 Haemophilus (16.9%) 是引起了 VAP 的主要细菌的种类。为 VAP 的独立风险因素被预付年龄,当前的吸烟地位,长期的妨碍的肺的疾病,和一个更高简化的尖锐生理学分数在承认之上的系统 II。Tracheostomy 是为 VAP 的一个独立保护的因素。在为确实开发了 VAP 的病人的 ICU 的停留的中部的长度是 8.0 和 6.5 天,分别地(P=0.006 ) 。在确实开发了 VAP 的病人之中的死亡是 16.8% 和 8.4% ,分别地(P < 0.001 ) 。因为通风的显著地扩大的持续时间, VAP 的潜在的经济影响高。一个预兆的回归模型与 95.3% 的敏感和 69.4% 的特性被开发。VAP 在并且谁正在经历 SHNC 的病人是普通的要求机械通风的超过 48 h。因此,创新预防措施应该在这张高风险的人口被开发并且适用。 | Yutao Liu Yaxia Di Shuai Fu | 2017 | Frontiers of Medicine2017，11，2： | 5 |
| 19 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 20 | Evaluation of etiological characteristics of Chinese women with recurrent spontaneous abortions: a single-centre study显示文摘贡献怀孕的损失的背景各种各样的病原学被建议了。尽管有缺乏建立并且为周期性的怀孕损失(RPL ) 的一致屏蔽方法,有几个因素,考虑明确(或可能) RPL 的原因。描述 RPL 的 etiological 特征的数据几乎完全由白种人人口组成。因为我们对中国人口感兴趣,这研究的目标是在中国 patients.Methods 决定 RPL 的 etiological 特征学习被与 RPL 分析 1122 个女人回顾地执行。病人们根据他们怀孕损失的数字被划分成三个组。诊断测试包括了下列 9 critiria:父母遗传,子宫的解剖,自体免疫的因素, alloimmune 因素, thrombophilic 因素,内分泌的参数,生殖器的感染, toxoplasma,风疹, cytomegalovirus,疱疹(火炬) titers 和 RH 血型。为反常结果的标准在我们发现了那的 diagnosis.Results 前被定义 87.1%(977/1122 ) 病人们仅仅有 3 个反常方面,并且全部的反常结果的比例在组之中是类似的。每测试的反常结果的流行没在组之中不同,除了在堵住抗体(MLR-Bf ) 的混合淋巴细胞反应的父母遗传,子宫的解剖和存在的情况中。MLR-Bf 的缺席,以及 CD3+CD19+ 和 CD56+CD16+ 房间的反常地增加的层次,通常在混乱玩的中国 RPL patients.Conclusion 免疫学的被检测在在中国病人之中的 RPL 的一个重要角色。 | MENG Li-li CHEN Hui TAN Jian-ping WANG Zheng-hua ZHANG Rui FU Shuai ZHANG Jian-ping | 2011 | Chinese Medical Journal2011，，9： | 5 |
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