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| 1 | Status quo of soil petroleum contamination and evolution of bioremediation显示文摘Along with the rapid development of oil industries internationally,petroleum prospecting and exploitation activities are growing intensively.Especially in China,with the fastest economic growth in the world and shortage of petroleum resources,we are leading the practices of petroleum deep exploitation.Obviously,the risk of damage to the natural environment from these activities is high.Oil contamination in soils and groundwater is becoming a big issue along with pesticide pollution,which makes organic pollution prevention and control (OPPC) much more complex.In this paper,based on recent research on oil-contaminated soil at home and abroad,we make comments on the remediation technologies for polluted soil,emphasizing bioremediation techniques and degradation mechanisms in order to push forward research into bound organic pollution prevention and control (OPPC),especially in China. | Du Weidong Wan Yunyang Zhong Ningning Fei Jiajia ZhangZhihuan Chen Lijun Hao Jiming | 2011 | Petroleum Science2011，8，4： | 19 |
| 2 | Silicon-based nanomaterials for lithium-ion batteries显示文摘Silicon-based nanomaterials have been of scientific and commercial interest in lithium-ion batteries due to the low cost,low toxicity,and high specific capacity with an order of magnitude beyond that of conventional graphite.The poor capacity retention,caused by pulverization of Si during cycling,triggers researchers and engineers to explore better battery materials.This review summarizes recent work in improving Si-based anode materials via different approaches from diverse Si nanostructures,Si/metal nanocomposites,to Si/C nanocomposites,and also offers perspectives of the Si-based anode materials. | YIN YaXia WAN LiJun GUO YuGuo | 2012 | Chinese Science Bulletin2012，57，32： | 16 |
| 3 | The role of gut microbiota in liver disease development and treatment显示文摘Liver cancer is the sixth most common cancer worldwide,and the third most common cause of cancer-related death.Hepatocellular carcinoma(HCC),which accounts for more than 90%of primary liver cancers,is an important public health problem.In addition to cirrhosis caused by hepatitis B viral(HBV)or hepatitis C viral(HCV)infection,non-alcoholic fatty liver disease(NAFLD)is becoming a major risk factor for liver cancer because of the prevalence of obesity.Non-alcoholic steatohepatitis(NASH)will likely become the leading indication for liver transplantation in the future.It is well recognized that gut microbiota is a key environmental factor in the pathogenesis of liver disease and cancer.The interplay between gut microbiota and liver disease has been investigated in animal and clinical studies.In this article,we summarize the roles of gut microbiota in the development of liver disease as well as gut microbiota-targeted therapies. | Lijun Wang Yu-Jui Yvonne Wan | 2019 | Liver Research2019，3，1： | 12 |
| 4 | Subduction tectonics vs.plume tectonics——Discussion on driving forces for plate motion显示文摘Plate tectonics describes the horizontal motions of lithospheric plates,the Earths outer shell,and interactions among them across the Earths surface.Since the establishment of the theory of plate tectonics about half a century ago,considerable debates have remained regarding the driving forces for plate motion.The early'Bottom up'view,i.e.,the convecting mantledriven mechanism,states that mantle plumes originating from the core-mantle boundary act at the base of plates,accelerating continental breakup and driving plate motion.Toward the present,however,the'Top down'idea is more widely accepted,according to which the negative buoyancy of oceanic plates is the dominant driving force for plate motion,and the subducting slabs control surface tectonics and mantle convection.In this regard,plate tectonics is also known as subduction tectonics.'Top down'tectonics has received wide supports from numerous geological and geophysical observations.On the other hand,recent studies indicate that the acceleration/deceleration of individual plates over the million-year timescale may reflect the effects of mantle plumes.It is also suggested that surface uplift and subsidence within stable cratonic areas are correlated with plumerelated magmatic activities over the hundred-million-year timescale.On the global scale,the cyclical supercontinent assembly and breakup seem to be coupled with superplume activities during the past two billion years.These correlations over various spatial and temporal scales indicate the close relationship and intensive interactions between plate tectonics and plume tectonics throughout the history of the Earth and the considerable influence of plumes on plate motion.Indeed,we can acquire a comprehensive understanding of the driving forces for plate motion and operation mechanism of the Earth's dynamic system only through joint analyses and integrated studies on plate tectonics and plume tectonics. | Ling CHEN Xu WANG Xiaofeng LIANG Bo WAN Lijun LIU | 2020 | Science China Earth Sciences2020，63，3： | 10 |
| 5 | Morphology control and shape evolution in 3D hierarchical superstructures显示文摘Hierarchical structures, in which structure is generated and controlled simultaneously at different size scales, have attracted increasing attention due to their potentials in both theoretical research and practical applications. In this review, a 'non-classical crystallization' mechanism is discussed for their possibilities in morphology control of hierarchically-structured materials. Differently, this crystallization route is not based on the attaching and detaching of monomers as happened in the classical case, but through the self-organization of preformed building blocks as nanosized subunits, whose oriented attachment leads to mesocrystals with favorable morphology and texture. Representative materials including both inorganic and organic crystals are reported with possible mechanisms proposed. Synthetic protocols based on this mechanism provide unique inspirations for materials design and could be applied to morphological and structural control of new materials with optimized functions. | CAO AnMin HU JinSong WAN LiJun | 2012 | Science China Chemistry2012，55，11： | 7 |
| 6 | Morphology and modulus evolution of graphite anode in lithium ion battery:An in situ AFM investigation显示文摘We investigated the interfacial electrochemical processes on graphite anode of lithium ion battery by using highly oriented pyrolytic graphite(HOPG)as a model system.In situ electrochemical atomic force microscopy experiments were performed in 1M lithium bis(trifluoromethanesulfonyl)imide/ethylene carbonate/diethyl carbonate to reveal the formation process of solid electrolyte interphase(SEI)on HOPG basal plane during potential variation.At 1.45 V,the initial deposition of SEI began at the defects of HOPG surface.After that,direct solvent decomposition took place at about 1.3 V,and the whole surface was covered with SEI.The thickness of SEI was 10.4±0.2 nm after one cycle,and increased to 13.8±0.2 nm in the second cycle,which is due to the insufficient electron blocking ability of the surface film.The Young’s modulus of SEI was measured by a peak force quantitative nanomechanical mapping(QNM).The Young’s modulus of SEI is inhomogeneous.The statistic value is 45±22 MPa,which is in agreement with the organic property of SEI on basal plane of HOPG. | DENG Xin LIU XingRui YAN HuiJuan WANG Dong WAN LiJun | 2014 | Science China Chemistry2014，57，1： | 7 |
| 7 | SnO_2 hollow spheres:Polymer bead-templated hydrothermal synthesis and their electrochemical properties for lithium storage显示文摘SnO2 hollow spheres have been synthesized via a facile hydrothermal method using sulfonated polystyrene beads as a template followed by a calcination process in air.X-ray diffraction,scanning electron microscopy,and transmission electron microscopy show that the as-obtained SnO2 hollow spheres have a wall thickness of about 50 nm,and consist of nanosized SnO2 particles with a mean diameter of about 15 nm.Electrochemical measurements indicate that the SnO2 hollow spheres exhibit improved electrochemical performance in terms of specific capacity and rate capability in comparison with commercial SnO2 when used as anode materials for lithium-ion batteries.The enhanced performance may be attributed to the spherical and hollow structure,as well as the building blocks of SnO2 nanoparticles. | YIN YaXia XIN Sen WAN LiJun LI CongJu GUO YuGuo | 2012 | Science China Chemistry2012，55，7： | 6 |
| 8 | Protective effects of effective ingredients of Danshen (Radix Salviae Miltiorrhizae)and Honghua (Flos Carthami)compatibility after rat hippocampal neurons induced by hypoxia injury显示文摘OBJECTIVE: To investigate the effective ingredients of Danshen(Radix Salviae Miltiorrhizae) and Honghua(Flos Carthami)(Danhong) on protective properties towards neonatal rat hippocampal neurons under hypoxia condition.METHODS: Primary culture of neonatal rat hippocampal neurons was used to model hypoxia damage on the hippocampus. Methyl thiazolyl tetrazolium(MTT) assay and preliminary experiments were conducted to identify the four effective ingredients of Danhong, along with the injection of positive drug onto hippocampal neurons at a non-toxic dosage level. The cultured cells were randomly divided into 12 groups: the normal group, model group,positive drug control group and nine compatibility groups of the four effective ingredients. Different test methods were applied to determine lactate dehydrogenasein(LDH), total superoxide dismutase(T-SOD), malondialdehyde(MDA), 6-keto prostaglandin F_(la)(6-keto-PGF_(1 a)), thromboxane B_2(TXB_2),mitochondrial membrane potential(MMP), free calcium ions concentration([Ca^(2 +)]i) and early onsetcell apoptosis.RESULTS: Different compatibility groups could inhibit the content of LDH and intracellular calcium overload, increase activity in T-SOD, decrease level of MDA and TXB2, improve level of 6-keto-PGF1 aand MMP, and prevent the early onset cell apoptosis.CONCLUSION: The compatibility of four effective ingredients of Danhong had protective effect toward hippocampi hypoxia. The mechanism might be related to inhibit oxidative stress damage and cell apoptosis, resist thrombosis, and reduce the intracellular calcium ion of overload. | Yu Li Wan Haofang Jin Weifeng Yang Jiehong Li Chang Dai Liuling Ge Lijun Zhou Huifen Wan Haitong He Yu | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 4 |
| 9 | Study of-amyloid adsorption and aggregation on graphite by STM and AFM显示文摘The scanning tunneling microscopy (STM) and the atomic force microscopy (AFM) have been applied to the direct study of the adsorption and aggregation of -amyloid(1-42)(A42) on the hydrophobic graphite surface. It was found that A42 were preferentially adsorbed on graphite defects such as the edges. A42 peptides self-assembled into intermediate protofibrils, which in turn self-associated to form fibrils. Usually, two or more fibrils intertwined to form the helical structure. These results will provide an important clue to studying the aggregation proc-ess of -amyloid. | WANG Zhigang, WAN Lijun, ZHOU Chunqing, FANG Xiaohong, WANG Chen & BAI Chunli Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Correspondence should be addressed to Bai Chunli (e-mail: clbai@ infoc3.icas.ac.cn) | 2003 | Chinese Science Bulletin2003，48，5： | 4 |
| 10 | Facile Synthesis of Mo2C Nanocrystals Embedded in Nanopo- rous Carbon Network for Efficient Hydrogen Evolution显示文摘为综合探索灵巧、容易可伸缩的方法地球丰富、划算、有效的氢进化反应(她的) electrocatalysts 作为一个干净、持续的精力搬运人为氢的大量生产是必要的。我们这里报导简单策略生产瞬间 2 在碳网络嵌入的 C nanocrystals (瞬间 2 C@C ) 由铵 molybdate 和 polyvinylpyrrolidone (PVP ) 的直接热分解。PVP 能有效地被用作单身的来源形成碳化物和碳网络,这被发现。有 PVP 的转变金属的长聚合物链和协调能力使形成连接的多孔的碳网络和分散得好的瞬间 2 在几纳米的 C nanocrystals。PVP 的碳化不仅在原处有效地阻止瞬间 2 C nanocrystals 在他们的形成期间,而且提供传导性的多孔的矩阵。作为结果,瞬间 2 C@C 合成展览为她的优异 electrocatalytic 性能,能从很多的小瞬间 2 | Yuyun Chen Yun Zhang Yuling Ma Tang Tang Zhihui Dai Jinsong Hu Lijun Wan | 2017 | Chinese Journal of Chemistry2017，35，6： | 4 |
| 11 | MiR-22 as a metabolic silencer and liver tumor suppressor显示文摘With obesity rate consistently increasing,a strong relationship between obesity and fatty liver disease has been discovered.More than 90%of bariatric surgery patients also have non-alcoholic fatty liver diseases(NAFLDs).NAFLD and non-alcoholic steatohepatitis(NASH),which are the hepatic manifesta-tions of metabolic syndrome,can lead to liver carcinogenesis.Unfortunately,there is no effective medicine that can be used to treat NASH or liver cancer.Thus,it is critically important to understand the mechanism underlying the development of these diseases.Extensive evidence suggests that microRNA 22(miR-22)can be a diagnostic marker for liver diseases as well as a treatment target.This review paper focuses on the roles of miR-22 in metabolism,steatosis,and liver carcinogenesis.Literature search is limited based on the publications included in the PubMed database in the recent 10 years. | Lijun Wang Yu-Shiuan Wang Eko Mugiyanto Wei-Chiao Chang Yu-Jui Yvonne Wan | 2020 | Liver Research2020，4，2： | 3 |
| 12 | Glypican-3: A molecular marker for the detection and treatment of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is a malignant tumor with a fairly poor prognosis(5-year survival of less than 50%).Using sorafenib,the only food and drug administration(FDA)-approved drug,HCC cannot be effectively treated;it can only be controlled at most for a couple of months.There is a great need to develop efficacious treatment against this debilitating disease.Glypican-3(GPC3),a member of the glypican family that attaches to the cell surface by a glycosylphosphatidylinositol anchor,is overex-pressed in HCC cases and is elevated in the serum of a large proportion of patients with HCC.GPC3 expression contributes to HCC growth and metastasis.Furthermore,several different types of antibodies targeting GPC3 have been developed.The aim of this review is to summarize the current literatures on the GPC3 expression in human HCC,molecular mechanisms of GPC3 regulation and antibodies targeting GPC3. | Tsung-Chieh Shih Lijun Wang Hsiao-Chi Wang Yu-Jui Yvonne Wan | 2020 | Liver Research2020，4，4： | 3 |
| 13 | Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle显示文摘Whether glucose is predomi nantly metabolized via oxidative phosphorylati on or glycolysis differs between quiesce nt versus proliferating cells,iincluding tumor cells.However,how glucose metabolism is coordinated with cell cycle in mammalian cells remains elusive.Here,we report that mammalian cells predominantly utilize the tricarboxylic acid(TCA)cycle in G1 phase,but prefer glycolysis in S phase.Mechanistically,coupling cell cycle with metabolism is largely achieved by timely destruction of IDH1/2,key TCA cycle enzymes,in a Skp2-dependent manner.As such,depleting SKP2 abolishes cell cycle-dependent fluctuation of IDH1 protein abundance,leading to reduced glycolysis in S phase.Furthermore,elevated Skp2 abundance in prostate cancer cells destabilizes IDH1 to favor glycolysis and subsequent tumorigenesis.Therefore,our study reveals a mechanistic link between two cancer hallmarks,aberrant cell cycle and addiction to glycolysis,and provides the underlying mechanism for the coupling of metabolic fluctuation with periodic cell cycle in mammalian cells. | Jing Liu Yunhua Peng Le Shi Lixin Wan Hiroyuki Inuzuka Jiangang Long Jianping Guo Jinfang Zhang Min Yuan Shuangxi Zhang Xun Wang Jing Gao Xiangpeng Dai Shozo Furumoto Lijun Jia Pier Paolo Pandolfic John M.Asara William G.Kaelin Jr. Jjankang Liu Wenyi Wei | 2021 | Cell Research2021，31，1： | 2 |
| 14 | Supercapacitor-battery hybrid energy storage devices from an aqueous nitroxide radical active material显示文摘A hybrid electrochemical energy storage device was fabricated in aqueous NaOH with the 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) nitroxide radical as the active material, hydroquinone as the counter electrode active material, and an OH -selective separating membrane. The working principle of this device was investigated and it can be considered as a supercapacitor-battery hybrid energy storage system. Device performance was characterized by cyclic voltammetry and galvanostatic charge-discharge testing. When using multi-walled carbon nanotubes (MWCNTs) as electrode support materials, a high pseudo-capacitance of 1280 F g -1 was obtained with the TEMPO nitroxide radical as the active material at a 1 mV s -1 scan rate. This was ~33 times larger than the inherent double layer capacitance of MWCNTs. The electrode material and active material dissolved in solution could potentially be substituted with similar materials. This simple design provides a new approach for fabricating high performance supercapacitor-battery hybrid energy storage devices. | GUO Wei XIN Sen JI MengBo GUO YuGuo WAN LiJun | 2011 | Chinese Science Bulletin2011，56，23： | 2 |
| 15 | Adlayer structure of TCNQ molecules on Cu(111): An in situ STM study显示文摘In situ electrochemical scanning tunneling microscopy (STM) was employed to examine tetracyano-quinodimethane (TCNQ) layer adsorbed on Cu(lll) electrode surface in 0.1 mol/L HC1O4 solution. The TCNQ molecules are found to form highly-ordered long range ad-layer with a (4×4) symmetry. Each TCNQ molecule is adsorbed on Cu(111) surface in flat-lying orientation. The molecules are preferentially aligned with their long axes inthe [ 121 ] direction. A structural model is proposed for the adlayer. | WAN Lijun & Kingo ItayaInstitute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Department of Applied Chemistry, Graduate School of Engineering, Tohoku University, Sendai, Japan | 2001 | Chinese Science Bulletin2001，46，5： | 2 |
| 16 | Synthesis and Characterization of Biomimetic Fe3O4/Coke Magnetic Nanoparticles Composite Material显示文摘A composite material(Fe_3O_4/Coke)using coke supported Fe_3O_4 magnetic nanoparticles was successfully prepared via an in-situ chemicaloxidation precipitation method and characterized by SEM,XRD,Raman,and FTIR.The results showed that the Fe_3O_4 nanoparticles existed steadily on the surface of coke,with better dispersing and smaller particle size.The catalytic ability of Fe_3O_4/Coke were investigatied by degrading p-nitrophenol(P-NP).The results showed that the apparent rate constant for the P-NP at 1.0 g·L^(-1) catalyst,30 mmol·L^(-1) H_2O_2,pH=3.0,30 ℃ and the best ratio of Coke/Fe_3O_4 0.6,was evaluated to be 0.027 min^(-1),the removalrate of CODCr was 75.47%,and the dissolubility of Fe was 2.42 mg·L^(-1).Compared with pure Fe_3O_4,the catalytic ability of Fe_3O_4/Coke in the presence of H_2O_2 was greatly enhanced.And Fe_3O_4/Coke was a green and environmentalcatalyst with high catalytic activity,showing a good chemicalstability and reusability. | 卢露露 李文兵 WANG Guanghua ZHANG Zheng WAN Dong Lü Lijun LIU Nianru CHEN Biao JIANG Shiyun | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，2： | 1 |
| 17 | Ordered Ni-Cu nanowire array with enhanced coercivity显示文摘 | Guo Yuguo Wan Lijun Zhu Chuanfeng | 2003 | Chem Mater2003，15，： | 1 |
| 18 | Ordered Ni-Cu nanowire array with enhanced coercivity 显示文摘 | Guo Yuguo Wan Lijun Zhu Chuanfeng | 2003 | Chem Mater2003，15，3： | 1 |
| 19 | Ordered arrays of semi-crown ligands on an Au(111) electrode surface: in situ STM study显示文摘In situ scanning tunneling microscopy (STM) and cyclic voltammetry were employed to investigate the adsorption structures of three semi-crown ligands on an Au(111) surface under the potential control. It is found that all the molecules formed ordered arrays in 0.1 mol/L HClO4 solution, although their geometric structures are complex and asymmetric. The driving force was supposed to come from the balance between intermolecular and molecule-substrate interactions. High resolution STM images revealed internal molecular structures, orientations and packing arrangements in the ordered adlayers. The results are useful for preparing ordered arrays of transition metal-mediated nanostructures. | PAN Gebo LI Huijing YUAN Qunhui CHEN Yongjun WAN Lijun BAI Chunli | 2004 | Science China Chemistry2004，47，4： | 1 |
| 20 | 显示文摘 | Kong Desheng Wan Lijun Chen Shenhao | 2003 | Corrosion & Protection2003，24，12： | 1 |
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