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| 1 | Comparison of chicoric acid,and its metabolites caffeic acid and caftaric acid:In vitro protection of biological macromolecules and inflammatory responses in BV2 microglial cells显示文摘Chicoric acid(CA),a natural phenolic acid,has been used as a nutraceutical food ingredient due to its powerful antioxidant,anti-HIV and anti-diabetic bioactivities.CA could be partly metabolized into caffeic acid(CFA)and caftaric acid(CTA)on cytochrome P450s in rat liver microsomes.To compare the protective effects of CA and its metabolites on biomolecules and inflammatory responses,oxidative damage induced by free radicals in vitro and microglial inflammation triggered by lipopolysaccharide in BV2 cells were constructed.Results showed that CA,CTA and CFA all significantly inhibited protein degradation and carbonylation induced by hydroxyl radicals and alcoxyl radicals,and suppressed hemin/nitrite/H2O2 triggered-nitration.Moreover,CA,CTA and CFA all exerted remarkable inhibition capacities on linoleic acid and soybean lecithin liposomes peroxidation in a dose-dependent manner,and restrained the oxidation of herring sperm DNA,as well as the breakage of pBR322 plasmid DNA.Furthermore,CA and its metabolites suppressed lipopolysaccharide-induced decline of BV2 cell viability and the production of NO and ROS.However,bioactivities of CA were significantly stronger than those of its metabolites within a certain concentration range.This study provides scientific basis for the application of CA and its metabolites as nutrition and natural antioxidants. | Qian Liu Fan Liu Liling Zhang Yajie Niu Zhigang Liu Xuebo Liu | 2017 | Food Science and Human Wellness2017，6，4： | 5 |
| 2 | Lactate Dehydrogenase as a Biomarker for Prediction of Refractory Mycoplasma pneumoniae Pneumonia in Children显示文摘 | Aizhen Lu Chuankai Wang Xiaobo Zhang Libo Wang Liling Qian | 2015 | Respiratory Care2015，，10： | 1 |
| 3 | Monolithic integration of nanorod arrays on microfluidic chips for fast and sensitive one-step immunoassays显示文摘Here,we present integrated nanorod arrays on microfluidic chips for fast and sensitive flow-through immunoassays of physiologically relevant macromolecules.Dense arrays of Au nanorods are easily fabricated through one-step oblique angle deposition,which eliminates the requirement of advanced lithography methods.We report the utility of this plasmonic structure to improve the detection limit of the cardiac troponin I(cTnI)assay by over 6x 105-fold,reaching down to 33.9fg mL^(-1)(-1.4fM) compared with an identical assay on glass substrates.Through monolithic integration with microfluidic elements,the device enables a flow-through assay for quantitative detection of cTnI in the serum with a detection sensitivity of 6.9 pg mL^(-1)(-0.3 pM)in<6 min,which was 4000 times lower than conventional glass devices.This ultrasensitive detection arises from the large surface area for antibody conjugation and metal-enhanced fluorescent signals through plasmonic nanostructures.Moreover,due to the parallel arrangement of flow paths,simultaneous detection of multiple cancer biomarkers,including prostate-specific antigen and carcinoembryonic antigen,has been fulfilled with increased signal-to-background ratios.Given the high performance of this assay,together with its simple fabrication process that is compatible with standard mass manufacturing techniques,we expect that the prepared integrated nanorod device can bring on-site point-of-care diagnosis closer to reality. | Ye Wang Jiongdong Zhao Yu Zhu Shurong Dong Yang Liu Yijun Sun Liling Qian Wenting Yang Zhen Cao | 2021 | Microsystems & Nanoengineering2021，7，4： | 0 |
| 4 | In situ electrochemical dehydrogenation of ultrathin Co(OH)_(2) nanosheets for enhanced hydrogen evolution显示文摘Transition metal hydroxides/oxyhydroxides have recently emerged as highly active electrocatalysts for oxygen evolution reaction in alkaline water electrolysis,while have not yet been widely investigated for hydrogen evolution electrocatalysts owing to their unfavorable H*-adsorption,making it difficult to construct an overall-water-splitting cell for hydrogen production.In this work,we proposed a straightforward and effective approach to develop an efficient in-plane heterostructured CoOOH/Co(OH)_(2) catalyst via in-situ electrochemical dehydrogenation method,in which the dehydrogenated–CoOOH and Co(OH)_(2) at the surface synergistically boost the hydrogen evolution reaction(HER)kinetics in base as confirmed by high-resolution transmission electron microscope,synchrotron X-ray absorption spectroscopy,and electron energy loss spectroscopy.Due to the in-situ dehydrogenation of ultrathin Co(OH)_(2) nanosheets,the catalytic activity of the CoOOH/Co(OH)_(2) heterostructures is progressively improved,which exhibit outstanding hydrogen-evolving activity in base requiring a low overpotential of 132 m V to afford 10 m A/cm^(2)with very fast reaction kinetics after 60 h dehydrogenation.The gradually improved catalytic performance for the CoOOH/Co(OH)2is probably due to the enhanced H*-adsorption induced by the synergistic effect of heterostructures and better conductivity of Co OOH relative to electrically insulating Co(OH)_(2).This work will open the opportunity for a new family of transition metal hydroxides/oxyhydroxides as active HER catalysts,and also highlight the importance of using in situ techniques to construct precious metal-free efficient catalysts for alkaline hydrogen evolution. | Qian Zhou Qihang Bian Liling Liao Fang Yu Dongyang Li Dongsheng Tang Haiqing Zhou | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
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