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| 1 | Treatment for gastric ‘indefinite for neoplasm/dysplasia' lesions based on predictive factors显示文摘BACKGROUND Gastric ‘indefinite for neoplasm/dysplasia'(IFND) is a borderline lesion that is difficult to diagnose as either regenerative or neoplastic. There is a need for guidance in the identification of a subset of patients, who have an IFND lesion with a higher risk of malignant potential, to enable risk stratification and optimal management.AIM To determine the clinical and pathologic factors for the accurate diagnosis of gastric IFND lesions.METHODS In total, 461 gastric lesions diagnosed via biopsy as IFND lesions were retrospectively evaluated. Endoscopic resection(n = 134), surgery(n = 22), and follow-up endoscopic biopsy(n = 305) were performed to confirm the diagnosis.The time interval from initial biopsy to cancer diagnosis was measured, and diagnostic delays were categorized as > 2 wk, > 2 mo, > 6 mo, and > 1 year. The IFND lesions presenting as regenerating atypia(60%) or atypical epithelia(40%)at initial biopsy were adenocarcinomas in 22.6%, adenomas in 8.9%, and gastritis in 68.5% of the cases.RESULTS Four clinical factors [age ≥ 60 years(2.445, 95%CI: 1.305-4.580, P = 0.005),endoscopic size ≥ 10 mm(3.519, 95%CI: 1.891-6.548, P < 0.001), single lesion(5.702, 95%CI: 2.212-14.696, P < 0.001), and spontaneous bleeding(4.056, 95%CI:1.792-9.180, P = 0.001)], and two pathologic factors [atypical epithelium(25.575,95%CI: 11.537-56.695, P < 0.001], and repeated IFND diagnosis [6.022, 95%CI:1.822-19.909, P = 0.003)] were independent risk factors for gastric cancer. With two or more clinical factors, the sensitivity and specificity for carcinoma were91.3% and 54.9%, respectively. Ten undifferentiated carcinomas were initially diagnosed as IFND. In the subgroup analysis, fold change(5.594, 95%CI: 1.458-21.462, P = 0.012) predicted undifferentiated or invasive carcinoma in the submucosal layers or deeper. Diagnostic delays shorter than 1 year were not associated with worse prognoses. Extremely well-differentiated adenocarcinomas accounted for half of the repeated IFND cases and resulted in low diagnostic accuracy even on retrospective blinded review.CONCLUSION More than two clinical and pathologic factors each had significant cut-off values for gastric carcinoma diagnosis; in such cases, endoscopic resection should be considered. | Mi Jung Kwon Ho Suk Kang Hyeon Tae Kim Jin Woo Choo Bo Hyun Lee Sung Eun Hong Kun Ha Park Dong Min Jung Hyun Lim Jae Seung Soh Sung Hoon Moon Jong Hyeok Kim Hye-Rim Park Soo Kee Min Jin won Seo Ji-Young Choe | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 2 | Prediction of effluent concentration in a wastewater treatment plant using machine learning models显示文摘Of growing amount of food waste, the integrated food waste and waste water treatment was regarded as one of the efficient modeling method. However, the load of food waste to the conventional waste treatment process might lead to the high concentration of total nitrogen(T-N) impact on the effluent water quality. The objective of this study is to establish two machine learning models—artificial neural networks(ANNs) and support vector machines(SVMs), in order to predict 1-day interval T-N concentration of effluent from a wastewater treatment plant in Ulsan, Korea. Daily water quality data and meteorological data were used and the performance of both models was evaluated in terms of the coefficient of determination(R^2), Nash–Sutcliff efficiency(NSE), relative efficiency criteria(d rel). Additionally, Latin-Hypercube one-factor-at-a-time(LH-OAT) and a pattern search algorithm were applied to sensitivity analysis and model parameter optimization, respectively. Results showed that both models could be effectively applied to the 1-day interval prediction of T-N concentration of effluent. SVM model showed a higher prediction accuracy in the training stage and similar result in the validation stage.However, the sensitivity analysis demonstrated that the ANN model was a superior model for 1-day interval T-N concentration prediction in terms of the cause-and-effect relationship between T-N concentration and modeling input values to integrated food waste and waste water treatment. This study suggested the efficient and robust nonlinear time-series modeling method for an early prediction of the water quality of integrated food waste and waste water treatment process. | Hong Guo Kwanho Jeong Jiyeon Lim Jeongwon Jo Young Mo Kim Jong-pyo Park Joon Ha Kim Kyung Hwa Cho | 2015 | Journal of Environmental Sciences2015，27，6： | 4 |
| 3 | Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial显示文摘 | Sung Hoon Noh Sook Ryun Park Han-Kwang Yang Hyun Cheol Chung Ik-Joo Chung Sang-Woon Kim Hyung-Ho Kim Jin-Hyuk Choi Hoon-Kyo Kim Wansik Yu Jong Inn Lee Dong Bok Shin Jiafu Ji Jen-Shi Chen Yunni Lim Stella Ha Yung-Jue Bang | 2014 | Lancet Oncology2014，，12： | 3 |
| 4 | Benidipine has effects similar to losartan on the central blood pressure and arterial stiffness in mild to moderate essential hypertension显示文摘 | Sang-Hyun Ihm Hui-Kyung Jeon Shung Chull Chae Do-Sun Lim Kee-Sik Kim Dong-Ju Choi Jong-Won Ha Dong-Soo Kim Kye Hun Kim Myeong-Chan Cho Sang Hong Baek | 2013 | Chinese Medical Journal2013，，11： | 3 |
| 5 | Easy calibration method of vision system for in-situ measurement of strain of thin films显示文摘An easy calibration method was presented for in-situ measurement of displacement in the order of nanometer during micro-tensile test for thin films by using CCD camera as a sensing device. The calibration of the sensing camera in the system is a central element part to measure displacement in the order of nanometer using images taken with the camera. This was accomplished by modeling the optical projection through the camera lens and relative locations between the object and camera in 3D space. A set of known 3D points on a plane where the film is located on is projected to an image plane as input data. These points, known as a calibration points, are then used to estimate the projection parameters of the camera. In the measurement system of the micro-scale by CCD camera, the calibration data acquisition and one-to-one matching steps between the image and 3D planes need precise data extraction procedures and repetitive user's operation to calibrate the measuring devices. The lack of the robust image feature extraction and easy matching prevent the practical use of these methods. A data selection method was proposed to overcome these limitations and offer an easy and convenient calibration of a vision system that has the CCD camera and the 3D reference plane with calibration marks of circular type on the surface of the plane. The method minimizes the user's intervention such as the fine tuning of illumination system and provides an efficient calibration method of the vision system for in-situ axial displacement measurement of the micro-tensile materials. | Jun-Hyub PARK Dong-Joong KANG Myung-Soo SHIN Sung-Jo LIM Son-Cheol YU Kwang-Soo LEE Jong-Eun HA Sung-Hoon CHOA | 2009 | 中国有色金属学会会刊:英文版2009，19，B09： | 3 |
| 6 | Broadband omnidirectional light detection in flexible and hierarchical ZnO/Si heterojunction photodiodes显示文摘灵活光电探测器的开发包括灵活图象传感器,生物医学的成像,和聪明的、便携系统为未来 optoelectronic 应用程序收到了大注意。以前,全向的光电探测器由多重光电探测器上的一个半球的 microlens 集会的集成仅仅是可完成的。此处,组织蜂房的 Si ( H-Si )膜上的 ZnO nanowires ( NW )的一个层次光电二极管图案被表明展出优秀全向的轻吸收的能力并且因此在女人上维持高光电流光谱为宽事件角度的范围( 365~1,100 nm )( 0io 是超过 6.00~10 个病人和 35 age-/gender-matched 控制吗(吝啬的 s ?? | Seongdong Lim Doo-Seung Um Minjeong Ha Qianpeng Zhang Youngsu Lee Yuanjing Lin Zhiyong Fan Hyunhyub Ko | 2017 | Nano Research2017，10，1： | 2 |
| 7 | Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase显示文摘Oncogenic H 地岬 G12V 和它的变体被显示了禁止肌肉区别。然而,在肌肉区别的 proto-oncogenic 地岬(c 地岬) 的角色仍然保持不清楚。地岬的活跃 GTP 固定的形式包括 Raf, phosphatidylinositol 3-kinase (PI3K ) , Ral-GDS,和播送下游的信号的另外的分子与多样的受动器为伙伴所知。我们假设那 c 地岬可以由有选择地激活 PI3K 刺激肌肉区别,为肌肉区别的一个重要调停人。在我们的实验,由 farnesyltransferase 禁止者和 H 地岬(地岬 S17N ) 的一种主导的否定形式的 c 地岬的抑制压制了肌肉区别。一致地,由 siRNAs 的 H 地岬, K 地岬,和 N 地岬击倒的个人都堵住了肌肉区别。有趣地,我们发现 c 地岬优先地与 PI3K 而非它的主要有约束力的搭挡 c-Raf 交往,在 myogenic 区别期间,与全部的 c 地岬活动仍然保持未改变。PI3K 和它的下游的 myogenic 小径, Nox2/NF-魏 B /inducible 氮的氧化物 synthase (iNOS ) 小径,被发现被 c 地岬活动的抑制在区别期间压制。而且, PI3K 的一种组成地活跃的形式的表示完全救了区别块并且在 c-Ras-inhibited 房间重新激活 Nox2/NF-魏 B /iNOS 小径。根据我们的结果,我们断定与 oncogenic 地岬相反, proto-oncogenic H 地岬, K 地岬,和 N 地岬直接经由 PI3K 和它的下游的发信号小径涉及肌肉区别的提升。另外, PI3K 小径激活与不同主要激活的 Raf/Mek/Erk 小径的并发的抑制被联系。 | Jisun Lee Kyu Jin Choi Min Jin Lim Feng Hong Tae Gyu Choi Eunyoung Tak Seonmin Lee Young-Joo Kim Sung Goo Chang Jin Man Cho Joohun Ha Sung Soo Kim | 2010 | Cell Research2010，20，8： | 2 |
| 8 | Radiofrequency ablationof benign non-functioning thyroid nodules: 4-year follow-upresults for 111 patients显示文摘 | LIM H K LEE J H HA E J | 2013 | Eur Radiol2013，23，4： | 1 |
| 9 | Tissue Doppler Imaging consistently detects myocardial Contraction Hypertrophy ,in a transgenic rabbit model of Human Hypertrophic Cardiomyopathy显示文摘 | Nagueh SF Kopelen HA Lim DS | 2000 | Circulation2000，102，： | 1 |
| 10 | Luffa cylindrica suppresses development of Dermatophagoides farinae-induced atopic dermatitis-like skin lesions in Nc/Nga mice显示文摘 | Ha H Lim HS Lee MY | 2015 | Pharmaceu Biol2015，53，4： | 1 |
| 11 | The human cervical Cancer oneogene protein is a biomarker for human hepatocellular carcinoma 显示文摘 | Yoon SK Lim NK Ha SA | 2004 | CancerRes2004，64，15： | 1 |
| 12 | The human cervical cancer oncogene protein is a biomarker for human hepatocellular carcinoma显示文摘 | Yoon SK Lim NK Ha SA | 2004 | Cancer Res2004，64，15： | 1 |
| 13 | Influence of liquid medium and surface morphology on the response of QCM during immobilization and hybridization of short oligonucleotides显示文摘 | Ha TH Kim S Lim G | 2004 | Biosens Bioelectron2004，20，2： | 1 |
| 14 | Transcriptional and post-translational regulation of Bim is essential for TGF-13 and TNF-ec-induced apoptosis of gastric cancer cell 显示文摘 | Ha Thi HT Lim HS Kim J | 2013 | Biochim Biophys Acta2013，1830，6： | 1 |
| 15 | Analysis of multiple factors af- fecting surgical outcomes of proximal middle cerebral aneurysms 显示文摘 | Ha S K Lim D J Kang S H | 2011 | Clin Neurol Neurosurg2011，113，5： | 1 |
| 16 | 显示文摘 | Fazrawi RP Ahmed HA | 1994 | Hepatology1994，20，41： | 1 |
| 17 | Visual abnormalities associated with high-energy microwave exposure 显示文摘 | Lim JI Fine SL Kues HA | 1993 | Retina1993，13，3： | 1 |
| 18 | Extracellular hydrogen peroxide contributes to oxidative glutamate toxicity 显示文摘 | Ha JS Lim HM Park SS | 2010 | Brain Res2010，1359，： | 1 |
| 19 | Laparoscopic-assisted combined colon and liver resection for primary colorectal cancer with synchronous liver metastases:initial experience显示文摘 | Kim SH Lim SB Ha YH | 2008 | World J Surg2008，32，12： | 1 |
| 20 | Tissue Doppler imaging consistently detects myocardial contraction and relaxation abnormalities,irrespective of cardiac hypertrophy, in a transgenic rabbit model of human hypertrophic cardiomyopathy显示文摘 | Kopelen HA Lim DS | 2000 | Circulation2000，102，12： | 1 |
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