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| 1 | Nitrous oxide emission by denitrifying phosphorus removal culture using polyhydroxyalkanoates as carbon source显示文摘Nitrous oxide(N2O) emission has been reported to be enhanced during denitrification when internally-stored compounds are used as carbon sources.However,negligible N2O emissions have been detected in the few studies where polyhydroxyalkanoates(PHA) were specifically used.This study investigated and compared the potential enhancement of N2O production,based on utilization of an internally-stored polymer and external carbon(acetate) by a denitrifying phosphorus removal culture.Results indicated that at relatively low chemical oxygen demand-to-nitrogen(COD/N) ratios,more nitrite was reduced to N2O in the presence of an external carbon source as compared to an internal carbon source(PHA).At relatively higher COD/N ratios,similar N2O reduction rates were obtained in all cases regardless of the type of carbon source available.N2O reduction rates were,however,generally higher in the presence of an internal carbon source.Results from the study imply that when the presence of an external carbon source is not sufficient to support denitrification,it is likely competitively utilized by different metabolic pathways of denitrifying polyphosphate accumulating organisms(DPAOs) and other ordinary denitrifiers.This study also reveals that the consumption of PHA is potentially the rate-limiting step for N2O reduction during denitrification. | Yan Zhou Melvin Lim Soekendro Harjono Wun Jern Ng | 2012 | Journal of Environmental Sciences2012，24，9： | 17 |
| 2 | Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy显示文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy. | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2020 | Cancer Communications2020，40，4： | 11 |
| 3 | Impacts of different drying strategies on drying characteristics,the retention of bio-active ingredient and colour changes of dried Roselle显示文摘The drying kinetics of Roselle(Hibiscus sabdariffa L) of variety Terengganu(UMKL-1) and the quality attribution of Roselle were studied. The experiments were conducted using four different drying methods, including solar greenhouse drying(SD), solar greenhouse with intermittent heat pump drying(SIHP), hot air drying(HA) and heat pump drying(HP). Among the four drying methods, HP achieved the highest drying rate at a range from0.054 g H_2 O·(g DM)^(-1) ·min^(-1) to 0.212 g H_2 O·(g DM)^(-1)·min^(-1) while SD had the lowest drying rate, measured at 0.042 g H_2 O·(g DM)^(-1)·min^(-1).The analysis on colour kinetics revealed that there is no significant colour loss(p > 0.05) observed from HP's dried Roselle. Greater amount of flavonoid compounds i.e. protocatechuic acid was found in SD and SIHP dried finished product whereas HP's dried Roselle contains higher percentage of catechin as compared to other drying methods. | Thing Chai Tham Mei Xiang Ng Shu Hui Gan Lee Suan Chua Ramlan Aziz Luqman Chuah Abdullah Sze Pheng Ong Nyuk Ling Chin Chung Lim Law | 2018 | Chinese Journal of Chemical Engineering2018，26，2： | 7 |
| 4 | Cytogenetic and molecular aberrations of multiple myeloma patients: a single-center study in Singapore显示文摘 | LIM Alvin Soon Tiong LIM Tse Hui SEE Karen Hsu Shien NG Yit Jun TAN Yu Min CHO0 Natasha Swee Lian LIM Sherry Xin Er YEE Yenny LAU Lai Ching TIEN Sim Leng Kumar Sathish TAN Daryl Chen Lung | 2013 | Chinese Medical Journal2013，，10： | 4 |
| 5 | Endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal polyps:A meta-analysis and metaregression with single arm analysis显示文摘BACKGROUND Endoscopic submucosal dissection(ESD)has shown to be effective in management of colorectal neoplasm in the Asian countries,while its implementation in Western countries where endoscopic mucosal resection(EMR)is preferred is still debatable.AIM To compare the surgical,histological,and oncological outcomes between ESD and EMR in the treatment of colorectal polyps,with subgroup analysis comparing the efficacy of ESD and EMR between Japan and the rest of the world.METHODS Embase and Medline databases were searched from inception to October 2020 in accordance with PRISMA guidelines for studies comparing en bloc,complete resection,margin involvement,resection time,need for additional surgery,complications,and recurrence rate of ESD with EMR.RESULTS Of 281344 colorectal polyps from 21 studies were included.When compared to EMR,the pooled analysis revealed ESD was associated with higher en bloc and complete resection rate,and lower lateral margin involvement and recurrence.ESD led to increased procedural time,need for additional surgery,and perforation risk.No significant difference in bleeding risk was found between the two groups.Meta-regression analysis suggested only right colonic polyps correlated with an increased perforation risk in ESD.Confounders including polyp size and invasion depth did not significantly influence the en bloc and complete resection rate,bleeding risk and recurrence.In subgroup analysis,Japan performed better than the rest of the world in both ESD and EMR with perforation risk of 4%and 0.0002%,respectively,as compared to perforation risk of 8%and 1%,respectively,in reports coming from rest of the world.CONCLUSION ESD resulted in better resection outcomes and lower recurrence compared to EMR.With appropriate training,ESD is preferred over EMR as the first-line therapy for resection of colorectal polyps,without restricting to lesions greater than 20 mm and those with high suspicion of submucosal invasion. | Xiong Chang Lim Kameswara Rishi Yeshayahu Nistala Cheng Han Ng Snow Yunni Lin Darren Jun Hao Tan Khek-Yu Ho Choon-Seng Chong Mark Muthiah | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 6 | Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria:a meta-analysis of 18,421 patients显示文摘Background:Outcomes after liver resection(LR)and liver transplantation(LT)for hepatocellular carcinoma(HCC)are heterogenous and may vary by region,over time periods and disease burden.We aimed to compare overall survival(OS)and disease-free survival(DFS)between LT versus LR for HCC within the Milan criteria.Methods:Two authors independently searched Medline and Embase databases for studies comparing survival after LT and LR for patients with HCC meeting the Milan criteria.Meta-analyses and meta-regression were conducted using random-effects models.Results:We screened 2,278 studies and included 35 studies with 18,421 patients.LR was associated with poorer OS[hazard ratio(HR)=1.44;95%confidence interval(CI):1.14-1.81;P<0.01]and DFS(HR=2.71;95%CI:2.23-3.28;P<0.01)compared to LT,with similar findings among intention-to-treat(ITT)studies.In uninodular disease,OS in LR was comparable to LT(P=0.13)but DFS remained poorer(HR=2.95;95%CI:2.30-3.79;P<0.01).By region,LR had poorer OS versus LT in North America and Europe(P≤0.01),but not Asia(P=0.25).LR had inferior survival versus LT in studies completed before 2010(P=0.01),but not after 2010(P=0.12).Cohorts that underwent enhanced surveillance had comparable OS after LT and LR(P=0.33),but cohorts undergoing usual surveillance had worse OS after LR(HR=1.95;95%CI:1.24-3.07;P<0.01).Conclusions:Mortality after LR for HCC is nearly 50%higher compared to LT.Survival between LR and LT were similar in uninodular disease.The risk of recurrence after LR is threefold that of LT. | Jin Hean Koh Darren Jun Hao Tan Yuki Ong Wen Hui Lim Cheng Han Ng Phoebe Wen Lin Tay Jie Ning Yong Mark D.Muthiah Eunice X.Tan Ning Qi Pang Beom Kyung Kim Nicholas Syn Alfred Kow Brian K.P.Goh Daniel Q.Huang | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 3 |
| 7 | Liver cirrhosis and splenomegaly associated with Schistosoma mansoni in a Sudanese woman in Malaysia:A case report显示文摘We report a case of a patient with Schistosoma mansoni infection who presented with liver cirrhosis and splenomegaly.She was diagnosed by a serological test and Kato-Katz thick smear stool examination.The patient was a 52-year-old woman from Sudan who came to Malaysia for a week to visit her sons.The patient lives in the middle of Rabak region,Sudan,a highly endemic area for schistosomiasis where her daily routine includes rearing of cows and farming.The site of toilet and sources of drinking water are canals and wells;both infested with snails.Patient had a long history of exposure and coming into contact with water from these canals and wells. | Yamuna Rajoo Rohela Mahmud Ng Rong Xiang Sharifah F.S.Omar G Kumar Yvonne A.L Lim Arine Fadzlun Ahmad Amirah Amir Zurainee Mohamed Nor Romano Ngui | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，4： | 2 |
| 8 | Mitochondrial homeostasis in Parkinson's disease-a triumvirate rule?显示文摘Mitochondrial dysfunction in Parkinson’s disease:Mitochondria are the primary energy generator of the cell and they are important for cell survival and apoptosis.Defective mitochondrial homeostasis is frequently reported in human diseases especially those affecting the brain. | Chee-Hoe Ng Liting Hang Kah-Leong Lim | 2017 | Neural Regeneration Research2017，12，8： | 2 |
| 9 | Gold nanoparticles in cancer therapy显示文摘特别地,最近的年里的纳米技术的快速的前进在 nanoparticle 研究的领域里造成了发芽兴趣它在医药竞技场的申请。金 nanoparticles (AuNPs ) 的性质的更好的理解上的常常膨胀的 knowledge based 结合了纳米技术的边疆常常正在被质问的无情的试验工具。目前,似乎是对到癌症的管理的 AuNPs 的申请的提高的兴趣,包含诊断,监视并且疾病的治疗。这些努力被承担希望为象癌症那样的 multifactorial 疾病革命化治疗和治疗策略的当前的方法。这评论将在癌症管理集中于 AuNPs 的当前的应用。 | Zhao-Zhin Joanna LIM Jia-En Jasmine LI Cheng-Teng NG Lin-Yue Lanry YUNG Boon-Huat BAY | 2011 | Acta Pharmacologica Sinica2011，32，8： | 2 |
| 10 | Drying kinetics of technical specified rubber显示文摘This paper reports the study of crumb rubber drying in different experimental designs.It is important to understand the characteristics of crumb rubber drying in order to formulate a better drying strategy that could give higher energy efficiency.Four experiments were carried out with constant heat at maximum 100℃ and a stainless steel container was used to hold the sample of crumb rubber under study.The surface temperature profile of the rubber was investigated using two types of drying methods,normal hot air drying and vacuum drying.It was found that when the sample was dried,external surface temperature for drying with hot air dryer was higher than vacuum dryer.The results showed the evolution of temperature profile was not in good agreement with the prediction which revealed that there was no temperature gradient within the drying samples.The energy consumption for vacuum drying was higher compared to hot air drying,where there was a difference of 0.7079 MJ/kg H2O evaporated for drying temperature at 100℃.The best fit model generated from the experimental data was the modified Henderson and Pabis model and the highest effective diffusivity obtained was 5.243×10^-9m^2/s heating by vacuum oven at 90℃ under zero atmospheric pressure. | Mei Xiang Ng Thing Chai Tham Sze Pheng Ong Chung Lim Law | 2015 | Information Processing in Agriculture2015，2，1： | 2 |
| 11 | Coexistence of Helicobacter pylori spiral and coccoid forms in experimental mice显示文摘AbstractAIMToinfectmicewithHelicobacterpylorianddetectimmuneresponseagainsttwoformsofH.pylori.METHODSAnisolateofH.pyloriobtai... | HUA Jiesong 1, HO Bow 1, ZHENG Pengyuan 1, YEOH Khay Guan 2, NG Han Chong 1 and LIM Seng Gee 2 | 1998 | World Journal of Gastroenterology1998，4，6： | 2 |
| 12 | 肿瘤免疫治疗时代的多重免疫组织化学/免疫荧光技术显示文摘常规免疫组织化学(immunohistochemistry,IHC)是组织病理学中广泛应用的诊断技术。但该技术存在诸多局限性,包括观察者间的变异性高,每张组织切片仅能标记一个标志物。本文详细描述了各种多重检测技术,这些技术克服了上述局限性,可在单张切片上同时检测多个标志物,可对细胞组成、细胞功能和细胞间相互作用进行整合研究。在这些技术中,多重免疫组织化学/免疫荧光(multiplex immunohistochemistry/immunofluorescence,mIHC/IF)已成为最具应用前景的技术。mIHC/IF为开展高重复性、高效、高性价比的组织研究提供了高通量多重染色技术和标准化的定量分析。该技术在转化研究和临床实践中,尤其是肿瘤免疫治疗中极具应用价值。 | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2021 | 癌症2021，40，9： | 2 |
| 13 | A Comparative Study of Three Warming Interventions to Determine the Most Effective in Maintaining Perioperative Normothermia显示文摘 | Siew-Fong Ng Cheng-Sim Oo Khiam-Hong Loh Poh-Yan Lim Yiong-Huak Chan Biauw-Chi Ong | 2003 | Anesthesia & Analgesia2003，，1： | 2 |
| 14 | Change in cerebral hemodynamics and cerebral oxygenation during surgical evacuation for hypertensive intracerebral putaminal hemorrhage显示文摘 | Ng I Yap E Lim J | 2005 | Acta Neurochir2005，95，： | 1 |
| 15 | Proline-rich tyrosine kinase 2 (Pyk2) promotes cell motility of hepatocellular carcinoma through induction of epithelial to mesenchymal transition显示文摘 | Sun CK Ng KT Lim ZX | 2011 | PLoS One2011，6，18： | 1 |
| 16 | A machine learning approach to coreference resolution of noun phrases显示文摘 | Soon W M Ng H T Lim D C Y | 2001 | Computational Linguistics2001，27，4： | 1 |
| 17 | Lower circulating irisin is associated with type 2 diabetes mellitus显示文摘 | Jian-Jun Liu Melvin D.S. Wong Wan Ching Toy Clara S.H. Tan Sylvia Liu Xiao Wei Ng Subramaniam Tavintharan Chee Fang Sum Su Chi Lim | 2013 | Journal of Diabetes and Its Complications2013，，4： | 1 |
| 18 | Processing of hydroxyapatite via microemulsion and emulsion routes 显示文摘 | Lim G K Wang J Ng S C | 1997 | Biomaterials1997，18，21： | 1 |
| 19 | Primitive neuroectodermal tumour of the chest wall-a report of two cases and review of literature显示文摘 | Naik MJ Ng SB | 2000 | Ann Acad Med Singapore2000，29，6： | 1 |
| 20 | On the relation between centrifugal force and radial pressure gradient in flow inside curved and S-shaped ducts显示文摘 | Ng T Y Luo S C Lim T T | 2008 | Physics of Fluids2008，，： | 1 |
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