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| 1 | Ly49 receptors activate angiogenic mouse DBA+ uterine natural killer cells显示文摘 | Patricia DA Lima Megan M Tu Mir Munir A Rahim Annie R Peng B Anne Croy Andrew P Makrigiannis | 2014 | Cellular & Molecular Immunology2014，11，5： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | ln vivo and in vitro studies on the anticancer activity of Copaifera multijuga Hayne and its fractions显示文摘 | Lima S R M Junior V F V Christo H B | 2003 | Phytotherapy Research2003，17，9： | 1 |
| 4 | Engineering properties of fiber reinforced cold asphalt mixes显示文摘 | BUENO B D SILVA W R D LIMA D C | 2003 | Journal of Environmental Engineering2003，129，10： | 1 |
| 5 | Effect of heat treatment on the microstructure of spray formed AISI M2 high-speed steel 显示文摘 | Lima R M Jesus E R B Rossi J L | 2003 | Materials Science Forum2003，，： | 1 |
| 6 | Arsenic trioxide/ascorbic acid therapy in patients with refractory metastatic colorectal carcinoma: a clinical experience显示文摘 | Subbarayan P R Lima M Ardalan B | 2007 | Acta Oncol2007，46，4： | 1 |
| 7 | Optimal design of submarine pipeline routes by genetic algorithm with different constraint handling techniques显示文摘 | LUCENA R R BAIOCO J S LIMA B | 2014 | Advances in Engineering Software2014，76，： | 1 |
| 8 | Thermal Spray Coatings Engi- neered from Nanostructured Ceramic Agglomerated Powders for Structural, Thermal Barrier and Biomedical Applications: A Review显示文摘 | LIMA R S MARPLE B R | 2007 | Joumal of Thermal Spray Technology2007，16，： | 1 |
| 9 | Fault tolerant reversible AC motor drive system 显示文摘 | Jacobina C B de Araujo Ribeiro R L Lima A M N | 2003 | IEEE Transactions on Industry Applications2003，39，4： | 1 |
| 10 | Silver nanoparticles: A brief review of cytotoxicity and genotoxicity of chemically and biogenically synthesized nanoparticles显示文摘 | de Lima R Seabra A B Duran N | 2012 | Journal of Applied Toxicology2012，32，11： | 1 |
| 11 | Nanostructured YSZ thermal barrier coatings engineered to counteract sintering effects显示文摘 | Lima R S Marple B R | | 0，，： | 1 |
| 12 | Thermal degradation of biodegradable edible films based on xanthan and starches from different sources显示文摘 | Soares R M D Lima A M F Oliveira R V B | 2005 | Polym Degrad Stab2005，4，7： | 1 |
| 13 | A Three-leg Voltage Source Inverter for Two-phase AC Motor Drive Systems显示文摘 | CORREA M B R JACOBINA C B LIMA A M N | 2002 | IEEE Transactions on Power Electronics2002，9，4： | 1 |
| 14 | Soybean root growth inhibition and lignification induced by p-coumaric acid显示文摘 | Zanardo D I L Lima R B Ferrarese M L L | 2009 | Environmental and Experimental Botany2009，66，1： | 1 |
| 15 | Fault-tolerant reversible AC motor drive system显示文摘 | Jacobina C B Ribeiro R L A Lima A M N | 2003 | IEEE Transactions on Industry Applications2003，39，4： | 1 |
| 16 | Transplanted bone marrow cells repair heart tissue and reduce myocarlitis in chronic chagasic mice显示文摘 | Soares M B Lima R S Rocha L L | 2004 | Am J Pathol2004，164，2： | 1 |
| 17 | Nanostructured Titania/Hydroxyapatite Composite Coatings Deposited by High Velocity Oxy-fuel (HVOF) Spraying显示文摘 | GAONA M LIMA R S MARPLE B R | 2007 | Materials Science and Engineering A2007，458，12： | 1 |
| 18 | Solid state NMR of SiO2 nanotube coated ammonium tartrate crystal显示文摘 | LIMA R SCHUENEMAN G M NOVAK T B | 1999 | Solid State Com- munications1999，110，： | 1 |
| 19 | Cataly-sis of Formaldehyde Oxidation By Electrodeposits of PtRu显示文摘 | Lima R B Massafera M P Batista E A Iwasita T | 2007 | Electroanal Chem J2007，603，1： | 1 |
| 20 | Engineering properties of fiber reinforced cold asphalt mixes显示文摘 | Bueno B D W R da Silva D C de Lima | 2003 | Journal of Environmental Engineering2003，129，10： | 1 |
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