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| 1 | Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure显示文摘AIM To analyze the expression and function of the notchsignaling target gene Hes1 in a rhesus rotavirusinduced mouse biliary atresia model. METHODS The morphologies of biliary epithelial cells in biliary atresia patients and in a mouse model were examined by immunohistochemical staining. Then, the differential expression of Notch signaling pathway-related molecules was investigated. Further, the effects of the si RNAmediated inhibition of Hes1 expression were examined using a biliary epithelial cell 3 D culture system.RESULTS Both immature(Ep CAM+) and mature(CK19+) biliary epithelial cells were detected in the livers of biliary atresia patients without a ductile structure and in the mouse model with a distorted bile duct structure. The hepatic expression of transcripts for most Notch signaling molecules were significantly reduced on day 7 but recovered to normal levels by day 14, except for the target molecule Hes1, which still exhibited lower m RNA and protein levels. Expression of the Hes1 transcriptional co-regulator, RBP-Jκ was also reduced. A 3 D gel culture system promoted the maturation of immature biliary epithelial cells, with increased expression of CK19+ cells and the formation of a duct-like structure. The administration of Hes1 si RNA blocked this process. As a result, the cells remained in an immature state, and no duct-like structure was observed.CONCLUSION Our data indicated that Hes1 might contribute to the maturation and the cellular structure organization of biliary epithelial cells, which provides new insight into understanding the pathology of biliary atresia. | Rui-Zhong Zhang Xin-Hao Zeng Ze-Feng Lin Ming-Fu Yan-Lu Tong Vincent CH Lui Paul KH Tam Jonathan R Lamb Hui-Min Xia Yan Chen | 2018 | World Journal of Gastroenterology2018，24，29： | 5 |
| 2 | Research on improving the measuring accuracy of laser autocollimator used over long distance显示文摘 | ZHAO M R LIN Y CH ZHANG P | 2002 | SPIE2002，4927，： | 1 |
| 3 | Design and performance evaluation of aquatic-pollution monitoring scheme over a waterborne wireless sensor network显示文摘 | CHEN M CH CHANG W R LIN H T | 2014 | Com- puter Communications2014，40，： | 1 |
| 4 | Metamaterial-inspired engineering of antennas显示文摘 | Ziolkowski R W Jin P Lin Ch Ch | 2011 | PROCEEDINGS OF THE IEEE2011，99，10： | 1 |
| 5 | Rational harmonic mode-locking pulse quality ofthe dark-optical-comb injected semiconductor optical amplifier fiber ring laser 显示文摘 | LIN G R LEE Ch K KANG J J | 2008 | Optics Express2008，16，12： | 1 |
| 6 | Vascularized groin lymph node transfer using the wrist as a recipient site for management of postmastectomy upper extremity lymphedema显示文摘 | Lin CH Ali R Chen SC | | 0，，04： | 1 |
| 7 | A fuzzy diagnosis approach using dynamic fault trees 显示文摘 | Chang Sh Y Lin Ch R Chang Ch T | 2002 | Chemical Engineering Science2002，，57： | 1 |
| 8 | Mouse hind limb transplantation:a new composite tissue allotransplantation model using nonsuture supermicrosurgery 显示文摘 | Sucher R Lin CH | 2010 | Transplantation2010，12，： | 1 |
| 9 | Particle size distribution and PAH concentrations of incense smoke in a combustion chamber 显示文摘 | Yang C R Lin T Ch Chang F H | 2007 | Environmental Pollution2007，145，2： | 1 |
| 10 | In vitro study of anticancer drug doxorubicin in PLGA-based microparticles显示文摘 | Lin R Ng LS Wang CH | 2005 | Biomateriats2005，26，21： | 1 |
| 11 | Vascularized groin lymph node transfer using the wrist as a recipient site for management of postmastectomy upper extremity lymphedema显示文摘 | Lin CH Ali R Chen SC | 2009 | Plast Reconstr Surg2009，123，4： | 1 |
| 12 | Novel near-infrared cyanine fluoro-chromes: synthesis, properties, and bioconjugation显示文摘 | Lin Y Weissleder R Tung CH | 2002 | Bioconjug Chem2002，13，3： | 1 |
| 13 | Novel near-infrared cyanine fluorochromes:synthesis, properties, and bioconjugation显示文摘 | Lin Y Weissleder R Tung CH | 2002 | Bioconjug Chem2002，13，3： | 1 |
| 14 | Self-phase-modulation in silica optical fibers显示文摘 | STOLEN R H LIN Ch L | 1978 | Physics Review1978，17，4： | 1 |
| 15 | Cy -totox icity of Gr aph ene Ox ide and Gr aph ene in H uman Er y -th r ocy tes and Sk in Fibr oblasts显示文摘 | Ken- H suan Liao Yu- Sh en Lin Ch r istoph er W | 2011 | ACS Applied Mater ials &Inter faces2011，3，： | 1 |
| 16 | A novel oncogenic role of inositol phosphatase SHIP2 in ER-negative breast cancer stem cells: involvement of JNK/vimentin acti- vation显示文摘 | Fu CH Lin R J Yu J | 2014 | Stem Cells2014，32，8： | 1 |
| 17 | Tracking and balance control of ball and plate system 显示文摘 | C Ker Ch Lin R Wang | 2007 | Journal of the Chinese institute of engineers (S0253-3839)2007，30，3： | 1 |
| 18 | Constructing a reassigning credit scoring model 显示文摘 | Chuang Ch L Lin R H | 2009 | Expert Systems with Applications2009，36，2： | 1 |
| 19 | Luminescence and site symmetry studies of new red phosphors (Ca, Ba)3(VO4)2:Eu3+ under blue excitation显示文摘 | LIN H Y FANG Y Ch HUANG X R CHU Sh Y | 2010 | Journal of the American Ceramic Journal of the American Ceramic Society2010，93，1： | 1 |
| 20 | Novel near-infrared cyanine fluoroehromes: synthesis, properties, and bioconjugation显示文摘 | Lin Yu-hui Weissleder R Tung CH | 2002 | Biocon- jugate Chem2002，13，3： | 1 |
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