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| 1 | Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer显示文摘渗入肿瘤的 Tregs 的起源,肿瘤免疫力的抑制的批评调停人,是不清楚的。这里,,我们证明在人的乳癌的渗入肿瘤的天真的 CD4 + T 房间和 Tregs 有重叠 TCR 全部剧目几乎别与传播 Tregs 重叠,建议 intratumoral Tregs 主要在 situ 而非从招募的 Tregs 从天真的 T 房间发展。而且,许多天真的 CD4 + T 房间和 Tregs 密切被相关,两个显示的穷人为乳癌病人的预后。天真的 CD4 + T 房间与许多生产 CCL18 巨噬细胞成比例遵守肿瘤片。而且,采纳地转移的人的天真的 CD4 + T 房间以一种 CCL18 依赖的方式渗入人的乳癌 orthotopic 异种皮移植。在在人性化的鼠标的人的乳癌异种皮移植,由将 PITPNM3 的表达式击倒堵住天真的 CD4 + T 房间的招募进肿瘤, CCL18 受体,显著地减少 intratumoral Tregs 并且禁止肿瘤前进。这些调查结果建议那个乳房渗入肿瘤的 Tregs 从在 situ 区分进 Tregs 的传播天真的 CD4 + T 房间的趋化性产生。由防碍 CCL18 的 PITPNM3 识别禁止天真的 CD4 + T 房间招募进肿瘤可以是为 anticancer 免疫疗法的吸引人的策略。 | Shicheng Su Jianyou Liao Jiang Liu Di Huang Chonghua He Fei Chen LinBing Yang Wei Wu Jianing Chen Ling Lin Yunjie Zeng Nengtai Ouyang Xiuying Cui Herui Yao Fengxi Su Jian-dong Huang Judy Lieberman Qiang Liu Erwei Song | 2017 | Cell Research2017，27，4： | 19 |
| 2 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 3 | The role of for-profit hospitals in medical expenditures: Evidence from aggregate data in China显示文摘 | Gordon G. Liu Lin Li Xiaohui Hou Judy Xu Daniel Hyslop | 2009 | China Economic Review2009，，4： | 1 |
| 4 | Online stickiness: its antecedents and effect on purchasing intention显示文摘 | Judy Chuan-Chuan Lin | 2007 | Behaviour & Information Technology2007，，6： | 1 |
| 5 | Towards an understanding of the behavioural intention to use a web site显示文摘 | Judy Chuan-Chuan Lin Hsipeng Lu | 2000 | International Journal of Information Management2000，，3： | 1 |
| 6 | Lung ischemia-reperfusion injury:a molecular and clinical view on a complex pathophysiological process显示文摘 | Willem A den Hengst Jan F Gielis Judy Y Lin | | 0，，05： | 1 |
| 7 | Acceptance of blog usage:The roles of technology acceptance,social influence and knowledge sharing motivation显示文摘 | Hsu Chin-Lung Lin Judy Chuan-Chuan | 2008 | Information and Management2008，45，1： | 1 |
| 8 | Modeling and optimizing passive valve designs for the implantable gold micro-shunt used in glaucoma treatment显示文摘 | LIN Judy L CLEVENGER Jason M | 2009 | Computers & Structures2009，87，1112： | 1 |
| 9 | On- line stickiness:its antecedents and ef- fect on purchasing Intention显示文摘 | Judy Chuan-Chuan Lin | 2007 | Behav- ior&Information Technology2007，26，6： | 1 |
| 10 | Acceptance of blog usage: The roles of technology acceptance, social influence and knowledge sharing motvation 显示文摘 | Chin-Lung Hsu Judy Chuan-Chuan Lin | 2008 | Information & Management2008，，45： | 1 |
| 11 | Towards an understanding of the behavioral intention to Use a web site显示文摘 | Chuan Lin Judy | 2000 | Intemational Journal of Information Management2000，，： | 1 |
| 12 | Acceptance of Blog Usage : The Roles of Technology Acceptance, Social Influence and Knowledge Sharing Motivation显示文摘 | Chin-Lung Hsua and Judy Chuan-Chuan Lin | 2008 | Information & Management2008，，1： | 1 |
| 13 | Accept- ance of blog usage : The roles of technology accept- ance, social influence and knowledge sharing moti- vation 显示文摘 | Chin-Lung Hsu Judy Chuan -Chuan Lin | 2008 | Information & Management2008，45，1： | 1 |
| 14 | Online stickiness: its antecedents and effect on purchasing intention显示文摘 | Judy Chuan-Chuan Lin | 2007 | Behaviour & Information Technology2007，，6： | 1 |
| 15 | Acceptance of blog usage:the roles of technology acceptance,social influence and knowledge sharing motivation显示文摘 | Hsu Chin-Lung Lin Judy Chuan-Chuan | | 0，，： | 1 |
| 16 | Acceptance of blog usage: The roles of technology acceptance, social influence and knowledge sharing motivation显示文摘 | Chin-Lung Hsu Judy Chuan-Chuan Lin | 2007 | Information & Management2007，，1： | 1 |
| 17 | Towards an understanding of the behavioral intention to use a web site显示文摘 | Lin Judy | 2000 | International Journal of InformationManagement2000，20，3： | 1 |
| 18 | Aeeeptanee of Blog Usage:The Roles of Technology Acceptance, Social Influence and Knowledge Sharing Motivation显示文摘 | Hsu C L Lin Judy C C | 2008 | Informa- tion & Management2008，，45： | 1 |
| 19 | Utilization of the Navien distal intracranial catheter in 78 cases of anterior circulation aneurysm treatment with the Pipeline embolization device显示文摘 | Geoffrey P Colby Li-Mei Lin Judy Huang Rafael J Tamargo Alexander L Coon | 2013 | Journal of NeuroInterventional Surgery . 2013 (Supp)2013，，： | 1 |
| 20 | Acceptance of blog usage: The roles of technology acceptance, social influence and knowledge sharing motivation显示文摘 | Chin-Lung Hsu Judy Chuan-Chuan Lin | 2008 | Information & Management2008，，1： | 1 |
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