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| 1 | The effect of Scuteilaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats显示文摘Flavonoids 被显示了改进认知功能并且推迟痴呆前进。然而,内在的机制留下逃犯。在现在的学习,我们检验了从 S 提取的黄芩 baicalensis 茎叶总数 flavonoids (SSTF ) 的效果。在脉管的痴呆(VaD ) 的空间学习和记忆上的 baicalensis Georgi 老鼠模型并且探索了它的分子的机制。VaD 老鼠被普通颈动脉动脉的永久双边的吸藏开发。在恢复以后的七天, VaD 老鼠与 SSTF 的 50 或 100 mg/kg 被对待 60 天。空间学习和记忆在莫利斯舞水迷宫(MWM ) 被评估测试。字形物 hyperphosphorylation 和相关蛋白质 kinases 或磷酸酶的层次被西方的污点分析检验。在 VaD 老鼠,在 100 mg/kg 的 SSTF 处理显著地在在 MWM 测试训练试用减少了逃跑潜伏。在探针试用, SSTF 治疗在目标象限增加了寻找的时间和旅行距离。SSTF 处理在 VaD 老鼠在外皮和马头鱼尾的怪兽禁止了字形物 phosphorylation。同时, SSTF 减少了肝糖 synthase kinase 的活动 3 并且 cyclin 依赖的 kinase 5 在 VaD 老鼠。相反, SSTF 处理在 VaD 老鼠增加了蛋白质磷酸酶 2A 子单元 B 的水平。SSTF 处理显著地在 VaD 老鼠改进了空间认知。我们的结果建议 SSTF 可以通过在击以后协调 kinases 和磷酸酶的活动减轻 tau-hyperphosphorylation-induced neurotoxicity。SSTF 可以为 VaD 被开发进有希望的新奇治疗学。 | Yanjing Cao Lizhen Liang Jian Xu Jiali Wu Yongxing Yan Ping Lin Qiang Chen Fengming Zheng Qin Wang Qian Ren Zengmei Gou Yifeng Du | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 10 |
| 2 | Ni/Co-based metal-organic frameworks as electrode material for high performance supercapacitors显示文摘A novel bimetallic Ni/Co-based metal-organic framework(Ni/Co-MOF) was successfully synthesized via a simple solvothermal method, and used as electrode material for high performance supercapacitors. After doping of Co element, the Ni/Co-MOF materials retain the original crystalline topology structure of Ni_3(BTC)_2·12H_2O.The as-obtained Ni/Co-MOF demonstrates an excellent specific capacitance of 1067 and 780 F/g at current density of 1 and 10 A/g, respectively, and can also retain 68.4% of the original capacitance after 2500 cycles. These results suggest that bimetallic Ni/Co-based MOFs are promising materials for the next generation supercapacitance,owing to their excellent electrochemical performance. The synthetic procedure can be applied to synthesize other bimetallic MOFs and enhance their conductive property. | Shaofei Zhao Lizhen Zeng Gao Cheng Lin Yu Huaqiang Zeng | 2019 | Chinese Chemical Letters2019，30，3： | 7 |
| 3 | High-conductivity free-standing Li_(6)PS_(5)Cl/poly(vinylidene difluoride)composite solid electrolyte membranes for lithium-ion batteries显示文摘Bulk-type all-solid-state batteries(ASSBs)using sulfide solid electrolyte are considered as a promising alternative to commercial lithium-ion batteries owing to their high energy density and safety.However,cell energy density is often comparatively low due to use of a thick solid electrolyte separator and a lithium alloy as anode.For achieving high-performance ASSBs,creating a thin free-standing electrolyte with high-conductivity and good cycling stability against lithium anode is essential.In this work,we present Li_(6)PS_(5)Cl/poly(vinylidene difluoride)(LPSCl/PVDF)composite electrolytes prepared by a slurry method.The influence of the PVDF content on the microstructure,morphology,ionic conductivity and activation energy of the LPSCl/PVDF electrolytes is systematically investigated.Free-standing LPSCl/PVDF membranes with a thickness of 100-120 mm and a high ionic conductivity of about 1·10^(-3) S cm^(-1) at 25℃ are obtained.After adding PVDF to the LPSCl electrolyte,the cycling stability of the LPSCl electrolyte against lithium metal improves significantly.Therefore,LPSCl/PVDF composite electrolytes are promising candidates to be used in ASSBs. | Shuo Wang Xue Zhang Sijie Liu Chengzhou Xin Chuanjiao Xue Felix Richter Liangliang Li Lizhen Fan Yuanhua Lin Yang Shen Jurgen Janek Ce-Wen Nan | 2020 | Journal of Materiomics2020，6，1： | 5 |
| 4 | High proton conductivity in metalloring-cluster based metalorganic nanotubes显示文摘Two novel anionic single-walled metal-organic nanotubes(MONTs),[(CH_(3))_(2)NH_(2)][ln(cdc)(thb)].2DMF.9.5H_(2)O(FJU-105)and[(CH_(3))_(2)NH_(2)][ln(cdc)(H-btc)]-2DMA·11H_(2)O(FJU-106)(H_(2)cdc=9H-carbazole-3,6-dicarboxylic acid,H_(2)thb=2,5-thiophene dicarboxylic acid,H3btc=1,3,5-benzene tricarboxylic acid),are achieved by employing[ln_(6)(cdc)_(6)]^(6+)metalloring cluster with largest diameter as the secondary building blocks(SBUs).The inner surface of FJU-106 is functionalized by uncoordinated-COOH groups of the H-btc linkers,leading to a higher proton conduction than FJU-105.At 70℃,FJU-106 displays the proton conduction performances among MONTs,up to 1.80×10^(-2)S·cm(^-1).And FJU-105 and FJU-106 are the first examples of MONT proton conductors operating at subzero temperature. | Quanjie Lin Yingxiang Ye Lizhen Liu Zizhu Yao Ziyin Li Lihua Wang Chulong Liu Zhangjing Zhang Shengchang Xiang | 2021 | Nano Research2021，14，2： | 2 |
| 5 | Phase diagram,growth and spectral characteristic of Yb^3+:KY(WO4)2 crystal显示文摘 | Tang Liyong Lin Zhoubin Zhang Lizhen Wang Guofu | 2005 | Journal of Crystal Growth2005，282，： | 1 |
| 6 | Photosynthetic parameters in the northern South China Sea in relation to phytoplankton community structure显示文摘 | Xie Yuyuan Huang Bangqin Lin Lizhen | 2015 | Journal of Geophysical Research:Oceans2015，120，6： | 1 |
| 7 | Spectral Parameters of Nd^3 + ion in g-Nd^3 + : LaSt3 ( BO3 )4 crystal 显示文摘 | Lin Zhoubin Hu Zushu Lizhen Zhang | 2002 | Phys Stat Sol2002，，231： | 1 |
| 8 | Hypoxia-Inducible Factor-1a Is Essential for Hypoxia-Induced Mesenchymal Stem Cell Mobilization into the Peripheral Blood显示文摘 | Lizhen Liu Qin Yu Jie Lin | | 0，，11： | 1 |
| 9 | Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts显示文摘一个单个哺乳动物的抄本通常编码一蛋白质,但是 GNAS (G 蛋白质伪 - 子单元) 的抄本包含二个读物框架并且生产二在结构上无关的蛋白质, XL 伪 s 和 ALEX。没有其它证实象 GNAS 一样双编码的抄本迄今为止被报导了,尽管许多如此的候选人基因被生物信息学分析预言了。在这研究,我们构造了一系列向量测试二个蛋白质产品怎么在 vitro 从一个单个抄本被翻译。ORF (开的读框架) 的长度,第一 8 月的位置和 Kozak 主题被发现是重要因素。这些因素,以及 55-bp NMD (调停胡说八道的 mRNA 腐烂) 规则,为候选人在生物信息学搜索被使用双编码的抄本。分别地, 1307, 750 和 474 个 two-ORF-containing 抄本的一个总数分别地, 170, 89 和 70 哪个被发现是潜在的双编码的抄本在人,老鼠和老鼠被发现。大多数抄本在种类之中显示出低保存。有趣地,双编码的抄本显著地从锌手指蛋白质家庭为抄本被充实,它通常是涉及抄写过程的规定的 DNA 有约束力的蛋白质。 | Heng Xu Ping Wang Yujie Fu Yufang Zheng Quan Tang Lizhen Si Jin You Zhenguo Zhang Yufei Zhu Li Zhou Zejun Wei Bin Lin Landian Hu Xiangyin Kong | 2010 | Cell Research2010，20，4： | 1 |
| 10 | Rho 1 participates in parasitoid wasp eggs maturation and host cellular immunity inhibition显示文摘Endoparasitoid wasps introduce venom into their host insects during the egglaying stage.Venom proteins play various roles in the host physiology,development,immunity,and behavior manipulation and regulation.In this study,we identified a venom protein,MmRhol,a small guanine nucleotide-binding protein derived from ovary in the endoparasitoid wasp Microplitis mediator and found that knockdown of its expression by RNA interference caused down-regulation of vitellogenin and juvenile hormone,egg production,and cocoons formation in the female wasps.We demonstrated that MmRho1 entered the cotton bollworm's(host)hemocytes and suppressed cellular immune responses after parasitism using immunofluorescence staining.Furthermore,wasp MmRhol interacted with the cotton bollworm's actin cytoskeleton rearrangement regulator diaphanous by yeast 2-hybrid and glutathione s-transferase pull-down.In conclusion,this study indicates that MmRho1 plays dual roles in wasp development and the suppression of the host insect cellular immune responses. | Ruijuan Wang Zhe Lin Lizhen Zhou Caihua Chen Xianhao Yu Junje Zhang Zhen Zou Zhiqiang Lu | 2023 | Insect Science2023，30，3： | 1 |
| 11 | Correction of Th1-dominant Cytokine Profiles by High-dose Dexamethasone in Patients with Chronic Idiopathic Thrombocytopenic Purpura显示文摘 | Chengshan Guo Xiaoxia Chu Yan Shi Weidong He Lizhen Li Lin Wang Yingxue Wang Jun Peng Ming Hou | 2007 | Journal of Clinical Immunology2007，，： | 1 |
| 12 | Enhanced ionic conductivity of polymer electrolytes containing nanocomposite SiOI Particles显示文摘 | Nan Cewen Fan Lizhen Lin Yuanhua | 2003 | Physical Review Letters2003，91，26： | 1 |
| 13 | Synthesis,growth and spectral properties of Tm3+/Yb3+ -doped YVO4 crystal显示文摘 | Zhang Lizhen Wang Guofu Lin Shukun | 2002 | Journal of Crystal Growth2002，241，： | 1 |
| 14 | Growth,structure and spectroscopic characterizations of Nd^3+-doped LiLa(WO4)2 crystal显示文摘 | Huang Xinyang Lin Zhoubin Hua Zushu Zhang Lizhen Huang Jingshun Wang Guofu | 2004 | Journal of Crystal Growth2004，269，： | 1 |
| 15 | Engineering Yarrowia lipolytica to produce nutritional fatty acids:Current status and future perspectives显示文摘Due to their vital physiological functions,nutritional fatty acids have great potential as nutraceutical food supplements for preventing an array of diseases such as inflammation,depression,arthritis,osteoporosis,diabetes and cancer.Microbial biosynthesis of fatty acids follows the trend of sustainable development,as it enables green,environmentally friendly and efficient production.As a natural oleaginous yeast,Yarrowia lipolytica is especially well-suited for the production of fatty acids.Moreover,it has a variety of genetic engineering tools and novel metabolic engineering strategies that make it a robust workhorse for the production of an array of value-added products.In this review,we summarize recent advances in metabolic engineering strategies for accumulating nutritional fatty acids in Y.lipolytica,including conjugated fatty acids and polyunsaturated fatty acids.In addition,the future prospects of nutritional fatty acid production using the Y.lipolytica platform are discussed in light of the current progress,challenges,and trends in this field.Finally,guidelines for future studies are also emphasized. | Lizhen Cao Mingxue Yin Tian-Qiong Shi Lu Lin Rodrigo Ledesma-Amaro Xiao-Jun Ji | 2022 | Synthetic and Systems Biotechnology2022，7，4： | 0 |
| 16 | High-performance organic electrochemical transistors gated with 3D-printed graphene oxide electrodes显示文摘Organic electrochemical transistors(OECTs)have garnered significant interest due to their ability to facilitate both ionic and electronic transport.A large proportion of research efforts thus far have focused on investigating high-performance materials that can serve as mixed ion doping and charge transport layers.However,relatively less attention has been given to the gateelectrode materials,which play a critical role in controlling operational voltage,redox processes,and stability,especially in the context of semiconductor-based OECTs working in accumulation mode.Moreover,the demand for planarity and flexibility in modern bioelectronic devices presents significant challenges for the commonly used Ag/AgCl electrodes in OECTs.Herein,we report the construction of high-performance accumulation-mode OECTs by utilizing a gate electrode made of three-dimensional(3D)-printed graphene oxide.The 3D-printed graphene oxide electrode incorporating one-dimensional(1D)carbon nanotubes,is directly printed using an aqueous-based ink and showcases exceptional mechanical flexibility and porosity properties,enabling high-throughput preparation for both top gates and integrated planar architecture,as well as fast ion/charge transport.OECTs with high performance comparable to that of Ag/AgCl-gated OECTs are thus achieved and present promising feasibility for electrocardiograph(ECG)signal recording.This provides a promising choice for the application of flexible bioelectronics in medical care and neurological recording. | Xingyu Jiang Zhiqiang Liang Miao Wu Jie Lu Cheng Shi Qi Wang Zi Wang Zhen Jin Lin Jiang Lizhen Huang Lifeng Chi | 2023 | Nano Research2023，16，11： | 0 |
| 17 | Near-microscopic grain boundary facilitates fatigue crack propagation in a polycrystalline Al–Zn–Mg–Cu alloy显示文摘In present study,grain characteristics with sizes within 10-30μm were fabricated from a same Al-Zn-Mg-Cu alloy,FCP behaviors of the alloys with small grain(SG alloy),medium grain(MG alloy)and large grain(LG alloy)were investigated and related fatigue fracture morphology was analyzed.With the enhancement of stress intensity factor range(ΔK),the alloy with larger grains possessed faster FCP rate,which were successively arranged as SG alloy>MG alloy>LG alloy at initial stage while turned to LG alloy>MG alloy>SG alloy at final stage for the stable expanding region.Except for conventional characteristics of striations,tearing ridges,secondary cracks,second phases,voids and dimples,more prominent grain boundary features appeared on fracture surface,espe-cially for MG and LG alloy.The calculation of cyclic plastic zone(CPZ)sizes proved that grain boundary participated and promoted FCP behavior when CPZ covered grain and grain boundary together. | Kai Wen Xiwu Li Baiqing Xiong Haitao Lin Qinghong Wen Yanan Li Hongwei Yan Lizhen Yan Yongan Zhang Zhihui Li Hongwei Liu | 2023 | Progress in Natural Science:Materials International2023，33，1： | 0 |
| 18 | A novel self-activated ultraviolet persistent luminescence material and its anti-counterfeiting application based on intensity and time resolution from persistent luminescence显示文摘Recently,the ultraviolet(UV)persistent luminescence material(PLM)has attracted extensive attention.However,the design and development of new UV PLM and exploring their promising advanced application remain challenges.Here,we developed a new dopant-free self-activated UVA PLM,Zn_(2)Al_(2)SiO_(7),which could be applied in anti-counterfeiting field.Zn_(2)Al_(2)SiO_(7)shows UVA persistent luminescence(PersL)peaking at 380 nm after 254 nm UV lamp excitation.Addition of Yb^(3+),the UVA PersL intensity and time are raised obviously,and the UVA PersL time lasts more than 24 h.In addition,Yb^(3+)-doped Zn_(2)Al_(2)SiO_(7)exhibits photostimulated properties with different light source.Finally,we design anticounterfeiting pattern based on intensity and time resolution from PersL of Zn_(2)Al_(2)SiO_(7),showing its advantages in the anti-counterfeiting field. | Shanshan Peng Lin Liu Lizhen Wang Rui Rong Liang Song Weixiong You Junpeng Shi Yun Zhang | 2022 | Journal of Rare Earths2022，40，9： | 0 |
| 19 | Topological Similarity-Based Multi-Target Correlation Localization for Aerial-Ground Systems显示文摘In this paper,an algorithm for solving the multi-target correlation and co-location problem of aerial-ground heterogeneous system is investigated.Aiming at the multi-target correlation problem,the fusion algorithm of visual axis correlation method and improved topological similarity correlation method are adopted in view of large parallax and inconsistent scale between the aerial and ground perspectives.First,the visual axis was preprocessed by the threshold method,so that the sparse targets were initially associated.Then,the improved topological similarity method was used to further associate dense targets with the relative position characteristics between targets.The shortcoming of dense target similarity with small di®erence was optimized by the improved topological similarity method.For the problem of colocation,combined with the multi-target correlation algorithm in this paper,the triangulation positioning model was used to complete the co-location of multiple targets.In the experimental part,simulation experiments and°ight experiments were designed to verify the e®ectiveness of the algorithm.Experimental results show that the proposed algorithm can e®ectively achieve multi-target correlation positioning,and that the positioning accuracy is obviously better than other positioning methods. | Xudong Li Lizhen Wu Yifeng Niu Shengde Jia Bosen Lin | 2021 | Guidance, Navigation and Control2021，1，3： | 0 |
| 20 | Efficient expansion of rare human circulating hematopoietic stem/progenitor cells in steady-state blood using a polypeptide-forming 3D culture显示文摘Although widely applied in treating hematopoietic malignancies,transplantation of hematopoietic stem/progenitor cells(HSPCs)is impeded by HSPC shortage.Whether circulating HSPCs(cHSPCs)in steady-state blood could be used as an alternative source remains largely elusive.Here we develop a three-dimensional culture system(3DCS)including arginine,glycine,aspartate,and a series of factors.Fourteen-day culture of peripheral blood mononuclear cells(PBMNCs)in 3DCS led to 125-and 70-fold increase of the frequency and number of CD34+cells.Further,3DCS-expanded cHSPCs exhibited the similar reconstitution rate com-pared to CD34+HSPCs in bone marrow.Mechanistically,3DCS fabricated an immunomodulatory niche,secreting cytokines as TNF to support cHSPC survival and proliferation.Finally,3DCS could also promote the expansion of cHSPCs in patients who failed in HSPC mobilization.Our 3DCS successfully expands rare cHSPCs,providing an alternative source for the HSPC therapy,particularly for the patients/donors who have failed in HSPC mobilization. | Yulin Xu Xiangjun Zeng Mingming Zhang Binsheng Wang Xin Guo Wei Shan Shuyang Cai Qian Luo Honghu Li Xia Li Xue Li Hao Zhang Limengmeng Wang Yu Lin Lizhen Liu Yanwei Li Meng Zhang Xiaohong Yu Pengxu Qian He Huang | 2022 | Protein & Cell2022，13，11： | 0 |
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