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| 1 | The effect of Scuteilaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats显示文摘Flavonoids 被显示了改进认知功能并且推迟痴呆前进。然而,内在的机制留下逃犯。在现在的学习,我们检验了从 S 提取的黄芩 baicalensis 茎叶总数 flavonoids (SSTF ) 的效果。在脉管的痴呆(VaD ) 的空间学习和记忆上的 baicalensis Georgi 老鼠模型并且探索了它的分子的机制。VaD 老鼠被普通颈动脉动脉的永久双边的吸藏开发。在恢复以后的七天, VaD 老鼠与 SSTF 的 50 或 100 mg/kg 被对待 60 天。空间学习和记忆在莫利斯舞水迷宫(MWM ) 被评估测试。字形物 hyperphosphorylation 和相关蛋白质 kinases 或磷酸酶的层次被西方的污点分析检验。在 VaD 老鼠,在 100 mg/kg 的 SSTF 处理显著地在在 MWM 测试训练试用减少了逃跑潜伏。在探针试用, SSTF 治疗在目标象限增加了寻找的时间和旅行距离。SSTF 处理在 VaD 老鼠在外皮和马头鱼尾的怪兽禁止了字形物 phosphorylation。同时, SSTF 减少了肝糖 synthase kinase 的活动 3 并且 cyclin 依赖的 kinase 5 在 VaD 老鼠。相反, SSTF 处理在 VaD 老鼠增加了蛋白质磷酸酶 2A 子单元 B 的水平。SSTF 处理显著地在 VaD 老鼠改进了空间认知。我们的结果建议 SSTF 可以通过在击以后协调 kinases 和磷酸酶的活动减轻 tau-hyperphosphorylation-induced neurotoxicity。SSTF 可以为 VaD 被开发进有希望的新奇治疗学。 | Yanjing Cao Lizhen Liang Jian Xu Jiali Wu Yongxing Yan Ping Lin Qiang Chen Fengming Zheng Qin Wang Qian Ren Zengmei Gou Yifeng Du | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 10 |
| 2 | miR-137, a new target for post-stroke depression?显示文摘Expression of miR-137 is downregulated in brain tissue from patients with depression and suicidal behavior,and is also downregulated in peripheral blood from stroke patients.However,it is not yet known if miR-137 acts as a bridge between stroke and depression.To test this,we used middle cerebral artery occlusion and chronic mild stress to establish a post-stroke depression model in rats.Compared with controls,we found significantly lower miR-137 levels in the brain and peripheral blood from post-stroke depression rats.Injection of a miR-137 antagonist into the brain ventricles upregulated miR-137 levels,and improved behavioral changes in post-stroke depression rats.Luciferase assays showed miR-137 bound to the 3′UTR of Grin2A,regulating Grin2A expression in a neuronal cell line.Grin2A gene overexpression in the brain of post-stroke depression rats,noticeably suppressed the inhibitory effect of miR-137 on post-stroke depression.Overall,our results show that miR-137 suppresses Grin2A protein expression through binding to Grin2A mRNA,thereby exerting an inhibitory effect on post-stroke depression.Our results offer a new therapeutic direction for post-stroke depression. | Lixia Zhao Huazi Li Ruiyou Guo Teng Ma Rongyao Hou Xiaowei Ma Yifeng Du | 2013 | Neural Regeneration Research2013，8，26： | 8 |
| 3 | Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus显示文摘Ganoderma lucidum is a traditional Chinese medicine,which has been shown to have both anti-oxidative and anti-inflammatory effects,and noticeably decreases both the infarct area and neuronal apoptosis of the ischemic cortex.This study aimed to investigate the protective effects and mechanisms of pretreatment with ganoderma lucidum(by intragastric administration)in cerebral ischemia/reperfusion injury in rats.Our results showed that pretreatment with ganoder-ma lucidum for 3 and 7 days reduced neuronal loss in the hippocampus,diminished the content of malondialdehyde in the hippocampus and serum,decreased the levels of tumor necrosis fac-tor-αand interleukin-8 in the hippocampus,and increased the activity of superoxide dismutase in the hippocampus and serum.These results suggest that pretreatment with ganoderma lucidum was protective against cerebral ischemia/reperfusion injury through its anti-oxidative and an-ti-inflammatory actions. | Wangxin Zhang Qiuling Zhang Wen Deng Yalu Li Guoqing Xing Xianjun Shi Yifeng Du | 2014 | Neural Regeneration Research2014，9，15： | 6 |
| 4 | Label-free fiber nanograting sensor for real-time in situ early monitoring of cellular apoptosis显示文摘The achievement of functional nanomodules for subcellular label-free measurement has long been pursued in order to fully understand cellular functions.Here,a compact label-free nanosensor based on a fiber taper and zinc oxide nanogratings is designed and applied for the early monitoring of apoptosis in individual living cells.Because of its nanoscale dimensions,mechanical flexibility,and minimal cytotoxicity to cells,the sensing module can be loaded in cells for long term in situ tracking with high sensitivity.A gradual increase in the nuclear refractive index during the apoptosis process is observed,revealing the increase in molecular density and the decrease in cell volume.The strategy used in our study not only contributes to the understanding of internal environmental variations during cellular apoptosis but also provides a new platform for nonfluorescent fiber devices for investigation of cellular events and understanding fundamental cell biochemical engineering. | Danran Li Nina Wang Tianyang Zhang Guangxing Wu Yifeng Xiong Qianqian Du Yunfei Tian Weiwei Zhao Jiandong Ye Shulin Gu Yanqing Lu Dechen Jiang Fei Xu | 2022 | Advanced Photonics2022，4，1： | 5 |
| 5 | N-doped ordered mesoporous carbon spheres derived by confined pyrolysis for high supercapacitor performance显示文摘Herein, we report a confined pyrolysis strategy to prepare mesoporous carbon nanospheres by which surface area of carbon spheres is increased, pore size is enlarged and effective N-doping is achieved. In this method, the mesoporous polymer sphere as carbon precursor and 2-methylimidazole as nitrogen precursor are encapsulated in a compact silica shell which provides a confined nano-space for the pyrolysis treatment. The in situ generated gases from mesoporous polymer sphere and 2-methylimidazole under pyrolysis diffuse into the pores of mesoporous polymer sphere in the confined compact silica shell,resulting in increased surface area, larger pore size and N-doping due to self-activation effect. As electrodes in supercapacitor, the N-doped mesoporous carbon nanospheres exhibit a significantly enhanced specific capacitance of 326 Fg^-1 at 0.5 Ag^-1, which is 2 times higher than that of mesoporous carbon spheres under unconfined pyrolysis condition, exhibiting its potential for electrode materials with high performance. | Juan Du Lei Liu Yifeng Yu Yue Zhang Haijun Lv Aibing Chen | 2019 | Journal of Materials Science & Technology2019，35，10： | 4 |
| 6 | Significant effect of as-cast microstructure on texture evolution and magnetic properties of strip cast non-oriented silicon steel显示文摘In this study, two types of as-cast microstructure produced by strip casting were cold rolled and annealed to investigate the effect of initial microstructure on the textural evolution and magnetic properties of non-oriented silicon steel. The results indicated that the cold-rolled sheets of coarse-grained strip with pronounced {100} components exhibited stronger 入 fiber(<100>//ND) and weaker γ fiber(<111>//ND)texture as composed to the fine-grained strip with strong Goss({110}(001)) texture. After annealing, the former was dominated by η fiber(<001>//RD) texture with a peak at {110}<001)orientation, while the latter consisted of strong {111}(112) and relatively weak {110}(001) texture. In addition, a number of precipitates of size ~30-150 nm restricted the grain growth during annealing, resulting in recrystallization of grain size of ~46 μm in the coarse-grained specimen and ~41μm in the fine-grained specimen.Ultimately, higher magnetic induction(~1.72 T) and lower core loss(~4.04 W/kg) were obtained in the final annealed sheets of coarse-grained strip with strong {100} texture. | Haitao Jiao Yunbo Xu Wenzheng Qiu Haijie xu R.D.K.Misra Yifeng Du Jianping Li Guodong Wang | 2018 | Journal of Materials Science & Technology2018，34，12： | 4 |
| 7 | Effects of L-3-n-butylphthalide on caspase-3 and nuclear factor kappa-B expression in primary basal forebrain and hippocampal cultures after beta-amyloid peptide 1-42 treatment显示文摘BACKGROUND:L-3-n-butylphthalide(L-NBP) can inhibit phosphorylation of tau protein and reduce the neurotoxicity of beta-amyloid peptide 1-42(Aβ_(1-42)). OBJECTIVE:To observe the neuroprotective effects of L-NBP on caspase-3 and nuclear factor kappa-B(NF-κB) expression in a rat model of Alzheimer's disease. DESIGN,TIME AND SETTING:A cell experiment was performed at the Central Laboratory of Provincial Hospital affiliated to Shandong University between January 2008 and August 2008. MATERIALS:L-NBP(purity>98%) was provided by Shijiazhuang Pharma Group NBP Pharmaceutical Company Limited.Aβ_(1-42),3-[4,5-dimethylthiazolo-2]-2,5 iphenyltetrazolium bromide(MTT),and rabbit anti-Caspase-3 polyclonal antibody were provided by Cell Signaling, USA;goat anti-choactase and rabbit anti-NF-κB antibodies were provided by Santa Cruz,USA. METHODS:Primary cultures were generated from rat basal forebrain and hippocampal neurons at 17 or 19 days of gestation.The cells were assigned into five groups:the control group,the Aβ_(1-42) group(2μmol/ L),the Aβ_(1-42) + 0.1μmol/L L-NBP group,the Aβ_(1-42)+ 1μmol/L L-NBP group,and the Aβ_(1-42)+ 10μmol/L L-NBP group.The neurons were treated with Aβ_(1-42)(2μmol/L) alone or in combination with L-NBP(0.1,1,10μmol/L) for 48 hours.Cells in the control group were incubated in PBS. MAIN OUTCOME MEASURES:Morphologic changes were evaluated using inverted microscopy, viability using the MTT method,and the changes in caspase-3 and NF-κB expression using Western blot. RESULTS:Induction with Aβ_(1-42) for 48 hours caused cell death and soma atrophy,and increased caspase-3 and NF-κB expression(P<0.05).L-NBP blocked these changes in cell morphology, decreased caspase-3 and NF-κB expression(P<0.05),and improved cell viability,especially at the high dose(P<0.05). CONCLUSION:Aβ_(1-42) is toxic to basal forebrain and hippocampal primary neurons;L-NBP protects against this toxicity and inhibits the induction of caspase-3 and NF-κB expression. | Ruixia Wang Yong Zhang Liangliang Jiang Guozhao Ma Qingxi Fu Jialong Li Peng Yan Lunqian Shen Yabo Feng Chunxia Li Zaiying Pang Yuanxiao Cui Chunfu Chen Yifeng Du Zhaokong Liu | 2009 | Neural Regeneration Research2009，4，4： | 3 |
| 8 | Effect of olfactory ensheathing cell transplantation on myelin repair and motor function in a rat model of experimental allergic encephalomyelitis显示文摘BACKGROUND:Olfactory ensheathing cell transplantation can activate axonal regeneration and enhance myelin repair,which are beneficial for treating demyelinating diseases. OBJECTIVE:To explore the effects of olfactory ensheathing cell transplantation on myelin repair, synaptophysin expression,and motor function in a rat model of experimental allergic encephalomyelitis. DESIGN,TIME AND SETTING:A randomized,controlled experiment was performed at the Laboratory of Provincial Hospital affiliated to Shandong University between August 2006 and September 2007. MATERIALS:Dibenzylamine(Hoechst 33342),luxol fast blue,and rabbit anti-rat synaptophysin antibody were provided by Sigma,USA. METHODS:Olfactory ensheathing cells extracted from neonatal Wistar rats were cultured for 10-14 days and labeled with dibenzylamine.Spinal cord extracted from a healthy guinea pig was homogenized and equally mixed with complete Freund's adjuvant;thereafter,the mixture was intracutaneously injected into two posterior voix pedis of healthy male Wistar rats to establish models of experimental allergic encephalomyelitis.Rats were randomly divided into a control encephalomyelitis group and an olfactory ensheathing cell transplantation group,36 rats in each group.Physiological saline(2μL) or an olfactory ensheathing cell suspension(2μL) was separately injected along lateral cerebral ventricle at day 7 post-model induction. MAIN OUTCOME MEASURES:The migration and distribution of olfactory ensheathing cells were observed under fluorescence microscopy;myelin repair was detected using hematoxylin-eosin staining and luxol fast blue staining;synaptophysin expression was measured using immunohistochemical staining;motor function was evaluated using a motor function scale. RESULTS:Olfactory ensheathing cells could survive in vivo and migrate to the distal end of the transplant focus and spinal cord,and survived 21 days.Hematoxylin-eosin staining and luxol fast blue staining indicated that myelin in the transplantation group was intact,and the inflammatory focus gradually disappeared.Transplantation increased synaptophysin expression(P<0.05 versus control) and motor function(P<0.05). CONCLUSION:Olfactory ensheathing cell transplantation can promote myelin repair,increase synaptophysin protein expression,and ameliorate motor function in a rat model of experimental allergic encephalomyelitis. | Yifeng Du Shougang Guo Feng Jin Minzhong Wang Gongming Wang | 2009 | Neural Regeneration Research2009，4，4： | 1 |
| 9 | Expression of miR-150 and miR-3940-5p is reduced in non-small cell lungcarcinoma and correlates with clinicopathological features显示文摘 | Yifeng Sun Bo Su Peng Zhang Huikang Xie Hui Zheng Yongjie Xu Qiaoling Du Huan Zeng Xiao Zhou Chang Chen Wen Gao | 2013 | Oncology Reports2013，，2： | 1 |
| 10 | 'Dissolution-reassembly' for N-doped hollow micro/meso-carbon spheres with high supercapacitor performance显示文摘Herein, we report a 'dissolution-reassembly' approach for preparation of N-doped hollow carbon spheres with mesoporous/microporous composite structure (H(Micro/Meso)CS). Basing on the compositional inhomogeneity inside the nanospheres of 3-aminophenol/formaldehyde (3-AF) polymerization, the internal 3-AF oligomer with low-molecular-weight is dissolved by acetone to form cavity. Then the dispersive 3-AF oligomer reassemble with silica oligomer as pore-forming agent and cetyltrimethyl-ammonium bromide as surfactant to form a mesoporous outer shell. In addition, the amount of acetone has a great influence on the morphology and structure of H(Micro/Meso)CS. The obtained H(Micro/Meso)CS shows uniform spherical and microporous/mesoporous shell structure and has a high specific capacity and excellent high rate capability. | Juan Du Lei Liu Yifeng Yu Yue Zhang Aibing Chen | 2019 | Chinese Chemical Letters2019，30，7： | 1 |
| 11 | Expression and biological activity of double replica retrovirus carrier-mediated neurotrophin-3 in olfactory ensheathing cells显示文摘BACKGROUND:Previous studies have demonstrated that the combination of olfactory ensheathing cells(OECs) and neurotrophic factor-3(NT-3) in the rat lateral ventricle can promote nerve axonal regeneration and myelin sheath repair.However,this effect remains very short-lived, OBJECTIVE:To transfect NT-3 into OECs and to observe the biological activity of OEC-expressing NT-3. DESIGN,TIME AND SETTING:This genetic engineering,in vitro experiment was performed in the Provincial Hospital Affiliated to Shandong University between January 2007 and October 2008. MATERIALS:Trizol Reagent kit was purchased from Gibco,USA;reverse transcription kit,NT-3 Emax^(?)ImmunoAssay System reagent was purchased from Promega,USA. METHODS:Neonatal Wistar rat OECs were established as primary cultures and were transfected with pN2A-NT-3 viral vector.The OECs with the highest virus titer and stable cellular growth served as the transfection group;OECs transfected with NT-3-free retrovirus carrier pN2A served as the empty vector group;un-transfected OECs served as the control group.After adherence,the logarithmically cultured PC12-TrkC cells were plated in OECs supernatant from the transfection and empty vector groups,as well as 20μL PBS,and cultured for 4 days. MAIN OUTCOME MEASURES:NT-3 mRNA expression in OECs,fluorescence of NT-3-positive cells in the transfection group and control group;influence of OECs secreting NT-3 on the differentiation ratio of PC12-TrkC cells. RESULTS:NT-3 mRNA expression was observed 24 hours after transfection and lasted for 28 days, which was greater than the control and empty vector groups(P<0.01).A large number of NT-3-positive cells were observed in the transfection group,and immunofluorescence was greater than the control and empty vector groups.PC12-TrkC cells co-cultured with OECs from the transfection group exhibited a thick and long cell process,increased cell density,and the differentiation ratio was increased(P<0.01). CONCLUSION:Recombinant double replica retrovirus NT-3 gene was stably and effectively expressed in OECs,and the expressed NT-3 possessed biological activity that promoted neuronal survival. | Shougang Guo Yifeng Du Feng Jin Minzhong Wang | 2009 | Neural Regeneration Research2009，4，7： | 0 |
| 12 | Recombinant adeno-associated virus delivered human thioredoxin-PR39 prevents hypoxia-induced apoptosis of ECV304 cells显示文摘Human thioredoxin and antibacterial peptide, PR39, have been shown to have potent antioxidant effects that may prolong survival of cells during hypoxia. The pSSCMV/human thioredoxin-PR39 vector was successfully constructed in this study and used to infect ECV304 cells. Transfected ECV304 cells were incubated at 1%, 5% hypoxic, and normal oxygen conditions. We found that the number of apoptotic cells after transfection with recombinant adeno-associated virus-human thioredoxin -PR39 was significantly lower than controls, suggesting a protective effect of the recombinant human thioredoxin-PR39 protein on hypoxic cells. | Xiyun Ruan Zhenguo Yuan Yifeng Du Guangxiao Yang Quanying Wang | 2012 | Neural Regeneration Research2012，7，9： | 0 |
| 13 | Multiple factor analysis of symptomatic intracranial arterial stenosis显示文摘Objective: To discuss the correlation among intracranial arterial stenosis and its risk factors. Methods: A total of 486 patients with transient ischemic attack(TIA) or ischemic cerebral infarction were examined using color doppler flow imaging(CDFI) and transcranial doppler ultrosonography(TCD). According to the degrees of extracranial arterial stenosis, patients with mild-to-moderate extracranial stenosis were classified into group A(435 cases) while those with constant severe stenosis or occlusion were classified into group B(51 cases). The differences between the two groups of risk factors were compared, and the multi-factor logistic regression analysis of risk factors associated with moderately severe intracranial arterial stenosis was performed. Results:(1) The risk factors that were significantly associated with intracranial arterial stenosis included age(P = 0.034) and gender(P = 0.044).(2) Intracranial artery stenosis was observed in both anterior and posterior cerebral arteries in patients with hypertension, diabetes, and coronary heart disease respectively(P < 0.05).(3) Compared with group A, patients in group B were older(P = 0.000), with a higher proportion of men(P = 0.037), and the intracranial arterial stenosis degrees were significantly higher(P = 0.013).(4) Multi-factor logistic regression analysis showed that diabetes is a risk factor for moderately severe intracranial arterial stenosis(P < 0.05), and hyperlipidemia is a protective factor(P = 0.012). Conclusions: Age, gender, hypertension, diabetes, coronary heart disease, and smoking are risk factors for the distribution of intracranial arterial stenosis. The degrees of intracranial arterial stenosis are related with extracranial arterial stenosis. Diabetes is a risk factor for moderately severe intracranial arterial stenosis while hyperlipidemia is a protective factor. | Chuanqiang Qu Yuanyuan Zhao Qinjian Sun Yifeng Du | 2017 | Translational Neuroscience and Clinics2017，3，2： | 0 |
| 14 | Generation of genetically modified olfactory ensheathing cells that secrete VEGF: Potential application in cell-based treatment of leukoaraiosis显示文摘Objective: We aimed to provide an alternative cell source for cell therapy in leukoaraiosis(LA). Methods: Olfactory ensheathing cells(OECs) from the olfactory bulb were isolated,cultured, and purified. Next, the lentivirus carrying human VEGF165 gene was constructed and transfected into OECs. Results: The proliferative capacity of primary OECs was strong. OECs were infected with different multiplicity of infection. The expression level of VEGF was confirmed by real-time PCR with specific primers for GAPDH and VEGF, indicating that the genetically engineered OECs-VEGF produced VEGF with functional activity. Conclusions: Our data showed that these engineered OECs-VEGF highly express functional VEGF and retain the characteristics of astrocytes and Schwann cells,providing an alternative cell source for cell therapy in LA. | Chuanqiang Qu Yuanyuan Zhao Qinjian Sun Yifeng Du | 2017 | Translational Neuroscience and Clinics2017，3，2： | 0 |
| 15 | Effects of Applying Trace Clements on Yield and Quality of Flue-cured Tobacco Cuibi-1显示文摘[Objectives]To optimize the fertilization technology of flue-cured tobacco Cuibi-1.[Methods]From 2015 to 2016,the experiment of spraying Saikun multi-trace element water-soluble fertilizer was carried out.[Results]7 d and 14 d after transplanting tobacco seedlings,3750 mL/ha,300 times diluted Sakun multi-trace element aqueous solution was sprayed,the growth period of Cuibi-1 in the field was extended by 3-5 d.The incidence of mosaic disease at the rosette stage and granuville wilt at the foot leaf harvesting and curing stage decreased by 4.50-20.85 kg/ha,the yield increased by 67.8-68.7 kg/ha,the proportion of high-quality tobacco increased by 1.29-3.01 percentage points,and the output value increased by 2692.5-3441 yuan/ha,the sensory smoking quality has improved.[Conclusions]Increasing the application of multiple trace elements can increase the economic benefit and industrial use value of tobacco leaf production of Cuibi-1. | Xingchuan HU Yifeng WANG Yufeng DU Yukuo HU Shanhe XU | 2020 | Asian Agricultural Research2020，12，8： | 0 |
| 16 | Fine-Tuning Pyridinic Nitrogen in Nitrogen-Doped Porous Carbon Nanostructures for Boosted Peroxidase-Like Activity and Sensitive Biosensing显示文摘Carbon materials have been widely used as nanozymes in bioapplications,attributing to their intrinsic enzyme-like activities.Nitrogen(N)-doping has been explored as a promising way to improve the activity of carbon material-based nanozymes(CMNs).However,hindered by the intricate N dopants,the real active site of N-doped CMNs(N-CMNs)has been rarely investigated,which subsequently retards the further progress of high-performance N-CMNs.Here,a series of porous N-CMNs with well-controlled N dopants were synthesized,of which the intrinsic peroxidase(POD)like activity has a positive correlation with the pyridinic N content.Density functional theory calculations also reveal that pyridinic N boosts the intrinsic POD-like activity of N-CMNs.Pyridinic-N dopant can effectively promote the first H_(2)O desorption process in comparison with the graphitic and pyrrolic N,which is the key endothermic reaction during the catalytic process.Then,utilizing the optimized nanozymes with high pyridinic N content(NP-CMNs)and superior POD-like activity,a facile total antioxidant capacity(TAC)assay was developed,holding great promise in the quality assessment of medicine tablets and antioxidant food for healthcare and healthy diet. | Hongye Yan Linzhe Wang Yifeng Chen Lei Jiao Yu Wu Weiqing Xu Wenling Gu Weiyu Song Dan Du Chengzhou Zhu | 2020 | Research2020，，1： | 0 |
| 17 | S-scheme heterojunction/Schottky junction tandem synergistic effect promotes visible-light-driven catalytic activity显示文摘Designing photocatalysts with high light utilization and efficient photogenerated carrier separation for pollutant degradation is one of the important topics for sustainable development.In this study,hierarchical core–shell materialα-Fe_(2)O_(3)@ZnIn_(2)S_(4)with a step-scheme(S-scheme)heterojunction is synthesized by in situ growth technique,and MXene Ti_(3)C_(2)quantum dots(QDs)are introduced to construct a double-heterojunction tandem mechanism.The photodegradation efficiency ofα-Fe_(2)O_(3)@ZnIn_(2)S_(4)/Ti_(3)C_(2)QDs to bisphenol A is 96.1%and its reaction rate constant attained 0.02595 min^(−1),which is 12.3 times that of pureα-Fe_(2)O_(3).Meanwhile,a series of characterizations analyze the reasons for the enhanced photocatalytic activity,and the charge transport path of the S-scheme heterojunction/Schottky junction tandem is investigated.The construction of the S-scheme heterojunction enables the photo-generated electrons ofα-Fe_(2)O_(3)and the holes of ZnIn2S4 to transfer and combine under the action of the reverse built-in electric field.Due to the metallic conductivity of Ti_(3)C_(2)QDs,the photogenerated electrons of ZnIn_(2)S_(4)are further transferred to Ti_(3)C_(2)QDs to form a Schottky junction,which in turn forms a double-heterojunction tandem mechanism,showing a remarkable charge separation efficiency.This work provides a new opinion for the construction of tandem double heterojunctions to degrade harmful pollutants. | Shuai Wang Xin Du Changhao Yao Yifeng Cai Huiyuan Ma Baojiang Jiang Jun Ma | 2023 | Nano Research2023，16，2： | 0 |
| 18 | Ablation of Zfhx4 results in early postnatal lethality by disrupting the respiratory center in mice显示文摘Breathing is an integrated motor behavior that is driven and controlled by a network of brainstem neurons.Zfhx4 is a zinc finger transcription factor and our results showed that it was specifically expressed in several regions of the mouse brainstem.Mice lacking Zfhx4 died shortly after birth from an apparent inability to initiate respiration.We also found that the electrical rhythm of brainstem‒spinal cord preparations was significantly depressed in Zfhx4-null mice compared to wild-type mice.Immunofluorescence staining revealed that Zfhx4 was coexpressed with Phox2b and Math1 in the brainstem and that Zfhx4 ablation greatly decreased the expression of these proteins,especially in the retrotrapezoid nucleus.Combined ChIP‒seq and mRNA expression microarray analysis identified Phox2b as the direct downstream target gene of Zfhx4,and this finding was validated by ChIP‒qPCR.Previous studies have reported that both Phox2b and Math1 play key roles in the development of the respiratory center,and Phox2b and Math1 knockout mice are neonatal lethal due to severe central apnea.On top of this,our study revealed that Zfhx4 is a critical regulator of Phox2b expression and essential for perinatal breathing. | Meiqin Zhang Sichen Du Huayuan Ou Renjie Cui Nan Jiang Yifeng Lin Runsheng Ge Duan Ma Jin Zhang | 2021 | Journal of Molecular Cell Biology2021，13，3： | 0 |
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