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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | Automated Sequencing and Subassembly Detection in Automobile Body Assembly Planning显示文摘The choice of the sequence in which parts or subass em blies are put together in the mechanical assembly of a product can drastical ly affect the efficiency of the assembly process. Unlike metal cutting operation s where computer aided system have been available for some 15 to 25 years to hel p manufacturing engineers in generating cutting sequences and NC programs, the m ajority of assembly planning tasks in automobile body design is still manually p erformed by assembly designers according to their past experiences. This has prolonged the production lead time and time to market. This paper describes a p rocedure to automatically derive all the feasible assembly sequences for automob ile body assembly. The procedure is based on a mathematical model of the automob ile body, obtained through the definitions of the connection matrix and contract ed matrix. These two matrices represent the precedence constraint knowledge amon g components and subassemblies. The possible subassemblies are automatically det ected by satisfying some mathematical conditions applicable to these matrices. F or each subassembly and the whole product, all the possible assembly sequences a re generated by rearranging the initial connection sub-matrix and the contracte d matrix. The procedure is applicable to compliant component assemblies, suc h as the automobile body assembly, aircraft frame assembly, and can solve the 'combinatorial explosion' problem efficiently. | ZHANG Yi-zhu 1, NI Jun 2, LIN Zhong-qin 1, LAI Xin-min 1 (1. Institute of Mechanics and Engineering, Shanghai Jiaotong Universit y, Shanghai 200030, China 2. Department of Mechanical Engineering, The University of Michigan, Michigan, U SA) | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 3 |
| 3 | Identification of tumorigenic retinal stem-like cells in human solid retinoblastomas显示文摘 | Zhong X U Y Peng F Huang B Lin J Zhang W et at | 2007 | Int J Cancer2007，121，10： | 1 |
| 4 | Markers within the regulatory region of the growth hormone receptor gene and their association with milk-related traits in Holsteins 显示文摘 | Aggrey S E Yao J Sabour M P Lin C Y Zadworoy D Hayes J F and Kunlein U | 1999 | Heredity1999，90，1： | 1 |
| 5 | Highprevalence of leftventricular systolic and diastolicasynchrony in patients with congestive heart failure and normal QRS duration显示文摘 | Y U C M LIN H ZHANG Q | 2003 | Heart2003，89，1： | 1 |
| 6 | Value of delayed ^18F FDGPET imaging in the detection of hepatocellular carcinoma显示文摘 | LIN W Y TSAI S C HUNG G U | 2005 | Nucl Med Commun2005，26，： | 1 |
| 7 | Dissolution rates of limestones of different sources 显示文摘 | SHIH S M LIN J P SHIA U G Y | 2000 | Journal of Hazardous Materials2000，79，： | 1 |
| 8 | Intramucosal variant of nasal natural killer(NK)/T cell lymphoma has a better survival than does invasive variant:implication on loss of E26 transformation-specific sequence 1(ETS-1)and T-box expressed in T cells(T-bet)with invasion显示文摘 | Lin T C Chen S U Chen Y F | 2012 | Histopathology2012，60，2： | 1 |
| 9 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 10 | Arsenic related hearing loss in miners显示文摘 | Gülin G?k?en Kesici ?lhan ünlü Arzu Ba?türk Top?u Ceylan Demir Bal Engin Tutkun ?mer H?n? Y?lmaz | 2016 | American Journal of Otolaryngology--Head and Neck2016，，1： | 1 |
| 11 | Thermodynamicassessment and calculation of the Ti-Al system 显示文摘 | KATTNER U R LIN J C CHANG Y A | 1999 | Physical Metallurgy and Materials Science (A)1999，23，8： | 1 |
| 12 | Thermodynamic assessment and calculation of the Ti-Al system显示文摘 | KATTNER U R LIN J C CHANG Y A | 1992 | Metallurgical Transactions A1992，23，8： | 1 |
| 13 | Performance evaluation of technological innovation capabilities in uncertainty 显示文摘 | Cheng Y I L I Lin Y U A N | 2012 | Procedia-Social and Behavioral Sciences2012，40，1： | 1 |
| 14 | On the-fly TCP path selection algorithm in access link load balaneing显示文摘 | LIN Y D TSAO S C LEONG U P | 2007 | Computer Communications2007，30，2： | 1 |
| 15 | Caesarean scar pregnancy : Issues in management显示文摘 | Seow K M Huang L W Lin Y U | 2004 | Ultrasound Obstet Gynecol2004，23，3： | 1 |
| 16 | Enhancement of shikonin production in single aiad two-phase?:spension cultures of Lithospermum erythrorhizon cells using low-energy ultrasound显示文摘 | Lin L D W u J Y | 2002 | Biotechnology and Bioengi- neering2002，78，1： | 1 |
| 17 | Distribution system load flow calculation with microcomputer implementation显示文摘 | Lin C E Huang Y U Huang C L | 1987 | EPSR1987，13，： | 1 |
| 18 | The Leachability of Heavy Metals in Hardened Fly Ash Cement and Cement-solidified Fly Ash显示文摘 | Qijun Y U Nagatakis LIN Jinmei | 2005 | Cement and Concrete Research2005，35，6： | 1 |
| 19 | Highly dispersive photonic band gap prim显示文摘 | Lin Hawn Y U | 1996 | Opt Lett1996，74，10： | 1 |
| 20 | Differences between symmetric and asymmetric facilitation matter:exploring the interplay between modes of positive and negative plant interactions显示文摘 | Lin Y Berger U Grimm V | 2012 | Journal of Ecology2012，100，6： | 1 |
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