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| 1 | Topology-aware virtual network embedding based on closeness centrality显示文摘 | Zihou WANG Yanni HAN Tao LIN Yuemei XU Song CI Hui TANG | 2013 | Frontiers of Computer Science2013，7，3： | 5 |
| 2 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 3 | Production sharing contract: An analysis based on an oil price stochastic process显示文摘Assuming that oil price follows the stochastic processes of Geometric Brownian Motion (GBM) or the Mean-Reverting Process (MRP), this paper takes the net present value (NPV) as an economic index and models the PSC in 11 different scenarios by changing the value of each contract element (i.e. royalty, cost oil, profit oil as well as income tax). Then the NPVs are shown in probability density graphs to investigate the effect of different elements on contract economics. The results show that under oil price uncertainty the influence of profit oil and income tax on NPV are more significant than those of royalty and cost oil, while a tax holiday could improve the contractor's financial status remarkably. Results also show that MRP is more appropriate for cases with low future oil price volatility, and GBM is best for high future oil price volatility. | Liu Mingming Wang Zhen Zhao Lin Pan Yanni Xiao Fei | 2012 | Petroleum Science2012，9，3： | 3 |
| 4 | Pandemic of the aging society—sporadic cerebral small vessel disease显示文摘Age-related sporadic cerebral small vessel disease(CSVD)has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population.The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers’understanding in the in vivo evolution of CSVD,its impact upon the brain,its risk factors,and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD.In this review,we aimed to provide an update on the pathophysiology,risk factors,biomarkers,and the determinants and spectrum of the clinical manifestation of sporadic CSVD. | Alexander Yuk Lun Lau Bonaventure Yiu Ming Ip Ho Ko Bonnie Yin Ka Lam Lin Shi Karen Ka Yan Ma Lisa Wing Chi Au Yannie Oi Yan Soo Thomas Wai Hong Leung Adrian Wong Vincent Chung Tong Mok | 2021 | Chinese Medical Journal2021，，2： | 3 |
| 5 | Reliability Analysis for Complex Systems Based on Dynamic Evidential Network Considering Epistemic Uncertainty显示文摘Fault tolerant technology has greatly improved the reliability of modern systems on one hand and makes their failure mechanisms more complex on the other.The characteristics of dynamics of failure,diversity of distribution and epistemic uncertainty always exist in these systems,which increase the challenges in the reliability assessment of these systems significantly.This paper presents a novel reliability analysis framework for complex systems within which the failure rates of components are expressed in interval numbers.Specifically,it uses a dynamic fault tree(DFT)to model the dynamic fault behaviors and copes with the epistemic uncertainty using Dempster-Shafer(D-S)theory and interval numbers.Furthermore,an approach is presented to convert a DFT into a dynamic evidential network(DEN)to calculate the reliability parameters.Additionally,a sorting method based on the possibility degree is proposed to rank the importance of components represented by interval numbers in order to obtain the most critical components,which can be used to provide the guidance for system design,maintenance planning and fault diagnosis.Finally,a numerical example is provided to illustrate the availability and efficiency of the proposed method. | Rongxing Duan Yanni Lin Longfei Hu | 2017 | Computer Modeling in Engineering & Sciences2017，，1： | 1 |
| 6 | Remote control of the recruitment and capture of endogenous stem cells by ultrasound for in situ repair of bone defects显示文摘Stem cell-based tissue engineering has provided a promising platform for repairing of bone defects.However,the use of exogenous bone marrow mesenchymal stem cells(BMSCs)still faces many challenges such as limited sources and potential risks.It is important to develop new approach to effectively recruit endogenous BMSCs and capture them for in situ bone regeneration.Here,we designed an acoustically responsive scaffold(ARS)and embedded it into SDF-1/BMP-2 loaded hydrogel to obtain biomimetic hydrogel scaffold complexes(BSC).The SDF-1/BMP-2 cytokines can be released on demand from the BSC implanted into the defected bone via pulsed ultrasound(p-US)irradiation at optimized acoustic parameters,recruiting the endogenous BMSCs to the bone defected or BSC site.Accompanied by the daily p-US irradiation for 14 days,the alginate hydrogel was degraded,resulting in the exposure of ARS to these recruited host stem cells.Then another set of sinusoidal continuous wave ultrasound(s-US)irradiation was applied to excite the ARS intrinsic resonance,forming highly localized acoustic field around its surface and generating enhanced acoustic trapping force,by which these recruited endogenous stem cells would be captured on the scaffold,greatly promoting them to adhesively grow for in situ bone tissue regeneration.Our study provides a novel and effective strategy for in situ bone defect repairing through acoustically manipulating endogenous BMSCs. | Yanni He Fei Li Peng Jiang Feiyan Cai Qin Lin Meijun Zhou Hongmei Liu Fei Yan | 2023 | Bioactive Materials2023，，3： | 1 |
| 7 | An Investigation Report on Production Conditions of Sugarcane in Guangxi in 2016显示文摘To predict and assess production conditions of sugarcane in Guangxi in 2016,by using methods of field survey and data collection,the seedling situation,breed structure,planting area,planting period,plant diseases and insect pests of sugarcane in six major sugarcane producing cities of Guangxi were surveyed. The results show that the overall situation of sugarcane seedlings in Guangxi in 2016 became slightly worse than that in 2015,but there were enough good sugarcane seedlings in 2016. The dead heart rate of sugarcane decreased in most sugarcane regions from 2015 to 2016,that is,the comprehensive control of borers gave initial results; the smut infection rate of sugarcane rose from 2015 to 2016 and tended to increase. The situation of decrease in the planting area of sugarcane in three consecutive years was controlled,and the planting area of sugarcane increased slightly from 2015 to 2016. Due to the construction of ' double high' bases,the breed variety of sugarcane in Guangxi was improved further in 2016. It is necessary to strengthen field management and conduct chemical weeding,prevention and control of borers and aphids in the later period in time. | Yuchi DENG Weizan WANG RonghuaZHANG Shiyun TANG Shanhai LIN Qiang LIANG Weixing DUAN Xiang LI Guoying LU Shijian HAN Youzong HUANG Yebin YANG Yanni HUANG Lunwang WANG | 2017 | Asian Agricultural Research2017，9，6： | 0 |
| 8 | 台北艺术中心显示文摘正近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座约2000席的大型演艺厅和一个1500席的中型剧院,再加上一个黑盒子剧场。标志性的外形,饰以典型19世纪做法的保守内部剧场布局,以及见证社会阶级观念的包厢。纵然剧院最基本的构造元素如舞台、镜框式剧场和观众席等已有三千多年的历史,但我们仍不应以此为借口,让现代剧场建筑的创新发展停滞不前。 | Yannis Chan Hin-Yeung Cheung Jim Dodson Inge Goudsmit Alasdair Graham Vincent Kersten Chiaju Lin Vivien Liu Kai Sun Luk Kevin Mak Slobodan Radoman Roberto Requejo Saul Smeding Elaine Tsui Viviano Villarreal Casey Wang Leonie Wenz Frans Parthesius Iwan Baan | 2012 | 建筑技艺2012，，4： | 0 |
| 9 | Methodology and Trends of Linguistic Research in the Era of Big Data显示文摘This paper presents methodology and trends of linguistic research in the era of big data.We begin with a discussion of the role of linguists in the information society and illustrate the opportunities and challenges linguists are currently facing.After highlighting the significance of authentic data on linguistic research,we argue that language is a complex adaptive system driven by humans.Then,from the perspective of philosophy of science,we introduce the research paradigm of quantitative linguistics through several cases.Finally,we discuss how China’s linguistic research will benefit from the data-intensive approach in terms of scientification and internationalization. | Liu Haitao Lin Yanni | 2020 | Contemporary Social Sciences2020，5，4： | 0 |
| 10 | Hierarchical structures,surface morphology and mechanical elasticity of lamellar crystals dominated by halogen effects显示文摘To understand the deformation mechanism of molecular crystals under mechanical forces will accelerate the molecular design and preparation of deformable crystals.Herein,the relationship between structural halogenation and molecular-level stacking,micro/nanoscale surface morphology,and macroscopic mechanical properties are investigated.Elastic crystals of halo-pyrimidinyl carbazoles(CzM-Cl,CzM-Br and CzM-I)with lamellar structure and brittle crystal(CzM-F)were quantitatively analyzed by crystal energy framework(CEF)providing the inter/intralayer interaction energy(Inter/Intra-IE).It is revealed that the elastic crystals bend under external force as a result from stronger Intra-IE to prevent cleavage and weaker Inter-IE for the short-range movement of molecules on the slip plane.This research will provide an insight for the molecular design of flexible crystals and facilitate the development of next-generation smart crystal materials. | Chuanxin Wei Jianfeng Wang Yanni Zhang Xuehua Ding Yanze Jiang Qiang Zhao Jinyi Lin Jianfeng Zhao Linghai Xie Wei Huang | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 11 | Cytokine storm promoting T cell exhaustion in severe COVID-19 revealed by single cell sequencing data analysis显示文摘Background:Evidence has suggested that cytokine storms may be associated with T cell exhaustion(TEX)in COVID-19.However,the interaction mechanism between cytokine storms and TEX remains unclear.Methods:With the aim of dissecting the molecular relationship of cytokine storms and TEX through single-cell RNA sequencing data analysis,we identified 14 cell types from bronchoalveolar lavage fluid of COVID-19 patients and healthy people.We observed a novel subset of severely exhausted CD8 T cells(Exh T_CD8)that co-expressed multiple inhibitory receptors,and two macrophage subclasses that were the main source of cytokine storms in bronchoalveolar.Results:Correlation analysis between cytokine storm level and TEX level suggested that cytokine storms likely promoted TEX in severe COVID-19.Cell–cell communication analysis indicated that cytokines(e.g.CXCL10,CXCL11,CXCL2,CCL2,and CCL3)released by macrophages acted as ligands and significantly interacted with inhibitory receptors(e.g.CXCR3,DPP4,CCR1,CCR2,and CCR5)expressed by Exh T_CD8.These interactions formed the cytokine–receptor axes,which were also verified to be significantly correlated with cytokine storms and TEX in lung squamous cell carcinoma.Conclusions:Cytokine storms may promote TEX through cytokine-receptor axes and be associated with poor prognosis in COVID19.Blocking cytokine-receptor axes may reverse TEX.Our finding provides novel insights into TEX in COVID-19 and new clues for cytokine-targeted immunotherapy development. | Minglei Yang Chenghao Lin Yanni Wang Kang Chen Yutong Han Haiyue Zhang Weizhong Li | 2022 | Precision Clinical Medicine2022，5，2： | 0 |
| 12 | Sealed model and computation of hazardous waste landfill high voltage DC leakage detection显示文摘According to the structural characteristics of hazardous waste landfill and the leakage current model of high voltage DC Landfill leakage detection,a sealed model is established and analyzed in detail.The detection layer of the hazardous waste landfill is considered as a sealed space and it is assumed that the source current flows through the leak entirely.The leak is regarded as a positive current resource +I located at the current entrance or a negative resource-I located at the current exit,which depends on the placement of the current supply.The electrical potential of an arbitrary in detection layer satisfies Poisson equation.The boundary condition is regarded as a natural boundary condition for the high resistivity of high density polyethylene(HDPE) membrane.Based on which a numerical calculation method is developed.Satisfactory agreement between experimental data and simulated data validates the analysis.Parametric studies show that a larger horizontal distance between the power supply electrode and leak and a smaller distance between the detector electrodes and the detected liner are helpful to leak location.More parametric curves show that parameters leaks can be detected effectively with optimum selection of field survey. | 杨萍 Tian Jinwen Wang Yanni Xue Lin | 2015 | High Technology Letters2015，21，4： | 0 |
| 13 | Alterations in DNA damage response and repair genes as potential biomarkers for immune checkpoint blockade in gastrointestinal cancer显示文摘Objective:Immune checkpoint inhibitors(ICIs)have achieved remarkable results in cancer treatments.However,there is no effective predictive biomarker for gastrointestinal(GI)cancer.Methods:We conducted integrative analyses of the genomic and survival data of ICI-treated GI cancer patients from the Memorial Sloan Kettering Cancer Center cohort(MSK-GI,n=227),the Janjigian cohort(n=40),and the Peking University Cancer Hospital&Institute cohort(PUCH,n=80)to determine the possible associations between DNA damage response and repair(DDR)gene mutations and clinical outcomes.Data from The Cancer Genome Atlas database were analyzed to determine the possible correlations between DDR gene mutations and the tumor microenvironment.Results:In the MSK cohort,the presence of≥2 DDR gene mutations was correlated with prolonged overall survival(OS).The Janjigian and PUCH cohorts further confirmed that subgroups with≥2 DDR gene mutations displayed a prolonged OS and a higher durable clinical benefit.Furthermore,the DDR gene mutation load could be considered as an independent prognostic factor,and exhibited a potential predictive value for survival in GI cancer patients treated with ICIs.Mechanistically,we showed that the presence of≥2 DDR gene mutations was correlated with higher levels of tumor mutation burden,neoantigen,and T cell infiltration.Conclusions:The DDR gene mutation status was correlated with favorable clinical outcomes in GI cancer patients receiving ICIs,which could serve as a potential biomarker to guide patient selection for immunotherapy. | Yujiao Wang Xi Jiao Shuang Li Huan Chen Xin Wei Chang Liu Jifang Gong Xiaotian Zhang Xicheng Wang Zhi Peng Changsong Qi Zhenghang Wang Yanni Wang Na Zhuo Jianling Zou Henghui Zhang Jian Li Lin Shen Zhihao Lu | 2022 | Cancer Biology & Medicine2022，19，8： | 0 |
| 14 | 台北艺术中心显示文摘为什么过去百年间最令人兴奋的剧场盛事总是发生在正规场所之外?建筑如何才能超越自身卑微的命运,摆脱那种限制各种可能的宿命?
近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座约2 000席的大型演艺厅和一个1 500席的中型剧院,再加上一个黑盒子剧场。 | Yannis Chan Hin-Yeung Cheung Inge Goudsmit Vincent Kersten Chiaju Lin Kevin Mak Jim Dodson Alasdair Graham Vivien Liu Kai Sun Luk Slobodan Radoman Roberto Requejo Saul Smeding Elaine Tsui Viviano Villarreal Casey Wang Leonie Wenz | 2014 | 城市环境设计2014，，6： | 0 |
| 15 | Green-synthesized,low-cost tetracyanodiazafluorene(TCAF) as electron injection material for organic light-emitting diodes显示文摘Two electron-deficient azaacenes including di-and tetra-cyanodiazafluorene(DCAF and TCAF)with the advantages of deep lowest unoccupied molecular orbital(LUMO),green-synthesis,low-cost,simply purification method,excellent yields have been obtained,characterized and used as electron injection materials(EIMs)in three groups of electroluminescence devices.Device B with TCAF as EIM exhibited the best performance including turn-on voltage of 5.0 V,stronger maximum luminance intensity of 31,549 cd/m2,higher luminance efficiency of 62.34 cd/A and larger power efficiency of 21.74 lm/W which are 0.53,6.7,9.3 and 15.3 times than that of device A with DCAF as EIMs,respectively.The enhanced interfacial electron injection ability of TCAF than that of DCAF is supported by its better electron mobility in electron-only device,deeper LUMO(-4.52 eV),and stronger electronic affinity.Best external quantum efficiency of 16.56%was achieved with optimized thicknesses of TCAF as EIM and TPBi as electron transporting layer.As a new comer of acceptor family,TCAF would push forward organic electronics with more fascinating and significant applications. | Bing Yang Jianfeng Zhao Zepeng Wang Zhenlin Yang Zongqiong Lin Yanni Zhang Jiewei Li Linghai Xie Zhongfu An Hongmei Zhang Jiena Weng Wei Huang | 2019 | Chinese Chemical Letters2019，30，11： | 0 |
| 16 | Gadolinium-containing semiconducting polymer nanoparticles for magnetic resonance/fluorescence dual-modal imaging and photothermal therapy of oral squamous cell carcinoma显示文摘Oral squamous cell carcinoma(OSCC)is the most common malignant tumor of the oral and maxillofacial region.Due to its unique location,earlier and more accurate diagnosis and more minimally invasive treatment of OSCC is of major importance.Herein,gadolinium-containing semiconductor polymer nanoparticles(SPN-Gd)were designed and prepared.The nanoparticles consist of a near-infrared(NIR)absorption semiconductor polymer(PCPDTBT)served as fluorescence signal source and a photothermal conversion agent(PTA)and a gadolinium-grafted triblock amphiphilic copolymer(F127-DTPA-Gd)served as a magnetic resonance imaging(MRI)contrast agent and nanocarrier.The experiments in vivo showed that SPN-Gd could act as an MRI contrast agent and optical image agent with a long retention time,and it had a significant inhibiting effect on tumors of OSCC mice model through photothermal therapy(PTT).Thus our study provides a simple nanotheranostic platform composed of two components for efficient MR/fluorescence dual-modal imaging-guided PTT. | Xiao Pan Antian Gao Yanni Hu Ziyang Hu Chen Xie Zitong Lin | 2023 | Nano Research2023，16，2： | 0 |
| 17 | A cost-effective ts CUT&Tag method for profiling transcription factor binding landscape显示文摘Knowledge of the transcription factor binding landscape(TFBL)is necessary to analyze gene regulatory networks for important agronomic traits.However,a low-cost and high-throughput in vivo chromatin profiling method is still lacking in plants.Here,we developed a transient and simplified cleavage under targets and tagmentation(tsCUT&Tag)that combines transient expression of transcription factor proteins in protoplasts with a simplified CUT&Tag without nucleus extraction.Our tsCUT&Tag method provided higher data quality and signal resolution with lower sequencing depth compared with traditional ChIP-seq.Furthermore,we developed a strategy combining tsCUT&Tag with machine learning,which has great potential for profiling the TFBL across plant development. | Leiming Wu Zi Luo Yanni Shi Yizhe Jiang Ruonan Li Xinxin Miao Fang Yang Qing Li Han Zhao Jiquan Xue Shutu Xu Tifu Zhang Lin Li | 2022 | Journal of Integrative Plant Biology2022，64，11： | 0 |
| 18 | Simultaneous Determination of Six Components in Wanjinxiang Shushuang Ointment by QAMS显示文摘[Objectives]To regulate the quality of Wanjinxiang Shushuang Ointment through simultaneously quantifying menthol,camphor,1,8-cineole,linalool,borneol and caryophyllene oxide by QAMS(quantitative analysis of multi-components by single-marker).[Methods]The method was performed using an Agilent DB-WAX(30 m×0.32 mm,0.25μm)polyethylene glycol chromatographic column;with nitrogen employed as a carrier gas.The constant pressure was 4.73 psi;and the injection temperature was 240℃,with a shunt ratio:of 10:1;The hydrogen flame ion detector with a detector temperature of 240℃;the injection volume was 0.3μL.To verify the accuracy and applicability of QAMS,the results were compared with those obtained using the internal standard method(naphthalene).[Results]In Wanjinxiang Shushuang Ointment,menthol,camphor,1,8-cineole,linalool,borneol,caryophyllene oxide and naphthalene were well separated by the same chromatography with good linearity in their respective ranges(R≥0.9992).The average recoveries were 99.66%,101.03%,98.07%,98.24%,101.39%,and 103.39%with RSD s of 0.69%,1.52%,1.25%,1.94%,1.44%,and 2.74%,respectively.The QAMS is similar to the internal standard method.[Conclusions]This simple,accurate method with high precision,separation and reproducibility can serve as a reference for the quality control of Wanjinxiang Shushuang Ointment. | Yanni MAO Lin YANG Xiaoyao XIE Jinyan JIA Qing WU Cun WU | 2023 | Medicinal Plant2023，14，5： | 0 |
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