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| 1 | Aquaporin 4 expression and ultrastructure of the blood-brain barrier following cerebral contusion injury显示文摘This study aimed to investigate aquaporin 4 expression and the ultrastructure of the blood-brain barrier at 2-72 hours following cerebral contusion injury,and correlate these changes to the formation of brain edema.Results revealed that at 2 hours after cerebral contusion and laceration injury,aquaporin 4 expression significantly increased,brain water content and blood-brain barrier permeability increased,and the number of pinocytotic vesicles in cerebral microvascular endothelial cells increased.In addition,the mitochondrial accumulation was observed.As contusion and laceration injury became aggravated,aquaporin 4 expression continued to increase,brain water content and blood-brain barrier permeability gradually increased,brain capillary endothelial cells and astrocytes swelled,and capillary basement membrane injury gradually increased.The above changes were most apparent at 12 hours after injury,after which they gradually attenuated.Aquaporin 4 expression positively correlated with brain water content and the blood-brain barrier index.Our experimental findings indicate that increasing aquaporin 4 expression and blood-brain barrier permeability after cerebral contusion and laceration injury in humans is involved in the formation of brain edema. | Xinjun Li Yangyun Han Hong Xu Zhongshu Sun Zengjun Zhou Xiaodong Long Yumin Yang Linbo Zou | 2013 | Neural Regeneration Research2013，8，4： | 2 |
| 2 | Experimental investigation of Z-pinch radiation source for indirect drive inertial confinement fusion显示文摘Z-pinch dynamic hohlraums(ZPDHs)could potentially be used to drive inertial confinement fusion targets.Double-or multishell capsules using the technique of volume ignition could exploit the advantages of ZPDHs while tolerating their radiation asymmetry,which would be unacceptable for a central ignition target.In this paper,we review research on Z-pinch implosions and ZPDHs for indirect drive targets at the Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics.The characteristics of double-shell targets and the associated technical requirements are analyzed through a one-dimensional computer code developed from MULTI-IFE.Some key issues regarding the establishment of suitable sources for dynamic hohlraums are introduced,such as soft X-ray power optimization,novel methods for plasma profile modulation,and the use of thin-shell liner implosions to inhibit the generation of prior-stagnated plasma.Finally,shock propagation and radiation characteristics in a ZPDH are presented and discussed,together with some plans for future work. | Zhenghong Li Zhen Wang Rongkun Xu Jianlun Yang Fan Ye Yanyun Chu Zeping Xu Faxin Chen Shijian Meng Jianmin Qi Qinyuan Hu Yi Qin Jiaming Ning Zhanchang Huang Linbo Li Shuqing Jiang | 2019 | Matter and Radiation at Extremes2019，4，4： | 1 |
| 3 | Exploring a particle-size-reduction strategy of YAG:Ce phosphor via a chemical breakdown method显示文摘Particle size reduction of Y_(3)Al_(5)O_(12):Ce(YAG:Ce) phosphor is highly needed for micro-LED display applications.In this work,size control of YAG:Ce phosphor particles is achieved via carbon coating and further heat treatment.A thin layer of carbon is deposited on the surface of YAG:Ce by chemical vapor deposition.During the heat treatment,carbon reacts with oxygen element in the phosphor and escapes from phosphor particles.The reaction results in the phosphor breaking into smaller particles.The phosphors were characterized by laser light scattering for particle size distribution,scanning electron microscopy(SEM),transmission electron microscopy for morphologies,X-ray diffraction refinements for crystal structure and electron energy-loss spectroscopy for elemental analysis.It is demonstrated that the median diameter(D_(50)) of the phosphor particle size is significantly reduced from 19.1 to 0.96 μm yet the photoluminescent properties have little changes.The carbon coating and further heat treatment method show potential application in size control of phosphors. | Hongren Chen Licheng Ju Li Zhang Xin Wang Linbo Zhang Xin Xu Lin Gao Kehui Qiu Liangjun Yin | 2021 | Journal of Rare Earths2021，39，8： | 1 |
| 4 | Coaxial metal nano-/mierocables with isolating sheath:synthetic methodolo- gy and their application as interconnects显示文摘 | GAO Minrui XU Weihong LUO Linbo | 2010 | Advanced Mate rials2010，22，17： | 1 |
| 5 | Overexpression of ERα inhibits proliferation and invasion of MKN28 gastriccancer cells by suppressing β-catenin显示文摘 | Jichun Zhou Rongyue Teng Chaoyang Xu Qinchuan Wang Jufeng Guo Chenpu Xu Ziduo Li Shuduo Xie Jianguo Shen Linbo Wang | 2013 | Oncology Reports2013，，4： | 1 |
| 6 | Temporal dynamic changes of connexin 43 expression in C6 cells following lipopolysaccharide stimulation显示文摘Connexin 43,a gap junction protein,is expressed mainly in glia in the central nervous system.Neuroinflammation plays an important role in central nervous system injury.Changes to glial connexin 43 levels and neuroinflammation may trigger brain injury and neurodegenerative diseases.To illustrate the relationship between connexin 43 and neuroinflammation,this study investigated how connexin 43 expression levels change in lipopolysaccharide-stimulated rat C6 glioma cells.C6 cells were treated with 0.05,0.25,0.5,1,2.5 and 5 μg/mL lipopolysaccharide for 24 hours.The nitrite estimation-detected nitric oxide release level was elevated substantially after lipopolysaccharide stimulation.To test the transcriptional level changes of inducible nitric oxide synthase,tumor necrosis factor-α and connexin 43 mRNA,C6 cells were treated with 5 μg/mL lipopolysaccharide for 3-48 hours.Reverse transcription-PCR showed that the expression of inducible nitric oxide synthase and tumor necrosis factor-α mRNA increased over time,but connexin 43 mRNA levels increased in lipopolysaccharide-stimulated C6 cells at 3 and 6 hours,and then decreased from 12 to 48 hours.Connexin 43 protein expression was detected by immunofluorescence staining,and the protein levels matched the mRNA expression levels.These results suggest that connexin 43 expression is biphasic in lipopolysaccharide-induced neuroinflammation in C6 cells,which may be correlated with the connexin 43 compensatory mechanism. | Ling Liu Zhenping Gao Linbo Zhang Lue Su Guojun Dong Haiyang Yu Jiayi Tian Hang Zhao Yanyan Xu Haiyan Liu | 2012 | Neural Regeneration Research2012，7，25： | 1 |
| 7 | Influence of alumina abrasive tool wear on ground surface characteristics and corrosion properties of K444 nickel-based superalloy显示文摘K444 nickel-based superalloy is an important material to manufacture the gas turbine due to its excellent mechanical properties at high temperatures and corrosion resistance.Currently,grinding is the mostly used method for the surface finish of the K444 alloy components.However,few studies worked on the effects of the abrasive tool wear on the ground surface characteristics and corrosion properties of K444 alloy.This study uses two different-type alumina abrasive tools,i.e.,white alumina(WA)and microcrystalline alumina(MA)wheels,to grind the K444 alloy.The influence of the alumina abrasive tool wear on ground surface characteristics and corrosion resistance performance are investigated.It is discovered that the MA wheel presents a slighter wheel wear and higher self-sharpening than the WA wheel.Compared to the WA wheel,the MA wheel has less material adhesion,which leads to a better surface finish.In the corrosion testing,the maximum corrosion depth is 80μm in the surface ground by the MA wheel but 100μm in the surface ground by the WA wheel,which demonstrates that the MA wheel grinding benefits the surface corrosion resistance of K444 alloy.Therefore,this study could provide a guide to selecting the abrasive tools and optimizing the grinding process of the K444 alloy. | Min LI Jingfei YIN Linbo CHE Wenfeng DING Jiuhua XU | 2022 | Chinese Journal of Aeronautics2022，35，6： | 0 |
| 8 | Weak Fault Detection of Rotor Winding Inter-Turn Short Circuit in Excitation System Based on Residual Interval Observer显示文摘Aiming at the fact that the rotor winding inter-turn weak faults can hardly be detected due to the strong electromagnetic coupling effect in the excitation system,an interval observer based on current residual is designed.Firstly,the mechanism of the inter-turn short circuit of the rotor winding in the excitation system is modeled under the premise of stable working conditions,and electromagnetic decoupling and system simplification are carried out through Park Transform.An interval observer is designed based on the current residual in the two-phase coordinate system,and the sensitive and stable conditions of the observer is preset.The fault diagnosis process based on the interval observer is formulated,and the observer gain matrix is convexly optimized by linear matrix inequality.The numerical simulation and experimental results show that the inter-turn short circuit weak fault is hardly detected directly through the current signal,but the fault is quickly and accurately diagnosed through the residual internal observer.Compared with the traditional fault diagnosis method based on excitation current,the diagnosis speed and accuracy are greatly improved,and the probability of misdiagnosis also decreases.This method provides a theoretical basis for weak fault identification of excitation systems,and is of great significance for the operation and maintenance of excitation systems. | Gang Liu Xinqi Chen Lijuan Bao Linbo Xu Chaochao Dai Lei Yang Chengmin Wang | 2023 | Structural Durability & Health Monitoring2023，17，4： | 0 |
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