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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | High-dose intravenows gammaglobulin therap for neonatal autoimmune 显示文摘 | BALLIN A ANDREW M LING E | 1998 | Thrombocytopenia J Pediatr1998，112，： | 1 |
| 3 | Pain flare following external beam radiotherapy and meaningful change in pain scores in the treatment of bone metastases显示文摘 | Chow E Ling A Davis L | 2005 | Radiother Oncol2005，75，1： | 1 |
| 4 | Alloys of magnesium显示文摘 | Huddle R A U Ling J Jessup A C Emley E F | | 0，，： | 1 |
| 5 | Synthesis of gasoline from syngas via dimethyl ether显示文摘 | KOLESNICHENKO N V KITAEV L E BUKINA Z M MARKOVA N A YUSHCHENKO V V YASHINA O V LING I ROZOVSKII A Y | 2007 | Kinet Catal2007，48，6： | 1 |
| 6 | Expression of purinergic receptors in non melanoma skin cancers and their functional roles in A431 cells显示文摘 | Greig A V Linge C Healy V Lim P Clayton E Rustin M H | 2003 | J Invest Dermatol2003，121，： | 1 |
| 7 | RFLP analysis of SLA haplotypes in Swiss Large White and American Hampshire pigs using SLA class Ⅰand class Ⅱ probes显示文摘 | Gautischi C Ling M S Beever J E Mclaren D G Lewin H A Schook L B | 1991 | Animal Biotechnology1991，2，： | 1 |
| 8 | An automated plant monitoring system using machine vision 显示文摘 | Giacomelli G A Ling P P Morden R E | | Acta Horticulturae0，440，： | 1 |
| 9 | The origin and nature of ramified and amoeboid microglia: a historical review and current concepts 显示文摘 | Ling E A Wong W C | 1993 | Glia1993，7，： | 1 |
| 10 | High-dose intravenous gammaglobulin therapy for neonatal autoimmune thrombocytopenia 显示文摘 | Ballin A Andrew M Ling E | 1988 | J Pediatr1988，112，5： | 1 |
| 11 | Seasonal trend of viral respiratory tract infections in the tropics显示文摘 | Chew F T Doraisingham S Ling A E | 1998 | Epidemiol Infect1998，121，： | 1 |
| 12 | CSF flow dynamics at the craniovertebral junction studied with an idealized model of the subarachnoid space and computational flow analysis显示文摘 | Linge S O Haughton V Lovgren A E | 2010 | AJNR2010，31，1： | 1 |
| 13 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014，344，6179： | 1 |
| 14 | High-dost intravenousgammaglobulin therapy for neonatal autoimmune thrombocytopenia显示文摘 | Andrew M Ling E | 1998 | J Pediatr1998，121，： | 1 |
| 15 | Urolithiasis in dogs V:regional comparisons of breed,age,sex,anatomic location,and mineral type of calculus显示文摘 | Franti C E Ling G V Ruby A L | 1999 | American Journal of Veterinary Research1999，60，1： | 1 |
| 16 | Antioxidants and neuroprotection inthe adult and developing central nervous system显示文摘 | KAUR C LING E A | 2008 | CurrMedChem2008，15，29： | 1 |
| 17 | SOCS-I protects from virally-induced CD8 T cell mediated type I diabetes 显示文摘 | BARRAL A M THOMAS H E LING E M | 2006 | Journal of Autoimmunity2006，27，3： | 1 |
| 18 | High-dose intravenous gammaglobulin therapy for neonatal autoimmune thrombocytopenia显示文摘 | BALLIN A ANDREW M LING E | 1998 | Pediatr1998，112，： | 1 |
| 19 | Effect of respiratory gating onquantifying PET images of lung cancer 显示文摘 | Nehmeh S A Erdi Y E Ling C C | 2002 | J Nucl Med2002，43，： | 1 |
| 20 | Testing the iron hypothesis in ecosystems of the equatorial Pacific Ocean 显示文摘 | Martin J H CoMe K H Johnson K S Fitzwater S E Gordon R M Tanner S J Hunter C N Elrod V A Nowicki J L Coley T L Barber R T Lindley S Watson A J Van Scoy K Law C S Liddicoat M I Ling R Stanton T Stoekel J Collins C Anderson A Bidigare R Ondrusek M Latasa M Millero F J Lee K Yao W Zhang J Z Friederich G Sakamoto C Chavez F Buck K Kolber Z Greene R Falkowski P Chisholm S W Hoge F Swift R Yangel J Turner S Nightingale P Hatton A Liss P Tindale N W | 1994 | Nature1994，371，6493： | 1 |
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