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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Surface states in TiO2 submicrosphere films and their effect on electron transport显示文摘 | Li'e Mo Wangchao Chen Ling Jiang Yong Ding Zhaoqian Li Linhua Hu Songyuan Dai | 2017 | Nano Research2017，10，11： | 3 |
| 3 | MORN3:MEIG1的分子伴侣在小鼠生精细胞中的表达显示文摘哺乳动物精子发生由细胞发育和分化的精细过程组成。减数分裂基因1(MEG1)在调节精子发生过程中起着重要作用。为探讨MEIGl的作用机制,采用酵母双杂交筛选出可能与MEIG1发生作用的多个蛋白,OJMORN3蛋白。通过制备全长MORN3蛋白N端的特异性多克隆抗体,分别在体外和体内研究MORN3的表达和定位。免疫荧光染色转染CHO细胞显示,MORN3定位在整个包浆。体内实验证实25kDa的MORN3蛋白仅在小鼠睾丸组织中表达,且主要在出生后20天开始表达,即主要表达于精子发生的第三阶段生精细胞变态期。在从成年野生型小鼠分离的混合睾丸细胞的整个生精细胞变态期,MORN3均表达于顶体,在长形精子期该蛋白同时也在精子领表达。在Meig—J基因敲除小鼠中,MORN3总体表达水平和在顶体中的定位没有改变,但在精子领的表达显著降低。以上研究表明MORN3作为MEIGl蛋白的分子伴侣,可能是精子发生过程的另一个重要调节因子。 | Ling Zhang Xue-Jun Shang Hong-Fei Li Yu-Qin Shi Wei Li Maria E Teves Zhi-Qiong Wang Gao-Feng Jiang Shi-Zhen Song Zhi-Bing Zhang | 2015 | Asian Journal of Andrology2015，17，1： | 3 |
| 4 | High-dose intravenows gammaglobulin therap for neonatal autoimmune 显示文摘 | BALLIN A ANDREW M LING E | 1998 | Thrombocytopenia J Pediatr1998，112，： | 1 |
| 5 | Positive inductive effect of IL-2 on virus-specific cellular responses elicited by a PRRSV-ORF7 DNA vaccine swine 显示文摘 | Rompato G Ling E Chen Z | 2006 | Vet Immunol immunop2006，109，12： | 1 |
| 6 | Pain flare following external beam radiotherapy and meaningful change in pain scores in the treatment of bone metastases显示文摘 | Chow E Ling A Davis L | 2005 | Radiother Oncol2005，75，1： | 1 |
| 7 | Predicting performance of Design-Build and Design-Bid-Build projects 显示文摘 | F Y Ling S L Chan E Chong | 2004 | Journal of Construction Engineering and Management2004，130，1： | 1 |
| 8 | Polymer memories: Bistable electrical switching and device performance显示文摘 | Ling Qidan Liaw D J Teo E Y H | 2007 | Polymer2007，48，18： | 1 |
| 9 | , Relation of Cd4+ CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease 显示文摘 | Ling E M Smith T Nguyen X D | 2004 | Lancet2004，363，9409： | 1 |
| 10 | IVF results in de novo DNA methylation and histonc metylation at an Igf2-H19 imprinting epigenetic switch 显示文摘 | Li T Vu TH Ulaner GA Littman E Ling JQ Chen HL | 2005 | Mol Hum Reprod2005，11，9： | 1 |
| 11 | Increased if-equency of regulator), T cells in peripheral blood and tu- rnout infiltrating lymphocytes in colorectal cancer patients 显示文摘 | LING K L PRATAP S E BATES G J | 2007 | Cancer Irnmun2007，28，7： | 1 |
| 12 | Contour based object detection using part bundles显示文摘 | Lu C E Adluru N Ling H B | 2010 | Computer Vision and Image Understand- ing2010，114，7： | 1 |
| 13 | Classification of larval circulating hemocytes of the silkworm,Bombyx mori,by acridine orange and propidium iodide staining显示文摘 | LING E SHIRAI K KIGUCHI K | 2004 | Histochem Cell Biol2004，120，： | 1 |
| 14 | Crystallization and morphology study of polyhedral oligomeric silsesquioxane (POSS) / polysiloxane elastomer composites prepared by melt blending显示文摘 | James E Liu Ling Tian Ming | 2007 | Polymer2007，48，： | 1 |
| 15 | A new 3D nickel(II) framework composed of large rings: ionothermal syn- thesis and crystal structure 显示文摘 | Ling X Choi E Y Kwon Y U | 2008 | J Solid State Chem2008，181，11： | 1 |
| 16 | Alloys of magnesium显示文摘 | Huddle R A U Ling J Jessup A C Emley E F | | 0，，： | 1 |
| 17 | Texture segmentation using hierarchical wavelet decomposition显示文摘 | Ling Z | 1995 | Pattern Recognition1995，28，12： | 1 |
| 18 | Synthesis and nearly monochromatic photoluminescence properties of conjugated copolymers containing fluorine and rare earth complexes显示文摘 | LING Q D KANG E T NEOH K G | 2003 | Macromolecules2003，36，19： | 1 |
| 19 | Synthesis of gasoline from syngas via dimethyl ether显示文摘 | KOLESNICHENKO N V KITAEV L E BUKINA Z M MARKOVA N A YUSHCHENKO V V YASHINA O V LING I ROZOVSKII A Y | 2007 | Kinet Catal2007，48，6： | 1 |
| 20 | Microsomal formation of apyrrolic alcohol glutathione conjugate of clivorine,Firmevidence for the form ation of a pyrrolic metabolite of anotonecine-type pyrrolizidine al- kaloid显示文摘 | LING CUI YY HAWES E M | 1998 | Drug Metab Dispos1998，26，2： | 1 |
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