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4篇 您的检索式:作者名="Ling Lunjiang"
    题名 作者 年代 出处 被引量
1Optimization of Molecular Similarity Index with Applications to Biomolecules显示文摘Lunjiang Ling Guoliang Xue 1999Journal of Global Optimization1999,,3:1
2Topological Structure Analysis of the Protein-protein Interaction Network in Budding Yeast显示文摘Sun Shiwei Ling Lunjiang Zhang Nan 2003Nucleic Acids Research2003,31,9:1
3Phylogeny of SARS-CoV as inferred from complete genome comparison显示文摘SARS-CoV, as the pathogeny of severe acute respiratory syndrome (SARS), is a mystery that the origin of the virus is still unknown even a few isolates of the virus were completely sequenced. To explore the genesis of SARS-CoV, the FDOD method previously developed by us was applied to comparing complete genomes from 12 SARS-CoV isolates to those from 12 previously identified coronaviruses and an unrooted phylogenetic tree was constructed. Our results show that all SARS-CoV isolates were clustered into a clique and previously identified coronaviruses formed the other clique. Meanwhile, the three groups of coronaviruses depart from each other clearly in our tree that is consistent with the results of prevenient papers. Differently, from the topology of the phylogenetic tree we found that SARS-CoV is more close to group 1 within genus coronavirus. The topology map also shows that the 12 SARS-CoV isolates may be divided into two groups determined by the association with the SARS-CoV from the Hotel M in Hong Kong that may give some information about the infectious relationship of the SARS.QI Zhen HU Yu LI Wei CHEN Yanjun ZHANG Zhihua SUN Shiwei LU Hongchao ZHANG Jingfen BU Dongbo LING Lunjiang CHEN Runsheng 2003Chinese Science Bulletin2003,48,12:0
4Molecular dynamics simulation of site-directed mutagenesis of HIV-1 Tat trans-activator显示文摘The Cys-rich domain, core region and basic domain are highly conserved and very important to the trans-activation activity of HIV-1 Tat trans-activator. The three-dimensional structures of 6 mutants of HIV-1 Tat protein were constructed with the methods of molecular dynamics simulation. The variations of the structures of the mutants have been analyzed and the factors that led to abolishment of trans-activation activity have been discussed.Yan Cui Lunjiang Ling Runsheng Chen Longchuan Bai Jiangang Yuan Boqin Qiang 1999Chinese Science Bulletin1999,44,8:0
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