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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Genomic-Sequence Comparison of Two Unrelated Isolates of the Human Gastric Pathogen Helicobacterpylori 显示文摘 | Alm R A Ling L L Moir D T | 1999 | Nature1999，397，14： | 1 |
| 3 | Direct numerical simulation of a three-dimensional temporal mixing layer with particle dispersion显示文摘 | Ling W Chung J N Troutt T R | 1998 | J Fluid Mech1998，358，： | 1 |
| 4 | Direct numerical simulation of a three-dimensional temporal mixing layer with particle dispersion 显示文摘 | Ling W Chung J N Troutt T R | 1998 | Journal of Fluid Mechanics1998，358，： | 1 |
| 5 | Effects of chromium on seed germination,root elongation and coleoptile growth in six pulses显示文摘 | LING T CUANGHUA Z JUN R | 2009 | Int J Environ Sci Tech2009，6，4： | 1 |
| 6 | Chiral high-performance liquid chromatographic separation of the three stereoisomers of 2,6-diaminopimelic acid without derivatisation 显示文摘 | Nagasawa T Ling J R Onodera R | 1993 | Journal of Chromatography1993，653，： | 1 |
| 7 | Pemetrexed overcomes primary and secondary resistance to erlotinib in human non-small cell lung cancer (NSCLC) cell lines显示文摘 | Li T Ling Y Perez-Soler R | 2006 | J Clin Oncol2006，24，18： | 1 |
| 8 | Generating the swept area of a body undergoing planar motion显示文摘 | Ling Zhi - Kui Chase T R | 1996 | Journal of Mechanical Design1996，118，： | 1 |
| 9 | Effect of hydration-dehydration cycleson germination of seven Calligonum species显示文摘 | Jun R Ling T | | Journalof Arid Environment0，55，： | 1 |
| 10 | ICOS is critical for CD40 mediated antibody class switching显示文摘 | McAdam A J Greenwald R J Levin M A Chernova T Malenkovich N Ling V | 2001 | Nature2001，409，： | 1 |
| 11 | Generating the swept area of a body undergoing planar motion显示文摘 | Chase T R | 1996 | Journal of Mechanical Design1996，118，2： | 1 |
| 12 | Room occupancies:Cruise lines out-do the hotels显示文摘 | Toh R S Rivers M J Ling T W | | 0，，01： | 1 |
| 13 | Influence of nano-scale dopants of Pt, CaO and SiO2 on the alcohol sensing of SnO2 thin films显示文摘 | Ling T R Tsai C M | 2006 | Sensors and Actuators B2006，119，2： | 1 |
| 14 | Effect of hydration-dehydration cycles on germination of seven Calligonum species显示文摘 | Jun R Ling T | | J Arid Envir0，55，： | 1 |
| 15 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014，344，6179： | 1 |
| 16 | Common single nucleotide polymorphism of hypoxia-inducible factor-lalpha and its impact on the clinicopathological features of esophageal squamous cell carcinoma显示文摘 | Ling T S Shi R H Zhang G X | 2005 | Chin J Dig Dis2005，6，： | 1 |
| 17 | Effects of chronically elevated glucose levels on the functional properties of rat pancreatic β-cell显示文摘 | Ling ZD Kiekens R Mablet T | 1996 | Diabetes1996，45，： | 1 |
| 18 | Tetracycline resistance and Class 1 integron genes associated with indoor and outdoor aerosols显示文摘 | Ling A L Pace N R Hernandez M T | 2013 | Environmental Science & Technology2013，47，9： | 1 |
| 19 | Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects显示文摘 | ILEE I H LING R CHEN C T | 2002 | FEMS Microbiol Lett2002，209，1： | 1 |
| 20 | Simulation of mutual coupling effect in circular arrays for direction-finding applications显示文摘 | T Su K R Dandekar H Ling | 2000 | Microwave and Optical Technology2000，，9： | 1 |
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