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| 1 | Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity显示文摘Six new indole alkaloid sulfonic acids(1–6), together with two analogues(7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95(H3N2), respectively. | Lingjie Meng Qinglan Guo Yufeng Liu Minghua Chen Yuhuan Li Jiandong Jiang Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 14 |
| 2 | Spiral Steel Wire Based Fiber-Shaped Stretchable and Tailorable Triboelectric Nanogenerator for Wearable Power Source and Active Gesture Sensor显示文摘Continuous deforming always leads to the performance degradation of a flexible triboelectric nanogenerator due to the Young’s modulus mismatch of different functional layers.In this work,we fabricated a fiber-shaped stretchable and tailorable triboelectric nanogenerator(FST-TENG)based on the geometric construction of a steel wire as electrode and ingenious selection of silicone rubber as triboelectric layer.Owing to the great robustness and continuous conductivity,the FST-TENGs demonstrate high stability,stretchability,and even tailorability.For a single device with ~6 cm in length and ~3 mm in diameter,the open-circuit voltage of ~59.7 V,transferred charge of ~23.7 nC,short-circuit current of ~2.67 μA and average power of ~2.13 μW can be obtained at 2.5 Hz.By knitting several FST-TENGs to be a fabric or a bracelet,it enables to harvest human motion energy and then to drive a wearable electronic device.Finally,it can also be woven on dorsum of glove to monitor the movements of gesture,which can recognize every single finger,different bending angle,and numbers of bent finger by analyzing voltage signals. | Lingjie Xie Xiaoping Chen Zhen Wen Yanqin Yang Jihong Shi Chen Chen Mingfa Peng Yina Liu Xuhui Sun | 2019 | Nano-Micro Letters2019，11，3： | 13 |
| 3 | Changing Proportions of HIV-1 Subtypes and Transmitted Drug Resistance Among Newly Diagnosed HIV/AIDS Individuals—China,2015 and 2018显示文摘Introduction:With the expansion of human immunodeficiency virus(HIV)antiretroviral therapy(ART),HIV drug resistance is becoming more and more serious.This study describes the changing prevalence of HIV-1 subtypes and transmitted drug resistance(TDR)among newly diagnosed individuals in China,2015 and 2018.Methods:A total of 8,980 individuals in 2015 and 2018 from 31 provincial-level administrative divisions(PLADs)were enrolled in this study.Viral RNAs were amplified and sequenced using an in-house polymerase chain reaction(PCR)protocol.The Stanford HIV Drug Resistance Database(HIVdb)was used to predict susceptibility to 12 antiretroviral drugs.Results:The prevalence of TDR was not significantly increased over time.The prevalence of TDR was 3.8%and 4.4%in 2015 and 2018,respectively(P=0.13).The prevalence of CRF55_01B increased from 2.3%in 2015 to 3.9%in 2018(P<0.001).The drug resistance prevalence of nonnucleoside reverse transcriptase inhibitors(NNRTI)increased from 2.4%in 2015 to 3.3%in 2018(P<0.01).The prevalence of E138(P<0.001),H221(P=0.03),and V179(P<0.001)mutations increased from 0.30%,0.09%,and 0.70%in 2015 to 1.10%,0.30%,and 1.70%in 2018,respectively.Conclusions:HIV drug resistance affects the effect of antiretroviral treatment,so the monitoring of HIV TDR should be strengthened to control the transmission of HIV drug resistance. | Jingjing Hao Shan Zheng Mengze Gan Aobo Dong Ruihua Kang Miaomiao Li Shuai Zhao Jing Hu Chang Song Lingjie Liao Yi Feng Yiming Shao Yuhua Ruan Hui Xing | 2021 | China CDC weekly2021，3，53： | 13 |
| 4 | 8,4′-Oxyneolignane glucosides from an aqueous extract of“ban lan gen”(Isatis indigotica root)and their absolute configurations显示文摘Three pairs of glycosidic 8,4′-oxyneolignane diastereoisomers, named isatioxyneolignosides A-F(1–6), were isolated from an aqueous extract of Isatis indigotica roots. Their structures and absolute configurations were elucidated by comprehensive spectroscopic data analysis and enzyme hydrolysis. The validity of Δδ_(C8-C7) values to distinguish threo and erythro aryl glycerol units and Cotton effects at 235±5 nm to determine absolute configurations at C-8 in 1–6 and their aglycones(1a–6a) are discussed. | Lingjie Meng Qinglan Guo Yufeng Liu Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，6： | 13 |
| 5 | Advanced technology for functionalization of carbon nanotubes显示文摘Functionalization of carbon nanotubes (CNTs) has attracted considerable interest in the fields of physics, chemistry, material science and biology. The functionalized CNTs exhibit improved properties enabling facile fabrication of novel nanomaterials and nanodevices.Most of the functionalization approaches developed at present could be categorized into the covalent attachment of functional groups and the non-covalent adsorption of various functional molecules onto the surface of CNTs. This review highlights recent development and our work in functionalization of carbon nanotubes, leading to biocompatible CNTs, fluorescent CNTs and transition metal functionalized CNTs. These novel methods possess advantages such as simplified technical procedures and reduced cost of novel nanomaterials and nanodevices fabrication. | Lingjie Meng, Chuanlong Fu, Qinghua Lu School of Chemistry and Chemical Technology, Shanghai Jiaotong University, Shanghai 200240, China | 2009 | Progress in Natural Science:Materials International2009，19，7： | 10 |
| 6 | Triboelectric–Electromagnetic Hybrid Generator for Harvesting Blue Energy显示文摘Progress has been developed in harvesting lowfrequency and irregular blue energy using a triboelectric–electromagnetic hybrid generator in recent years. However,the design of the high-efficiency, mechanically durable hybrid structure is still challenging. In this study, we report a fully packaged triboelectric–electromagnetic hybrid generator(TEHG), in which magnets were utilized as the trigger to drive contact–separation-mode triboelectric nanogenerators(CS-TENGs) and coupled with copper coils to operate rotary freestanding-mode electromagnetic generators(RF-EMGs). The magnet pairs that produce attraction were used to transfer the external mechanical energy to the CS-TENGs, and packaging of the CS-TENGpart was achieved to protect it from the ambient environment. Under a rotatory speed of 100 rpm, the CS-TENGs enabled the TEHG to deliver an output voltage, current,and average power of 315.8 V, 44.6 μA, and ~ 90.7 μW,and the output of the RF-EMGs was 0.59 V, 1.78 m A, and 79.6 μW, respectively. The cylinder-like structure made the TEHG more easily driven by water flow and demonstrated to work as a practical power source to charge commercial capacitors. It can charge a 33μF capacitor from 0 to 2.1 V in 84 s, and the stored energy in the capacitor can drive an electronic thermometer and form a self-powered water-temperature sensing system. | Huiyun Shao Ping Cheng Ruixuan Chen Lingjie Xie Na Sun Qingqing Shen Xiaoping Chen Qianqian Zhu Yi Zhang Yina Liu Zhen Wen Xuhui Sun | 2018 | Nano-Micro Letters2018，10，3： | 9 |
| 7 | The status of exploitation techniques of natural gas hydrate显示文摘Natural gas hydrate(NGH)has been widely considered as an alternative form of energy with huge potential,due to its tremendous reserves,cleanness and high energy density.Several countries involving Japan,Canada,India and China have launched national projects on the exploration and exploitation of gas hydrate resources.At the beginning of this century,an early trial production of hydrate resources was carried out in Mallik permafrost region,Canada.Japan has conducted the first field test from marine hydrates in 2013,followed by another trial in 2017.China also made its first trial production from marine hydrate sediments in 2017.Yet the low production efficiency,ice/hydrate regeneration,and sand problems are still commonly encountered;the worldwide progress is far before commercialization.Up to now,many gas production techniques have been proposed,and a few of them have been adopted in the field production tests.Nevertheless,hardly any method appears really promising;each of them shows limitations at certain conditions.Therefore,further efforts should be made on the economic efficiency as well as sustainability and environmental impacts.In this paper,the investigations on NGH exploitation techniques are comprehensively reviewed,involving depressurization,thermal stimulation,chemical inhibitor injection,CO2–CH4 exchange,their combinations,and some novel techniques.The behavior of each method and its further potential in the field test are discussed.The advantages and limitations of laboratory studies are also analyzed.The work could give some guidance in the future formulation of exploitation scheme and evaluation of gas production behavior from hydrate reservoirs. | Lei Yang Yulong Liu Hanquan Zhang Bo Xiao Xianwei Guo Rupeng Wei Lei Xu Lingjie Sun Bin Yu Shudong Leng Yanghui Li | 2019 | Chinese Journal of Chemical Engineering2019，27，9： | 9 |
| 8 | Isatindolignanoside A, a glucosidic indole-lignan conjugate from an aqueous extract of the Isatis indigotica roots显示文摘A glucosidic indole-lignan conjugate with a novel carbon skeleton, named isatindolignanoside A(1), was isolated from an aqueous extract of the Isatis indigotica roots 'ban lan gen'. Its structure was elucidated by comprehensive analysis of spectroscopic data, including J-and NOESY correlation-based configurational analysis, circular dichroism(CD) data, enzyme hydrolysis, and theoretical ECD calculation. In a preliminary assay, compound 1 showed antiviral activity against Coxsackie virus B3. This compound is the first example of natural product having a structural feature of conjugation between indole and lignan units, and its biosynthetic pathway is postulated. | Lingjie Meng Qinglan Guo Minghua Chen JiANDong Jiang Yuhuan Li Jiangong Shi | 2018 | Chinese Chemical Letters2018，29，8： | 7 |
| 9 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 10 | Pickering emulsions stabilized by colloidal surfactants:Role of solid particles显示文摘Pickering emulsions are emulsions stabilized by colloidal surfactants,i.e.solid particles.Compared with traditional molecular suffactant-stabilized emulsions,Pickering emulsions show many advantages,such as high resistance to coalescence,long-term stability,good biocompatibility and tunable properties.In recent years,Pickering emulsions are widely applied in scientific researches and industrial applications.In this review,we focus on the influences of particle properties on Pickering emulsions,including particle amphiphilicity,concentration,size and shape,and summarize the strategies developed for the preparation of amphiphilic Janus particles.The applications of Pickering emulsions in food industry,cosmetic industry,material science,drug delivery,biomedical research and vaccine adjuvant will also be covered.Pickering emulsions are a unique system for multi-disciplinary studies and will become more and more important in the future. | Zhu Sun Xiaoxiao Yan Yao Xiao Lingjie Hu Max Eggersdorfer Dong Chen Zhenzhong Yang David AWeitz | 2022 | Particuology2022，20，5： | 6 |
| 11 | Translational Research in Oncology Research & Development and Its Impact on Early Development in China: report of the 5th Annual Meeting of the US Chinese Anti-Cancer Association (USCACA) at 2013 AACR Annual Meeting显示文摘In April 2013, the US Chinese Anti-Cancer Association (USCACA) held its 5th annual meeting in conjunction with the American Association for Cancer Research (AACR) 2013 Annual Meeting in Washington DC. The USCACA executive committee reported activities and programs and highlighted the partnership and collaboration between USCACA and other major organizations. The key initiatives and programs of USCACA included 1) USCACA-TIGM Esophageal Cancer Program that funds translational research of esophageal cancer prevention and treatment at the Xinxiang Medical University in Henan province, China; 2) the USCACA-NFCR-AFCR Scholarship Program, which has supported 10 young outstanding Chinese cancer researchers and will award 4 fellowships at the Guangzhou International Symposium on Oncology in November this year; 3) USCACA-Hengrui Training Program for Early Phase Clinical Research, which has supported the training of a Chinese scholar at two major cancer centers in the US; and 4) USCACA has continued its partnership with the Chinese Journal of Cancer, which has reached significant international impact. | Lingjie Guan Yun Dai Roger Luo | 2013 | Chinese Journal of Cancer2013，32，7： | 6 |
| 12 | Vertical‐organic‐nanocrystal‐arrays for crossbar memristors with tuning switching dynamics toward neuromorphic computing显示文摘Memristors proposed by Leon Chua provide a new type of memory device for novel neuromorphic computing applications.However,the approaching of distinct multi‐intermediate states for tunable switching dynamics,the con-trolling of conducting filaments(CFs)toward high device repeatability and reproducibility,and the ability for large‐scale preparation devices,remain full of challenges.Here,we show that vertical‐organic‐nanocrystal‐arrays(VONAs)could make a way toward the challenges.The perfect one‐dimensional structure of the VONAs could confine the CFs accurately with fine‐tune resistance states in a broad range of 103 ratios.The availability of large‐area VONAs makes the fabrication of large‐area crossbar memristor arrays facilely,and the analog switching characteristic of the memristors is to effectively imitate different kinds of synaptic plasticity,indicating their great potential in future applications. | Fangxu Yang Lingjie Sun Qingxi Duan Huanli Dong Zhaokun Jing Yuchao Yang Rongjin Li Xiaotao Zhang Wenping Hu Leon Chua | 2021 | SmartMat2021，2，1： | 5 |
| 13 | Preparation and properties of SiC honeycomb ceramics by pressureless sintering technology显示文摘SiC honeycomb ceramics with parallel channels and macroporous walls were prepared by combining extrusion molding with pressureless sintering technology in the presence of starch.The extrusion molding constructed honeycomb structure with parallel channels,while the starch formed spherical macropores on the channel walls.The density and bending strength of SiC honeycomb ceramics decreased with the increase of starch content,while the phase compositions did not vary with the starch content.The control in starch addition could adjust the pore structures on the channel walls of SiC honeycomb ceramics. | Xingzhong GUO Xiaobo CAI Lin ZHU Lingjie ZHANG Hui YANG | 2014 | Journal of Advanced Ceramics2014，3，1： | 5 |
| 14 | Bridging the US and China together to conquer cancer: report of the 4th annual meeting of the US Chinese Anti-Cancer Association (USCACA)显示文摘A global collaborative effort is pivotal to conquer cancer. Themed 'Emerging role of China in global clinical development of novel anti-cancer drugs', the US Chinese Anti-Cancer Association (USCACA) held its 4th annual meeting in Chicago on June 2, 2012, in conjunction with the American Society of Clinical Oncology (ASCO) annual meeting to further bridge the US and China together to outsmart cancer. Although a young organization, USCACA has made significant contributions to this goal in the 3 years since its inception through extensive collaboration with academic organizations, the pharmaceutical industry, and governmental agencies. USCACA has engaged various stakeholders in developing translational and personalized medical strategies to facilitate new anti-cancer drug development and clinical trials in China. USCACA has initiated and implemented the USCACA-National Foundation for Cancer Research (NFCR) scholarship to encourage overseas returnees to continue cancer research in China. USCACA announced the Hengrui-USCACA scholarship to fund clinical trial staff from China to conduct the observation of early oncologic clinical trials in the US. During the annual meeting, distinguished panelists and the audience discussed the following critical topics:(1) oncologic translational research and early development capabilities in China;(2) novel chemical entity development and partnership with Chinese companies; and (3) Chinese participation in global anti-cancer drug development. USCACA will continue to promote collaborations among cancer researchers and clinicians in the US and China by engaging in more frequent communications and joint efforts across fields, disciplines, and countries, diligently working together toward curing and eliminating cancers. | Wancai Yang Lingjie Guan | 2012 | Chinese Journal of Cancer2012，31，7： | 5 |
| 15 | Synthesis of Poly (3-acetylpyrrolyl methine) with Azobenzene Side Groups and Study on Its Third-order Nonlinear Optical Property显示文摘A novel soluble 7r-conjugated polymer, poly [(3-acetylpyrrole-2, 5-diyl) p-(N, N-dimethylamino) azobenzylidene] (PA-PDMAABE), was synthesized by condensation of 3-acetylpyrrole with 4-aldehyde-4’-dimethylaminoazobenzene (AD-MAA). The chemical structure of PAPDMAABE was characterized by Fourier transform infrared spectroscopy (FTIR),1H-NMR, and UV-Vis-NIR spectra. Transmission electron microscope (TEM) analysis for PAPDMAABE indicatesthat part of PAPDMAABE is in crystal state, due to the short-range order of the polymer. Thermogravimetric analy-sis (TGA) curve shows that the polymer has good thermal stability and its decomposition temperature is 248°C. Theoptical band gap of PAPDMAABE obtained from the optical absorption spectrum is about 1.73 eV. The resonantthird-order nonlinear optical property of PAPDMAABE at 532 nm was studied using degenerate four-wave mixing(DFWM) technique. The resonant third-order nonlinear optical susceptibility of the polymer is about 7.48×10-8 esu. | Zhigang ZHANG Hongcai WU Lingjie MENG Wenhui YI | 2005 | Journal of Materials Science & Technology2005，21，5： | 4 |
| 16 | Wheat breeding history reveals synergistic selection of pleiotropic genomic sites for plant architecture and grain yield显示文摘Diversity surveys of crop germplasm are important for gaining insights into the genomic basis for plant architecture and grain yield improvement,which is still poorly understood in wheat.In this study,we exome sequenced 287 wheat accessions that were collected in the past 100 years.Population genetics analysis identified that 6.7%of the wheat genome falls within the selective sweeps between landraces and cultivars,which harbors the genes known for yield improvement.These regions were asymmetrically distributed on the A and B subgenomes with regulatory genes being favorably selected.Genome-wide association study(GWAS)identified genomic loci associated with traits for yield potential,and two underlying genes,TaARF12 encoding an auxin response factor and TaDEP1 encoding the G-proteinγ-subunit,were located and characterized to pleiotropically regulate both plant height and grain weight.Elite single-nucleotide haplotypes with increased allele frequency in cultivars relative to the landraces were identified and found to have accumulated over the course of breeding.Interestingly,we found that TaARF12 and TaDEP1 function in epistasis with the classical plant height Rht-1 locus,leading to propose a“Green Revolution”-based working model for historical wheat breeding.Collectively,our study identifies selection signatures that fine-tune the gibberellin pathway during modern wheat breeding and provides a wealth of genomic diversity resources for the wheat research community. | Aili Li Chenyang Hao Zhenyu Wang Shuaifeng Geng Meiling Jia Fang Wang Xiang Han Xingchen Kong Lingjie Yin Shu Tao Zhongyin Deng Ruyi Liao Guoliang Sun Ke Wang Xingguo Ye Chengzhi Jiao Hongfeng Lu Yun Zhou Dengcai Liu Xiangdong Fu Xueyong Zhang Long Mao | 2022 | Molecular Plant2022，15，3： | 4 |
| 17 | Enhanced low-temperature performance of slight Mn-substituted LiFePO_4/C cathode for lithium ion batteries显示文摘Low temperature performance of LiFePO4/C cathode was remarkably improved by slight Mn-substitution. Electrochemical measurements showed that about 95% of the discharge capacity of LiFe0.98Mn0.02PO4/C cathode at 20°C was obtained at 0°C, compared to 85% of that of LiFePO4/C cathode. The LiFe0.98Mn0.02PO4/C sample also presented enhanced rate performance at –20°C with the discharge capacities of 124.4 mA h/g (0.1C), 99.8 mA h/g (1C), 80.7mAh/g (2C) and 70 mA h/g (5C), respectively, while pristine LiFePO4/C only delivered capacities of 120.5 mA h/g (0.1C), 90.7 mA h/g (1C), 70.4 mA h/g (2C) and 52.2 mA h/g (5C). Cyclic voltammetry measurements demonstrated an obvious improvement of the lithium insertion-extraction process of the LiFePO4/C cathode by slight Mn-substitution. The results of FSEM observation and electrical conductivity measurement indicated that slight Mn-substitution minimized the particle size of LiFe0.98Mn0.02PO4/C and also obviously improved the electrical conductivity of the compound, thus obviously enhances the interface reaction process on the cathode. | ZENG LingJie GONG Qiang LIAO XiaoZhen HE Li HE YuShi MA ZiFeng | 2011 | Chinese Science Bulletin2011，56，12： | 4 |
| 18 | Highly ordered anodic TiO 2 nanotube arrays and their stabilities as photo(electro)catalysts显示文摘 | Lingjie Li Zhuqing Zhou Jinglei Lei Jianxin He Shengtao Zhang Fusheng Pan | 2011 | Applied Surface Science2011，，8： | 3 |
| 19 | A new method for splice site prediction based on the sequence patterns of splicing signals and regulatory elements显示文摘It is of significance for splice site prediction to develop novel algorithms that combine the sequence patterns of regulatory elements such as enhancers and silencers with the patterns of splicing signals.In this paper,a statistical model of splicing signals was built based on the entropy density profile(EDP) method,weight array method(WAM) and κ test;moreover,the model of splicing regulatory elements was developed by an unsupervised self-learning method to detect motifs associated with regulatory elements.With two models incorporated,a multi-level support vector machine(SVM) system was de-vised to perform ab initio prediction for splice sites originating from DNA sequence in eukaryotic ge-nome.Results of large scale tests on human genomic splice sites show that the new method achieves a comparative high performance in splice site prediction.The method is demonstrated to be with at least the same level of performance and usually better performance than the existing SpliceScan method based on modeling regulatory elements,and shown to have higher accuracies than the traditional methods with modeling splicing signals such as the GeneSplicer.In particular,the method has evident advantage over splice site prediction for the genes with lower GC content. | SUN ZongXiao SANG LingJie JU LiNing ZHU HuaiQiu | 2008 | Chinese Science Bulletin2008，53，21： | 3 |
| 20 | Hybrid waveguide scheme for silicon-based quantum photonic circuits with quantum light sources显示文摘We propose a hybrid silicon waveguide scheme to avoid the impact of noise photons induced by pump lights in application scenarios of quantum photonic circuits with quantum light sources.The scheme is composed of strip waveguide and shallow-ridge waveguide structures.It utilizes the difference of biphoton spectra generated by spontaneous four-wave mixing(SFWM)in these two waveguides.By proper pumping setting and signal/idler wavelength selection,the generation of desired photon pairs is confined in the strip waveguide.The impact of noise photons generated by SFWM in the shallow-ridge waveguide can be avoided.Hence,the shallowridge waveguide could be used to realize various linear operation devices for pump light and quantum state manipulations.The feasibility of this scheme is verified by theoretical analysis and a primary experiment.Two applications are proposed and analyzed,showing its great potential in silicon-based quantum photonic circuits. | LINGJIE YU CHENZHI YUAN RENDUO QI YIDONG HUANG WEI ZHANG | 2020 | Photonics Research2020，8，3： | 3 |
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