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| 1 | Seasonal variations of stable isotope in precipitation and moisture transport at Yushu,eastern Tibetan Plateau显示文摘Precipitation δ 18O at Yushu, eastern Tibetan Plateau, shows strong fluctuation and lack of clear seasonality. The seasonal pattern of precipitation stable isotope at Yushu is apparently different from either that of the southwest monsoon region to the south or that of the inland region to the north. This different seasonal pattern probably reflects the shift of different moisture sources. In this paper, we present the spatial comparison of the seasonal patterns of precipitation δ 18O, and calculate the moisture transport flux by using the NCAR/NCEP reanalysis data. This allows us to discuss the relation between moisture transport flux and precipitation δ 18O. This study shows that both the southwest monsoon from south and inland air mass transport from north affected the seasonal precipitation δ 18O at Yushu, eastern Tibetan Plateau. Southwest monsoon brings the main part of the moisture, but southwest transport flux is weaker than in the southern part of the Tibetan Plateau. However, contribution of the inland moisture from north or local evaporation moisture is enhanced. The combined effect is the strong fluctuation of summer precipitation δ 18O at Yushu and comparatively poor seasonality. | TIAN LiDe MA LingLong YU WuSheng LIU ZhongFang YIN ChangLiang ZHAO ZhongPing TANG Wei WANG Yu | 2008 | Science China Earth Sciences2008，51，8： | 9 |
| 2 | 2D organic semiconductors, the future of green nanotechnology显示文摘The discovery of 2D organic semiconductors of atomically thin structures has attracted great attention due to their emerging optical, electronic, optoelectronic and mechatronic properties. Recent progress in such organic nanostructures has opened new opportunities for engineering material properties in many ways, such as, 0D/1D/2D nanoparticles hybridization, strain engineering, atomic doping etc. Moreover, 2D organic nanostructures exhibit a unique feature of bio–functionality and are highly sensitive to bio-analytes. Such peculiar behavior in 2D organics can be utilized to design highly-efficient bio-sensors. Also, a bio-molecular integrated electronic/optoelectronic device with enhanced performance can be attained. Furthermore, the bio-degradable, biocompatible, biometabolizable, non-toxic behaviour and natural origin of organic nanomaterials can address the current ecological concerns of increasing inorganic material based electronic waste. This review highlights the benefits of 2D organic semiconductors. Considering the importance of strategic techniques for growing thin 2D organic layers,this review summarizes progress towards this direction. The possible challenges for long-time stability and future research directions in 2D organic nano electronics/optoelectronics are also discussed. We believe that this review article provides immense research interests in organic 2D nanotechnology for exploiting green technologies in the future. | Guru Prakash Neupane Wendi Ma Tanju Yildirim Yilin Tang Linglong Zhang Yuerui Lu | 2019 | Nano Materials Science2019，1，4： | 3 |
| 3 | Carcinoma: Prognostic Value and Staging Categories Retropharyngeal Lymph Node Metasta- sis in Nasopharyngeal显示文摘 | Jun Ma Lizhi Liu Linglong Tang | 2007 | Clin Cancer Res2007，13，： | 1 |
| 4 | A prospective future towards bio/medical technology and bioelectronics based on 2D vdWs heterostructures显示文摘Nano-biotechnology research has become extremely important due to the possibilities in manipulation and characterization of biological molecules through nanodevices.Nanomaterials exhibit exciting electrical,optoelectronic,magnetic,mechanical and chemical properties that can be exploited to develop efficient biosensors or bio-probes.Those unique properties in nanomaterials can also be used in bioimaging and cancer therapeutics,where biomolecules influence the inherent properties in nanomaterials.Effective manipulation of nanomaterial properties can lead to many breakthroughs in nanotechnology applications.Nowadays,2D nanomaterials have emerged as viable materials for nanotechnology.Large cross-section area and functional availability of 2D or 1D quantum limit in these nanomaterials allow greater flexibility and better nanodevice performance.2D nanomaterials enable advanced bioelectronics to be more easily integrated due to their atomic thickness,biocompatibility,mechanical flexibility and conformity.Furthermore,with the development of 2D material heterostructures,enhanced material properties can be obtained which can directly influence bio-nanotechnology applications.This article firstly reviews the development of various types of 2D heterostructures in a wide variety of nano-biotechnology applications.Furthermore,future 2D heterostructure scopes in bioimaging,nanomedicine,bio-markers/therapy and bioelectronics are discussed.This paper can be an avenue for providing a wide scope for 2D van der Waals(vdWs)heterostructures in bio-and medical fields. | Guru Prakash Neupane Linglong Zhang Tanju Yildirim Kai Zhou Bowen Wang Yilin Tang Wendi Ma Yunzhou Xue Yuerui Lu | 2020 | Nano Research2020，13，1： | 1 |
| 5 | Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma显示文摘Metastasis and recurrence account for 95%of deaths from nasopharyngeal carcinoma(NPC).Cancer stem cells(CSCs)are regarded as one of the main reasons for tumor cell resistance to clinical therapy,and cancer metastasis or recurrence,while little is known about CSCs in NPC.The present study uncovers a subpopulation of cells labeled as CD45 EPCAM PROCR4 in NPC biopsy samples that exhibit stem cell-like characteristics.A relatively low number of these cells initiate xenograft tumors in mice. | Panpan Zhang Qiuping He Yaqin Wang Guanqun Zhou Yupei Chen Linglong Tang Yuan Zhang Xiaohong Hong Yanping Mao Qingmei He Xiaojing Yang Na Liu Jun Ma | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 0 |
| 6 | Functional characterization of CYP81C16 involved in the tanshinone biosynthetic pathway in Salvia miltiorrhiza显示文摘Danshen,the dried roots and rhizomes of Salvia miltiorrhiza Bunge(S.miltiorrhiza),is widely used in the treatment of cardiovascular and cerebrovascular diseases.Tanshinones,the bioactive compounds from Danshen,exhibit a wide spectrum of pharmacological properties,suggesting their potential for future therapeutic applications.Tanshinone biosynthesis is a complex process involving at least six P450 enzymes that have been identified and characterized,most of which belong to the CYP76 and CYP71 families.In this study,CYP81C16,a member of the CYP71 clan,was identified in S.miltiorrhiza.An in vitro assay revealed that it could catalyze the hydroxylation of four para-quinone-type tanshinones,namely neocryptotanshinone,deoxyneocryptotanshinone,and danshenxinkuns A and B.SmCYP81C16 emerged as a potential broad-spectrum oxidase targeting the C-18 position of para-quinone-type tanshinones with an impressive relative conversion rate exceeding 90%.Kinetic evaluations and in vivo assays underscored its highest affinity towards neocryptotanshinone among the tested substrates.The overexpression of SmCYP81C16 promoted the accumulation of(iso)tanshinone in hairy root lines.The characterization of SmCYP81C16 in this study accentuates its potential as a pivotal tool in the biotechnological production of tanshinones,either through microbial or plant metabolic engineering. | REN Li LUO Linglong HU Zhimin MA Ying WANG Jian CHENG Yatian JIN Baolong CHEN Tong TANG Jinfu CUI Guanghong GUO Juan HUANG Luqi | 2023 | Chinese Journal of Natural Medicines2023，21，12： | 0 |
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