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| 1 | Bioinspired Adhesive and Antibacterial Microneedles for Versatile Transdermal Drug Delivery显示文摘Microneedles have attracted increasing interest among various medical fields due to their painless,noninvasive,and efficient way of drug delivery.However,practical applications of these microneedles in different epidermal locations and environments are still restricted by their low adhesion and poor antimicrobial activity.Here,inspired by the antibacterial strategy of Paenibacillus polymyxa and adhesion mechanisms of mussel byssi and octopus tentacles,we develop hierarchical microneedles with multifunctional adhesive and antibacterial abilities.With polydopamine hydrogel as the microneedle base and a loop of suctioncup-structured concave chambers encircling each microneedle,the generated microneedles can fit the skin well;keep strong adhesion in dry,moist,and wet environments;and realize self-repair after being split into two parts.Besides,as polymyxin is loaded into both the hydrogel tips and the polydopamine base,the microneedles are endowed with excellent ability to resist common bacteria during storage and usage.We have demonstrated that these microneedles not only showed excellent adhesion when applied to knuckles and ideal antibacterial activity but also performed well in drug-sustained release and treatment for the osteoarthritis rat model.These results indicate that bioinspired multifunctional microneedles will break through the limitation of traditional methods and be ideal candidates for versatile transdermal drug delivery systems. | Xiaoxuan Zhang Guopu Chen Yunru Yu Lingyu Sun Yuanjin Zhao | 2020 | Research2020，，1： | 14 |
| 2 | Microfluidic Generation of Microsprings with Ionic Liquid Encapsulation for Flexible Electronics显示文摘Inspired by helical or spiral veins,which endow plants with excellent fexibility and elasticity to withstand storms,we present novel hollow microsprings with ionic liquid encapsulation for fexible and stretchable electronics.Te microsprings were generated by using a coaxial capillary microfuidic device to consecutively spin poly(vinylidene fuoride)(PVDF)presolution and an ionic liquid,which formed laminar fows in the coaxial injection microfuidic channels.Te fast phase inversion of PVDF helps to form the core-shell structure of a microfber and guarantees the in situ encapsulation of ionic liquid.Te hybrid microfber can then spiral and be further solidifed to maintain the helical structure with increasing fow rates of the injection fuids.Because of the feasible and precise control of the injection fuids during the microfuidic spinning,the resultant microsprings have controlled core-shell structures,helical pitches,and corresponding electromechanical properties.By further embedding them into stretchable flms,the simple paradigm of a fexible device shows great conductive performance in tensile tests and even motion cycles,which could be explored as a promising candidate in stretchable sensors,fexible electronics,and electronic skins. | Yunru Yu Jiahui Guo Lingyu Sun Xiaoxuan Zhang Yuanjin Zhao | 2019 | Research2019，，1： | 14 |
| 3 | Bio-inspired clamping microneedle arrays from flexible ferrofluid-configured moldings显示文摘Microneedle(MN)arrays have demonstrated value for cosmetics,diagnosis,transdermal drug delivery,and other biomedical areas.Much effort has been devoted to developing simple stratagem for creating versatile moldings and generating functional MN arrays.Here,inspired by the serrated microstructure of mantises’forelegs,we present a novel serration-like clamping MN array based on ferrofluidconfigured moldings.Benefiting from the flexibility and versatility of ferrofluids,negative microhole array moldings with various sizes and angles toward the midline could be created easily.The corresponding biocompatible polymer MN arrays with both isotropic and anisotropic structures could then be produced feasibly and cost-effectively by simply replicating these moldings.It was found that the resultant serrated clamping MN arrays had the ability to adhere to skin firmly,enabling them to be used over a relatively long time and while the recipient was moving.This proposed technology performed well in minimally invasive drug administration and sustained glucocorticoids release during treatment for imiquimod-induced psoriasis in mice.These features indicated that such MN arrays could play important roles in wearable transdermal drug delivery systems and in other applications. | Xiaoxuan Zhang Fengyuan Wang Yunru Yu Guopu Chen Luoran Shang Lingyu Sun Yuanjin Zhao | 2019 | Science Bulletin2019，64，15： | 11 |
| 4 | Chinese herb microneedle patch for wound healing显示文摘Traditional Chinese medicine and Chinese herbs have a demonstrated value for disease therapy and sub-health improvement.Attempts in this area tend to develop new forms to make their applications more convenient and wider.Here,we propose a novel Chinese herb microneedle(CHMN)patch by integrating the herbal extracts,Premna microphylla and Centella asiatica,with microstructure of microneedle for wound healing.Such path is composed of sap extracted from the herbal leaves via traditional kneading method and solidified by plant ash derived from the brine induced process of tofu in a well-designed mold.Because the leaves of the Premna microphylla are rich in pectin and various amino acids,the CHMN could be imparted with medicinal efficacy of heat clearing,detoxicating,detumescence and hemostatic.Besides,with the excellent pharmaceutical activity of Asiatic acid extracted from Centella asiatica,the CHMN is potential in promoting relevant growth factor genes expression in fibroblasts and showing excellent performance in anti-oxidant,anti-inflammatory and anti-bacterial activity.Taking advantages of these pure herbal compositions,we have demonstrated that the derived CHMN was with dramatical achievement in anti-bacteria,inhibiting inflammatory,collagen deposition,angiogenesis and tissue reconstruction during the wound closure.These results indicate that the integration of traditional Chinese herbs with progressive technologies will facilitate the development and promotion of traditional Chinese medicine in modern society. | Junjie Chi Lingyu Sun Lijun Cai Lu Fan Changmin Shao Luoran Shang Yuanjin Zhao | 2021 | Bioactive Materials2021，6，10： | 8 |
| 5 | MXene-Integrated Microneedle Patches with Innate Molecule Encapsulation for Wound Healing显示文摘Wound healing is a complex physiological process that involves coordinated phases such as inflammation and neovascularization.Attempts to promote the healing process tend to construct an effective delivery system based on different drugs and materials.In this paper,we propose novel MXene-integrated microneedle patches with adenosine encapsulation for wound healing.Owing to the dynamic covalent bonding capacity of boronate molecules with adenosine,3-(acrylamido)phenylboronic acid-(PBA-)integrated polyethylene glycol diacrylate(PEGDA)hydrogel is utilized as the host material of microneedle patches.Benefitting from photothermal conversion capacity of MXene,the release of loaded adenosine could be accelerated under NIR irradiation for maintaining the activation signal around injury site.In vitro cell experiments proved the effect of MXene-integrated microneedle patches with adenosine encapsulation in enhancing angiogenesis.When applied for treating animal models,it is demonstrated that the microneedle patches efficiently promote angiogenesis,which is conductive to wound healing.These features make the proposed microneedle patch potential for finding applications in wound healing and other biomedical fields. | Lingyu Sun Lu Fan Feika Bian Guopu Chen Yuetong Wang Yuanjin Zhao | 2021 | Research2021，，1： | 6 |
| 6 | Bio-inspired angle-independent structural color films with anisotropic I colloidal crystal array domains显示文摘Structural color materials with the property of angle-independence have attracted increasing interest in recent years because of their applications in various research fields.In this paper,inspired by the anisotropic lattice microstructure of the Parides sesostris butterfly,we i present a novel angle-independent structural material by simply doping spinous pollen particles into the colloidal crystal arrays to interfere their self-assembling process.The resultant composited materials have anisotropic dose-packed colloidal crystal domains around the spikes of the pollens.These differently oriented domains could reflect the light to a wide range of viewing angles,and thus imparted the composite materials with the same wide angle of structural colors.Attractively,the materials were endowed with light-controlled reversible structural color changing behavior by incorporating photothermal responsive graphene-tagged hydrogels.These features of the bioinspired angle-independent structural color materials showed their potential values in constructing intelligent sensors,anti-counterfeiting barcode labels,and so on. | Zhuohao Zhang Zhuoyue Chen Lingyu Sun Xiaoxuan Zhang Yuanjin Zhao | 2019 | Nano Research2019，12，7： | 4 |
| 7 | Three-dimensional reconstruction of Picea wilsonii Mast. pollen grains using automated electron microscopy显示文摘Three-dimensional electron microscopy(3 D-EM) has attracted considerable attention because of its ability to provide detailed information with respect to developmental analysis. However, large-scale high-resolution 3 D reconstruction of biological samples remains challenging. Herein, we present a 3 D view of a Picea wilsonii Mast. pollen grain with 100 nm axial and38.57 nm lateral resolution using AutoCUTS-SEM(automatic collector of ultrathin sections-scanning electron microscopy). We established a library of 3,127 100 nm thick serial sections of pollen grains for preservation and observation, demonstrating that the protocol can be used to analyze large-volume samples. After obtaining the SEM images, we reconstructed an entire pollen grain comprising 734 serial sections. The images produced by 3D reconstruction clearly revealed the main components of the P.wilsonii pollen grain, i.e., two sacci and pollen corpus, tube cell, generative cell, and two degenerated prothallial cells, and their internal organization. In addition, we performed a quantitative analysis of the different pollen grain cells, including sacci, and found that there were 202 connections within a saccus SEM image. Thus, for the first time, this study provided a global 3D view of the entire pollen grain, which will be useful for analyzing pollen development and growth. | Weiwei Shen Lingyu Ma Xi Zhang Xixia Li Yuanyuan Zhao Yanping Jing Yun Feng Xueke Tan Fei Sun Jinxing Lin | 2020 | Science China(Life Sciences)2020，63，2： | 3 |
| 8 | Origin area and migration route: Chloroplast DNA diversity in the arctic-alpine plant Koenigia islandica显示文摘The Hengduan Mountains(henceforth H-D Mountains) on the Tibet Plateau are a distribution and diversity center for many alpine genera. We examine patterns of genetic variation in an arctic-alpine plant to evaluate the possibility that the H-D Mountains constitute the area of origin of the species as well as to uncover postglacial migration routes. 220 individuals of the arctic-alpine plant Koenigia islandica were sampled from 26 populations distributed in western China and northern Finland. DNA haplotypes were identified using restriction site analysis of two chloroplast DNA intergene spacer regions, atpB-rbcL and trnL-trnF. We examined the geographical distribution of haplotype diversity in relation to latitude, and also compared various indices of diversity in putatively glaciated and unglaciated regions. Patterns of migration were inferred using nested clade analysis. A total of 25 haplotypes were detected. High haplotype diversity was found in the H-D Mountains. H3 and its radiated haplotypes were distributed in the Himalayas. Two haplotypes were fixed concurrently in the H-D Mountains and northern Finland. High genetic diversity of K. islandica and high species diversity of K. islandica are expected in the origin area. Our observations suggest that the H-D Mountains are not only the place of origin of K. islandica, but also the refugia for K. islandica on the Tibet Plateau. What is more, the migration route for the arctic-alpine plant K. islandica must have originated in the region defined by the H-D Mountains in western China extending northward to the Arctic circumpolar, and moved westward along the Himalayas, then northward across the Altay Mountains and the Central Siberian Plateau at different time periods. | LONG Cong MIN YunJiang ZHAO XiuXia YANY ChunLei SUN Hang Lü HouYuan TANG LingYu ZHOU ZhongZe | 2014 | Science China Earth Sciences2014，57，8： | 2 |
| 9 | Energy absorption capability of nanocomposites: A review显示文摘 | Lingyu Sun Ronald F. Gibson Faramarz Gordaninejad Jonghwan Suhr | 2009 | Composites Science and Technology2009，，14： | 1 |
| 10 | Biomass Microcapsules with Stem Cell Encapsulation for Bone Repair显示文摘Bone defects caused by trauma,tumor,or osteoarthritis remain challenging due to the lack of effective treatments in clinic.Stem cell transplantation has emerged as an alternative approach for bone repair and attracted widespread attention owing to its excellent biological activities and therapy effect.The attempts to develop this therapeutic approach focus on the generation of effective cell delivery vehicles,since the shortcomings of direct injection of stem cells into target tissues.Here,we developed a novel core-shell microcapsule with a stem cell-laden core and a biomass shell by using all-aqueous phase microfluidic electrospray technology.The designed core-shell microcapsules showed a high cell viability during the culture procedure.In addition,the animal experiments exhibited that stem cell-laden core-shell microcapsules have good biocompatibility and therapeutic effect for bone defects.This study indicated that the core-shell biomass microcapsules generated by microfluidic electrospray have promising potential in tissue engineering and regenerative medicine. | Lei Yang Yuxiao Liu Lingyu Sun Cheng Zhao Guopu Chen Yuanjin Zhao | 2022 | Nano-Micro Letters2022，14，1： | 1 |
| 11 | Change-point detection for expected shortfall in time series显示文摘Expected shortfall(ES)is a popular risk measure and plays an important role in risk and portfolio management.Recently,change-point detection of risk measures has been attracting much attention in finance.Based on the self-normalized CUSUM statistic in Fan,Glynn and Pelger(2018)and the Wild Binary Segmentation(WBS)algorithm in Fryzlewicz(2014),this paper proposes a variant WBS procedure to detect and estimate change points of ES in time series.The strengthened Schwarz information criterion is also introduced to determine the number of change points.Monte Carlo simulation studies are conducted to assess the finite-sample performance of our variant WBS procedure about ES in time series.An empirical application is given to illustrate the usefulness of our procedure. | Lingyu Sun Dong Li | 2021 | Journal of Management Science and Engineering2021，6，3： | 1 |
| 12 | A review on the application of nanofluids in enhanced oil recovery显示文摘Enhanced oil recovery(EOR)has been widely used to recover residual oil after the primary or secondary oil recovery processes.Compared to conventional methods,chemical EOR has demonstrated high oil recovery and low operational costs.Nanofluids have received extensive attention owing to their advantages of low cost,high oil recovery,and wide applicability.In recent years,nanofluids have been widely used in EOR processes.Moreover,several studies have focused on the role of nanofluids in the nanofluid EOR(N-EOR)process.However,the mechanisms related to N-EOR are unclear,and several of the mechanisms established are chaotic and contradictory.This review was conducted by considering heavy oil molecules/particle/surface micromechanics;nanofluidassisted EOR methods;multiscale,multiphase pore/core displacement experiments;and multiphase flow fluid-solid coupling simulations.Nanofluids can alter the wettability of minerals(particle/surface micromechanics),oil/water interfacial tension(heavy oil molecules/water micromechanics),and structural disjoining pressure(heavy oil molecules/particle/surface micromechanics).They can also cause viscosity reduction(micromechanics of heavy oil molecules).Nanofoam technology,nanoemulsion technology,and injected fluids were used during the EOR process.The mechanism of N-EOR is based on the nanoparticle adsorption effect.Nanoparticles can be adsorbed on mineral surfaces and alter the wettability of minerals from oil-wet to water-wet conditions.Nanoparticles can also be adsorbed on the oil/water surface,which alters the oil/water interfacial tension,resulting in the formation of emulsions.Asphaltenes are also adsorbed on the surface of nanoparticles,which reduces the asphaltene content in heavy oil,resulting in a decrease in the viscosity of oil,which helps in oil recovery.In previous studies,most researchers only focused on the results,and the nanoparticle adsorption properties have been ignored.This review presents the relationship between the adsorption properties of nanoparticles and the N-EOR mechanisms.The nanofluid behaviour during a multiphase core displacement process is also discussed,and the corresponding simulation is analysed.Finally,potential mechanisms and future directions of N-EOR are proposed.The findings of this study can further the understanding of N-EOR mechanisms from the perspective of heavy oil molecules/particle/surface micromechanics,as well as clarify the role of nanofluids in multiphase core displacement experiments and simulations.This review also presents limitations and bottlenecks,guiding researchers to develop methods to synthesise novel nanoparticles and conduct further research. | Jinjian Hou Jinze Du Hong Sui Lingyu Sun | 2022 | Frontiers of Chemical Science and Engineering2022，16，8： | 1 |
| 13 | Energy Absorption Capability of Nanocomposites: a Review 显示文摘 | Sun Lingyu Gibson Ronald F Gordaninejad Faramarz | 2009 | Composites Science and Technology2009，69，： | 1 |
| 14 | Pollens derived magnetic porous particles for adsorption of low-density lipoprotein from plasma显示文摘Adsorption of low-density lipoprotein from plasma is vital for the treatment of dyslipidemia.Appropriate adsorbent material for efficient and selective adsorption of low-density lipoprotein is highly desired.In this work,we developed pollens-derived magnetic porous particles as adsorbents for this purpose.The natural pollen grains were modified to obtain high surface porosity,a large inner cavity,magnet responsiveness,and specific wettability.The resultant particles exhibited satisfying performance in the adsorption of a series of oils and organic solvents out of water.Besides,the particles were directly utilized to the adsorption of low-density lipoprotein in plasma,which showed high selectivity,and achieved an outstanding adsorption capacity as high as 34.9%within 2 h.Moreover,their salient biocompatibility was demonstrated through simulative hemoperfusion experiments.These features,together with its abundant source and facile fabrication,makes the pollens-derived magnetic porous particles excellent candidate for low-density lipoprotein-apheresis and water treatment applications. | Yuetong Wang Lingyu Sun Jiahui Guo Keqing Shi Luoran Shang Jian Xiao Yuanjin Zhao | 2021 | Bioactive Materials2021，6，6： | 1 |
| 15 | Human ether-à-go-go-related gene expression is essential for cisplatinto induce apoptosis in human gastric cancer显示文摘 | Riping Zhang Pei Tian Qiang Chi Jizhou Wang Yongwei Wang Lingyu Sun Yang Liu Suli Tian Qifan Zhang | 2012 | Oncology Reports2012，，2： | 1 |
| 16 | Astragaloside IV derivative HHQ16 ameliorates infarctioninduced hypertrophy and heart failure through degradation of lncRNA4012/9456显示文摘Reversing ventricular remodeling represents a promising treatment for the post-myocardial infarction(MI)heart failure(HF).Here,we report a novel small molecule HHQ16,an optimized derivative of astragaloside IV,which effectively reversed infarction-induced myocardial remodeling and improved cardiac function by directly acting on the cardiomyocyte to reverse hypertrophy.The effect of HHQ16 was associated with a strong inhibition of a newly discovered Egr2-affliated transcript Inc9456 in the heart.While minimally expressed in normal mouse heart,Inc9456 was dramatically upregulated in the heart subjected to left anterior descending coronary artery ligation(LADL)and in cardiomyocytes subjected to hypertrophic stimulation.The critical role of Inc9456 in cardiomyocyte hypertrophy was confirmed by specific overexpression and knockout in vitro.A physical interaction between Inc9456 and G3BP2 increased NF-kB nuclear translocation,triggering hypertrophy-related cascades.HHQ16 physically bound to Inc9456 with a high-affinity and induced its degradation.Cardiomyocyte-specific Inc9456 overexpression induced,but knockout prevented LADL-induced,cardiac hypertrophy and dysfunction.HHQ16 reversed the effect of Inc9456 overexpression while lost its protective role when Inc9456 was deleted,further confirming Inc9456 as the bona fide target of HHQ16.We further identified the human ortholog of Inc9456,also an Egr2-affliated transcript,Inc4012.Similarly,Inc4012 was significantly upregulated in hypertrophied failing hearts of patients with dilated cardiomyopathy.HHQ16 also specifically bound to Inc4012 and caused its degradation and antagonized its hypertrophic effects.Targeted degradation of pathological increased Inc4012/lnc9456 by small molecules might serve as a novel promising strategy to regress infarction-induced cardiac hypertrophy and HF. | Jingjing Wan Zhen Zhang hennan Wu Saisai Tianbei Zang Ge Jin Qingyan Sun Pin Wang Xin Luan Yili Yang Xuelin Zhan Lingyu Linda Ye Dayue Darrel Duan Xia Liu Weidong Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 17 | Knowledge-Based Efficient N-1 Analysis Calculation Method for Urban Distribution Networks with CIM File Data显示文摘The N-1 criterion is a critical factor for ensuring the reliable and resilient operation of electric power distribution networks.However,the increasing complexity of distribution networks and the associated growth in data size have created a significant challenge for distribution network planners.To address this issue,we propose a fast N-1 verification procedure for urban distribution networks that combines CIM file data analysis with MILP-based mathematical modeling.Our proposed method leverages the principles of CIM file analysis for distribution network N-1 analysis.We develop a mathematical model of distribution networks based on CIM data and transfer it into MILP.We also take into account the characteristics of medium voltage distribution networks after a line failure and select the feeder section at the exit of each substation with a high load rate to improve the efficiency of N-1 analysis.We validate our approach through a series of case studies and demonstrate its scalability and superiority over traditional N-1 analysis and heuristic optimization algorithms.By enabling online N-1 analysis,our approach significantly improves the work efficiency of distribution network planners.In summary,our proposed method provides a valuable tool for distribution network planners to enhance the accuracy and efficiency of their N-1 analyses.By leveraging the advantages of CIM file data analysis and MILP-based mathematical modeling,our approach contributes to the development of more resilient and reliable electric power distribution networks. | Lingyu Liang Xiangyu Zhao Wenqi Huang Liming Sun Ziyao Wang Yaosen Zhan | 2023 | Energy Engineering2023，120，12： | 0 |
| 18 | Transitions between mesenchymal and epithelial states and the concomitant gene expression changes显示文摘Epithelial-mesenchymal transition(EMT),mesenchymal-epithelial transition(MET),and even the sequential EMT-MET can be observed during multiple cell fate conversions including cancer progression and embryonic development.In the current review,we first focused on the existence and beneficial roles of the sequential EMT-MET during three typical cell fate conversions,differentiation from pluripotent stem cells(PSCs)to neurons,de-differentiation from mouse embryonic fibroblasts(MEFs)to PSCs,and trans-differentiation from MEFs to neurons.We tried to provide some preliminary hypotheses to connect EMT-MET and cell fate conversions,like the possible contributions of the intermediate mesenchymal state to iPSCs generation and neurontrans-differentiation.The intermediate mesenchymal state during sequential EMT-MET was further discussed by exploring the conserved signatures on gene expression during a variety of EMT.Discussion on the interaction among vitamin C,DNA methylation,and EMT/MET was also provided. | LIANG LiNing SUN Hao LI LingYu ZHENG Hui | 2016 | Science Foundation in China2016，24，1： | 0 |
| 19 | Improvement in Liquid Helium System of SECRAL显示文摘 | Guo Xiaohong Zhao Hongwei Zhang Xuezhen Sun Liangting Lu Wang Li Jinyu Feng Yucheng Li Xixia Xie Zuqi Gong Linghui Xu Xiangdong Xu Dong Li wei Chen Lingyu | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 0 |
| 20 | Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo显示文摘Background:Currently,direct conversion from somatic cells to neurons requires virus-mediated delivery of at least one transcriptional factor or a combination of several small-molecule compounds.Delivery of transcriptional factors may affect genome stability,while small-molecule compounds may require more evaluations when applied in vivo.Thus,a defined medium with only conventional growth factors or additives for cell culture is desirable for inducing neuronal trans-differentiation.Results:Here,we report that a defined medium(5C)consisting of basic fibroblast growth factor(bFGF),N2 supplement,leukemia inhibitory factor,vitamin C(Vc),andβ-mercaptoethanol(βMe)induces the direct conversion of somatic cells to cells with neuronal characteristics.Application of 5C medium converted mouse embryonic fibroblasts(MEFs)into TuJ+neuronal-like cells,which were capable of survival after being transplanted into the mouse brain.The same 5C medium could convert primary rat astrocytes into neuronal-like cells with mature electrophysiology characteristics in vitro and facilitated the recovery of brain injury,possibly by inducing similar conversions,when infused into the mouse brain in vivo.Crucially,5C medium could also induce neuronal characteristics in several human cell types.Conclusions:In summary,this 5C medium not only provides a means to derive cells with neuronal characteristics without viral transfection in vitro but might also be useful to produce neurons in vivo for neurodegenerative disease treatment. | Songwei He Yiping Guo Yixin Zhang Yuan Li Chengqian Feng Xiang Li Lilong Lin Lin Guo Haitao Wang Chunhua Liu Yi Zheng Chuanming Luo Qiang Liu Fuhui Wang Hao Sun Lining Liang Lingyu Li Huanxing Su Jiekai Chen Duanqing Pei Hui Zheng | 2015 | Cell Regeneration2015，4，1： | 0 |
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