|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Distribution and drug resistance of pathogenic bacteria isolated from cancer hospital in 2013显示文摘Objective: To understand distribution and drug resistance of pathogenic bacteria from a specialized cancer hospital in 2013 in order to provide a basis for rational clinical antimicrobial agents. Methods: Pathogenic bacteria identification and drug sensitivity tests were performed with a VITEK 2 compact automatic identification system and data were analyzed using WHONET5.6 software.Results: Of the 1,378 strains tested, 980 were Gram-negative bacilli, accounting for 71.1%, in which Klebsiella pneumonia, Escherichia coli and Pseudomonas aeruginosa were the dominant strains. We found 328 Gram-positive coccus, accounting for 23.8%, in which the amount of Staphylococcus aureus was the highest. We identified 46 fungi, accounting for 4.1%. According to the departmental distribution within the hospital, the surgical departments isolated the major strains, accounting for 49.7%. According to disease types, lung cancer, intestinal cancer and esophagus cancer were the top three, accounting for 20.9%, 17.3% and 14.2%, respectively. No strains were resistant to imipenem, ertapenem or vancomycin.Conclusions: Pathogenic bacteria isolated from the specialized cancer hospital have different resistance rates compared to commonly used antimicrobial agents; therefore antimicrobial agents to reduce the morbidity and mortality of infections should be used. | Linjuan Liu Qi Li Qingyun Zhang Guohong Wang Guobin Xu Ji Zhang | 2014 | Chinese Journal of Cancer Research2014，26，6： | 10 |
| 2 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 3 | Piperlongumine Inhibits Zika Virus Replication In vitro and Promotes Up-Regulation of HO-1 Expression, Suggesting An Implication of Oxidative Stress显示文摘Owing to the widespread distribution of mosquitoes capable of transmitting Zika virus, lack of clinical vaccines and treatments, and poor immunity of populations to new infectious diseases, Zika virus has become a global public health concern. Recent studies have found that Zika virus can continuously infect human brain microvascular endothelial cells.These cells are the primary components of the blood–brain barrier of the cerebral cortex, and further infection of brain tissue may cause severe damage such as encephalitis and fetal pituitary disease. The present study found that a biologically active base, piperlongumine(PL), inhibited Zika virus replication in human brain microvascular endothelial cells, Vero cells, and human umbilical vein endothelial cells. PL also significantly increased heme oxygenase-1(HO-1) gene expression, while silencing HO-1 expression and using the reactive oxygen species scavenger, N-acetylcysteine, attenuated the inhibitory effect of PL on Zika virus replication. These results suggest that PL induces oxidative stress in cells by increasing reactive oxygen species. This, in turn, induces an increase in HO-1 expression, thereby inhibiting Zika virus replication. These findings provide novel clues for drug research on the prevention and treatment of Zika virus. | Weizhi Lu Linjuan Shi Jing Gao Huimin Zhu Ying Hua Jintai Cai Xianbo Wu Chengsong Wan Wei Zhao Bao Zhang | 2021 | Virologica Sinica2021，36，3： | 4 |
| 4 | Notch signaling:Its essential roles in bone and craniofacial development显示文摘Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much more.More specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the skeleton.The craniofacial skeleton is complex and understanding its development has remained an important focus in biology.In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face develop.We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future. | Mikhail Pakvasa Pranav Haravu Michael Boachie-Mensah Alonzo Jones Elam Coalson Junyi Liao Zongyue Zeng Di Wu Kevin Qin Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Michael J.Lee Jennifer Moriatis Wolf Aravind Athiviraham Sherwin S.Ho Tong-Chuan He Kelly Hynes Jason Strelzow Mostafa El Dafrawy Russell R.Reid | 2021 | Genes & Diseases2021，8，1： | 4 |
| 5 | Global transcriptomic analysis reveals Lnc-ADAMTS9 exerting an essential role in myogenesis through modulating the ERK signaling pathway显示文摘Background:Long non-coding RNAs(lncRNAs)are emerging key regulators involved in a variety of biological processes such as cell differentiation and development.The balance between myogenesis and adipogenesis is crucial for skeletal muscle homeostasis in humans and meat quality in farm animals.The present study aimed to reveal the global transcriptomic profiles of adipogenic(Adi-)and myogenic(Myo-)precursors derived from porcine skeletal muscle and identify lncRNAs involved in the modulation of myogenesis homeostasis in porcine skeletal muscle.Results:In this study,a total of 655 novel individual lncRNAs including differentially expressed 24 lncRNAs,and 755 differentially expressed mRNAs were identified(fold change≥2 or≤0.5 and adjusted P<0.05).Integrated results of Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis accompanied by the variation of intracellular Ca2+concentration highlighted Lnc-ADAMTS9 involved in the modulation of myogenesis homeostasis in porcine skeletal muscle.Although Lnc-ADAMTS9 knock-down did not alter the mRNA expression of ADAMTS9,we demonstrated that Lnc-ADAMTS9 can promote myogenic proliferation and myogenic differentiation of myogenic precursors through inhibiting the ERK/MAPK signaling pathway.Conclusion:We deciphered a comprehensive catalog of mRNAs and lncRNAs that might be involved in the regulation of myogenesis and adipogenesis homeostasis in the skeletal muscle of pigs.The Lnc-ADAMTS9 exerts an essential role in myogenesis through the ERK signaling pathway. | Liqi Wang Ting He Xin Zhang Yubo Wang Kai Qiu Ning Jiao Linjuan He Jingdong Yin | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 3 |
| 6 | Degradation of X-3B dye by immobilized TiO2photocatalysis coupling anodic oxidation on BDD electrode显示文摘 | Chunyong Zhang Linjuan Gu Yihua Lin YongxiangWang | | 0，，： | 1 |
| 7 | Suppression of pancreatic tumor growth by targeted arsenic delivery with anti-CD44v6 single chain antibody conjugated nanoparticles显示文摘 | Chenchen Qian Yong Wang Yinting Chen Linjuan Zeng Qiubo Zhang Xintao Shuai Kaihong Huang | 2013 | Biomaterials2013，，26： | 1 |
| 8 | Characterization of an immunologically active pectin from the fruits of Lycium ruthenicum显示文摘 | Qiang Peng Qingsong Xu Heng Yin Linjuan Huang Yuguang Du | 2014 | International Journal of Biological Macromolecules2014，，： | 1 |
| 9 | Isolation and structural characterization of the polysaccharide LRGP1 from Lycium ruthenicum显示文摘 | Qiang Peng Xiaopeng Lv Qingsong Xu Yu Li Linjuan Huang Yuguang Du | 2012 | Carbohydrate Polymers2012，，1： | 1 |
| 10 | Molten-salt synthesis of porous La0.6Sr0.4Co0.2Fe0.8O2.9 perovskite as an efficient electrocatalyst for oxygen evolution显示文摘 | Sanzhao Song Jing Zhou Shuo Zhang Linjuan Zhang Jiong Li Yu Wang Ling Han Youwen Long Zhiwei Hu Jian-Oiang Wang | 2018 | Nano Research2018，11，9： | 1 |
| 11 | Prognostic significance of several biomarkers in epithelial ovarian Cancer: a meta-analysis of published studies 显示文摘 | Xu Linjuan Cai Jing Yang Qiang | 2013 | J Cancer Res Clin Oneol2013，139，8： | 1 |
| 12 | Green chemical functionalization of multiwalled carbon nanotubes with poly(?-caprolactone) in ionic liquids显示文摘 | Yingkui Yang Shengqiang Qiu Chengen He Wenjie He Linjuan Yu Xiaolin Xie | 2010 | Applied Surface Science2010，，3： | 1 |
| 13 | CEO credibility, perceived organizational reputation and employee engagement 显示文摘 | LINJUAN R M | 2012 | Public relations review2012，38，1： | 1 |
| 14 | Registration of intervention trials of Traditional Chinese Medicine for four neurological diseases on Chinese Clinical Trial Registry and Clinical Trials.gov:a narrative review显示文摘OBJECTIVE:To analyze the current status of clinical trial registration of Traditional Chinese Medicine(TCM)for the treatment of neurological diseases.METHODS:Interventional clinical trials of TCM treatment for ischemic stroke,hemorrhagic stroke,vascular cognitive impairment,tension-type headache before September 22,2020 on the platform of Chinese Clinical Trial Registry(Chi CTR),and Clinical Trials.gov were searched.Two researchers independently selected the literature and extracted data.RESULTS:A total of 180 interventional clinical trials were included for analysis.Out of 180 trials,127 were from Chi CTR and 53 from Clinical Trials.gov.The countries primary sponsoring the included trials were China(176,97.8%),and the common categories of primary sponsors were hospital(131,72.8%).Among the study design,the largest proportion of allocation was randomized(172,95.6%),interventional model assignment was parallel(163,90.6%),masking was double blind 49(27.2%),and the sample size was≤400(144,80.0%).The trials were most carried out at a single center(102,56.7%).Among the included studies,112(62.2%)registered on Chi CTR attached the ethical approval documents.In terms of trial stages,50(27.7%)studies were in phaseⅣ.The mostly used intervention was Chinese herbal medicines(99,55%),acupuncture(68,37.8%)was the second.By searching the registration number on China National Knowledge Infrastructure Database and Pub Med,38(21.1%)registered trials were published,including 25 protocol studies and 14 research results with one(NCT02275949)published both the protocol and the results.CONCLUSIONS:Irregular and inadequate reporting,untimely update and publication,insufficient information on traditional medicine unique characteristics,and lack of international collaborations are the problems existing in the interventional clinical registration trials of traditional medicine treatment on neurological diseases.More efforts need to be made from the above aspects to standardize and improve the registration of traditional medicine trials. | WEI Jingjing GUO Rongjuan FU Guojing LIANG Xiao XU Zhenmin JIA Min ZENG Zixiu DU Wanqing JIAO Weiwei SUN Linjuan LIU Hongmei GUO Chunli TONG Chenguang ZHANG Yunling LIAO Xing | 2022 | Journal of Traditional Chinese Medicine2022，42，1： | 1 |
| 15 | Effects of plasma treatment time on modification of acrylic denture material显示文摘客观: 学习在血浆治疗时间和功效之间的关系。方法: 测试标本在 2 公里×的尺寸从丙烯酸的树脂假牙材料被准备 10 公里× 10 公里。血浆治疗在不同时间在 Polymethyl methacrylate (PMMA ) 的表面上被执行。XPS 研究,红外系列研究和弄湿角度的测量被执行。结果:XPS 显示出相应于当治疗继续了,变得更高的 C-0 的山峰,然而在 120 秒点,山峰没再增加并且部分在 60 秒的持续时间与山峰交叉。红外系列证明当 O_2 血浆治疗继续了,相应于 C-H 的波浪被减少,然后改变了很少。然而,当反应继续了,开始弄湿角度戏剧性地减少了,弄湿稍微增加的角度。结论: 平衡被伸手取介绍包含氧的组并且 C-H 变化。当处理继续了,弄湿角度稍微增加了。 | Huaiqin Zhang Linjuan Liu Jianglin Fang | 2007 | Journal of Nanjing Medical University2007，21，5： | 1 |
| 16 | Safety Analysis of Riding at Intersection Entrance Using Video Recognition Technology显示文摘To study riding safety at intersection entrance,video recognition technology is used to build vehicle-bicycle conflict models based on the Bayesian method.It is analyzed the relationship among the width of nonmotorized lanes at the entrance lane of the intersection,the vehicle-bicycle soft isolation form of the entrance lane of intersection,the traffic volume of right-turning motor vehicles and straight-going non-motor vehicles,the speed of right-turning motor vehicles,and straight-going non-motor vehicles,and the conflict between right-turning motor vehicles and straight-going nonmotor vehicles.Due to the traditional statistical methods,to overcome the discreteness of vehicle-bicycle conflict data and the differences of influencing factors,the Bayesian random effect Poisson-log-normal model and random effect negative binomial regression model are established.The results show that the random effect Poisson-log-normal model is better than the negative binomial distribution of random effects;The width of non-motorized lanes,the form of vehicle-bicycle soft isolation,the traffic volume of right-turning motor vehicles,and the coefficients of straight traffic volume obey a normal distribution.Among them,the type of vehicle-bicycle soft isolation facilities and the vehicle-bicycle traffic volumes are significantly positively correlated with the number of vehicle-bicycle conflicts.The width of non-motorized lanes is significantly negatively correlated with the number of vehicle-bicycle conflicts.Peak periods and flat periods,the average speed of right-turning motor vehicles,and the average speed of straight-going non-motor vehicles have no significant influence on the number of vehicle-bicycle conflicts. | Xingjian Xue Linjuan Ge Longxin Zeng Weiran Li Rui Song Neal N.Xiong | 2022 | Computers, Materials & Continua2022，，9： | 1 |
| 17 | Detection of carbohydrates using a pre-column derivatization reagent 1-(4-isopropyl) phenyl-3-methyl-5-pyrazolone by high-performance liquid chromatography coupled with electrospray ionization mass spectrometry显示文摘 | Ping Zhang Zhongfu Wang Mingming Xie Wanli Nie Linjuan Huang | 2010 | Journal of Chromatography B2010，，15： | 1 |
| 18 | Arginine promotes myogenic differentiation and myotube formation through the elevation of cytoplasmic calcium concentration显示文摘This study aimed to explore the mechanism underlying arginine-promoted myogenesis of myoblasts.C2C12 cells were cultured with a medium containing 0.1,0.4,0.8,or 1.2 mmol/L arginine,respectively.Cell proliferation,viability,differentiation indexes,cytoplasmic Ca^(2+)concentration,and relative mRNA expression levels of myogenic regulatory factors(MRF)and key Ca2+channels were measured in the absence or presence of 2 chemical inhibitors,dantrolene(DAN,10μmol/L)and nisoldipine(NIS,10μmol/L),respectively.Results demonstrated that arginine promoted myogenic differentiation and myotube formation.Compared with the control(0.4 mmol/L arginine),1.2 mmol/L arginine upregulated the relative mRNA expression levels of myogenin(MyoG)and Myomaker at d 2 during myogenic induction(P<0.05).Cytoplasmic Ca^(2+)concentrations were significantly elevated by arginine supplementation at d 2 and 4(P<0.05).Relative mRNA expression levels of Ca^(2+)channels including the type 1 ryanodine recepto r(RyR1)and voltage-gated Ca^(2+)channel(Cav1.1)were upregulated by 1.2 mmol/L arginine during2-d myogenic induction(P<0.01).However,arginine-promoted myogenic potential of myoblasts was remarkably compromised by DAN and NIS,respectively(P<0.05).These findings evidenced that the supplementation of arginine promoted myogenic differentiation and myotube formation through increasing cytoplasmic Ca^(2+)concentration from both extracellular and sarcoplasmic reticulum Ca^(2+). | Lu Gong Xin Zhang Kai Qiu Linjuan He Yubo Wang Jingdong Yin | 2021 | Animal Nutrition2021，，4： | 1 |
| 19 | SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES显示文摘Superoxide dismutase(SOD)is an important enzyme in the antioxidant system of plants and plays a vital role in stress responses by maintaining the dynamic balance of reactive oxygen species(ROS)concentrations.Genome-wide analysis of the SOD gene family in various plant species has been conducted but little is known about this gene family in watermelon(Citrullus lanatus).Here,eight SOD genes were identified in the watermelon genome and are designated Cl CSD1-5,Cl FSD1-2 and Cl MSD according to their metal cofactors.Phylogenetic analysis shows that SOD proteins from various plant species can be classified into five groups and members in the same group possess the same metal cofactor and similar subcellular localizations.Expression analysis of the Cl SOD genes indicates that they had tissue-specific expression patterns with high expression in different tissues including the leaves,flowers and fruits.In addition,the expression of Cl SOD genes differed appreciably under salinity,drought and abscisic acid(ABA)treatments,indicating that they may be involved in ROS scavenging under different abiotic stresses via an ABA-dependent signaling pathway.These results lay the foundation for elucidating the function of Cl SOD genes in stress tolerance and fruit development in watermelon. | Yong ZHOU Linjuan OUYANG Dahu ZHOU Yicong CAI Haohua HE | 2021 | Frontiers of Agricultural Science and Engineering2021，8，4： | 1 |
| 20 | On a Leslie-Gower predator-prey model incorporating a prey refuge显示文摘 | Chert Fengde Chen Linjuan Xie Xiangdong | 2009 | Nonlinear Analysis: Real World Applications2009，10，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员