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| 1 | Application of intraoperative O-arm-assisted real-time navigation technique for spinal fixation显示文摘This study explored the combined use of the O-arm and real-time navigation during spinal fixation. The clinical data for 60 patients undergoing spinal fixation, at Beijing Tsinghua Chang Gung Hospital between May 5, 2015 and May 1, 2017, were retrospectively analyzed. Pre-, intra-, and postoperative imaging findings were assessed. The patients were classified into the occipitocervical fusion(32 cases) and thoracic/lumbar/sacral spine fixation(28 cases, including 6 cases of percutaneous pedicle screw) groups. Lesion resections were performed microscopically. An O-arm, combined with real-time navigation, was used to assess spinal fixation. Efficacy was evaluated using operative times, X-ray times, screw positioning, and complications. Within the occipitocervical fusion group, 182 screws were placed in the cervical spine and 96 in the occipital bone. However, 6 screws penetrated the bone cortex and were adjacent to the vertebral arteries, based on O-arm three-dimensional imaging; therefore, the precision rate was 96.7%. Within the thoracic/lumbar/sacral spine fixation group, 148 pedicle screws were implanted, with 4 initially outside the vertebral body,yielding a precision rate of 97.3%. Ten percutaneous pedicle screws were implanted and well positioned. O-arm scans were performed 3 times/patient, with an average of 20–30 min/time. Screw implantation times were 5–7 min(cervical spine), 8–10 min(thoracic spine), and 6–8 min(lumbar spine). Intraoperative O-arm scans, combined with real-time navigation technology, allow real-time observation of screw angles and depths, improving the accuracy and safety of posterior screw fixations and reducing the radiation dose and frequency experienced by patients and surgeons. | Zhenxing Sun Dan Yuan Yaxing Sun Zhanquan Zhang Guihuai Wang Yi Guo Guoqin Wang Dongkang Liu Peng Chen Linkai Jing Feng Yang Peihai Zhang Huifang Zhang Youtu Wu Wei Shi James Wang | 2017 | Translational Neuroscience and Clinics2017，3，3： | 2 |
| 2 | Diffuse midline glioma treated with epigenetic agent-based immunotherapy显示文摘Dear Editor,Diffuse midline glioma,H3K27-altered(DMG),is a pediatric-type high-grade diffuse glioma that preferentially localizes to the brainstem or pons,thalamus,and spinal cord.Surgical resection is challenging and biopsy is often performed in most cases.To date,no conventional,targeted or immune therapy has been convincingly shown to improve patients’overall survival(OS). | Linkai Jing Zhihong Qian Qiang Gao Rui Sun Zili Zhen Guihuai Wang Xuejun Yang Haitao Li Tiannan Guo Wei Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 3 | The response and anti-stress mechanisms of nitrifying sludge under long-term exposure to Cd Se quantum dots显示文摘The wide application of CdSe quantum dots(QDs)increases its stress risk to sewage treatment systems.This study evaluated the response of nitrification performance,floc characteristics and microbial community of nitrifying sludge under long-term exposure to CdSe QDs.Results showed CdSe QDs(≥1 mg/L)would decrease the activity of ammonia monooxygenase(AMO).Under the stress of 30 mg/L CdSe QDs,the activity of AMO was reduced by 66%,while the activities of hydroxylamine oxidase and nitrite oxidoreductase were enhanced by 19.1%and 26%,respectively.Thus,the final nitrification effects were not adversely affected,and the production rates of NO_(2)^(-)-N and NO_(3)^(-)-N were accelerated.Additionally,CdSe QDs improved biomass concentration in sludge and maintained the stability of sludge settleability.High throughput sequencing analysis showed that CdSe QDs evidently reduced the abundance and diversity of microbial community in nitrifying sludge.The abundances of amino acid metabolism and lipid metabolism were enriched.Moreover,CdSe QDs decreased the fluorescence intensity of tryptophan-like protein from 2,326 to 1,179 a.u.in loosely bound extracellular polymeric substances(EPSs)and from 3,792 to 3,117 a.u.in tightly bound EPSs.To relieve CdSe QD stress,the polysaccharide content increased from0.31 to 0.61 mg/g MLSS and intracellular antioxidant defense was activated.With CdSe QD level increasing to 30 mg/L,the total antioxygenic capacity and the activities of catalase were enhanced up to 411%and 143.2%,respectively.Thereby,CdSe QDs had little adverse effects on cell membrane integrity,microbial metabolism and the abundance of Nitrospirae. | Linkai Guo Lei Yang Yongxiang Ren Shen Cui Xiaotong Li Jia Wang Jun Lan Haoqi Lu Yuchao Wang | 2024 | Journal of Environmental Sciences2024，，1： | 0 |
| 4 | Fluorescein sodium use during spinal ependymoma resection显示文摘Spinal ependymomas(SEs) are common adult intramedullary tumors; however,determining the absolute boundary between the tumor and the tumor residual may be difficult. We assessed outcomes following the use of fluorescein sodium(FS) during surgical removal of SEs. We performed a retrospective analysis of 112 patients with SEs who were treated at Beijing Tsinghua Changgung Hospital between December 2014 and December 2016. Each patient received intravenous FS(3–4 mg/kg) to determine the SE boundaries during surgery. Tumor removal efficiencies and tumor residuals were assessed using magnetic resonance imaging(MRI) at 10 days and 3 months after surgical recovery; McC ormick's spinal function classification was also performed at the 3-month follow-up. The complete tumor removal rate was 92%(103/112). Ninetyfour patients underwent tumor removal under fluorescent light, which provided distinctive tumor fluorescence. Tumor removal under white light was performed in18 patients; fluorescent images were invisible or indistinctive in these 18 patients. At the 3-month follow-up, sensory function(85.8%(91/106)) and movement(84.3%(86/102)) were improved in patients with pre-surgical dysfunction; urination and defecation functions were improved in 66.7%(16/24). The Mc Cormick spinal cord functional classifications, at the 3-month follow-up, showed significant differences in the percentages of patients with disease classified to each grade(I–IV), compared with preoperative classifications(each, P < 0.05). There was no MRI evidence of tumor relapse or residuals at the 3-month follow-up. FS use during the surgical treatment of SE enables complete tumor removal and detection of tumor residuals. | Zhenxing Sun Dan Yuan Yaxing Sun Zhanquan Zhang James Wang Yi Guo Guoqin Wang Dongkang Liu Peng Chen Linkai Jing Feng Yang Peihai Zhang Huifang Zhang Youtu Wu Wei Shi Guihuai Wang | 2017 | Translational Neuroscience and Clinics2017，3，3： | 0 |
| 5 | Posterior mediastinal ganglioneuroma: A case report and literature review显示文摘Objectives: Ganglioneuroma is a rare, benign neurogenic tumor arising from the sympathetic ganglia. In this report, we reviewed and summarized the clinical features,treatment, and prognosis of a posterior mediastinal ganglioneuroma. Case: Here, we report on a 29-year-old man referred to us with transient pain in the right side of the chest, lasting for three days. Physical examination revealed no abnormalities.The results of routine laboratory tests were within the normal ranges. Thoracic spinal magnetic resonance imaging showed a well-defined, solid mass in the right paravertebral region at the T5-T8 level, measuring 7.5 cm × 4.2 cm × 1.5 cm. To accurately locate the lesion during surgery, O-arm intraoperative imaging was used in conjunction with the Stealth Station navigation system. The tumor was completely excised and no related complications occurred. The tumor was an encapsulated mass with a solid, homogenous, grayish-tan cut surface. Histopathological examinations confirmed that the mass was a ganglioneuroma. Conclusions: Ganglioneuroma is a rare, benign tumor. Prior to treatment, a careful imaging evaluation is necessary in order to obtain an accurate diagnosis. A definitive diagnosis can be made by histological examination. En bloc resection is the preferred treatment for ganglioneuroma as it has an excellent prognosis. | Linkai Jing Zhenxing Sun Yi Guo Youtu Wu James Wang Guihuai Wang | 2017 | Translational Neuroscience and Clinics2017，3，3： | 0 |
| 6 | Surgical resection of a cervical intramedullary schwannoma: A case report and literature review显示文摘Schwannomas are the most common type of spinal tumor, and they most commonly occur in intradural extramedullary locations. Intramedullary schwannomas of the central nervous system are very rare and are difficult to diagnose using preoperative imaging. Here, we report a rare, tiny cervical intramedullary schwannoma and review the literature regarding the clinical presentation, magnetic resonance imaging, pathology,and surgical experience associated with this rare tumor type. | Peihai Zhang Zhenxing Sun Dan Yuan Yaxing Sun Zhanquan Zhang James Wang Yi Guo Guoqin Wang Dongkang Liu Peng Chen Linkai Jing Feng Yang Huifang Zhang Wei Shi Guihuai Wang | 2017 | Translational Neuroscience and Clinics2017，3，3： | 0 |
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