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3篇 您的检索式:作者名="Linmu Xu"
    题名 作者 年代 出处 被引量
1Erratum to“3D collagen matrices modulate the transcriptional trajectory of bone marrow hematopoietic progenitors into macrophage lineage commitment”[Bioact.Mater.10C(April 2022)255-268]显示文摘The publisher regrets the omission of the below footnote for the author Dr.Nu Zhang.The publisher would like to apologise for any inconvenience caused.Pan Zhang Linmu Xu Jingsong Gao Guangkui Xu Yanping Song Guang Li Jingjing Ren Yunjie Zhang Cheng Yang Yu Zhang Ruiheng Xie Nu Zhang Hui Yang 2023Bioactive Materials2023,,4:1
23D collagen matrices modulate the transcriptional trajectory of bone marrow hematopoietic progenitors into macrophage lineage commitment显示文摘Physical signals provided by the extracellular matrix(ECM)are key microenvironmental parameters for the fate decision of hematopoietic stem and progenitor cells(HSPC)in bone marrow.Insights into cell-ECM interactions are critical for advancing HSC-based tissue engineering.Herein,we employed collagen hydrogels and collagen-alginate hydrogels of defined stiffness to study the behaviors of hematopoietic progenitor cells(HPCs).Three-dimensional(3D)collagen hydrogels with a stiffness of 45 Pa were found to promote HPC maintenance and colony formation of monocyte/macrophage progenitors.Using single-cell RNA sequencing(scRNA-seq),we also characterized the comprehensive transcriptional profiles of cells randomly selected from two-dimensional(2D)and 3D hydrogels.A distinct maturation trajectory from HPCs into macrophages within the 3D microenvironment was revealed by these results.3D-derived macrophages expressed high levels of various cytokines and chemokines,such as Saa3,Cxcl2,Socs3 and Tnf.Furthermore,enhanced communication between 3D-macrophages and other hematopoietic clusters based on ligand-repair interactions was demonstrated through bioinformatic analyses.Our research underlines the regulatory role of matrix-dimensionality in HPC differentiation and therefore probably be applied to the generation of specialized macrophages.Pan Zhang Linmu Xu Jingsong Gao Guangkui Xu Yanping Song Guang Li Jingjing Ren Yunjie Zhang Cheng Yang Yu Zhang Ruiheng Xie Nu Zhang Hui Yang 2022Bioactive Materials2022,7,4:0
3Does Urban and Rural Subsistence Security System Reduce Future Poverty?Empirical Analysis Based on Vulnerability to Poverty显示文摘For a long time,related literature on researching the relationship between subsistence security system and poverty focuses on the current effects while ignoring its long-term effects.With the aid of CFPS2012 micro survey data,this paper empirically investigates the impact of the urban and rural subsistence security system on the household vulnerability to poverty.The Method of Propensity Score Matching(PSM)has been adopted in this paper to eliminate the sample selection bias as far as possible.Basic results show that subsistence security system has not significantly improved the vulnerability to poverty of the family,and may increase the possibility of falling into poverty in the future,which conclusion is valid for both urban and rural households.Chao Xu Linmu Li 2018China Finance and Economic Review2018,7,2:0
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