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您的检索式：作者名="Linpei Liu"
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| 1 | Metabolic engineering using acetate as a promising building block for the production of bio‐based chemicals显示文摘The production of biofuels and biochemicals derived from microbial fermentation has received a lot of attention and interest in light of concerns about the depletion of fossil fuel resources and climatic degeneration.However,the economic viability of feedstocks for biological conversion remains a barrier,urging researchers to develop renewable and sustainable low-cost carbon sources for future bioindustries.Owing to the numerous advantages,acetate has been regarded as a promising feedstock targeting the production of acetyl-CoA-derived chemicals.This review aims to highlight the potential of acetate as a building block in industrial biotechnology for the production of bio-based chemicals with metabolic engineering.Different alternative approaches and routes com-prised of lignocellulosic biomass,waste streams,and C1 gas for acetate generation are briefly described and evaluated.Then,a thorough explanation of the metabolic pathway for biotechnological acetate conversion,cel-lular transport,and toxin tolerance is described.Particularly,current developments in metabolic engineering of the manufacture of biochemicals from acetate are summarized in detail,with various microbial cell factories and strategies proposed to improve acetate assimilation and enhance product formation.Challenges and future development for acetate generation and assimilation as well as chemicals production from acetate is eventually shown.This review provides an overview of the current status of acetate utilization and proves the great potential of acetate with metabolic engineering in industrial biotechnology. | Guiping Gong Bo Wu Linpei Liu Jianting Li Qili Zhu Mingxiong He Guoquan Hu | 2022 | Engineering Microbiology2022，2，4： | 1 |
| 2 | Flat soliton microcomb source显示文摘Mode-locked microcombs with flat spectral profiles provide the high signal-to-noise ratio and are in high demand for wavelength division multiplexing(WDM)-based applications,particularly in future high-capacity communication and parallel optical computing.Here,we present two solutions to generate local relatively flat spectral profiles.One microcavity with ultra-flat integrated dispersion is pumped to generate one relatively flat single soliton source spanning over 150 nm.Besides,one extraordinary soliton crystal with single vacancy demonstrates the local relatively flat microcomb lines when the inner soliton spacings are slightly irregular.Our work paves a new way for soliton-based applications owing to the relatively flat spectral characteristics. | Xinyu Wang Xuke Qiu Mulong Liu Feng Liu Mengmeng Li Linpei Xue Bohan Chen Mingran Zhang Peng Xie | 2023 | Opto-Electronic Science2023，2，12： | 1 |
| 3 | Amoeba-inspired magnetic microgel assembly assisted by engineered dextran-binding protein for vaccination against lifethreatening systemic infection显示文摘Vaccination is critical for population protection from pathogenic infections.However,its efficiency is frequently compromised by a failure of antigen retention and presentation.Herein,we designed a dextran-binding protein DexBP,which is composed of the carbohydrate-binding domains of Trichoderma reesei cellobiohydrolases Cel6A and Cel7A,together with the sequence of the fluorescent protein mCherry.DexBP was further prepared by engineered Escherichia coli cells and grafted to magnetic nanoparticles.The magnetic nanoparticles were integrated with a dextran/poly(vinyl alcohol)framework and a reactive oxygen species-responsive linker,obtaining magnetic polymeric microgels for carrying pathogen antigen.Similar to amoeba aggregation,the microgels self-assembled to form aggregates and further induced dendritic cell aggregation.This step-by-step assembly retained antigens at lymph nodes,promoted antigen presentation,stimulated humoral immunity,and protected the mice from lifethreatening systemic infections.This study developed a magnetic microgel-assembling platform for dynamically regulating immune response during protection of the body from dangerous infections. | Shuo Liu Yan Zhao Linpei Guo Qilin Yu | 2023 | Nano Research2023，16，1： | 0 |
| 4 | The Shale Gas Accumulation of the Triassic Yanchang Formation in the Ordos Basin,China显示文摘The Chang 7 dark mud shale of the Triassic Yanchang Formation in the Ordos Basin is an important source rock.The Chang 7 member has favorable prospect of shale gas showed by the latest exploration.The gas generation and trapping in the Chang 7 are studied using of 279 well logging data and the laboratory analysis test data of | WANG Fengqin DU Zhili LIU Hongjun FAN Linpei BAI Shenbao TIAN Ya ZHANG Hengyi | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 0 |
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