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| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | Determination of the oxidation states of manganese in brain, liver, and heart mitochondria 显示文摘 | Thomas E G Lisa M M Claire E G Roman E Jason S Linas B Andrei A Sean H Karlene K G | 2004 | Journal of Neuroehemistry2004，88，： | 1 |
| 3 | Modeling cognitive adaptation: a longitudinal investigation of the impact of individual differences and coping on college adjustment and performance显示文摘 | Lisa G A Shelley E T | 1992 | Journal of Personality and Social Psychology1992，，6： | 1 |
| 4 | Long-term outcome of neoadjuvant therapy for locally advanced breast carcinoma effective clinical downstaging allows breast preservation and predicts outstanding local control and survival显示文摘 | William G Cance MD Lisa A | 2002 | Ann Surg2002，236，3： | 1 |
| 5 | 9-Tetrahydrocannabinol suppresses vomiting behavior and Fos expression in both acute and delayed phases of cisplatin-incluced emesis in the least shrew 显示文摘 | Andrew P R Lisa G Nissar A D | 2009 | Behavioural Brain Research2009，196，： | 1 |
| 6 | The adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result form the rapid and prolonged activation of antigen-specific CD8+T cells in vivo显示文摘 | Elizabeth G I Julie M C | 2002 | J Immunol2002，169，： | 1 |
| 7 | Kinetics of aerobic come- tabolism of chlorinated solvents 显示文摘 | LISA A C Jr SPEITEL G E | 2001 | Biodegradation2001，12，2： | 1 |
| 8 | A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States显示文摘Background:Autism spectrum disorder(ASD)is defined by standardized criteria of qualitative impairments in social interaction,qualitative impairments in communication,and restricted and stereotyped patterns of behavior,interests,and activities.A significant number of children diagnosed with ASD suffer a loss of previously-acquired skills,which is suggestive of neurodegeneration or a type of progressive encephalopathy with an etiological pathogenic basis occurring after birth.To date,the etiology of ASD remains under debate,however,many studies suggest toxicity,especially from mercury(Hg),in individuals diagnosed with an ASD.The present study evaluated concerns about the toxic effects of organic-Hg exposure from Thimerosal(49.55%Hg by weight)in childhood vaccines by conducting a two-phased(hypothesis generating/hypothesis testing)study with documented exposure to varying levels of Thimerosal from vaccinations.Methods:A hypothesis generating cohort study was undertaken to evaluate the relationship between exposure to organic-Hg from a Thimerosal-containing Diphtheria-Tetanus-acellular-Pertussis(DTaP)vaccine in comparison to a Thimerosal-free DTaP vaccine administered,from 1998 through 2000,for the risk of ASD as reported in the Vaccine Adverse Event Reporting System(VAERS)database(phase I).A hypothesis testing case–control study was undertaken to evaluate the relationship between organic-Hg exposure from Thimerosal-containing hepatitis B vaccines administered at specific intervals in the first six months of life among cases diagnosed with an ASD and controls born between 1991 through 1999 in the Vaccine Safety Datalink(VSD)database(phase II).Results:In phase I,it was observed that there was a significantly increased risk ratio for the incidence of ASD reported following the Thimerosal-containing DTaP vaccine in comparison to the Thimerosal-free DTaP vaccine.In phase II,it was observed that cases diagnosed with an ASD were significantly more likely than controls to receive increased organic-Hg from Thimerosal-containing hepatitis B vaccine administered within the first,second,and sixth month of life.Conclusions:Routine childhood vaccination is an important public health tool to reduce the morbidity and mortality associated with infectious diseases,but the present study provides new epidemiological evidence supporting an association between increasing organic-Hg exposure from Thimerosal-containing childhood vaccines and the subsequent risk of an ASD diagnosis. | David A Geier Brian S Hooker Janet K Kern Paul G King Lisa K Sykes Mark R Geier | 2013 | Translational Neurodegeneration2013，2，1： | 1 |
| 9 | The predictive utility of com- puter- simulated exercinieal technique 显示文摘 | Sarah A G Lisa P D June A S | 2003 | J Dent Educ2003，67，11： | 1 |
| 10 | Effect of calcium supplementation on serum cholesterol and blood pressure 显示文摘 | ROBERD M B LISA F GREG A G | 2000 | Arch Faro Med2000，9，： | 1 |
| 11 | PCNL: tips and tricks in targeting, puncture and dilation显示文摘 | De Lisa A Caddeo G | 2010 | Arch Ital Urol Androl2010，82，1： | 1 |
| 12 | Synthesis and photochronfic behavior of new polyimides containing azobenzene side groups 显示文摘 | Sava I Resmerita A M Lisa G | 2008 | Polymer2008，49，： | 1 |
| 13 | Detection rates of clinically significant genomic alterations by microarray analysis for specific anomalies detected by ultrasound显示文摘 | Lisa G Shaffer Jill A Rosenfeld Mindy P Dabell Justine Coppinger Anne M Bandholz Jay W Ellison J Britt Ravnan Beth S Torchia Blake C Ballif Allan J Fisher | 2012 | Prenat Diagn2012，，10： | 1 |
| 14 | Greenhouse gas emissions from heavy-duty vehicles显示文摘 | Lisa A G Greg R Deborah R | 2008 | Atmospheric Environment2008，42，19： | 1 |
| 15 | Investigation of thermal degradation of some ferrocene liquid crystals显示文摘 | LISA G WILSON D A SCUTARU D | 2010 | Thermochimica Acta2010，，： | 1 |
| 16 | Consideration of moving tooth load in gear crack propagation predictions 显示文摘 | Lewicki David G Spievak Lisa E Wawrzynek Paul A | 2002 | Gear Technology2002，19，： | 1 |
| 17 | Human amniotic fluid-derived stem cells are rejected after transplantation in the myocardium of normal, ischemic, immuno-suppressed or immuno-deficient rat 显示文摘 | Angela C Sveva B Michela P Saverio S Andrea C Lisa G Jenny T Martina P Elisabetta L Gino G Igor V Emanuele C Annalisa A Laura I Giovanni F Z Anthony A Paolo D C and Saverio S | 2007 | Journal of Molecular and Cellular Cardiology2007，42，4： | 1 |
| 18 | Arabidopsis CPR5 is a senescence-regulatory gene with pleiotropic functions as predicted by the evolutionary theory of senes- cence 显示文摘 | JING H C LISA A MARCEL J G | 2007 | Journal of Experimental Botany2007，58，14： | 1 |
| 19 | Capillary electrophoresis deter-minative and GC-MS confirmatory method for water-solu-ble organic acids in airborne particulate matter and vehicle-emission显示文摘 | Ewa D Rocio A Lisa G | 2005 | Inter science J Sep Sci2005，562，28： | 1 |
| 20 | Real-time RT-PCR fluorescent detection of tomato spotted wilt virus显示文摘 | CASSIE A R RALF G D LISA A H | 2000 | J Virol Methods2000，，88： | 1 |
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