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| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 3 | A Social Influence Model of Consumer Participation in Network and Small-Group-Based Virtual Communities显示文摘 | Dholakia U M Bagozzi R P Lisa K P | 2004 | International Journal of Research in Marketing2004，21，3： | 1 |
| 4 | Computational and experimental study of axisymmetric coflow partially premixed methane/air flames显示文摘 | Beth A V B Charles S M Lisa D P | 2000 | Combustion and Flame2000，123，4： | 1 |
| 5 | Ovomucoid is not Superior to egg white testing in Predicting Tolerance to Baked Egg显示文摘 | Lisa M B William J S Wanda P | 2013 | The Journal of Allergy and Clinical Immunology:In Practice2013，1，4： | 1 |
| 6 | Obesity-related Differential Gene Expression in the Visceral Adipose Tissue显示文摘 | Ancha Baranova Rochelle Collantes Shobha J Gowder Hazem Elariny Karen Schlauch Abraham Younoszai Steve King Manpreet Randhawa Sitapati Pusulury Tariq Alsheddi Janus P Ong Lisa M Martin Vikas Chandhoke Zobair M Younossi | 2005 | Obesity Surgery2005，，6： | 1 |
| 7 | Macrophage-mediated immunostimulation modulates therapeutic efficacy of interleukin-2 based chemoimmunotherapy in advanced metastatic melanoma patients显示文摘 | Bernengo M G Quaglino P Cappello N Lisa F Osella-Abate S Fierro M T | | 0，，01： | 1 |
| 8 | Characterization of non- methane hydrocarbons in the rural southeast United States显示文摘 | Hagerman Lisa M Aneja Viney P Lonneman William A | 1997 | Atmospheric environment1997，31，： | 1 |
| 9 | The changing landscape of hospital capacity in large cities and suburbs: implications for the safety net in metropolitan America 显示文摘 | Dennis P Andrulis Lisa M Duchon | 2007 | Journal of urban health: bulletin of the New York Academy of Medicine2007，84，3： | 1 |
| 10 | Multinational Review of Recent Trends and Report in Dementia Caregiver Bur- den显示文摘 | Frank M A Lisa P Shelby D | 2004 | Lippincott Williams&Wilkins Inc2004，18，2： | 1 |
| 11 | The utility of problem-solving training that emphasizes self-management principles显示文摘 | Heppner P Paul Baumgardner H Ann Larson M Lisa | 1988 | Counseling Psychology Quarterly1988，1，2： | 1 |
| 12 | Wall Shear Stress and DifferentialPressure in Large-diameter Horizontal Multiphase Pipelines显示文摘 | LISA C M JEPSON W P | 2000 | Journal of Energy Resources Technology2000，122，： | 1 |
| 13 | Detection rates of clinically significant genomic alterations by microarray analysis for specific anomalies detected by ultrasound显示文摘 | Lisa G Shaffer Jill A Rosenfeld Mindy P Dabell Justine Coppinger Anne M Bandholz Jay W Ellison J Britt Ravnan Beth S Torchia Blake C Ballif Allan J Fisher | 2012 | Prenat Diagn2012，，10： | 1 |
| 14 | Structure of the Chicken Interferon -γ Gene and Comparison to Mammalian Homologues显示文摘 | Hester P K Wain M Lisa R | 1998 | Gene1998，7，： | 1 |
| 15 | Pressurized stabilization of desulfurization residues fromgasification processes显示文摘 | Yrjas P Hupa M Lisa K | 1996 | Energy Fuels1996，10，6： | 1 |
| 16 | Generation of Angiostatin by reductionand proteolysis of Plasmin 显示文摘 | Stathakis P Fitzgerald M Lisa J | 1997 | J biolog chemi1997，272，20： | 1 |
| 17 | Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner显示文摘 | Susan M Galloway Kenneth P McNatty Lisa M Cambridge | 2000 | Nature Genetics2000，25，： | 1 |
| 18 | Association of cementoenamel junction- alveolar bone crest distance and proximal caries in prinary molars 显示文摘 | Argyro P Lisa P | 1998 | J Clin Pediatr Dent1998，23，1： | 1 |
| 19 | Factors influencing texture retention of salt- free,acidified,red bell peppersduringstorage显示文摘 | Lisa M Papageorge Roger F Mcfeeters Henry P Fleming | | 0，，05： | 1 |
| 20 | Levetiracetam prophylaxis in pediatricmigraine:An open label study显示文摘 | Ann P Donna K Lisa M | 2007 | Headache2007，47，42： | 1 |
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