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| 1 | Insights into CYP2B6-mediated drug–drug interactions显示文摘Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug metabolism than was previously believed.The discovery of multiple important substrates of CYP2B6 as well as polymorphic differences has sparked increasing interest in the genetic and xenobiotic factors contributing to the expression and function of the enzyme.The expression of CYP2B6 is regulated primarily by the xenobiotic receptors constitutive androstane receptor(CAR) and pregnane X receptor(PXR) in the liver.In addition to CYP2B6,these receptors also mediate the inductive expression of CYP3A4,and a number of important phase II enzymes and drug transporters.CYP2B6 has been demonstrated to play a role in the metabolism of 2%–10% of clinically used drugs including widely used antineoplastic agents cyclophosphamide and ifosfamide,anesthetics propofol and ketamine,synthetic opioids pethidine and methadone,and the antiretrovirals nevirapine and efavirenz,among others.Significant inter-individual variability in the expression and function of the human CYP2B6 gene exists and can result in altered clinical outcomes in patients receiving treatment with CYP2B6-substrate drugs.These variances arise from a number of sources including genetic polymorphism,and xenobiotic intervention.In this review,we will provide an overview of the key players in CYP2B6 expression and function and highlight recent advances made in assessing clinical ramifications of important CYP2B6-mediated drug–drug interactions. | William D.Hedrich Hazem E.Hassan Hongbing Wang | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 14 |
| 2 | Management of complex and redo cases of pelvic fracture urethral injuries显示文摘Objectives:Pelvic fracture urethral injuries(PFUI)result from traumatic disruption of the urethra.A significant proportion of cases are complex rendering their management challenging.We described management strategies for eight different complex PFUI scenarios.Methods:Our centre is a tertiary referral centre for complex PFUI cases.We maintain a prospective database(1995e2016),which we retrospectively analysed.All patients with PFUI managed at our institute were included.Results:Over two decades 1062 cases of PFUI were managed at our institute(521 primary and 541 redo cases).Most redo cases were referred to us from other centres.Redo cases had up to five prior attempts at urethroplasty.We managed complex cases,which included bulbar ischemia,young boys and girls with PFUI,PFUI with double block,concomitant PFUI and iatrogenic anterior urethral strictures.Bulbar ischemia merits substitution urethroplasty,most commonly,using pedicled preputial tube.PFUI in young girls is usually associated with urethrovaginal fistula.Young boys with PFUI commonly have a long gap necessitating trans-abdominal approach.Our success rate with individualised management is 85.60%in primary cases,79.13%in redo cases and 82.40%in cases of bulbar ischemia.Conclusion:The definition of complex PFUI is ever expanding.The best chance of success is at the first attempt.Anastomotic urethroplasty for PFUI should be performed in experienced hands at high volume centres. | Sanjay BKulkarni Sandesh Surana Devang JDesai Hazem Orabi Subramanian Iyer Jyotsna Kulkarni Ajit Dumawat Pankaj M.Joshi | 2018 | Asian Journal of Urology2018，5，2： | 13 |
| 3 | Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells显示文摘AIM: To explore the approaches exerted by mesenchymal stem cells(MSCs) to improve Parkinson's disease(PD) pathophysiology.METHODS: MSCs were harvested from bone marrowof femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group(1) was control, Groups(2) and(3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group(2) was left untreated, while Group(3) was treated with single intravenous dose of bone marrow derived MSCs(BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1(TGF-β1), monocyte chemoattractant protein-1(MCP-1) and brain derived neurotrophic factor(BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase(TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also done.RESULTS: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1(489.7 ± 13.0 vs 691.2 ± 8.0, P < 0.05) and MCP-1(89.6 ± 2.0 vs 112.1 ± 1.9, P < 0.05) levels associated with significant increase in serum BDNF(3663 ± 17.8 vs 2905 ± 72.9, P < 0.05) and brain DA(874 ± 15.0 vs 599 ± 9.8, P < 0.05) levels as well as brain TH(1.18 ± 0.004 vs 0.54 ± 0.009, P < 0.05) and nestin(1.29 ± 0.005 vs 0.67 ± 0.006, P < 0.05) genes expression levels. In addition to, producing insignificant increase in the number of positive cells for survivin(293.2 ± 15.9 vs 271.5 ± 15.9, P > 0.05) expression. Finally, the brain sections showed intact histological structure of the striatum as a result of treatment with BM-MSCs. CONCLUSION: The current study sheds light on the therapeutic potential of BM-MSCs against PD pathophysiology via multi-mechanistic actions. | Hanaa H Ahmed Ahmed M Salem Hazem M Atta Emad F Eskandar Abdel Razik H Farrag Mohamed A Ghazy Neveen A Salem Hadeer A Aglan | 2016 | World Journal of Stem Cells2016，8，3： | 9 |
| 4 | 噬菌体在食品安全控制中的研究进展显示文摘近年来,噬菌体在食品科学领域中的应用受到国内外研究学者的广泛关注。噬菌体的自身特性表明,其可作为一种杀菌/抑菌的生物制剂来控制食源性病原菌对食品的污染,是保障食品安全的理想工具。此外,基因工程技术的发展进一步促进了噬菌体及其产物的安全、高效使用及噬菌体产品的出现。本文就噬菌体在食品安全控制中的研究进展以及应用前景等方面进行综述。 | 吕阳 尹平 Khairy Morsy MOHAMED 高磊 袁超 周洋 邱宁 邹璐瑶 李志 Abdelnabby HAZEM 王小红 李锦铨 | 2018 | 食品科学2018，39，15： | 8 |
| 5 | 特征自提取的深度学习血压预测模型研究显示文摘介绍了一种包含上下文连接层的基于循环神经网络(RNN)的血压预测模型及其实现过程。由于信号硬件采集电路以及人体生理的巨大差异,光电容积脉搏波(PPG)波形的特征点变化较大,影响血压模型的鲁棒性。针对这个问题,在数据增强和模型改进方面做了一些探索性工作,包括数据方面设计丰富脉搏波波形的数据采集实验、改进一般归一化方法、利用滤波后以及原始的光电容积脉搏波信号进行预测,模型方面加入个人体征信息,构建一种增加了上下文连接层的基于循环神经网络的血压预测模型,在同种模型中,模型复杂度最低,达到了符合AAMI标准的测试精度:收缩压(4. 87±7. 80) mm Hg,舒张压(4. 60±6. 09) mm Hg。 | 师荣堃 Hazem Mohammed 林炳辉 王敏 王国兴 | 2020 | 传感器与微系统2020，39，4： | 5 |
| 6 | 基于高阶黎曼近似解的膛内多相燃烧过程研究显示文摘为了更加精确地描述制导炮弹膛内多相燃烧过程,保证其发射安全性,基于高阶近似黎曼解模型,构造了某制导炮弹双一维内弹道两相流高精度近似黎曼离散格式,对膛内高温高压多相燃烧过程进行了相关数值模拟。数值仿真结果与实验结果符合较好,数值结果准确地描述了制导炮弹膛内复杂多相燃烧过程,完整地呈现了高温高压变截面条件下的膛内复杂波系发展过程,为后续研究不同装药条件对制导炮弹的内弹道特性及发射安全性的影响奠定了理论基础。 | 程诚 张小兵 Mahmoud M.Rashad Hazem Elsadek | 2013 | 弹道学报2013，25，3： | 4 |
| 7 | Assessment of heme oxygenase-1 (HO-1) activity in the cavernous tissues of sildenafil citrate-treated rats显示文摘瞄准:估计他我在勃起组织 ofsildenafil 的 oxygenase-1 (HO-1 ) 活动对待柠檬酸盐的老鼠。方法:192 只 Sprague-Dawley 雄的老鼠,划分了成四个相等的组,被调查。组织 1,控制组,收到的常规动物食物;由胃内试管组织 2 收到的 sildenafil 柠檬酸盐;组 3 收到的 sildenafiland 惊讶禁止者(锌原卟啉, ZnPP ) ;并且组 4 收到了 sildenafil 和氮的 oxidesynthase (NOS ) 禁止者 L-nitroarginine 甲基酉旨(L 名字) 。从每个组的 12 只老鼠在 0.5 h, 1 h, 2 h 和药管理的 3 h 以后被打死。然后,在勃起组织的 HO-1 活动, cGMP 层次和 NOSenzymatic 活动被估计。结果:在勃起组织, HO-1activity, NOS 酶的活动和 cGMP,集中在整个实验与另外的组相比增加了显著地对待 insildenafil 的老鼠。收到任何一个 HOor NOS 禁止者的老鼠在这些参数显示出重要减少。酶的活动表明了的 HO-1 勃起组织活动和 NOS 与 cGMP 层次的积极重要关联(r =0.646, r = 0.612 分别地;P <
0.001 ) 。结论:在勃起组织的 PDE_5 禁止者 sildenafilcitrate 的行动部分通过在 HO-1 和 NOS 活动之间的相互依赖的关系被调停。 | M. Talaat Abdel Aziz M. Farid Al-Asmar Taymour Mostafa Hazem Atta Laila Rashed Dina Sabry Shedeed Ashour Ahmed T. Abdel Aziz | 2007 | Asian Journal of Andrology2007，9，3： | 4 |
| 8 | Endoscopic assessment and management of early esophageal adenocarcinoma显示文摘Esophageal carcinoma affects more than 450000people worldwide and the incidence is rapidly increasing.In the United States and Europe,esophageal adenocarcinoma has superseded esophageal squamous cell carcinoma in its incidence.Esophageal cancer has a high mortality rates secondary to the late presentation of most patients at advanced stages.Endoscopic screening is recommended for patients with multiple risk factors for cancer in Barrett’s esophagus.These risk factors include chronic gastroesophageal reflux disease,hiatal hernia,advanced age,male sex,white race,cigarette smoking,and obesity.The annual risk of esophageal cancer is approximately 0.25%for patients without dysplasia and 6%for patients with high-grade dysplasia.Twenty percent of all esophageal adenocarcinoma in the United States is early stage with disease confined to the mucosa or submucosa.The significant morbidity and mortality of esophagectomy make endoscopic treatment an attractive option.The American Gastroenterological Association recommends endoscopic eradication therapy for patients with high-grade dysplasia.Endoscopic modalities for treatment of early esophageal adenocarcinoma include endoscopic resection techniques and endoscopic ablative techniques such as radiofrequency ablation,photodynamic therapy and cryoablation.Endoscopic therapy should be precluded to patients with no evidence of lymphovascular invasion.Local tumor recurrence is low after endoscopic therapy and is predicted by poor differentiation of tumor,positive lymph node and submucosal invasion.Surgical resection should be offered to patients with deep submucosal invasion. | Ghassan M Hammoud Hazem Hammad Jamal A Ibdah | 2014 | World Journal of Gastrointestinal Oncology2014，6，8： | 4 |
| 9 | Ghrelin attenuates gastrointestinal epithelial damage induced by doxorubicin显示文摘AIM:To examine the influence of ghrelin on the regenerative potential of gastrointestinal(GI)epithelium.METHODS:Damage to GI epithelium was induced in mice by two intravenous injections of doxorubicin(10 and 6 mg/kg).Some of the doxorubicin-treated mice received a continuous subcutaneous infusion of ghrelin(1.25μg/h)for 10 d via implanted mini-osmotic pumps.To label dividing stem cells in the S-phase of the cell cycle,all mice received a single intraperitoneal injection of 5'-bromo-2'-deoxyuridine(BrdU)one hour before sacrifice.The stomach along with the duodenum were then removed and processed for histological examination and immunohistochemistry using anti-BrdU antibody.RESULTS:The results showed dramatic damage to the GI epithelium 3 d after administration of chemotherapy which began to recover by day 10.In ghrelintreated mice,attenuation of GI mucosal damage was evident in the tissues examined postchemotherapy.Immunohistochemical analysis showed an increase in the number of BrdUlabeled cells and an alteration in their distribution along the epithelial lining in response to damage by doxorubicin.In mice treated with both doxorubicin and ghrelin,the number of BrdUlabeled cells was reduced when compared with mice treated with doxorubicin alone.CONCLUSION:The present study suggests that ghrelin enhances the regenerative potential of the GI epithelium in doxorubicintreated mice,at least in part,by modulating cell proliferation. | Mohamed A Fahim Hazem Kataya Rkia El-Kharrag Dena AM Amer Basel al-Ramadi Sherif M Karam | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 10 | Tunica albuginea allograft: a new model of LaPeyronie's disease with penile curvature and subtunical ossification显示文摘LaPeyronie 的疾病(PD ) 的 pathophysiology 被认为是 multifactorial,包含愈合的基因倾向,损伤,发炎和改变的创伤。然而,这些因素还没用动物模型被验证了。在这研究,我们介绍了 tunica albuginea allograft 获得的一个新模型。40 的一个总数, 16-week-old 男性老鼠被使用。这些, 8 只老鼠用作控制并且经历了 10 ×有随后的 autografting 的 2-mm-wide tunical 切除,而留下 32 与另一只老鼠的 tunica 与缺点的 grafting 经历了一样的切除。词法、功能测试在 grafting 以后在 1, 3, 7 和 12 个星期被执行。Intracavernous 压力,阴茎弯曲的度和有弹性的纤维长度为在 allograft 和控制组之间的比较被评估。纸巾为组织学的检查被获得。阴茎弯曲作为与控制老鼠相比在 allografted 老鼠是显著地更大的。可勃起的功能在所有老鼠被维持,除了在在 12 个星期估计的那些。弹力素纤维长度作为与控制相比在 allografted tunica 被减少。SMAD2 表示在 allograft 的内部部分被检测,并且 collagen-II- 和 osteocalcin 积极的房间也被注意。在老鼠的 Tunica albuginea (TA ) allograft 是 PD 的一个优秀模型。在 12 个星期和在 TA 的内部层的骨化的存在以后的弯曲的坚持类似于与 PD 在人观察的那些。用这个动物模型的确认研究将为有效治疗学的干预帮助 PD pathophysiology 的理解。 | Ludovic Ferretti Thomas M Fandel Xuefeng Qiu Haiyang Zhang Hazem Orabi Alex K Wu Lia Banie Guifang Wang Guiting Lin Ching-Shwun Lin Tom FLue | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 11 | Total pancreatectomy: Short- and long-term outcomes at a high-volume pancreas center显示文摘AIM To identify the current indications and outcomes of total pancreatectomy at a high-volume center. METHODS A single institutional retrospective study of patients undergoing total pancreatectomy from 1995 to 2014 was performed.RESULTS One hundred and three patients underwent totalpancreatectomy for indications including: Pancreatic ductal adenocarcinoma(n = 42, 40.8%), intraductal papillary mucinous neoplasms(n = 40, 38.8%), chronic pancreatitis(n = 8, 7.8%), pancreatic neuroendocrine tumors(n = 7, 6.8%), and miscellaneous(n = 6, 5.8%). The mean age was 66.2 years, and 59(57.3%) were female. Twenty-four patients(23.3%) underwent a laparoscopic total pancreatectomy. Splenic preservation and portal vein resection and reconstruction were performed in 24(23.3%) and 18 patients(17.5%), respectively. The 90 d major complications, readmission, and mortality rates were 32%, 17.5%, and 6.8% respectively. The 1-, 3-, 5-, and 7-year survival for patients with benign indications were 84%, 82%, 79.5%, and 75.9%, and for malignant indications were 64%, 40.4%, 34.7% and 30.9%, respectively.CONCLUSION Total pancreatectomy, including laparoscopic total pancreatectomy, appears to be an appropriate option for selected patients when treated at a high-volume pancreatic center and through a multispecialty approach. | Hazem M Zakaria John A Stauffer Massimo Raimondo Timothy A Woodward Michael B Wallace Horacio J Asbun | 2016 | World Journal of Gastrointestinal Surgery2016，8，9： | 3 |
| 12 | Small for size syndrome difficult dilemma: Lessons from 10 years single centre experience in living donor liver transplantation显示文摘AIM To analyze the incidence, risk factors, prevention, treatment and outcome of small for size syndrome(SFSS) after living donor liver transplantation(LDLT). METHODS Through-out more than 10 years: During the period from April 2003 to the end of 2013, 174 adult-to-adults LDLT(A-ALDLT) had been performed at National Liver Institute, Menoufiya University, Shibin Elkoom, Egypt. We collected the data of those patients to do this cohort study that is a single-institution retrospective analysis of a prospectively collected database analyzing the incidence, risk factors, prevention, treatment and outcome of SFSS in a period started from the end of 2013 to the end of 2015. The median period of follow-up reached 40.50 m, range(0-144 m). RESULTS SFSS was diagnosed in 20(11.5%) of our recipients. While extra-small graft [small for size graft(SFSG)], portal hypertension, steatosis and left lobe graft were significant predictors of SFSS in univariate analysis(P = 0.00, 0.04, 0.03, and 0.00 respectively); graft size was the only independent predictor of SFSS on multivariate analysis(P = 0.03). On the other hand, there was lower incidence of SFSS in patients with SFSG who underwent splenectomy [4/10(40%) SFSS vs 3/7(42.9%) no SFSS] but without statistical significance, However, there was none significant lower incidence of the syndrome in patients with right lobe(RL) graft when drainage of the right anterior and/or posterior liver sectors by middle hepatic vein, V5, V8, and/or right inferior vein was done [4/10(28.6%) SFSS vs 52/152(34.2%) no SFSS]. The 6-mo, 1-, 3-, 5-, 7-and 10-year survival in patients with SFSS were 30%, 30%, 25%, 25%, 25% and 25% respectively, while, the 6-mo, 1-, 3-, 5-, 7-and 10-year survival in patients without SFSS were 70.1%, 65.6%, 61.7%, 61%, 59.7%, and 59.7% respectively, with statistical significant difference(P = 0.00). CONCLUSION SFSG is the independent and main factor for occurrence of SFSS after A-ALDLT leading to poor outcome. However, the management of this catastrophe depends upon its prevention(i.e., selecting graft with proper size, splenectomy to decrease portal venous inflow, and improving hepatic vein outflow by reconstructing large draining veins of the graft). | Hany Shoreem Emad Hamdy Gad Hosam Soliman Osama Hegazy Sherif Saleh Hazem Zakaria Eslam Ayoub Yasmin Kamel Kalid Abouelella Tarek Ibrahim Ibrahim Marawan | 2017 | World Journal of Hepatology2017，9，21： | 3 |
| 13 | Stem cell applications for pathologies of the urinary bladder显示文摘New stem cell based therapies are undergoing intense research and are widely investigated in clinical fields including the urinary system. The urinary bladder performs critical complex functions that rely on its highly coordinated anatomical composition and multiplex of regulatory mechanisms. Bladder pathologies resulting in severe dysfunction are common clinical encounter and often cause significant impairment of patient's quality of life. Current surgical and medical interventions to correct urinary dysfunction or to replace an absent or defective bladder are sub-optimal and are associated with notable complications. As a result, stem cell based therapies for the urinary bladder are hoped to offer new venues that could make up for limitations of existing therapies. In this article, we review research efforts that describe the use of different types of stem cells in bladder reconstruction, urinary incontinence and retention disorders. In particular, stress urinary incontinence has been a popular target for stem cell based therapies in reported clinical trials. Furthermore, we discuss the relevance of the cancer stem cell hypothesis to the development of bladder cancer. A key subject that should not be overlooked is the safety and quality of stem cell based therapies introduced to human subjects either in a research or a clinical context. | Noha A Mousa Hisham A Abou-Taleb Hazem Orabi | 2015 | World Journal of Stem Cells2015，7，5： | 2 |
| 14 | Correlation between corneal demarcation line depth in epithelium-off and trans-epithelium accelerated corneal cross linking and keratoconus progression显示文摘AIM:To compare corneal demarcation line(DL)depth in both accelerated epithelium-off and trans-epithelium cross linking(CXL)using anterior segment optical coherence tomography(AS-OCT)and its relation to maximum keratometry(Kmax)progression in both techniques.METHODS:A prospective comparative interventional study where patients with mild to moderate keratoconus(KC)were classified into two groups:accelerated epitheliumoff and trans-epithelium CXL based on corneal pachymetry.Assessment of corneal DL depth was carried out after 3mo by AS-OCT.Kmax readings were evaluated after one year follow up using the Scheimpflug imaging system.RESULTS:Study included 74 eyes of 44 patients.Group A underwent epithelium-off CXL(41 eyes),while Group B underwent trans-epithelium CXL(33 eyes).At 3mo follow up,mean corneal DL depth in Group A was 219.9±58.4μm while in Group B was 127.2±7.8μm(P<0.05).The mean Kmaxchangedfrom51.9±3.9to51.3±4.2dioptersin Group A and from 53.1±4.1 to 53.6±5 diopters in Group B with insignificant difference in Kmax changes in either group(P>0.05).In addition,no significant change in corneal pachymetry was found in both groups(meanchange at 1y:6.4±4.7 and-10.1±2.3μm in Groups A and B respectively).CONCLUSION:Despite a significantly deeper corneal DL depth created by accelerated epithelium-off CXL technique compared to accelerated trans-epithelium CXL,there is no significant impact on keratoconus progression. | Mahmoud Abdel-Radi Zeiad Eldaly Hazem Abdelmotaal Reham Abdelrahman Mohamed Sayed Kamel Soliman | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 15 | Association between nonalcoholic fatty liver disease and the incidence of cardiovascular and renal events显示文摘 | Hamdy Abd El Azeem El-Shazly Abdul Khalek Hazem El-Akabawy Hussein Naeim Hammouda Abdul Khalik Abdul Aziz Alfifi | 2013 | Journal of the Saudi Heart Association2013，，4： | 2 |
| 16 | 圆管状钢结构节点的应力集中因子研究现状显示文摘管状结构由于优良的结构性能和简洁的外观,被广泛应用于海上设施、桁架、高层建筑、航站楼、火车站、大型体育场、避雷针、道路信号杆等。应力集中会引起脆性材料断裂,使物体产生疲劳裂纹,从而造成构件破坏。在管状钢结构的焊接节点的疲劳设计中,应力集中现象应着重考虑。应力集中因子反映了应力集中的程度,是一个大于1的系数,它的大小取决于节点的几何形状、焊缝尺寸及加载情况。就迄今为止一些学者对管状钢结构应力集中因子所做的研究进行整理,并进行总结与探讨,着重讨论了圆形空心截面管状钢结构应力集中因子的确定及其评估方法,对一些学者推导出的应力集中因子公式的准确性及适用性做了简要对比,并提出了下一步的研究方向。 | 董事尔 李潇 Hazem 孙傲雪 鲜岸江 | 2018 | 机械2018，45，9： | 2 |
| 17 | Using a distributed approach to relieve and integrate information from heterogeneous distributed databases显示文摘 | Hazem T EL-Khatib Howard Williams David H Matwick | 2002 | Computer Journal2002，45，4： | 1 |
| 18 | A modified 2D chain code algorithm for object segmentation and contour tracing显示文摘 | Walid Shahab Hazem Al-Otum Farouq Al-Ghoul | 2007 | The International Arab Journal of Information Technology2007，6，3： | 1 |
| 19 | Cell-Seeded Tubularized Scaffolds for Reconstruction of Long Urethral Defects: A Preclinical Study显示文摘 | Hazem Orabi Tamer AbouShwareb Yuanyuan Zhang James J. Yoo Anthony Atala | 2012 | European Urology2012，，： | 1 |
| 20 | Enhancement of dissolution amount and in vivo bioavailability of itraconazole by complexation with β-cyclodextrin using supercritical carbon dioxide显示文摘 | Hazem A Hassan Ali H | 2007 | J Pharm Bio Analysis2007，45，2： | 1 |
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