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| 1 | Differential secretome analysis reveals CST6 as a suppressor of breast cancer bone metastasis显示文摘骨头转移从疾病是乳癌的经常的复杂并发症和病态和死亡的一个普通原因。在转移期间,分泌蛋白质在在癌症房间和主人基质之间的相互作用起关键作用。为了描绘分泌蛋白质,那与乳癌骨头转移被联系,我们比较四个 MDA-MB-231 (MDA231 ) 衍生物房间的 secretomes 的没有标签的 proteomic 分析与骨头转移的改变的能力衬里的 preformed。128 蛋白质的一个总数被发现是一致地在骨头回归线癌症房间的调节媒介的 up-/down-regulated。改变的蛋白质的充实的分子的函数包括了受体绑定和 peptidase 抑制。通过乳癌房间的另外的 transcriptomic 分析,我们选择了 cystatin E/M (CST6 ) ,在骨头变形的房间下面调整的一个半胱氨酸朊酶禁止者,为进一步功能的研究。我们的结果证明 CST6 压制了乳癌房间的增长,殖民地形成,迁居和侵略。对癌症房间活动性的镇压功能被癌症执行导出房间的可溶的 CST6。更重要地,在癌症房间的 CST6 的宫外的表示在动物学习救了老鼠免于公开 osteolytic 转移和死亡,当时 CST6 击倒的显著地提高的癌症房间骨头转移和弄短的动物幸存。总的来说,我们的学习提供了乳癌骨头向性的全身的 secretome 分析并且作为乳癌 osteolytic 转移的真正的 suppressor 建立了分泌 CST6。 | Lei Jin Yan Zhang Hui Li Ling Yao Da Fu Xuebiao Yao Lisa X Xu Xiaofang Hu Guohong Hu | 2012 | Cell Research2012，22，9： | 15 |
| 2 | Evaluation of alternate cooling and heating for tumor treatment显示文摘 | Sun Jianqi Zhang Aili Xu Lisa X | 2008 | International Journal of Heat and Mass Transter2008，，51： | 1 |
| 3 | Design of a nonlinear disturbance observer 显示文摘 | LISA Pathfinder drag-free control Classical and Quantum Gravity Chen X K Komada S Fukuda T | 2000 | IEEE Transactions on Industrial Electronics2000，47，2： | 1 |
| 4 | Down and Out:An Investigation of the Relationship between Mood and Employee Withdrawal Behavior显示文摘 | Lisa H P Katherine R X | 1999 | Journal of Management1999，25，6： | 1 |
| 5 | Identification of a novel cleavage activity of the first papain-like proteinase domain encoded by open reading frame 1a of the coronavirus avian infectious bronchitis virus and characterization of the cleavage products显示文摘 | Lim K P Lisa F P Liu D X | | J Virolo0，，： | 1 |
| 6 | Identification of a 24kD polypeptide processed from the coronavirus infectious bronchitis virus 1a polyprotein by the 3c-like proteinase and determination of its cleavage sites显示文摘 | Lisa F P Liu D X | 1998 | Virology1998，243，： | 1 |
| 7 | Down and Out: An investiga tion of the Relationship between Mood and Employee With- drawal Behavior显示文摘 | Lisa H P Katherine R X | 1999 | Journal of Management1999，25，6： | 1 |
| 8 | A new fiuxdamental bioheat equation for muscle tissue-part II: temperature of SAV vessels显示文摘 | Liang Z Lisa X He QH et at | 2002 | J Biomech Eng2002，124，： | 1 |
| 9 | Overcoming bioanalytical challenges in an Onglyza<sup>®</sup> intravenous [<sup>14</sup>C]microdose absolute bioavailability study with accelerator MS显示文摘 | Xiaohui (Sophia) Xu Stephen R Dueker Lisa J Christopher Pete N Lohstroh Chi Fung (Anther) Keung Kai (Kevin) Cao Samuel J Bonacorsi Laura Cojocaru Jim X Shen W Griffith Humphreys Bruce Stouffer Mark E Arnold | 2012 | Bioanalysis2012，，15： | 1 |
| 10 | New Thermal wave aspects on burn evaluation of skin subjected to instantaneous heating显示文摘 | LIU J XU C LISA X X | 1999 | Transactions on Biomedical Engineering1999，46，4： | 1 |
| 11 | Xu, Evaluation of alternative cooling and heating for tumor treatment 显示文摘 | Jianqi Sun Aili Zhang Lisa X | 2008 | International Journal of Heat and Mass Transfer2008，51，： | 1 |
| 12 | New thermal wave aspects on burn evaluation of skin subjected to instantaneous heating显示文摘 | LIU J XU Lisa X | 1999 | IEEE Transaction on Biomedical Engineering1999，46，9： | 1 |
| 13 | Growth and Cu Accumulation by Plants Grown on Cu Containing Mine Tailings in Cyprus显示文摘 | LISA J CONSTANTIONS X NIKONS M EVA S MARIA G | 2005 | Applied Geochemistry2005，20，： | 1 |
| 14 | Growth and Cu accumulation by plants grown on Cu containing mine tailings in Cyprus 显示文摘 | Lisa J Constantinos X Nikos M | 2005 | Applied Geochemistry2005，20，1： | 1 |
| 15 | Quantification of the 3-D electromagnetic power absorption rate in tissue during transurethral prostatic microwave themotherapy using heat transfer model显示文摘 | ZHU Liang XU Lisa X Norbert Chencinski | 1998 | IEEE mansactions on biomedical engineering1998，45，9： | 1 |
| 16 | Hunting down the dominating subclone of cancer stem cells as a potential new therapeutic target in multiple myeloma: An artificial intelligence perspective显示文摘The development of single-cell subclones,which can rapidly switch from dormant to dominant subclones,occur in the natural pathophysiology of multiple myeloma(MM)but is often'pressed'by the standard treatment of MM.These emerging subclones present a challenge,providing reservoirs for chemoresistant mutations.Technological advancement is required to track MM subclonal changes,as understanding MM's mechanism of evolution at the cellular level can prompt the development of new targeted ways of treating this disease.Current methods to study the evolution of subclones in MM rely on technologies capable of phenotypically and genotypically characterizing plasma cells,which include immunohistochemistry,flow cytometry,or cytogenetics.Still,all of these technologies may be limited by the sensitivity for picking up rare events.In contrast,more incisive methods such as RNA sequencing,comparative genomic hybridization,or whole-genome sequencing are not yet commonly used in clinical practice.Here we introduce the epidemiological diagnosis and prognosis of MM and review current methods for evaluating MM subclone evolution,such as minimal residual disease/multiparametric flow cytometry/next-generation sequencing,and their respective advantages and disadvantages.In addition,we propose our new single-cell method of evaluation to understand MM's mechanism of evolution at the molecular and cellular level and to prompt the development of new targeted ways of treating this disease,which has a broad prospect. | Lisa X Lee Shengwen Calvin Li | 2020 | World Journal of Stem Cells2020，12，8： | 1 |
| 17 | New thermal wave aspects on burn evaluation of skin subjected to instantaneous heating 显示文摘 | Liu J Chen XU Lisa X | 1999 | IEEE Transactions on Biomedical Engineering1999，46，4： | 1 |
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