|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Direct reprogramming of induced neural progenitors: a new promising strategy for AD treatment显示文摘Alzheimer’s disease(AD)is a prominent form of dementia,characterized by aggregation of the amyloidβ-peptide(Aβ)plaques and neurofibrillary tangles,loss of synapses and neurons,and degeneration of cognitive functions.Currently,although a variety of medications can relieve some of the symptoms,there is no cure for AD.Recent breakthroughs in the stem cell field provide promising strategies for AD treatment.Stem cells including embryonic stem cells(ESCs),neural stem cells(NSCs),mesenchymal stem cells(MSCs),and induced pluripotent stem cells(iPSCs)are potentials for AD treatment.However,the limitation of cell sources,safety issues,and ethical issues restrict their applications in AD.Recently,the direct reprogramming of induced neural progenitor cells(iNPCs)has shed light on the treatment of AD.In this review,we will discuss the latest progress,challenges,and potential applications of direct reprogramming in AD treatment. | Siqiang Lai Min Zhang Dongsheng Xu Yiying Zhang Lisha Qiu Changhai Tian Jialin Charlie Zheng | 2015 | Translational Neurodegeneration2015，4，1： | 4 |
| 2 | Imaging changes in neural circuits in patients with depression using 1 H-magnetic resonance spectroscopy and diffusion tensor imaging显示文摘1 H-magnetic resonance spectroscopy imaging and diffusion tensor imaging were performed in 19 patients with mild depression and in 13 controls.The mean age of the patients was 31 years.The mean Hamilton depression score of the patients was 22.5±13.2.N-acetylaspartate,choline and creatine concentrations and the average diffusion coefficient and fractional anisotropy values were measured in the bilateral hippocampus,striatum,thalamus and prefrontal deep white matter. Compared with the control group,the mild depressed patients had:(1)a higher choline/creatine ratio and a negative correlation between the choline/creatine ratio and the average diffusion coefficient in the hippocampus;(2)a lower choline/creatine ratio and a higher fractional anisotropy in the striatum;(3)a lower fractional anisotropy and a positive correlation between the fractional anisotropy and the choline/creatine ratio in the prefrontal deep white matter;and(4)a higher average diffusion coefficient and a positive correlation between the choline/creatine ratio and the N-acetylaspartate/creatine ratio in the thalamus,as well as positive correlation between the choline/creatine ratio and Hamilton depression scores.These data suggest evidence of abnormal connectivity in neurofibrotic microstructures and abnormal metabolic alterations in the limbic-cortical-striatal-pallidal-thalamic neural circuit in patients with mild depression. | Shaoqiong Chen Lisha Lai Zhuang Kang Xiao Luo Jiansheng Zhang Jianfang Li | 2012 | Neural Regeneration Research2012，7，24： | 2 |
| 3 | Generation of rat blood vasculature and hematopoietic cells in rat-mouse chimeras by blastocyst complementation显示文摘Interspecies chimera through blastocyst complementation could be an alternative approach to create human organs in animals by using human pluripotent stem cells.A mismatch of the major histocompatibility complex of vascular endothelial cells between the human and host animal will cause graft rejection in the transplanted organs.Therefore,to achieve a transplantable organ in animals without rejection,creation of vascular endothelial cells derived from humans within the organ is necessary.In this study,to explore whether donor xeno-pluripotent stem cells can compensate for blood vasculature in host animals,we generated rat-mouse chimeras by injection of rat embryonic stem cells(rESCs)into mouse blastocysts with deficiency of Flk-1 protein,which is associated with endothelial and hematopoietic cell development.We found that rESCs could differentiate into vascular endothelial and hematopoietic cells in the rat-mouse chimeras.The whole yolk sac(YS)of Flk-1^EGFP/ECFP rat-mouse chimera was full of rat blood vasculature.Rat genes related to vascular endothelial cells,arteries,and veins,blood vessels formation process,as well as hematopoietic cells,were highly expressed in the YS.Our results suggested that rat vascular endothelial cells could undergo proliferation,migration,and self-assembly to form blood vasculature and that hematopoietic cells could differentiate into B cells,T cells,and myeloid cells in rat-mouse chimeras,which was able to rescue early embryonic lethality caused by Flk-1 deficiency in mouse. | Xiaomin Wang Hui Shi Juanjuan Zhou Qingjian Zou Quanjun Zhang Shixue Gou Pengfei Chen Lisha Mou Nana Fan Yangyang Suo Zhen Ouyang Chengdan Lai Quanmei Yan Liangxue Lai | 2020 | Journal of Genetics and Genomics2020，47，5： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员