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| 1 | Species-dependent neuropathology in transgenic SOD' aigs显示文摘 | Huaqiang Yang Guohao Wang Haitao Sun Runzhe Shu Tao Liu Chuan-En Wang Zhaoming Liu Yu Zhao Bentian Zhao Zhen Ouyang Dongshan Yang Jiao Huang Yueling Zhou Shihua Li Xiaodan Jiang Zhicheng Xiao Xiao-Jiang Li Liangxue Lai | 2014 | Cell Research2014，24，4： | 13 |
| 2 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 3 | Optical generation,detection and non-destructive testing applications of terahertz waves显示文摘Optoelectronic terahertz generation and detection play a key role in the applications of non-destructive testing,which involves different areas such as physics,biological,material science,imaging,explosions detection,astronomy applications,semiconductor technology and superconductiong electronics. In this article,we present a reviewof the principle and performance of typical terahertz sources,detectors and non-destructive testing applications. On this basis,the newdevelopment and trends of terahertz radiation detectors are also discussed. | ZHANG Weili LIANG Dachuan TIAN Zhen HAN Jiaguang GU Jianqiang HE Mingxia OUYANG Chunmei | 2016 | Instrumentation2016，3，1： | 8 |
| 4 | Terahertz surface plasmonic waves: a review显示文摘Terahertz science and technology promise many cutting-edge applications.Terahertz surface plasmonic waves that propagate at metal–dielectric interfaces deliver a potentially effective way to realize integrated terahertz devices and systems.Previous concerns regarding terahertz surface plasmonic waves have been based on their highly delocalized feature.However,recent advances in plasmonics indicate that the confinement of terahertz surface plasmonic waves,as well as their propagating behaviors,can be engineered by designing the surface environments,shapes,structures,materials,etc.,enabling a unique and fascinating regime of plasmonic waves.Together with the essential spectral property of terahertz radiation,as well as the increasingly developed materials,microfabrication,and time-domain spectroscopy technologies,devices and systems based on terahertz surface plasmonic waves may pave the way toward highly integrated platforms for multifunctional operation,implementation,and processing of terahertz waves in both fundamental science and practical applications.We present a review on terahertz surface plasmonic waves on various types of supports in a sequence of properties,excitation and detection,and applications.The current research trend and outlook of possible research directions for terahertz surface plasmonic waves are also outlined. | Xueqian Zhang Quan Xu Lingbo Xia Yanfeng Li Jianqiang Gu Zhen Tian Chunmei Ouyang Jiaguang Han Weili Zhang | 2020 | Advanced Photonics2020，2，1： | 7 |
| 5 | Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering显示文摘Dear Editor,Type1diabetes(T1D)isa lifelong(chronic)disease and a major health problem throughout the world.This disease can be treatedby either insulin injection or islet transplantation.Islet transplantation is considered as a better treatment for T1D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control. | Yi Yang Kepin Wang Han Wu Qin Jin Degong Ruan Zhen Ouyang Bentian Zhao Zhaoming Liu Yu Zhao Quanjun Zhang Nana Fan Qishuai Liu Shimei Guo Lei Bu Yong Fan Xiaofang Sun Xiaoping Li Liangxue Lai | 2016 | Journal of Molecular Cell Biology2016，8，2： | 6 |
| 6 | Hadron Physics Programs at HIRFL-CSRm: Plan and Status显示文摘 | ZHENG Chuan XIAO Zhi-Gang XU Hu-Shan XIAO Guo-Qing ZHAN Wen-Long LI Zhan-Kui DUAN Li-Min SUN Zhi-Yu YAO Nan YUAN Xiao-Hua ZHANG Xue-Ying WANG Jian-Song CHEN Ruo-Fu FAN Rui-Rui FU Fen HUANG Tian-Heng LIANG Jin-Jie OUYANG Zhen YU Yu-Hong YUE Ke ZHANG Xue-Heng ZHANG Ya-Peng LI Xi-Guo LI Jin | 2007 | 高能物理与核物理2007，31，12： | 5 |
| 7 | Atractylodes lancea rhizome water extract reduces triptolide-induced toxicity and enhances anti-inflammatory effects显示文摘The present study was designed to explore the influence of water extracts of Atractylodes lancea rhizomes on the toxicity and anti-inflammatory effects of triptolide(TP). A water extract was prepared from A. lancea rhizomes and co-administered with TP in C57BL/6 mice. The toxicity was assayed by determining serum biochemical parameters and visceral indexes and by liver histopathological analysis. The hepatic CYP3A expression levels were detected using Western blotting and RT-PCR methods. The data showed that the water extract of A. lancea rhizomes reduced triptolide-induced toxicity, probably by inducing the hepatic expression of CYP3A. The anti-inflammatory effects of TP were evaluated in mice using a xylene-induced ear edema test. By comparing ear edema inhibition rates, we found that the water extract could also increase the anti-inflammatory effects of TP. In conclusion, our results suggested that the water extract of A. lancea rhizomes, used in combination with TP, has a potential in reducing TP-induced toxicity and enhancing its anti-inflammatory effects. | WEI Yuan SUI Dan-Juan XU Hai-Miao OUYANG Zhen WU Na WANG Du-Jun ZHANG Xiao-Yan QIAN Da-Wei | 2017 | Chinese Journal of Natural Medicines2017，15，12： | 5 |
| 8 | Plasmon-induced transparency in terahertz metamaterials显示文摘The quantum phenomena of electromagnetically induced transparency(EIT)or plasmonic analogue of electromagnetically induced transparency(PIT)can be mimicked in the classical resonators,leading to a unique way to explore the coherent coupling mechanism in metamaterial systems.Various metamaterial structures have been proposed to excite and manipulate the PIT efect with flexibility and performance with geometry-controllable,polarization-independent,broadband-transparency and active-modulated characteristics.These in turn promise the fascinating functionalities and applications of the PIT efects,such as slow-light components,nonlinear devices and high-sensitivity sensors.Here,we present a review on the progress in developing the PIT efect in terahertz metamaterials over the past few years. | JING HuiHui ZHU ZhiHua ZHANG XueQian GU JianQiang TIAN Zhen OUYANG ChunMei HAN JiaGuang ZHANG WeiLi | 2013 | Science China(Information Sciences)2013，56，12： | 5 |
| 9 | Polarization-independent all-silicon dielectric metasurfaces in the terahertz regime显示文摘Dielectric metasurfaces have achieved great success in realizing high-efficiency wavefront control in the optical and infrared ranges. Here, we experimentally demonstrate several efficient, polarization-independent, all-silicon dielectric metasurfaces in the terahertz regime. The metasurfaces are composed of cylindrical silicon pillars on a silicon substrate, which can be easily fabricated using etching technology for semiconductors. By locally tailoring the diameter of the pillars, full control over abrupt phase changes can be achieved. To show the controlling ability of the metasurfaces, an anomalous deflector, three Bessel beam generators, and three vortex beam generators are fabricated and characterized. We also show that the proposed metasurfaces can be easily combined to form composite devices with extended functionalities. The proposed controlling method has promising applications in developing low-loss, ultra-compact spatial terahertz modulation devices. | HUIFANG ZHANG XUEQIAN ZHANG QUAN XU QIU WANG YUEHONG XU MINGGUI WEI YANFENG LI JIANQIANG GU ZHEN TIAN CHUNMEI OUYANG XIXIANG ZHANG CONG HU JIAGUANG HAN WEILI ZHANG | 2018 | Photonics Research2018，9，1： | 4 |
| 10 | Mechanical Properties of Small-diameter Superfine Silk Powder/Polyurethane Vascular Graft Reinforced by Tubular Knitted Fabric显示文摘In this paper,a kind of composite microtube,which is made from superfine silk powder and polyurethane,reinforced by polyster and spandex tubular fabrics,was examined.The cross-section of composite microtubes were microporous,and micropores were uniform distributed,the inner surface was relatively smooth.The results showed that the wall thickness of composite microtubes increased,which led to the strength,the breaking work and the initial modulus incresead;that the spandex content increased brought about the initial modulus and the breaking work decreased,but the breaking extension and the breaking load were firstly increased and then decreased;and all the mechanical properties decreased as the SFSP content increased. | ZHU Guo-cheng YANG Hong-jun OUYANG Chen-xi XU Wei-lin ZHANG Zhen YAN Yun | 2010 | Chinese Journal of Biomedical Engineering(English Edition)2010，19，2： | 3 |
| 11 | Generation and antitumor effects of an engineered and energized fusion protein VL-LDP-AE composed of single-domain antibody and lidamycin显示文摘Type IV collagenase plays a pivotal role in invasion, metastasis and angiogenesis of tumor. Single domain antibodies are attractive as tumor-targeting vehicle because of their much smaller size com-pared with antibody molecules produced by conventional methods. Lidamycin (LDM) is a potent enediyne-containing antitumor antibiotic. In this study an engineered and energized fusion protein VL-LDP-AE composed of lidamycin and VL domain of mAb 3G11 directed against type IV collagenase was prepared using a novel two-step method. First a VL-LDP fusion protein was constructed by DNA recombination. Secondly VL-LDP-AE was obtained by molecular reconstitution. In MTT assay, VL-LDP-AE showed potent cytotoxicity to HT-1080 cells and KB cells with IC50 values of 8.55×10-12 and 1.70×10-11 mol/L, respectively. VL-LDP-AE showed antiangiogenic activity in chick chrorioallantoic membrane (CAM) assay and tube formation assay. In in vivo experiments, VL-LDP-AE was proved to be more effective than free LDM against the growth of subcutaneously transplanted hepatoma 22 in mice. Drugs were given intravenously on day 3 and 10 after tumor transplantation. Compared in terms of maximal tolerated doses, VL-LDP-AE at 0.25 mg/kg suppressed the tumor growth by 89.5%, LDM at 0.05 mg/kg by 69.9%, and mitomycin at 1 mg/kg by 35%. Having a molecular weight of 25.2 kDa, VL-LDP-AE was much smaller than other reported antibody-based drugs. The results suggested that VL-LDP-AE would be a promising candidate for tumor targeting therapy. And the 2-step approach could serve as a new technology platform for making a series of highly potent engineered antibody-based drugs for a variety of cancers. | MIAO QingFang, SHANG BoYang, OUYANG ZhiGang, LIU XiaoYun & ZHEN YongSu Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China | 2007 | Science China(Life Sciences)2007，50，4： | 3 |
| 12 | Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice显示文摘亲爱的编辑, | Dekun Wang Qingwen Meng Lihong Huo Meng Yang Lingling Wang Xinyu Chen JianchaoWang Zhiguo Li Xiaoying Ye Na Liu Qiuyan Li Zhen Dai Hongsheng Ouyang Ning Li Jun Zhou Lingyi Chen Lin Liu | 2015 | Protein & Cell2015，6，2： | 3 |
| 13 | Three-year Follow-up on the Safety and Effectiveness of Rituximab Plus Chemotherapy as First-Line Treatment of Diffuse Large B-Cell Lymphoma and Follicular Lymphoma in Real-World Clinical Settings in China: A Prospective, Multicenter, Noninterventional Study显示文摘 | Jian-Qiu WU Yong-Ping Song Li-Ping Su Ming-Zhi Zhang Wei Li Yu Hu Xiao-Hong Zhang Yu-Huan Gao Zuo-Xing Niu Ru Feng Wei Wang Jie-Wen Peng Xiao-Lin Li Xue-Nong Ouyang Chang-Ping Wu Wei-Jing Zhang Yun Zeng Zhen Xiao Ying-Min Liang Yong-Zhi Zhuang Ji-Shi Wang Zi-Min Sun Hai Bai Tong-Jian Cui Ji-Feng Feng | 2018 | Chinese Medical Journal2018，，15： | 3 |
| 14 | Chinese research into severe ulcerative colitis has increased in quantity and complexity显示文摘AIM To investigate the current state of research output from Chinese studies into severe ulcerative colitis(SUC) using a bibliometric analysis of publications. METHODS The contents of the Chinese periodical databases WANFANG, VIP, and China National Knowledge Infrastructure were searched for all papers regarding UC or SUC published in last the 15 years (from 2001 to 2015). The number of publications in each year was recorded to assess the temporal trends of research output. All SUC related publications were downloaded and the complexity of this research was evaluated with methods described previously. The number of patients with SUC reported each year was recorded and their clinical characteristics were analyzed using information available in the relevant papers. RESULTS There were 13499 publications regarding UC published in Chinese medical journals between 2001 and 2015, of which 201 focused on SUC. The number of publications increased rapidly with more than half of all papers being published in the most recent 5-year period. There was a significant increase in analyticalstudies and clinical trials over the study period (P < 0.01), with research into the management of SUC, included pharmacotherapy, nutrition support as well as surgery, predominating. Almost half (46.2%) of the observational analytical studies and clinical trials focused on Traditional Chinese Medicine, with little research on the efficacy of cyclosporin and infliximab in disease management. About 6222 patients with SUC were reported in the 201 SUC relevant papers, with a ratio of male/female of 1.38. The number of patients reported in each 5-year period significantly increased. The colectomy rate and short-term mortality rate were 7.7% and 0.8% respectively. The most commonly employed operation was total proctocolectomy with ileal pouch-anal anastomosis.CONCLUSION The output and complexity of research related to SUC in China increased significantly over the previous 15 years, however few of these studies focused on salvage therapy. | Cheng-Xin Luo Zhong-Hui Wen Yu Zhen Zhu-Jun Wang Jing-Xi Mu Min Zhu Qin Ouyang Hu Zhang | 2018 | World Journal of Clinical Cases2018，6，3： | 2 |
| 15 | Loss of FOXC1 contributes to the corneal epithelial fate switch and pathogenesis显示文摘Forkhead box C1(FOXC1)is required for neural crest and ocular development,and mutations in FOXC1 lead to inherited Axenfeld-Rieger syndrome.Here,we find that FOXC1 and paired box 6(PAX6)are co-expressed in the human limbus and central corneal epithelium.Deficiency of FOXC1 and alternation in epithelial features occur in patients with corneal ulcers.FOXC1 governs the fate of the corneal epithelium by directly binding to lineage-specific open promoters or enhancers marked by H3K4me2.FOXC1 depletion not only activates the keratinization pathway and reprograms corneal epithelial cells into skin-like epithelial cells,but also disrupts the collagen metabolic process and interferon signaling pathways.Loss of interferon regulatory factor 1 and PAX6 induced by FOXC1 dysfunction is linked to the corneal ulcer.Collectively,our results reveal a FOXC1.mediated regulatory network responsible for corneal epithelial homeostasis and provide a potential therapeutic target for corneal ulcer. | Mingsen Li Liqiong Zhu Jiafeng Liu Huaxing Huang Huizhen Guo Li Wang Lingyu Li Sijie Gu Jieying Tan Jing Zhong Bowen Wang Zhen Mao Yong Fan Chunqiao Liu Jin Yuan Hong Ouyang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 2 |
| 16 | Generation of rat blood vasculature and hematopoietic cells in rat-mouse chimeras by blastocyst complementation显示文摘Interspecies chimera through blastocyst complementation could be an alternative approach to create human organs in animals by using human pluripotent stem cells.A mismatch of the major histocompatibility complex of vascular endothelial cells between the human and host animal will cause graft rejection in the transplanted organs.Therefore,to achieve a transplantable organ in animals without rejection,creation of vascular endothelial cells derived from humans within the organ is necessary.In this study,to explore whether donor xeno-pluripotent stem cells can compensate for blood vasculature in host animals,we generated rat-mouse chimeras by injection of rat embryonic stem cells(rESCs)into mouse blastocysts with deficiency of Flk-1 protein,which is associated with endothelial and hematopoietic cell development.We found that rESCs could differentiate into vascular endothelial and hematopoietic cells in the rat-mouse chimeras.The whole yolk sac(YS)of Flk-1^EGFP/ECFP rat-mouse chimera was full of rat blood vasculature.Rat genes related to vascular endothelial cells,arteries,and veins,blood vessels formation process,as well as hematopoietic cells,were highly expressed in the YS.Our results suggested that rat vascular endothelial cells could undergo proliferation,migration,and self-assembly to form blood vasculature and that hematopoietic cells could differentiate into B cells,T cells,and myeloid cells in rat-mouse chimeras,which was able to rescue early embryonic lethality caused by Flk-1 deficiency in mouse. | Xiaomin Wang Hui Shi Juanjuan Zhou Qingjian Zou Quanjun Zhang Shixue Gou Pengfei Chen Lisha Mou Nana Fan Yangyang Suo Zhen Ouyang Chengdan Lai Quanmei Yan Liangxue Lai | 2020 | Journal of Genetics and Genomics2020，47，5： | 2 |
| 17 | Production of transgenic pigs over-expressing theantiviral gene Mx1显示文摘The myxovirus resistance gene (Mx1) has a broad spectrum of antiviral activities. It is therefore an interestingcandidate gene to improve disease resistance in farm animals. In this study, we report the use of somatic cellnuclear transfer (SCNT) to produce transgenic pigs over-expressing the Mx1 gene. These transgenic pigs expressapproximately 15–25 times more Mx1 mRNA than non-transgenic pigs, and the protein level of Mx1 was alsomarkedly enhanced. We challenged fibroblast cells isolated from the ear skin of transgenic and control pigs withinfluenza A virus and classical swine fever virus (CFSV). Indirect immunofluorescence assay (IFA) revealed a profounddecrease of influenza A proliferation in Mx1 transgenic cells. Growth kinetics showed an approximately 10-foldreduction of viral copies in the transgenic cells compared to non-transgenic controls. Additionally, we found thatthe Mx1 transgenic cells were more resistant to CSFV infection in comparison to non-transgenic cells. These resultsdemonstrate that the Mx1 transgene can protect against viral infection in cells of transgenic pigs and indicate thatthe Mx1 transgene can be harnessed to develop disease-resistant pigs. | Quanmei Yan Huaqiang Yang Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Nana Fan Hongsheng Ouyang Weiwang Gu Liangxue Lai | 2014 | Cell Regeneration2014，3，1： | 2 |
| 18 | Organic Synthesis in Ionic Liquids: Condensation of 3-Methyl-1-phenyl-5-pyrazolone with Carbonyl Compounds Catalyzed by Ethylenediammonium Diacetate (EDDA)显示文摘An efficient and environmental benign method is reported for the condensation of 3-methyl-1-phenyl-5-pyrazolone with carbonyl compounds in ionic liquids [Bmim]BF4 and [Bmim]PF6 catalyzed by ethylenediammonium diacetate. | Yi HU Ping WEI Hua ZHOU Ping Kai OUYANG Zhen Chu CHEN | 2006 | Chinese Chemical Letters2006，17，3： | 1 |
| 19 | Analysis of vibration intensity over criterion of a diesel engine based on vibration theory and experiment measurements显示文摘 | LIU Zhen GAO Hongbin OUYANG Guangyao | 2007 | ICEMI 2007:Proceedings of 2007 8th International Conference on Electronic Measurement & Instruments2007，1，： | 1 |
| 20 | In vivo pharmacokinetic comparisons of ferulic acid and puerarin after oral administration of monomer, medicinal substance aqueous extract and Nao-De-Sheng to rats显示文摘 | Zhen Ouyang Ming Zhao Jianming Tang Lulin Pan | 2012 | Pharmacognosy Magazine2012，，32： | 1 |
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