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| 1 | miR-21 promotes the differentiation of hair folliclederived neural crest stem cells into Schwann cells显示文摘Hair follicle-derived neural crest stem cells can be induced to differentiate into Schwann cells in vivo and in vitro. However, the underlying regulatory mechanism during cell differentiation remains poorly understood. This study isolated neural crest stem cells from human hair follicles and induced them to differentiate into Schwann cells. Quantitative RT-PCR showed that microRNA(miR)-21 expression was gradually increased during the differentiation of neural crest stem cells into Schwann cells. After transfection with the miR-21 agonist(agomir-21), the differentiation capacity of neural crest stem cells was enhanced. By contrast, after transfection with the miR-21 antagonist(antagomir-21), the differentiation capacity was attenuated. Further study results showed that SOX-2 was an effective target of miR-21. Without compromising SOX2 mRNA expression, miR-21 can down-regulate SOX protein expression by binding to the 3′-UTR of miR-21 mRNA. Knocking out the SOX2 gene from the neural crest stem cells significantly reversed the antagomir-21 inhibition of neural crest stem cells differentiating into Schwann cells. The results suggest that miR-21 expression was increased during the differentiation of neural crest stem cells into Schwann cells and miR-21 promoted the differentiation through down-regulating SOX protein expression by binding to the 3′-UTR of SOX2 mRNA. | Yuxin Ni Kaizhi Zhang Xuejuan Liu Tingting Yang Baixiang Wang Li Fu Lan A Yanmin Zhou | 2014 | Neural Regeneration Research2014，9，8： | 9 |
| 2 | Electrochemical Deposition of Zirconia Films on Diamond, Electrochemical and Solid-State Letters 显示文摘 | Baixiang Liu Jingping Hu John s Foord | 2011 | 14(2) : D20-D222011，14，2： | 1 |
| 3 | Geology of the Sandaowanzi telluride gold deposit of the northern Great Xing'an Range, NE China: Geochronology and tectonic controls 显示文摘 | Liu Junlai Dong Baixiang Zhao Shenjing | 2011 | Journal of Asian Earth Sciences2011，41，2： | 1 |
| 4 | Flow injection solid-phase extraction using multi-walled carbon nanotubes packed micro-column for the determination of polycyclic aromatic hydrocarbons in water by gas chromatography–mass spectrometry显示文摘 | Hong Wu Xuecui Wang Bing Liu Jie Lu Baixiang Du Luxin Zhang Jingjing Ji Qiaoyu Yue Baoping Han | 2010 | Journal of Chromatography A2010，，17： | 1 |
| 5 | Benidipine-loaded nanoflower-likemagnesium silicate improves bone regeneration显示文摘Regeneration and reconstruction of bone tissue is always a challenge for clinicians due to the uncertainty of bone repair materials in terms of long-term and efficient effects on osteoblasts.Here,we propose a novel strategy combining benidipine,an antihypertensive drug and nanoparticles to synergistically promote the healing of bone defects.Loose and porous benidipine-loaded magnesium silicate nanoparticles were prepared and validated for their biosafety.The nanoparticles were efficiently taken up by preosteoblasts and uniformly distributed around the nucleus.After internalization into cells,the nanosystem is degraded by lysosomes,and the effect of promoting osteogenic differentiation is reflected by the continuous release of benidipine,silicon and magnesium ions.Our results clearly evaluated that the nanoflower-like magnesium silicate delivering benidipine tends to be more appropriate for the bone regeneration in preosteoblasts,indicating that it might be a potential approach in guiding bone repair in clinical applications. | Jingyi Lu Miao Sun Jingyu Zhang Xiaofu Yang Minyi Dong Huihui He An Liu Mengfei Yu Baixiang Wang Huiming Wang | 2023 | Bio-Design and Manufacturing2023，6，5： | 0 |
| 6 | Research on cross-chain and interoperability for blockchain system显示文摘At present, there is an urgent need for blockchain interoperability technology to realize interconnection between various blockchains, data communication and value transfer between blockchains, so as to break the ‘value silo’ phenomenon of each blockchain. Firstly, it lists what people understand about the concept of interoperability. Secondly, it gives the key technical issues of cross-chain, including cross-chain mechanism, interoperability, eventual consistency, and universality. Then, the implementation of each cross-chain key technology is analyzed, including Hash-locking, two-way peg, notary schemes, relay chain scheme, cross-chain protocol, and global identity system. Immediately after that, five typical cross-chain systems are introduced and comparative analysis is made. In addition, two examples of cross-chain programmability and their analysis are given. Finally, the current state of cross-chain technology is summarized from two aspects: key technology implementation and cross-chain application enforcement. The cross-chain technology as a whole has formed a centralized fixed mechanism, as well as a trend of modular design, and some of the solutions to mature applications were established in the relevant standards organizations, and the cross-chain technology architecture tends to be unified, which is expected to accelerate the evolution of the open cross-chain network that supports the real needs of the interconnection of all chains. | Li Ming Qiu Honglin Xu Quanqing Song Wenpeng Liu Baixiang | 2021 | The Journal of China Universities of Posts and Telecommunications2021，28，5： | 0 |
| 7 | Trusted data access and authorization protocol显示文摘Threshold proxy re-encryption(PRE) authorizes the data access right of data subject to multiple proxies, who authorize the right again to delegatee to accomplish the end-to-end data encryption process from storage to authorization. Based on threshold PRE algorithm, in order to build a complete trusted data storage and authorization system, the four protocols, which are data access protocol, authorization proxy protocol, authorization proxy cancellation protocol and data reading authorization protocol, are defined completely. On that basis, an efficient data searching method is constructed by specifying the data delegatee. At last, to ensure the right to know of data, the audit log is processed with trusted data right confirmation based on distributed ledger technology. Meanwhile, a parallel data right confirmation processing method is defined based on hierarchical derivation algorithm of public and private key. In the end, the performance evaluation analysis of the protocol are given. Trusted data access and authorization protocol is convenient to build a complete data processing system on the premise of protecting data privacy based on public cloud storage system or distributed storage system. | Song Wenpeng Li Ming Liu Baixiang | 2021 | The Journal of China Universities of Posts and Telecommunications2021，28，5： | 0 |
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