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| 1 | A metabonomic investigation on the biochemical perturbation in liver failure patients caused by hepatitis b virus显示文摘 | Yu, K Sheng, GP Sheng, JF Chen, YM Xu, W Liu, XL Cao, HC Qu, HB Cheng, YY Li, LJ | 2007 | 中国生物学文摘2007，21，11： | 25 |
| 2 | Up-regulation of PIK3CA promotes metastasis in gastric carcinoma显示文摘AIM:To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase(PI3K)/Akt pathway.METHODS:mRNA and protein levels of PIK3CA were assessed,respectively,by real-time quantitative polymerase chain reaction and immunohistochemistry in specimens of normal gastric mucosa,primary foci and lymph node and distant metastasis of gastric cancer.Akt and phosphorylated Akt protein were also examined by Western blotting in these tissues,in order to analyze the effect of PIK3CA expression level changes on the activation of PI3K/Akt signaling pathway.RESULTS:PIK3CA mRNA in lymph node metastasis were approximately 5 and 2 folds higher,respectively,than that in the corresponding normal gastric mucosa and primary gastric cancer tissues(P<0.05),while no statistical significance was found compared with distant metastasis.Immunohistochemically,PIK3CA protein expression was discovered in 7(35%)specimens of 20 primary foci vs 10(67%)of 15 of lymph node metastasis or 11(61%)of 18 of distant metastasis(35%vs 67%,P=0.015;35%vs 61%,P=0.044).With the increased level of PIK3CA expression,the total Akt protein expression remained almost unchanged,but p-Akt protein was upregulated markedly.CONCLUSION:Increased expression of PIK3CA is expected to be a promising indicator of metastasis in gastric cancer.Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling. | Liu JF Zhou XK Chen JH Yi G Chen HG Ba MC Lin SQ Qi YC. | 2010 | World Journal of Gastroenterology2010，16，39： | 20 |
| 3 | Study and Application of Polarographic Catalytic Wave of Chlordiazepoxide in the Presence of Persulfate显示文摘Polarographic catalytic wave of chlordiazepoxide in the presence of K2S2O8 was studied in aqueous and DMF/H2O mixed solutions,The results showed that a single reduction wave in alkaline medium was the reduction of the N=C bond in 1,2-position of chlordiazepoxide via an intermediate free radical in two one-electron successive additions,When K2S2O8 was present,the free radical of the N=C bond was oxidized to regenerate the original,producing a parallel catalytic wave of chlordiazepoxide,It was determined that the apparent rate constant kf of the oxidation reaction was 3.2×10^3 mol^-1.L.s^-1,Using the catalytic wave the trace of chlordiazepoxide can be determined by linear-potential scan polarography,In NH3/NH4Cl(pH 10.2±0.1,0.12mol/L)/K2S2O8(0.016mol/L)supporting electrolyte,the second-order derivative peak current of the catalytic wave was rectilinear to chlordiazepoxide concentration in the range of 3.20×10^-8-1.60×10^-7,1.60×10^-7-1.44×10^-6 and 1.44×10^-6-1.44×10^-5mol/L,respectively.The limit of detection was 9.0×10^-9mol/L. | Guo, W Lin, H Liu, LM Guo, ZA Song, JF | 2002 | Chinese Journal of Chemistry2002，20，5： | 3 |
| 4 | Rapamycin inhibits cell growth by induction of apoptosis on hepatocellular carcinoma cells in vitro显示文摘 | Zhang JF Liu JJ Lu MQ | 2007 | Transpl Immunol2007，17，3： | 1 |
| 5 | Identification of a new HLA-A ^*0201-restricted cytotoxic T lymphocyte epitope from CML28 显示文摘 | Han JF Zhao TT Liu HL | 2006 | Cancer Immunol Immunother2006，55，12： | 1 |
| 6 | Assessing the effect of land use/ land cover change on the change of urban heat island intensity显示文摘 | JF He JY Liu DF Zhang | 2007 | Theor Appl Climatol2007，，： | 1 |
| 7 | The sweet potato sporamin promoter confers high- level phytase expression and improves organic phosphorus acquisition and tuber yield of transgenic potato 显示文摘 | Hong YF Liu CY Cheng KJ Hour AL Chan MT Tseng TH Chert KY Shaw JF Yu SM | 2008 | Plant Mol Biol2008，67，： | 1 |
| 8 | Expression and prognostic significance of EphA2 and EphrinA- 1 in ovarian serous carcinomas显示文摘 | Han LP Liu JF Liu XR | 2011 | Sichuan Da Xue Xue Bao Yi Xue Ban2011，42，2： | 1 |
| 9 | Characteristics of premaxillary supernumerary teeth: a survey of 112 cases 显示文摘 | Liu JF | 1995 | ASDC J Child1995，62，4： | 1 |
| 10 | Annealing hardening in detwinning deformation of Mg-3AHZn alloy显示文摘 | YC Xin XJ Zhou HW Chen JF Nie H Zhang YY Zhang Qg Liu | 2014 | Materials Science and Engineering:A2014，594，： | 1 |
| 11 | Phosphate ion targeted colorimetrie and fluorescent probe and its use to monitor endogeneous phosphate ion in a hemichannel-closed cell 显示文摘 | Goo LE Zhang JF Liu XY | 2015 | Analytical Chemistry2015，87，： | 1 |
| 12 | Uptake and conversion of carbonyl sulfide in a lawn soil显示文摘 | Liu JF Mu YJ Geng CM | 2007 | Atmospheric Environment2007，41，： | 1 |
| 13 | FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway 显示文摘 | Liu JF Crepin M Liu JM | 2002 | Biochem Biophys Res Commun2002，293，4： | 1 |
| 14 | Prediction of Alzheimer's disease in mild cognitive impairment: A prospective study in Taiwan显示文摘 | Wang PN Limg JF Lin KN Chang FC Liu HC | 2006 | 中国生物学文摘2006，20，8： | 1 |
| 15 | Correlation of magnetic resonance images with neuropathology in acute Wernicke's encephalopathy显示文摘 | Liu YT Fuh JL Lirng JF | 2006 | Clin Neurol Neurosurg2006，108，7： | 1 |
| 16 | Comparing the autoantibody levels and clinical efficacy of double filtration plasmapheresis,immunoadsorption,and intravenous immunoglobulin for the treatment of late-onset myasthenia gravis显示文摘 | Liu JF Wang WX Xue J | 2010 | Ther Apher Dial2010，14，2： | 1 |
| 17 | Characteristics of premaxillary supernumerary teeth:a survey of 112 cases显示文摘 | Liu JF | 1995 | ASDC J Dent Child1995，62，4： | 1 |
| 18 | Guided migration of neu- ral stem cells derived from human embryonic stem cells by an electric field显示文摘 | Feng JF Liu J Zhang XZ | 2012 | Stem Cells2012，30，2： | 1 |
| 19 | Value of ultra-guided biopsy for diagnosing diffuse breast lesions显示文摘 | Liu AL Liu RH Fu JF | 2001 | Chinese J Ultrasound Med(Chinese)2001，17，： | 1 |
| 20 | Henrylactones A-E and an-ti-HBV constituents from Illicium henryi 显示文摘 | Liu JF Jiang ZY Zhang Q | 2010 | Planta Med2010，76，： | 1 |
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